GREMLIN Database
DUF1361 - Protein of unknown function (DUF1361)
PFAM: PF07099 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 168 (161)
Sequences: 4820 (3740)
Seq/√Len: 294.8
META: 0.883

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_I80_G3.4371.00
40_F118_S3.3081.00
130_W145_D3.1891.00
8_I12_L3.1181.00
33_L91_M2.6931.00
50_L74_L2.3641.00
8_I39_F2.3531.00
116_F162_G2.2041.00
12_L32_L2.1301.00
38_L132_S2.1221.00
40_F88_L2.1211.00
12_L35_L2.0941.00
134_D137_T2.0791.00
88_L115_L2.0031.00
92_Q107_G1.9731.00
13_A90_L1.9611.00
138_N141_G1.9451.00
120_F124_L1.9441.00
34_L38_L1.9351.00
51_I70_L1.9011.00
16_L91_M1.8621.00
37_L114_V1.8431.00
46_I73_L1.8341.00
7_W83_L1.7531.00
38_L135_V1.7021.00
92_Q108_W1.7001.00
123_Y128_L1.6651.00
100_G107_G1.6621.00
111_V115_L1.6451.00
119_S162_G1.6081.00
47_L74_L1.5931.00
16_L94_I1.5391.00
130_W142_L1.5361.00
40_F84_G1.5161.00
17_Y90_L1.5111.00
151_H155_W1.4911.00
36_W87_S1.4801.00
158_T162_G1.4681.00
119_S158_T1.4241.00
124_L128_L1.4101.00
70_L74_L1.3851.00
99_F105_A1.3731.00
92_Q111_V1.3691.00
154_A158_T1.3591.00
96_R107_G1.3581.00
149_R154_A1.3521.00
151_H154_A1.3411.00
77_A80_G1.3381.00
131_N134_D1.3271.00
1_W4_F1.3181.00
153_R156_G1.3101.00
72_L76_F1.2961.00
95_V110_F1.2781.00
107_G111_V1.2771.00
124_L146_I1.2691.00
10_L83_L1.2551.00
68_Y72_L1.2531.00
144_R148_D1.2531.00
96_R103_R1.2441.00
114_V118_S1.2431.00
120_F158_T1.2431.00
4_F8_I1.2391.00
115_L119_S1.2351.00
69_D72_L1.2291.00
2_N49_D1.2061.00
1_W131_N1.2031.00
51_I126_R1.1961.00
120_F149_R1.1821.00
12_L16_L1.1761.00
51_I127_F1.1741.00
67_W127_F1.1731.00
99_F107_G1.1491.00
16_L32_L1.1351.00
153_R157_F1.1271.00
95_V107_G1.1201.00
15_L32_L1.1111.00
73_L77_A1.0991.00
14_L90_L1.0751.00
46_I49_D1.0651.00
115_L165_L1.0511.00
80_G88_L1.0481.00
11_L15_L1.0301.00
152_P155_W1.0261.00
154_A162_G1.0141.00
23_R28_L1.0131.00
50_L70_L1.0101.00
163_V166_L1.0001.00
79_T82_L0.9881.00
145_D149_R0.9841.00
130_W141_G0.9841.00
10_L90_L0.9661.00
71_L160_L0.9471.00
141_G144_R0.9441.00
21_R24_R0.9411.00
65_P68_Y0.9341.00
49_D52_H0.9341.00
100_G103_R0.9331.00
46_I77_A0.9281.00
79_T83_L0.9271.00
120_F146_I0.9171.00
19_L32_L0.9121.00
127_F157_F0.9071.00
115_L162_G0.9061.00
44_P118_S0.8901.00
109_L113_A0.8761.00
15_L18_R0.8681.00
158_T161_F0.8581.00
162_G166_L0.8571.00
55_E58_S0.8561.00
143_L147_L0.8531.00
40_F44_P0.8511.00
93_R96_R0.8431.00
100_G105_A0.8331.00
30_L34_L0.8271.00
20_S23_R0.8211.00
38_L136_L0.8211.00
154_A157_F0.8201.00
152_P157_F0.8181.00
20_S97_R0.8171.00
16_L33_L0.8081.00
37_L117_L0.7940.99
51_I66_L0.7930.99
44_P84_G0.7920.99
1_W133_W0.7860.99
47_L81_L0.7820.99
5_L129_R0.7810.99
35_L136_L0.7800.99
