GREMLIN Database
DUF1360 - Protein of unknown function (DUF1360)
PFAM: PF07098 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (98)
Sequences: 3859 (2386)
Seq/√Len: 241.0
META: 0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_G94_V4.3331.00
30_E41_E2.7571.00
74_G82_T2.7071.00
14_A63_L2.6011.00
6_T68_A2.5621.00
9_L89_L2.5111.00
78_A81_A2.3791.00
10_S14_A2.0951.00
4_L90_A2.0561.00
7_F93_A1.9671.00
85_V89_L1.9121.00
64_G92_A1.8901.00
72_V84_L1.8621.00
33_A39_E1.8361.00
71_L86_A1.7891.00
19_T22_L1.7891.00
12_L18_V1.7771.00
59_C62_C1.6741.00
28_E41_E1.6591.00
89_L92_A1.6441.00
9_L67_V1.4931.00
65_T92_A1.4681.00
65_T89_L1.4601.00
26_F53_I1.4371.00
76_V84_L1.4311.00
72_V88_V1.4231.00
16_D19_T1.4201.00
93_A97_F1.3891.00
46_G50_R1.2901.00
29_Y40_E1.2831.00
81_A84_L1.2641.00
17_K32_D1.2611.00
6_T67_V1.2601.00
12_L19_T1.2161.00
17_K55_E1.1931.00
72_V76_V1.1831.00
63_L67_V1.1461.00
64_G95_A1.1461.00
21_P25_P1.1321.00
49_L53_I1.1231.00
8_K16_D1.1221.00
25_P54_G1.1111.00
72_V87_A1.0841.00
11_R16_D1.0491.00
15_K60_P1.0311.00
29_Y32_D1.0301.00
18_V23_R1.0211.00
72_V75_L1.0171.00
26_F54_G0.9921.00
61_F100_A0.9821.00
22_L25_P0.9771.00
11_R15_K0.9721.00
34_G37_E0.9671.00
47_G51_R0.9641.00
49_L52_A0.9541.00
46_G51_R0.9451.00
74_G78_A0.9381.00
48_G51_R0.9301.00
27_T58_T0.9211.00
29_Y38_V0.9161.00
96_D99_Q0.9151.00
13_I63_L0.8991.00
90_A93_A0.8961.00
9_L71_L0.8580.99
51_R55_E0.8490.99
2_L75_L0.8370.99
69_A73_A0.8370.99
69_A88_V0.8310.99
35_P100_A0.8270.99
2_L71_L0.8230.99
86_A91_A0.8140.99
42_P51_R0.8140.99
97_F100_A0.7950.99
92_A95_A0.7860.99
13_I67_V0.7850.99
2_L91_A0.7840.99
64_G68_A0.7670.99
75_L91_A0.7640.99
7_F99_Q0.7610.98
20_S24_A0.7610.98
57_L63_L0.7530.98
11_R60_P0.7460.98
90_A94_V0.7370.98
65_T72_V0.7250.98
73_A77_L0.7170.98
68_A92_A0.7070.98
17_K20_S0.6980.97
72_V91_A0.6970.97
34_G73_A0.6940.97
47_G50_R0.6930.97
17_K61_F0.6920.97
88_V92_A0.6880.97
59_C66_W0.6870.97
5_A86_A0.6830.97
10_S61_F0.6820.97
19_T23_R0.6760.97
10_S64_G0.6730.97
8_K11_R0.6650.96
61_F65_T0.6560.96
73_A88_V0.6510.96
81_A87_A0.6440.96
7_F64_G0.6430.96
31_G34_G0.6390.96
20_S29_Y0.6370.95
58_T61_F0.6360.95
14_A60_P0.6260.95
88_V91_A0.6250.95
74_G80_R0.6240.95
43_R46_G0.6210.95
64_G99_Q0.6210.95
12_L16_D0.6200.95
42_P58_T0.6190.95
31_G39_E0.6180.95
29_Y33_A0.6180.95
74_G85_V0.6120.94
8_K92_A0.6040.94
10_S95_A0.5980.94
1_L86_A0.5960.94
71_L75_L0.5910.93
32_D35_P0.5900.93
54_G58_T0.5870.93
61_F96_D0.5820.93
19_T25_P0.5730.92
12_L65_T0.5720.92
10_S15_K0.5720.92
22_L57_L0.5700.92
28_E33_A0.5700.92
61_F92_A0.5570.91
65_T69_A0.5550.91
75_L86_A0.5540.91
94_V97_F0.5520.91
82_T87_A0.5480.90
86_A93_A0.5460.90
30_E39_E0.5350.89
17_K21_P0.5330.89
84_L87_A0.5330.89
75_L87_A0.5270.89
80_R83_R0.5240.88
62_C66_W0.5190.88
84_L88_V0.5160.88
91_A94_V0.5090.87
77_L84_L0.5070.87
5_A71_L0.5060.87
26_F57_L0.5030.86
16_D96_D0.5020.86
68_A72_V0.5000.86
89_L93_A0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l34A 2 0.1176 6.3 0.907 Contact Map
4eneA 2 0.3333 4.2 0.915 Contact Map
4q9hA 1 1 3.9 0.916 Contact Map
3nd0A 2 0.3137 3.2 0.919 Contact Map
4wfiA 1 0.5392 2.6 0.923 Contact Map
4f4cA 1 0.9608 2.2 0.926 Contact Map
1j4nA 4 0.2647 2 0.928 Contact Map
4mwaA 4 0.4902 1.9 0.929 Contact Map
3wmgA 1 0.9804 1.9 0.929 Contact Map
4xp4A 1 0.2843 1.7 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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