GREMLIN Database
DUF1326 - Protein of unknown function (DUF1326)
PFAM: PF07040 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 177 (172)
Sequences: 13645 (7581)
Seq/√Len: 578.0
META: 0.969

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_R105_R4.5861.00
29_H44_N4.0921.00
61_T99_E3.2281.00
68_E107_P3.0541.00
59_N98_G2.9931.00
24_A49_A2.8091.00
80_A85_Q2.7591.00
109_E120_R2.7341.00
120_R126_E2.5591.00
76_E80_A2.5191.00
61_T101_L2.5041.00
34_H37_G2.4281.00
165_S170_D2.4241.00
35_Y86_A2.3841.00
111_E118_R2.2771.00
27_A119_V2.2461.00
80_A86_A2.2451.00
23_E50_D2.2391.00
45_V82_F2.2041.00
65_Y106_A2.0731.00
148_H151_G1.9661.00
72_D76_E1.9621.00
43_L70_A1.8281.00
43_L69_R1.8141.00
6_D19_H1.7921.00
76_E79_L1.7891.00
43_L78_L1.7521.00
73_E76_E1.7321.00
147_G155_V1.7191.00
46_A121_I1.6741.00
72_D105_R1.6691.00
32_E41_D1.6591.00
21_Y50_D1.6261.00
79_L103_V1.6051.00
35_Y40_L1.5591.00
66_V105_R1.5031.00
75_R79_L1.4701.00
2_N127_A1.4021.00
147_G150_A1.4011.00
27_A46_A1.3871.00
118_R128_E1.3791.00
37_G73_E1.3411.00
34_H39_D1.3391.00
50_D61_T1.3241.00
28_W45_V1.3201.00
44_N69_R1.2981.00
4_N19_H1.2921.00
72_D75_R1.2841.00
136_V139_E1.2801.00
25_V125_V1.2761.00
116_R130_E1.2721.00
141_V145_N1.2541.00
62_V97_I1.2461.00
53_G57_E1.2441.00
104_E124_V1.2221.00
63_G104_E1.2221.00
44_N108_I1.1661.00
35_Y81_I1.1581.00
144_R147_G1.1511.00
91_A94_A1.1451.00
10_P18_T1.1401.00
35_Y80_A1.1321.00
130_E159_G1.1291.00
126_E160_R1.1161.00
134_G137_T1.1011.00
4_N21_Y1.0991.00
66_V70_A1.0981.00
155_V158_A1.0971.00
29_H110_F1.0941.00
92_V95_P1.0901.00
121_I125_V1.0881.00
51_W60_W1.0731.00
16_P54_A1.0551.00
79_L83_S1.0171.00
65_Y124_V1.0161.00
144_R155_V1.0151.00
32_E39_D1.0041.00
17_P20_G1.0031.00
40_L81_I1.0001.00
144_R152_E1.0001.00
64_L82_F0.9981.00
130_E133_R0.9931.00
8_G13_F0.9831.00
71_S74_Q0.9741.00
35_Y77_A0.9721.00
147_G151_G0.9721.00
45_V78_L0.9671.00
113_D116_R0.9661.00
44_N67_D0.9551.00
162_S165_S0.9521.00
81_I90_F0.9491.00
63_G102_G0.9451.00
16_P57_E0.9411.00
142_R145_N0.9401.00
116_R140_P0.9381.00
46_A108_I0.9301.00
7_V15_A0.9291.00
6_D18_T0.9221.00
104_E166_A0.9211.00
163_R172_D0.9161.00
38_V73_E0.9121.00
65_Y104_E0.9101.00
6_D15_A0.9081.00
51_W96_L0.9001.00
64_L79_L0.8961.00
66_V75_R0.8881.00
65_Y121_I0.8801.00
70_A105_R0.8771.00
51_W55_M0.8721.00
164_V167_F0.8721.00
54_A57_E0.8691.00
64_L100_V0.8671.00
66_V103_V0.8651.00
64_L83_S0.8621.00
62_V100_V0.8591.00
145_N158_A0.8591.00
108_I121_I0.8551.00
107_P122_G0.8551.00
141_V144_R0.8441.00
109_E118_R0.8351.00
