GREMLIN Database
DUF1375 - Protein of unknown function (DUF1375)
PFAM: PF07119 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (73)
Sequences: 2572 (2032)
Seq/√Len: 237.8
META: 0.816

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_Y70_T5.9411.00
15_T29_S3.7911.00
16_L76_T3.5191.00
61_D65_S2.9751.00
12_T68_A2.2001.00
31_V66_A2.1641.00
11_G34_D2.0521.00
27_V77_L1.7701.00
15_T72_L1.7641.00
30_G68_A1.7281.00
16_L72_L1.6991.00
34_D65_S1.6461.00
29_S76_T1.5841.00
54_L58_A1.5541.00
37_A58_A1.4801.00
35_V39_S1.4411.00
27_V73_L1.3841.00
16_L29_S1.3701.00
35_V62_L1.2951.00
30_G65_S1.2781.00
38_L58_A1.2401.00
12_T29_S1.2371.00
60_L63_P1.2221.00
27_V76_T1.2211.00
12_T72_L1.1851.00
63_P66_A1.1431.00
30_G64_F1.1261.00
68_A71_L1.0201.00
32_R36_C0.9991.00
12_T30_G0.9981.00
30_G76_T0.9721.00
11_G33_L0.9531.00
4_L7_L0.9511.00
72_L75_Y0.9481.00
12_T16_L0.9451.00
34_D62_L0.9441.00
61_D64_F0.9331.00
72_L76_T0.9231.00
64_F68_A0.9181.00
64_F67_V0.9141.00
73_L77_L0.9001.00
12_T65_S0.8850.99
24_G36_C0.8590.99
14_A17_T0.8570.99
33_L37_A0.8550.99
11_G15_T0.8540.99
15_T26_R0.8480.99
34_D37_A0.8460.99
11_G29_S0.8210.99
68_A72_L0.8100.99
38_L55_P0.8100.99
43_G46_A0.7980.99
30_G66_A0.7890.99
66_A70_T0.7740.99
51_G54_L0.7730.99
43_G49_G0.7680.98
38_L56_P0.7640.98
53_A56_P0.7630.98
34_D38_L0.7610.98
42_G49_G0.7580.98
11_G31_V0.7430.98
26_R76_T0.7420.98
38_L59_L0.7400.98
24_G29_S0.7300.98
26_R29_S0.7110.98
26_R32_R0.7090.97
8_S11_G0.7070.97
3_L7_L0.7040.97
45_P51_G0.7030.97
42_G45_P0.6810.97
12_T64_F0.6640.96
53_A58_A0.6590.96
13_I32_R0.6420.96
16_L19_G0.6410.95
31_V34_D0.6400.95
42_G46_A0.6330.95
31_V62_L0.6310.95
42_G48_D0.6250.95
29_S72_L0.6200.95
23_G32_R0.6120.94
42_G47_P0.6100.94
13_I17_T0.6100.94
59_L63_P0.6020.94
28_Y66_A0.6000.94
45_P48_D0.5910.93
7_L39_S0.5880.93
17_T20_D0.5870.93
5_L51_G0.5820.93
15_T30_G0.5810.92
44_G51_G0.5750.92
18_G33_L0.5750.92
18_G22_E0.5740.92
52_A55_P0.5740.92
55_P62_L0.5720.92
43_G48_D0.5600.91
16_L30_G0.5540.91
69_D74_P0.5510.90
19_G22_E0.5480.90
39_S48_D0.5420.90
32_R60_L0.5400.89
70_T73_L0.5360.89
56_P59_L0.5350.89
56_P60_L0.5320.89
6_L39_S0.5250.88
5_L38_L0.5240.88
19_G44_G0.5240.88
47_P51_G0.5200.88
46_A53_A0.5170.87
44_G49_G0.5130.87
46_A50_F0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbiC 1 0.3636 5.2 0.877 Contact Map
2x2zA 1 0 2 0.9 Contact Map
1ypfA 3 0.3506 1.9 0.901 Contact Map
2w7yA 1 0.7143 1.9 0.901 Contact Map
3uorA 1 0.8182 1.8 0.903 Contact Map
1hq0A 1 0.961 1.6 0.905 Contact Map
2gs0B 1 0.0649 1.6 0.905 Contact Map
3sgzA 4 0.3247 1.5 0.908 Contact Map
3ucpA 1 0.5974 1.5 0.908 Contact Map
2b3gB 2 0.2208 1.2 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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