GREMLIN Database
PhaC_N - Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus
PFAM: PF07167 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 173 (170)
Sequences: 15323 (8426)
Seq/√Len: 646.2
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_R132_E4.7081.00
112_E115_R4.3971.00
75_T82_N3.3131.00
164_S167_N3.0741.00
73_R77_E2.8771.00
7_D70_E2.8411.00
78_T85_R2.7261.00
81_E85_R2.7211.00
65_L71_V2.6661.00
74_R77_E2.5441.00
64_F67_T2.3651.00
74_R78_T2.3021.00
9_A73_R2.3001.00
126_F131_I2.2751.00
123_K137_A2.2741.00
121_P139_T2.1841.00
35_D49_R2.1341.00
169_L173_L2.0721.00
7_D73_R2.0691.00
112_E116_N2.0351.00
8_P12_E2.0121.00
139_T171_R1.9631.00
27_A56_L1.9231.00
41_D44_T1.9121.00
128_N131_I1.8501.00
75_T83_L1.8141.00
166_E171_R1.8051.00
28_R32_D1.7761.00
3_R6_A1.7531.00
30_L52_T1.7201.00
92_E96_R1.6761.00
78_T82_N1.6751.00
85_R88_R1.5411.00
136_Y158_Y1.4581.00
53_R57_D1.4551.00
17_D21_Q1.4421.00
113_V119_T1.4311.00
34_V52_T1.4261.00
31_Q49_R1.4121.00
31_Q53_R1.3911.00
65_L83_L1.3871.00
42_P46_R1.3341.00
13_N16_F1.3331.00
17_D20_K1.3291.00
11_Q20_K1.3181.00
16_F72_L1.3161.00
22_S26_T1.2891.00
43_H46_R1.2891.00
121_P137_A1.2811.00
96_R108_E1.2741.00
167_N171_R1.2531.00
23_Y27_A1.2441.00
16_F67_T1.2411.00
113_V117_L1.2341.00
104_S108_E1.2231.00
95_E103_I1.2181.00
87_L91_L1.2041.00
46_R49_R1.1971.00
32_D36_D1.1931.00
73_R76_L1.1821.00
65_L72_L1.1771.00
90_L94_L1.1741.00
40_L44_T1.1671.00
92_E104_S1.1581.00
81_E84_V1.1491.00
13_N17_D1.1301.00
31_Q35_D1.1081.00
150_I170_V1.0851.00
76_L79_G1.0761.00
43_H47_R1.0511.00
71_V82_N1.0491.00
137_A141_E1.0401.00
91_L95_E1.0391.00
107_D110_A1.0371.00
153_P156_N1.0351.00
96_R104_S1.0261.00
30_L56_L1.0221.00
44_T47_R1.0191.00
111_F116_N1.0171.00
89_N92_E1.0131.00
45_R49_R1.0131.00
35_D45_R1.0041.00
84_V88_R1.0031.00
99_G103_I1.0021.00
28_R31_Q0.9861.00
155_I160_I0.9721.00
26_T30_L0.9671.00
119_T165_P0.9591.00
88_R92_E0.9541.00
164_S171_R0.9541.00
21_Q24_L0.9541.00
113_V116_N0.9441.00
72_L75_T0.9431.00
120_T171_R0.9351.00
18_F22_S0.9341.00
150_I169_L0.9141.00
71_V83_L0.9121.00
120_T139_T0.9101.00
27_A31_Q0.9091.00
140_T143_V0.9081.00
75_T78_T0.9041.00
148_L173_L0.9031.00
92_E95_E0.9021.00
135_Q143_V0.8971.00
150_I161_L0.8911.00
42_P45_R0.8821.00
30_L33_A0.8791.00
37_V40_L0.8601.00
20_K24_L0.8581.00
122_G134_I0.8521.00
55_L59_L0.8511.00
74_R82_N0.8441.00
161_L169_L0.8371.00
115_R119_T0.8291.00
70_E74_R0.8241.00
85_R89_N0.8211.00
5_F23_Y0.8161.00
26_T29_W0.8151.00
94_L98_G0.8111.00
120_T136_Y0.8091.00
126_F133_L0.8081.00
102_R105_Q0.8061.00
123_K135_Q0.7931.00
49_R53_R0.7881.00
34_V49_R0.7861.00
34_V48_V0.7841.00
29_W33_A0.7841.00
112_E119_T0.7691.00
51_A55_L0.7681.00
15_L19_L0.7681.00
33_A37_V0.7671.00
40_L45_R0.7641.00
151_V172_W0.7591.00
126_F129_E0.7581.00