53_L73_L0.7790.99
78_W82_L0.7790.99
146_I149_R0.7750.99
66_L70_L0.7750.99
153_R164_F0.7700.99
100_G104_L0.7670.99
84_G87_S0.7650.99
88_L111_V0.7610.99
86_L90_L0.7590.99
140_G144_R0.7570.99
47_L70_L0.7530.99
74_L77_A0.7510.99
33_L95_V0.7480.99
85_F111_V0.7460.99
108_W166_L0.7430.99
71_L164_F0.7400.99
13_A17_Y0.7390.99
2_N5_L0.7380.99
157_F161_F0.7360.99
2_N6_A0.7360.99
19_L22_R0.7280.99
67_W70_L0.7280.99
155_W162_G0.7260.99
65_P69_D0.7220.99
15_L19_L0.7200.99
137_T142_L0.7200.99
73_L76_F0.7190.99
128_L145_D0.7150.99
155_W159_L0.7110.99
19_L24_R0.7020.99
81_L85_F0.6860.98
34_L135_V0.6840.98
157_F166_L0.6740.98
54_R66_L0.6690.98
119_S161_F0.6670.98
75_S115_L0.6600.98
142_L146_I0.6580.98
3_L76_F0.6580.98
138_N142_L0.6530.98
20_S26_R0.6490.98
135_V142_L0.6480.98
110_F114_V0.6440.98
94_I97_R0.6390.98
120_F142_L0.6350.97
9_P43_A0.6300.97
3_L7_W0.6280.97
20_S94_I0.6280.97
64_V69_D0.6260.97
50_L53_L0.6220.97
91_M110_F0.6210.97
99_F103_R0.6160.97
91_M95_V0.6080.97
26_R98_R0.6030.97
13_A91_M0.6030.97
29_L94_I0.6020.97
157_F164_F0.6000.96
10_L13_A0.6000.96
112_L116_F0.5990.96
92_Q96_R0.5970.96
115_L166_L0.5960.96
156_G164_F0.5960.96
160_L164_F0.5950.96
36_W91_M0.5940.96
15_L26_R0.5920.96
111_V118_S0.5900.96
16_L29_L0.5850.96
20_S98_R0.5790.96
116_F119_S0.5790.96
161_F166_L0.5790.96
17_Y93_R0.5770.96
42_N125_G0.5760.96
40_F165_L0.5750.96
21_R26_R0.5750.96
8_I35_L0.5740.95
64_V68_Y0.5730.95
143_L146_I0.5720.95
22_R28_L0.5690.95
85_F115_L0.5680.95
74_L78_W0.5650.95
138_N144_R0.5620.95
112_L166_L0.5600.95
116_F120_F0.5580.95
7_W14_L0.5580.95
11_L14_L0.5580.95
89_Y92_Q0.5560.95
56_R59_G0.5520.94
156_G160_L0.5490.94
49_D126_R0.5490.94
48_T67_W0.5470.94
96_R100_G0.5460.94
70_L73_L0.5410.94
50_L126_R0.5400.94
44_P121_G0.5390.94
96_R108_W0.5390.94
107_G110_F0.5350.93
134_D138_N0.5340.93
44_P122_I0.5330.93
18_R22_R0.5330.93
149_R158_T0.5300.93
68_Y76_F0.5290.93
19_L23_R0.5290.93
9_P13_A0.5270.93
40_F65_P0.5240.93
24_R27_W0.5220.93
154_A164_F0.5150.92
104_L109_L0.5150.92
20_S24_R0.5140.92
22_R33_L0.5140.92
76_F143_L0.5130.92
89_Y93_R0.5100.92
42_N129_R0.5060.91
28_L31_L0.5050.91
124_L149_R0.5050.91
159_L163_V0.5030.91
141_G145_D0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4or2A 2 0.4405 3.7 0.95 Contact Map
2fyuK 1 0.0952 3.5 0.951 Contact Map
2j5dA 2 0.25 2.7 0.953 Contact Map
3m73A 3 0.494 1.4 0.96 Contact Map
1fftB 1 0.2083 1.3 0.96 Contact Map
2vpzC 2 0.6012 1.3 0.961 Contact Map
4xp4A 1 0.9167 1.3 0.961 Contact Map
4yayA 1 0.5774 1.2 0.961 Contact Map
3j9pD 4 0.869 1.2 0.962 Contact Map
2lnlA 1 0.6071 1.1 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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