GREMLIN Database
DUF1385 - Protein of unknown function (DUF1385)
PFAM: PF07136 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 227 (226)
Sequences: 9385 (5815)
Seq/√Len: 386.8
META: 0.909

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_R212_D4.7961.00
118_E128_Y4.6441.00
126_R215_L3.8671.00
109_K209_E3.7841.00
197_A201_W3.4921.00
118_E127_K3.0531.00
118_E124_N2.9731.00
121_T124_N2.8121.00
131_L204_R2.7421.00
183_L187_H2.6501.00
102_Q214_Q2.6151.00
116_A128_Y2.5781.00
23_F27_V2.5191.00
43_A47_V2.4561.00
125_V215_L2.4291.00
122_V212_D2.4201.00
89_W93_R2.3641.00
125_V219_I2.1461.00
220_A223_K2.1061.00
93_R98_R2.0231.00
51_A55_G1.9751.00
84_F144_M1.8731.00
45_T49_S1.8561.00
59_L163_I1.7721.00
99_R211_D1.7441.00
142_I181_I1.7241.00
190_P194_I1.6961.00
220_A224_A1.6861.00
184_A196_S1.6861.00
141_L202_L1.6421.00
124_N127_K1.6351.00
110_T222_L1.6341.00
9_A13_S1.6291.00
47_V51_A1.6191.00
190_P193_R1.6071.00
98_R208_R1.6061.00
38_S41_A1.5911.00
119_P124_N1.5751.00
63_L67_L1.5731.00
189_N192_V1.5641.00
3_F175_G1.5411.00
97_I100_V1.5231.00
113_A125_V1.5111.00
39_G43_A1.5041.00
15_V19_K1.4901.00
165_S168_L1.4881.00
110_T125_V1.4681.00
22_N26_N1.4571.00
46_V50_L1.4431.00
54_I59_L1.4191.00
98_R102_Q1.4111.00
201_W204_R1.4101.00
130_T209_E1.4041.00
59_L63_L1.4041.00
169_L172_V1.3881.00
123_E212_D1.3861.00
93_R208_R1.3621.00
91_I97_I1.3611.00
50_L54_I1.3591.00
77_G148_I1.3491.00
91_I101_F1.3481.00
102_Q211_D1.3481.00
26_N29_L1.3401.00
112_N133_P1.3311.00
40_W44_L1.3291.00
122_V126_R1.3101.00
18_M22_N1.3021.00
150_V176_I1.3021.00
55_G59_L1.2961.00
99_R102_Q1.2951.00
86_G90_L1.2841.00
110_T219_I1.2751.00
85_L89_W1.2611.00
161_L164_L1.2601.00
181_I184_A1.2431.00
76_E166_R1.2421.00
90_L93_R1.2381.00
141_L145_V1.2371.00
3_F7_V1.2281.00
102_Q208_R1.2271.00
63_L66_S1.1961.00
95_K98_R1.1911.00
7_V11_I1.1851.00
164_L168_L1.1811.00
70_L73_N1.1751.00
122_V219_I1.1641.00
41_A44_L1.1601.00
193_R197_A1.1521.00
65_T75_V1.1271.00
55_G60_L1.1231.00
183_L192_V1.1201.00
84_F88_L1.1171.00
112_N131_L1.1031.00
113_A124_N1.0981.00
11_I15_V1.0901.00
222_L226_L1.0861.00
148_I152_S1.0821.00
56_L83_I1.0761.00
62_L162_R1.0761.00
149_L153_L1.0721.00
92_S208_R1.0641.00
71_L74_L1.0631.00
140_L144_M1.0541.00
40_W43_A1.0511.00
126_R209_E1.0491.00
65_T72_F1.0471.00
112_N130_T1.0461.00
160_W164_L1.0451.00
113_A118_E1.0371.00
110_T218_A1.0311.00
90_L94_M1.0301.00
83_I86_G1.0191.00
46_V49_S1.0101.00
