GREMLIN Database
DUF1376 - Protein of unknown function (DUF1376)
PFAM: PF07120 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (84)
Sequences: 11254 (9445)
Seq/√Len: 1030.5
META: 0.963

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_H27_R4.2851.00
10_Y22_H3.3451.00
26_L30_D2.8741.00
5_F26_L2.5651.00
19_L23_G2.0721.00
5_F30_D1.9611.00
7_I30_D1.8581.00
21_E63_A1.8431.00
77_R82_D1.7251.00
18_T21_E1.7111.00
12_A34_L1.6751.00
32_Y81_L1.6381.00
8_G34_L1.6371.00
61_V65_L1.6321.00
32_Y82_D1.6181.00
8_G12_A1.5731.00
80_R84_E1.5441.00
6_Y9_D1.5291.00
72_T77_R1.4731.00
31_H35_T1.4651.00
57_W61_V1.4541.00
41_D71_L1.4421.00
38_P75_G1.4381.00
20_E56_E1.3951.00
15_A51_G1.3541.00
19_L52_A1.2961.00
3_Y30_D1.2921.00
19_L27_R1.2831.00
19_L24_A1.2571.00
29_L81_L1.2431.00
11_L30_D1.2291.00
9_D80_R1.2111.00
43_D61_V1.1871.00
3_Y7_I1.1741.00
54_T58_R1.1681.00
33_W81_L1.1341.00
20_E60_A1.0761.00
22_H51_G1.0731.00
11_L15_A1.0611.00
10_Y27_R1.0131.00
22_H26_L1.0081.00
43_D62_E0.9961.00
45_R49_I0.9901.00
72_T75_G0.9801.00
16_H67_E0.9701.00
78_N81_L0.9661.00
45_R63_A0.9601.00
31_H49_I0.9511.00
5_F10_Y0.9331.00
15_A31_H0.9201.00
32_Y68_F0.9111.00
24_A60_A0.8811.00
4_P84_E0.8721.00
19_L22_H0.8671.00
16_H45_R0.8661.00
21_E60_A0.8421.00
7_I34_L0.8381.00
19_L50_A0.8331.00
47_A54_T0.8191.00
10_Y26_L0.8161.00
10_Y14_T0.8121.00
13_D34_L0.8051.00
32_Y77_R0.7961.00
70_T79_K0.7921.00
62_E66_A0.7881.00
63_A67_E0.7831.00
71_L76_W0.7741.00
43_D47_A0.7731.00
41_D76_W0.7631.00
20_E23_G0.7591.00
64_V68_F0.7581.00
7_I11_L0.7541.00
53_S56_E0.7521.00
65_L68_F0.7511.00
7_I33_W0.7491.00
42_D45_R0.7431.00
29_L33_W0.7411.00
55_K59_K0.7411.00
70_T76_W0.7361.00
65_L76_W0.7261.00
79_K83_E0.7261.00
16_H31_H0.7221.00
28_L50_A0.7151.00
16_H35_T0.7121.00
32_Y38_P0.7071.00
3_Y33_W0.7061.00
11_L34_L0.7041.00
43_D57_W0.6981.00
33_W85_I0.6881.00
43_D58_R0.6821.00
25_Y29_L0.6771.00
10_Y29_L0.6751.00
39_L46_L0.6671.00
47_A50_A0.6541.00
17_L67_E0.6541.00
15_A27_R0.6521.00
47_A62_E0.6471.00
50_A57_W0.6201.00
44_R54_T0.6031.00
27_R51_G0.6001.00
11_L27_R0.5981.00
24_A50_A0.5971.00
13_D79_K0.5931.00
22_H30_D0.5911.00
38_P82_D0.5881.00
44_R48_R0.5861.00
16_H48_R0.5781.00
82_D85_I0.5761.00
47_A52_A0.5701.00
23_G26_L0.5661.00
28_L39_L0.5621.00
60_A63_A0.5531.00
64_V67_E0.5501.00
11_L51_G0.5281.00
24_A52_A0.5221.00
62_E65_L0.5201.00
55_K58_R0.5191.00
81_L85_I0.5191.00
29_L78_N0.5141.00
47_A57_W0.5131.00
32_Y76_W0.5121.00
47_A58_R0.5081.00
14_T27_R0.5061.00
37_G82_D0.5051.00
32_Y78_N0.5031.00
23_G27_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w48A 3 0.7586 41.2 0.847 Contact Map
4pt7A 3 0.977 31.1 0.856 Contact Map
2v79A 4 0.977 30.7 0.857 Contact Map
3dv8A 2 1 30.1 0.858 Contact Map
2pjpA 1 0.7701 29.3 0.858 Contact Map
2wteA 2 0.9195 27.4 0.86 Contact Map
4ev0A 2 1 22.5 0.866 Contact Map
2g9wA 2 0.7816 20.7 0.868 Contact Map
3b02A 2 1 20.1 0.869 Contact Map
2b0lA 4 0.9655 20 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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