GREMLIN Database
DUF1353 - Protein of unknown function (DUF1353)
PFAM: PF07087 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (89)
Sequences: 8827 (7069)
Seq/√Len: 749.3
META: 0.949

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_R67_D2.6631.00
75_R84_R2.4461.00
54_L66_A2.3951.00
25_T49_V2.3821.00
28_A48_A2.2501.00
46_R77_L1.9671.00
71_R84_R1.8961.00
23_F53_Y1.8831.00
70_F87_M1.8781.00
20_P53_Y1.8251.00
55_Y67_D1.8171.00
62_T65_E1.7431.00
55_Y63_R1.7111.00
10_V16_V1.7031.00
50_V73_A1.6711.00
27_G45_R1.6651.00
71_R85_W1.6141.00
85_W89_A1.6041.00
41_D45_R1.5401.00
35_W40_P1.5401.00
32_R35_W1.5341.00
33_I36_S1.5281.00
47_A73_A1.5171.00
35_W39_P1.5061.00
8_V18_T1.5051.00
26_D29_S1.4991.00
47_A77_L1.4431.00
11_D14_G1.4281.00
81_K85_W1.3861.00
71_R75_R1.3621.00
30_I34_L1.3581.00
8_V16_V1.3471.00
81_K84_R1.3071.00
6_D18_T1.2461.00
15_E61_V1.2311.00
64_K68_R1.1701.00
25_T48_A1.1511.00
19_V53_Y1.1331.00
54_L69_I1.1191.00
71_R88_Y1.0941.00
50_V69_I1.0191.00
17_I54_L1.0161.00
68_R88_Y1.0121.00
6_D21_A1.0021.00
74_M79_V1.0001.00
19_V23_F0.9991.00
32_R36_S0.9971.00
82_W86_L0.9801.00
28_A70_F0.9751.00
68_R72_E0.9701.00
73_A76_A0.9661.00
48_A70_F0.9561.00
44_Y87_M0.9441.00
56_G59_Q0.9411.00
85_W88_Y0.9251.00
11_D72_E0.8901.00
42_G45_R0.8891.00
65_E69_I0.8811.00
61_V65_E0.8811.00
28_A44_Y0.8761.00
74_M91_V0.8711.00
20_P23_F0.8701.00
10_V14_G0.8681.00
83_K86_L0.8531.00
72_E76_A0.8451.00
9_Y73_A0.8451.00
38_I87_M0.8391.00
69_I73_A0.8351.00
74_M87_M0.8301.00
15_E65_E0.8281.00
38_I83_K0.8241.00
23_F57_D0.8211.00
11_D15_E0.8081.00
27_G40_P0.8051.00
19_V50_V0.8041.00
61_V66_A0.8031.00
75_R81_K0.7811.00
11_D17_I0.7681.00
62_T66_A0.7661.00
12_P72_E0.7581.00
44_Y74_M0.7511.00
7_F46_R0.7401.00
34_L38_I0.7351.00
70_F74_M0.7221.00
19_V49_V0.7121.00
72_E75_R0.7111.00
34_L90_A0.7061.00
79_V84_R0.6981.00
55_Y66_A0.6931.00
56_G61_V0.6921.00
10_V13_D0.6921.00
47_A74_M0.6901.00
83_K87_M0.6861.00
86_L89_A0.6851.00
5_E21_A0.6831.00
79_V83_K0.6791.00
80_P83_K0.6741.00
39_P44_Y0.6721.00
45_R77_L0.6671.00
46_R73_A0.6661.00
41_D44_Y0.6561.00
29_S52_D0.6551.00
53_Y58_T0.6531.00
65_E68_R0.6531.00
57_D61_V0.6491.00
54_L73_A0.6421.00
7_F50_V0.6401.00
34_L37_L0.6191.00
40_P45_R0.6171.00
27_G49_V0.5971.00
44_Y79_V0.5881.00
28_A87_M0.5871.00
3_L19_V0.5861.00
70_F91_V0.5751.00
29_S48_A0.5681.00
12_P15_E0.5591.00
74_M84_R0.5571.00
14_G17_I0.5551.00
35_W38_I0.5541.00
26_D48_A0.5521.00
54_L61_V0.5511.00
64_K88_Y0.5501.00
9_Y76_A0.5481.00
29_S55_Y0.5461.00
17_I69_I0.5451.00
87_M90_A0.5421.00
18_T21_A0.5401.00
5_E8_V0.5251.00
56_G60_T0.5181.00
27_G41_D0.5061.00
69_I72_E0.5051.00
44_Y47_A0.5041.00
54_L58_T0.5031.00
13_D65_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aupA 1 0.956 91.1 0.781 Contact Map
1lwbA 1 0.956 88.6 0.792 Contact Map
4iovA 7 0 12.1 0.889 Contact Map
3k1tA 2 0.9451 9.2 0.894 Contact Map
4g0rA 6 0 7.3 0.899 Contact Map
2b7eA 1 0.3297 5.9 0.903 Contact Map
3ng9A 7 0 5.1 0.906 Contact Map
3hhsB 1 0.989 4.1 0.91 Contact Map
3hhsA 1 0.989 3.9 0.912 Contact Map
2jucA 1 0.3187 3.7 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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