112_N129_S1.0061.00
74_L78_L1.0041.00
138_S184_A1.0011.00
44_L48_L0.9951.00
64_L67_L0.9841.00
52_L56_L0.9811.00
9_A178_Y0.9771.00
37_L41_A0.9771.00
187_H192_V0.9661.00
81_L144_M0.9611.00
64_L83_I0.9551.00
82_A86_G0.9481.00
146_V177_S0.9451.00
158_S161_L0.9451.00
7_V175_G0.9411.00
156_R162_R0.9411.00
4_L7_V0.9241.00
146_V173_I0.9241.00
44_L47_V0.9081.00
143_V177_S0.9061.00
54_I58_F0.9061.00
86_G89_W0.9061.00
154_L165_S0.9021.00
112_N116_A0.9011.00
42_M45_T0.9001.00
20_A23_F0.8841.00
8_V12_E0.8831.00
85_L202_L0.8831.00
181_I185_G0.8771.00
130_T204_R0.8661.00
18_M46_V0.8651.00
78_L82_A0.8621.00
161_L165_S0.8611.00
56_L60_L0.8591.00
194_I197_A0.8581.00
3_F176_I0.8561.00
154_L169_L0.8551.00
147_S151_F0.8551.00
180_L195_L0.8391.00
3_F172_V0.8371.00
113_A128_Y0.8331.00
215_L218_A0.8321.00
36_K40_W0.8301.00
112_N128_Y0.8281.00
142_I199_G0.8281.00
62_L76_E0.8221.00
205_L208_R0.8211.00
27_V30_E0.8191.00
80_R166_R0.8171.00
39_G42_M0.8111.00
162_R166_R0.8101.00
162_R165_S0.8041.00
62_L72_F0.8021.00
64_L79_I0.8001.00
113_A116_A0.7971.00
196_S200_L0.7941.00
99_R213_D0.7941.00
88_L101_F0.7891.00
142_I177_S0.7841.00
89_W92_S0.7821.00
133_P193_R0.7781.00
16_L19_K0.7781.00
120_L125_V0.7781.00
150_V173_I0.7741.00
92_S205_L0.7741.00
22_N42_M0.7721.00
37_L40_W0.7701.00
142_I180_L0.7701.00
12_E16_L0.7691.00
155_G158_S0.7611.00
191_L194_I0.7551.00
50_L53_A0.7531.00
58_F62_L0.7531.00
73_N155_G0.7521.00
143_V173_I0.7481.00
213_D216_E0.7461.00
3_F8_V0.7451.00
176_I180_L0.7441.00
156_R165_S0.7401.00
138_S142_I0.7381.00
155_G162_R0.7341.00
22_N46_V0.7321.00
212_D215_L0.7301.00
92_S101_F0.7301.00
110_T114_Y0.7231.00
112_N125_V0.7231.00
7_V10_L0.7231.00
1_L4_L0.7231.00
26_N30_E0.7231.00
80_R147_S0.7201.00
109_K126_R0.7191.00
188_D193_R0.7131.00
42_M46_V0.7051.00
119_P223_K0.7031.00
157_P160_W0.7021.00
93_R101_F0.6960.99
48_L52_L0.6920.99
109_K215_L0.6910.99
91_I94_M0.6910.99
131_L200_L0.6910.99
75_V79_I0.6890.99
53_A58_F0.6860.99
3_F10_L0.6860.99
99_R214_Q0.6830.99
72_F162_R0.6830.99
41_A45_T0.6820.99
81_L85_L0.6810.99
141_L200_L0.6810.99
155_G165_S0.6800.99
13_S111_I0.6800.99
120_L219_I0.6780.99
114_Y222_L0.6770.99
102_Q213_D0.6740.99
146_V180_L0.6730.99
221_A224_A0.6720.99
84_F148_I0.6710.99
146_V150_V0.6680.99
60_L83_I0.6670.99
4_L8_V0.6640.99
57_F87_Y0.6540.99
91_I100_V0.6530.99
80_R144_M0.6510.99
146_V176_I0.6500.99
113_A121_T0.6480.99
109_K129_S0.6460.99
151_F170_L0.6450.99
