GREMLIN Database
DUF1351 - Protein of unknown function (DUF1351)
PFAM: PF07083 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 210 (193)
Sequences: 1251 (1049)
Seq/√Len: 75.5
META: 0.823

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_K62_E4.2691.00
93_D97_K3.9221.00
57_E61_K3.9151.00
53_K86_D3.5291.00
75_E79_K3.1891.00
64_K75_E3.1871.00
54_K58_D3.0481.00
66_E69_A2.6411.00
23_E84_L2.6191.00
101_E105_E2.6111.00
19_K80_E2.5921.00
143_K147_E2.5051.00
57_E60_R2.4641.00
46_R50_N2.3141.00
141_S144_K2.3051.00
57_E82_I2.2671.00
102_K106_E2.0831.00
14_N17_E2.0201.00
105_E109_E1.9841.00
49_L85_I1.8901.00
52_L85_I1.8891.00
26_L84_L1.8851.00
156_K160_D1.8451.00
61_K65_K1.8371.00
19_K84_L1.8361.00
15_F77_Q1.8001.00
131_F136_L1.7721.00
110_E142_L1.7241.00
50_N89_I1.7001.00
103_R138_K1.6951.00
132_D148_E1.6851.00
112_K116_E1.6821.00
68_L72_E1.6731.00
27_E30_K1.6691.00
105_E108_R1.6221.00
64_K71_Y1.6131.00
69_A73_E1.6121.00
40_K44_K1.6021.00
22_L26_L1.5940.99
68_L71_Y1.5900.99
111_I145_I1.5570.99
46_R93_D1.5330.99
42_A92_I1.5320.99
15_F81_L1.5310.99
47_A50_N1.5240.99
22_L81_L1.5240.99
73_E77_Q1.5130.99
19_K23_E1.4850.99
96_V103_R1.4720.99
164_I167_L1.4630.99
58_D61_K1.4310.99
108_R112_K1.4250.99
140_T144_K1.4230.99
124_L157_I1.4150.99
58_D62_E1.3600.98
35_T38_T1.3500.98
51_K54_K1.3450.98
98_E102_K1.3440.98
67_Y71_Y1.3390.98
34_V42_A1.3150.98
7_T10_V1.3080.98
174_K177_A1.2880.98
30_K87_E1.2640.97
185_Y188_L1.2580.97
34_V45_D1.2310.97
109_E112_K1.2290.97
194_D197_E1.2250.97
140_T145_I1.1990.96
57_E71_Y1.1990.96
156_K159_K1.1840.96
163_E167_L1.1810.96
46_R89_I1.1770.96
118_K151_D1.1440.95
129_I135_W1.1420.95
106_E110_E1.1390.95
144_K147_E1.1310.95
191_E194_D1.1200.95
114_Y146_K1.1180.95
46_R96_V1.1080.94
110_E113_E1.1070.94
147_E152_A1.1000.94
51_K55_A1.0930.94
72_E75_E1.0690.93
63_I71_Y1.0570.93
115_F125_D1.0460.92
54_K61_K1.0370.92
167_L170_E1.0350.92
47_A51_K1.0280.92
151_D155_E1.0240.92
185_Y189_L1.0160.91
65_K72_E1.0150.91
172_E176_K1.0140.91
114_Y151_D1.0080.91
107_K142_L1.0080.91
57_E75_E0.9940.90
79_K82_I0.9780.90
25_K28_K0.9750.89
190_K194_D0.9710.89
86_D89_I0.9700.89
170_E176_K0.9690.89
64_K68_L0.9670.89
36_E99_F0.9600.89
80_E84_L0.9580.89
88_A91_K0.9570.89
90_D94_E0.9470.88
60_R75_E0.9360.87
69_A72_E0.9300.87
159_K162_E0.9260.87
152_A156_K0.9200.86
193_K198_I0.9170.86
83_A87_E0.9110.86
158_K162_E0.9100.86
53_K89_I0.8980.85
9_A67_Y0.8940.85
78_V85_I0.8880.84
140_T148_E0.8830.84
47_A93_D0.8820.84
153_K156_K0.8810.84
187_R190_K0.8710.83
56_L85_I0.8630.83
179_Y185_Y0.8480.82
31_G91_K0.8440.81
194_D199_L0.8390.81
33_V38_T0.8390.81
70_P74_F0.8360.81
74_F78_V0.8350.81
193_K197_E0.8300.80
38_T41_E0.8280.80
72_E76_A0.8270.80
132_D135_W0.8220.80
104_K136_L0.8220.80
169_S172_E0.8210.80
15_F19_K0.8180.79
8_P13_F0.8160.79
56_L78_V0.8130.79
139_T144_K0.8030.78
189_L193_K0.7900.77
49_L92_I0.7880.77
22_L84_L0.7870.77
60_R82_I0.7850.76
22_L52_L0.7800.76
168_K172_E0.7780.76
13_F77_Q0.7750.75
44_K48_E0.7710.75
162_E165_E0.7680.75
19_K77_Q0.7510.73
53_K82_I0.7500.73
171_I174_K0.7470.73
135_W148_E0.7440.72
134_K137_N0.7430.72
50_N86_D0.7360.72
172_E177_A0.7270.71
