GREMLIN Database
OPA3 - Optic atrophy 3 protein (OPA3)
PFAM: PF07047 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 126 (123)
Sequences: 654 (474)
Seq/√Len: 42.7
META: 0.242

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_E114_E4.8861.00
116_R121_E4.8081.00
17_N20_K2.8711.00
104_E108_E2.4401.00
34_I64_E2.3341.00
91_E94_R2.2191.00
48_R52_L1.9840.99
9_R13_K1.9710.99
81_F85_G1.9520.99
79_F83_V1.9040.99
2_K6_L1.8900.99
103_E107_A1.8580.99
18_R21_A1.8000.98
24_K69_E1.7940.98
99_E102_K1.7690.98
115_E119_E1.7640.98
12_S16_A1.6990.97
23_A33_C1.6390.97
31_Y35_P1.6340.97
38_Q62_L1.6180.96
11_L115_E1.6070.96
37_A63_N1.6040.96
44_E48_R1.5980.96
118_E121_E1.5560.96
14_P77_E1.5270.95
40_Y74_L1.5120.95
6_L20_K1.4890.94
53_G75_L1.4800.94
38_Q59_I1.4610.94
106_V109_E1.4490.93
15_I20_K1.4450.93
110_L114_E1.4320.93
112_E116_R1.4180.93
33_C37_A1.3900.92
4_G7_A1.3880.92
49_M81_F1.3320.90
38_Q41_H1.3100.89
46_R50_R1.2950.89
62_L67_A1.2950.89
37_A84_A1.2820.88
43_I47_L1.2740.88
98_K101_K1.2710.88
40_Y70_L1.2570.87
85_G88_I1.1970.85
101_K104_E1.1970.85
41_H62_L1.1830.84
36_L74_L1.1830.84
103_E106_V1.1750.84
7_A10_T1.1670.83
2_K14_P1.1650.83
29_F33_C1.1630.83
6_L91_E1.1540.82
11_L16_A1.1270.81
70_L88_I1.1170.80
76_G80_I1.0960.79
23_A29_F1.0760.78
41_H59_I1.0190.74
28_R31_Y1.0180.74
64_E120_L1.0140.73
4_G81_F1.0070.73
65_E68_I1.0070.73
38_Q67_A0.9950.72
37_A48_R0.9950.72
79_F103_E0.9880.71
42_R88_I0.9720.70
112_E121_E0.9570.69
11_L15_I0.9560.69
45_M59_I0.9510.68
8_I95_S0.9430.68
4_G68_I0.9410.68
37_A62_L0.9410.68
119_E123_E0.9340.67
107_A111_E0.9310.67
15_I78_A0.9260.66
3_L80_I0.9230.66
6_L10_T0.8860.63
37_A92_Y0.8860.63
12_S76_G0.8680.61
7_A87_L0.8650.61
102_K107_A0.8640.61
10_T81_F0.8630.61
116_R119_E0.8610.61
62_L70_L0.8520.60
114_E121_E0.8350.58
44_E76_G0.8350.58
115_E122_E0.8280.58
27_P86_G0.8250.57
9_R84_A0.8250.57
114_E118_E0.8230.57
31_Y42_R0.7990.55
84_A95_S0.7960.55
13_K16_A0.7930.54
37_A70_L0.7920.54
9_R95_S0.7900.54
83_V88_I0.7890.54
112_E115_E0.7870.54
106_V113_L0.7840.54
30_R64_E0.7830.53
100_A103_E0.7790.53
22_Q26_H0.7750.53
10_T13_K0.7730.53
86_G97_R0.7710.52
64_E76_G0.7670.52
23_A75_L0.7640.52
33_C71_G0.7620.51
49_M63_N0.7550.51
117_I121_E0.7550.51
76_G92_Y0.7520.51
90_Y94_R0.7480.50
59_I77_E0.7370.49
81_F88_I0.7340.49
116_R120_L0.7330.49
16_A19_I0.7330.49
9_R15_I0.7200.47
117_I123_E0.7180.47
13_K81_F0.7100.47
31_Y39_A0.7060.46
7_A114_E0.6990.46
17_N21_A0.6900.45
29_F37_A0.6900.45
113_L116_R0.6880.44
53_G60_R0.6880.44
2_K91_E0.6820.44
117_I120_L0.6810.44
107_A118_E0.6800.44
28_R32_F0.6790.44
82_S96_S0.6780.44
16_A20_K0.6770.43
48_R54_L0.6750.43
21_A24_K0.6750.43
114_E117_I0.6710.43
49_M54_L0.6710.43
101_K118_E0.6710.43
55_K115_E0.6680.43
74_L86_G0.6680.43
15_I110_L0.6670.43
113_L118_E0.6640.42
78_A82_S0.6580.42
10_T14_P0.6570.42
64_E88_I0.6360.40
18_R27_P0.6320.39
37_A99_E0.6320.39
78_A97_R0.6140.38
32_F82_S0.6130.38
20_K91_E0.6120.38
7_A11_L0.6090.37
36_L70_L0.6000.36
22_Q25_E0.6000.36
7_A28_R0.5980.36
1_A76_G0.5950.36
60_R66_K0.5890.36
69_E79_F0.5840.35
9_R14_P0.5800.35
24_K73_D0.5800.35
19_I24_K0.5790.35
37_A42_R0.5720.34
19_I65_E0.5560.33
53_G56_P0.5520.32
50_R54_L0.5500.32
87_L100_A0.5490.32
49_M53_G0.5460.32
12_S63_N0.5460.32
89_I114_E0.5430.32
23_A30_R0.5380.31
54_L90_Y0.5340.31
35_P42_R0.5340.31
7_A81_F0.5340.31
82_S111_E0.5290.30
107_A110_L0.5270.30
38_Q72_A0.5270.30
38_Q44_E0.5250.30
2_K13_K0.5240.30
42_R81_F0.5210.30
92_Y120_L0.5210.30
102_K106_V0.5180.30
80_I107_A0.5170.30
37_A68_I0.5160.29
27_P31_Y0.5120.29
118_E122_E0.5110.29
108_E123_E0.5090.29
43_I108_E0.5080.29
12_S18_R0.5070.29
81_F84_A0.5000.28
37_A44_E0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rh7A 1 0.7937 27.4 0.905 Contact Map
3wuqA 1 0.7857 14.8 0.916 Contact Map
3rvyA 3 0.7063 11.1 0.921 Contact Map
1f5nA 1 0.881 9.8 0.923 Contact Map
1kd8A 1 0.1429 8.3 0.925 Contact Map
4cgkA 3 0.1825 6.2 0.929 Contact Map
2j5uA 4 0.2063 6.1 0.929 Contact Map
4etpA 1 0.3016 5.9 0.93 Contact Map
1fxkA 2 0.7063 5.9 0.93 Contact Map
2l5gA 1 0.2619 5.6 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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