9_A70_E0.7521.00
9_A12_E0.7501.00
27_A57_D0.7501.00
21_Q25_L0.7311.00
154_W160_I0.7191.00
94_L97_G0.7181.00
8_P11_Q0.7161.00
99_G102_R0.7151.00
56_L59_L0.7151.00
107_D116_N0.7141.00
47_R51_A0.7101.00
32_D35_D0.7091.00
5_F24_L0.7081.00
87_L90_L0.7051.00
103_I106_T0.7021.00
72_L76_L0.7001.00
90_L97_G0.6941.00
142_K145_A0.6901.00
71_V75_T0.6891.00
68_N72_L0.6881.00
50_F54_Q0.6881.00
34_V37_V0.6881.00
31_Q56_L0.6841.00
102_R108_E0.6761.00
20_K62_S0.6741.00
141_E145_A0.6741.00
38_E45_R0.6731.00
27_A34_V0.6711.00
70_E73_R0.6691.00
146_R153_P0.6651.00
83_L87_L0.6651.00
131_I152_P0.6631.00
150_I155_I0.6621.00
44_T55_L0.6601.00
9_A13_N0.6601.00
2_D5_F0.6591.00
25_L28_R0.6591.00
97_G103_I0.6571.00
91_L94_L0.6541.00
154_W161_L0.6531.00
117_L164_S0.6521.00
105_Q108_E0.6481.00
18_F26_T0.6461.00
13_N18_F0.6391.00
25_L29_W0.6361.00
110_A116_N0.6311.00
124_V134_I0.6301.00
148_L169_L0.6241.00
54_Q57_D0.6221.00
152_P155_I0.6221.00
87_L95_E0.6191.00
46_R51_A0.6181.00
154_W170_V0.6161.00
151_V154_W0.6131.00
19_L26_T0.6121.00
16_F20_K0.6121.00
135_Q140_T0.6111.00
12_E73_R0.6101.00
27_A32_D0.6081.00
112_E117_L0.6081.00
84_V87_L0.6001.00
151_V161_L0.5951.00
113_V118_A0.5951.00
117_L167_N0.5951.00
11_Q17_D0.5941.00
165_P171_R0.5931.00
96_R102_R0.5921.00
19_L23_Y0.5921.00
146_R154_W0.5921.00
130_L154_W0.5911.00
89_N104_S0.5901.00
48_V52_T0.5901.00
49_R52_T0.5891.00
5_F62_S0.5891.00
2_D62_S0.5851.00
9_A77_E0.5831.00
26_T56_L0.5831.00
74_R85_R0.5831.00
19_L67_T0.5821.00
15_L22_S0.5741.00
57_D62_S0.5721.00
137_A142_K0.5691.00
34_V56_L0.5621.00
131_I149_L0.5621.00
66_L72_L0.5601.00
13_N19_L0.5581.00
95_E99_G0.5561.00
26_T59_L0.5561.00
120_T158_Y0.5561.00
34_V40_L0.5511.00
148_L160_I0.5491.00
52_T56_L0.5491.00
30_L34_V0.5461.00
97_G102_R0.5441.00
156_N160_I0.5441.00
37_V48_V0.5431.00
146_R156_N0.5391.00
107_D111_F0.5381.00
57_D160_I0.5371.00
11_Q14_P0.5350.99
134_I158_Y0.5330.99
23_Y26_T0.5310.99
78_T81_E0.5300.99
9_A62_S0.5250.99
71_V74_R0.5240.99
143_V146_R0.5220.99
146_R150_I0.5210.99
106_T109_S0.5170.99
109_S116_N0.5160.99
14_P18_F0.5150.99
155_I161_L0.5130.99
55_L58_A0.5110.99
111_F117_L0.5100.99
92_E106_T0.5100.99
117_L163_L0.5080.99
15_L18_F0.5060.99
170_V173_L0.5050.99
150_I160_I0.5030.99
59_L64_F0.5020.99
66_L71_V0.5010.99
119_T164_S0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ee4A 2 0.3699 26.6 0.955 Contact Map
3nrdA 5 0.341 14.8 0.96 Contact Map
4q34A 2 0.4162 8.3 0.964 Contact Map
3au4A 1 0.341 7.4 0.965 Contact Map
3icvA 2 0.4335 6.1 0.966 Contact Map
2bbhA 2 0.3121 5.1 0.967 Contact Map
3czqA 3 0.4682 4.5 0.968 Contact Map
2hn1A 2 0.289 4.5 0.968 Contact Map
3j7yW 1 0.4509 4.3 0.968 Contact Map
4ujqJ 1 0.2659 4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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