34_V99_F0.7270.71
77_Q81_L0.7260.71
16_E77_Q0.7260.71
82_I85_I0.7220.70
25_K52_L0.7210.70
182_A186_I0.7200.70
71_Y75_E0.7160.70
46_R100_E0.7150.69
179_Y182_A0.7150.69
24_E27_E0.7140.69
117_E146_K0.7110.69
95_Q99_F0.7070.69
44_K51_K0.7020.68
194_D198_I0.7020.68
181_E185_Y0.6960.67
39_I99_F0.6960.67
189_L198_I0.6950.67
154_I158_K0.6940.67
34_V92_I0.6890.67
59_K63_I0.6880.67
186_I198_I0.6880.67
170_E174_K0.6850.66
164_I169_S0.6830.66
29_Y49_L0.6820.66
120_G123_G0.6810.66
89_I93_D0.6750.65
173_E177_A0.6750.65
196_A199_L0.6720.65
6_Q9_A0.6720.65
53_K57_E0.6680.64
42_A45_D0.6680.64
167_L171_I0.6680.64
163_E166_A0.6670.64
84_L92_I0.6660.64
188_L194_D0.6600.63
23_E27_E0.6560.63
181_E184_D0.6550.63
101_E104_K0.6500.62
57_E64_K0.6490.62
15_F22_L0.6480.62
57_E78_V0.6470.62
107_K141_S0.6460.62
173_E176_K0.6440.61
103_R106_E0.6420.61
152_A155_E0.6410.61
108_R131_F0.6400.61
132_D153_K0.6380.61
5_E12_E0.6360.60
18_L22_L0.6340.60
84_L88_A0.6300.60
45_D48_E0.6290.60
164_I168_K0.6240.59
97_K103_R0.6220.59
171_I175_A0.6210.59
126_F131_F0.6200.59
63_I74_F0.6190.58
190_K193_K0.6190.58
50_N93_D0.6180.58
49_L89_I0.6150.58
109_E113_E0.6130.58
16_E20_A0.6130.58
22_L85_I0.6110.57
184_D188_L0.6080.57
108_R133_D0.6060.57
98_E101_E0.6040.57
14_N29_Y0.6040.57
107_K148_E0.6010.56
115_F126_F0.6010.56
71_Y78_V0.6000.56
122_L154_I0.6000.56
61_K71_Y0.5990.56
13_F95_Q0.5980.56
17_E20_A0.5960.56
179_Y186_I0.5940.55
41_E44_K0.5900.55
55_A59_K0.5870.54
97_K101_E0.5850.54
188_L195_L0.5840.54
50_N54_K0.5840.54
34_V38_T0.5840.54
32_L92_I0.5820.54
20_A24_E0.5800.54
165_E176_K0.5770.53
185_Y191_E0.5770.53
155_E159_K0.5760.53
24_E28_K0.5750.53
113_E116_E0.5730.53
164_I170_E0.5690.52
29_Y92_I0.5670.52
52_L56_L0.5670.52
171_I176_K0.5650.52
89_I96_V0.5650.52
184_D189_L0.5640.52
158_K161_L0.5630.51
26_L81_L0.5630.51
188_L191_E0.5610.51
100_E139_T0.5590.51
119_I123_G0.5580.51
38_T42_A0.5580.51
161_L164_I0.5560.51
56_L82_I0.5560.51
184_D187_R0.5560.51
141_S145_I0.5530.50
60_R65_K0.5520.50
182_A185_Y0.5490.50
196_A200_K0.5490.50
90_D93_D0.5480.50
134_K140_T0.5470.49
125_D128_K0.5420.49
18_L49_L0.5370.48
197_E200_K0.5360.48
36_E39_I0.5340.48
172_E175_A0.5320.48
34_V95_Q0.5320.48
33_V95_Q0.5320.48
20_A94_E0.5320.48
153_K157_I0.5290.47
22_L88_A0.5280.47
60_R74_F0.5260.47
81_L85_I0.5260.47
188_L193_K0.5260.47
134_K144_K0.5240.47
185_Y190_K0.5240.47
157_I160_D0.5210.46
104_K131_F0.5200.46
18_L52_L0.5190.46
114_Y149_I0.5190.46
121_E158_K0.5170.46
18_L85_I0.5160.46
190_K196_A0.5150.45
13_F18_L0.5150.45
187_R191_E0.5140.45
76_A83_A0.5090.45
131_F137_N0.5090.45
115_F129_I0.5070.44
50_N53_K0.5060.44
36_E103_R0.5030.44
193_K199_L0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ghgA 2 0.6714 26.5 0.926 Contact Map
1deqA 1 0.7619 24 0.928 Contact Map
2dfsA 2 0.5429 20 0.93 Contact Map
4j7oA 1 0.9286 8.7 0.941 Contact Map
2lemA 1 0.8476 7.2 0.943 Contact Map
4j2cA 1 0.3 6.9 0.943 Contact Map
2l7bA 1 0.6571 6.8 0.944 Contact Map
3mq9A 4 0.4619 6.4 0.944 Contact Map
4tqlA 1 0.3905 6.3 0.944 Contact Map
2q12A 2 0.7905 6 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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