94_M97_I0.6440.99
192_V196_S0.6400.99
181_I196_S0.6390.99
145_V149_L0.6330.99
109_K130_T0.6310.99
219_I223_K0.6310.99
31_E34_E0.6300.99
60_L63_L0.6300.99
89_W205_L0.6300.99
66_S159_L0.6280.99
188_D192_V0.6270.99
26_N37_L0.6230.99
124_N128_Y0.6180.99
2_P5_R0.6160.99
85_L205_L0.6160.99
112_N138_S0.6120.99
62_L166_R0.6110.99
13_S182_R0.6110.99
1_L8_V0.6070.99
185_G196_S0.6050.99
69_S73_N0.6010.99
25_A28_A0.6000.99
211_D214_Q0.6000.99
58_F170_L0.6000.99
189_N194_I0.5990.98
69_S157_P0.5960.98
138_S199_G0.5950.98
93_R96_D0.5920.98
49_S52_L0.5920.98
159_L162_R0.5910.98
70_L74_L0.5900.98
122_V128_Y0.5890.98
16_L20_A0.5880.98
153_L157_P0.5870.98
114_Y226_L0.5850.98
112_N222_L0.5840.98
144_M147_S0.5830.98
73_N76_E0.5810.98
143_V147_S0.5800.98
222_L225_V0.5790.98
15_V42_M0.5790.98
64_L68_L0.5780.98
60_L64_L0.5770.98
25_A29_L0.5750.98
157_P162_R0.5740.98
182_R186_R0.5730.98
95_K102_Q0.5720.98
63_L163_I0.5700.98
111_I114_Y0.5650.98
119_P122_V0.5640.98
21_L24_S0.5600.98
143_V174_A0.5580.98
23_F26_N0.5570.98
68_L75_V0.5570.98
108_H135_C0.5570.98
72_F156_R0.5560.98
154_L157_P0.5540.98
15_V18_M0.5540.98
111_I222_L0.5530.97
62_L65_T0.5500.97
89_W208_R0.5490.97
14_L18_M0.5490.97
165_S169_L0.5480.97
18_M50_L0.5480.97
134_R185_G0.5480.97
62_L156_R0.5470.97
65_T166_R0.5460.97
149_L152_S0.5460.97
29_L33_E0.5460.97
65_T76_E0.5440.97
177_S181_I0.5430.97
151_F155_G0.5430.97
197_A204_R0.5410.97
26_N36_K0.5360.97
138_S196_S0.5350.97
21_L100_V0.5310.97
69_S155_G0.5300.97
89_W101_F0.5290.97
35_E40_W0.5280.97
52_L83_I0.5270.97
73_N152_S0.5270.97
169_L173_I0.5200.96
104_H107_E0.5190.96
104_H108_H0.5190.96
197_A200_L0.5170.96
184_A192_V0.5150.96
62_L163_I0.5150.96
35_E39_G0.5140.96
150_V169_L0.5140.96
53_A87_Y0.5130.96
72_F76_E0.5110.96
30_E33_E0.5100.96
74_L149_L0.5100.96
58_F80_R0.5100.96
73_N166_R0.5080.96
133_P185_G0.5050.96
183_L195_L0.5050.96
45_T48_L0.5030.96
36_K39_G0.5030.96
116_A130_T0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zdmA 4 0.1894 6.6 0.961 Contact Map
4gofA 2 0.1674 5.5 0.963 Contact Map
4k5yA 1 0.3921 3.8 0.965 Contact Map
3j1zP 8 0.8414 3.6 0.965 Contact Map
3r84A 2 0.2335 3.2 0.967 Contact Map
3bijA 5 0.2687 3.1 0.967 Contact Map
4qr2A 2 0.2467 2.6 0.968 Contact Map
2m20A 2 0.2511 2.2 0.969 Contact Map
4p6vB 1 0.3568 2.2 0.969 Contact Map
3fxdA 1 0.0837 2.1 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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