43_L67_D0.8351.00
70_A75_R0.8331.00
133_R140_P0.8311.00
143_V146_T0.8221.00
8_G12_Q0.8191.00
162_S173_L0.8191.00
142_R152_E0.8181.00
47_L62_V0.8071.00
26_L47_L0.8051.00
137_T140_P0.7991.00
141_V146_T0.7971.00
43_L71_S0.7921.00
47_L64_L0.7851.00
120_R123_G0.7831.00
25_V48_V0.7781.00
112_V117_G0.7761.00
30_I82_F0.7721.00
79_L85_Q0.7691.00
129_I159_G0.7641.00
29_H112_V0.7621.00
100_V103_V0.7581.00
116_R128_E0.7441.00
134_G138_G0.7421.00
154_T158_A0.7421.00
84_G87_G0.7401.00
27_A110_F0.7371.00
79_L105_R0.7351.00
20_G53_G0.7351.00
83_S100_V0.7341.00
36_G86_A0.7291.00
164_V172_D0.7281.00
110_F119_V0.7231.00
29_H42_G0.7191.00
38_V74_Q0.7151.00
163_R166_A0.7111.00
48_V63_G0.7101.00
52_P58_G0.7061.00
68_E105_R0.7051.00
106_A121_I0.7021.00
118_R126_E0.7001.00
164_V171_W0.6951.00
140_P145_N0.6911.00
167_F171_W0.6881.00
115_D133_R0.6861.00
44_N110_F0.6851.00
164_V169_I0.6831.00
97_I100_V0.6791.00
163_R170_D0.6661.00
36_G80_A0.6561.00
38_V77_A0.6551.00
117_G129_I0.6541.00
128_E159_G0.6521.00
5_C11_C0.6521.00
94_A97_I0.6511.00
148_H153_L0.6501.00
8_G15_A0.6501.00
102_G167_F0.6471.00
162_S166_A0.6471.00
143_V148_H0.6401.00
154_T157_E0.6381.00
153_L157_E0.6281.00
165_S169_I0.6261.00
6_D16_P0.6201.00
155_V159_G0.6191.00
78_L82_F0.6181.00
159_G162_S0.6131.00
133_R139_E0.6131.00
7_V132_I0.6111.00
106_A122_G0.6091.00
165_S171_W0.6081.00
133_R136_V0.6071.00
153_L158_A0.6071.00
79_L100_V0.6071.00
91_A95_P0.6051.00
162_S170_D0.6041.00
15_A18_T0.6031.00
132_I141_V0.6031.00
133_R138_G0.5981.00
115_D140_P0.5961.00
7_V13_F0.5951.00
90_F93_L0.5951.00
68_E106_A0.5891.00
92_V97_I0.5871.00
12_Q24_A0.5831.00
115_D142_R0.5791.00
25_V127_A0.5731.00
60_W98_G0.5701.00
7_V14_N0.5701.00
35_Y38_V0.5681.00
119_V127_A0.5670.99
7_V12_Q0.5650.99
88_G91_A0.5640.99
30_I78_L0.5620.99
94_A98_G0.5600.99
140_P143_V0.5600.99
19_H23_E0.5570.99
81_I86_A0.5570.99
42_G69_R0.5560.99
7_V160_R0.5560.99
119_V125_V0.5530.99
87_G91_A0.5520.99
46_A125_V0.5510.99
66_V79_L0.5510.99
48_V65_Y0.5500.99
47_L90_F0.5490.99
122_G125_V0.5460.99
14_N56_H0.5450.99
4_N23_E0.5440.99
30_I33_G0.5440.99
49_A62_V0.5320.99
13_F18_T0.5300.99
63_G167_F0.5300.99
12_Q15_A0.5270.99
95_P98_G0.5270.99
162_S167_F0.5260.99
90_F95_P0.5240.99
136_V145_N0.5230.99
163_R174_S0.5230.99
101_L104_E0.5220.99
17_P53_G0.5200.99
55_M93_L0.5190.99
128_E160_R0.5170.99
63_G168_G0.5160.99
134_G141_V0.5160.99
8_G14_N0.5160.99
61_T98_G0.5160.99
65_Y166_A0.5160.99
25_V119_V0.5130.99
123_G126_E0.5130.99
63_G124_V0.5120.99
63_G101_L0.5080.99
2_N25_V0.5080.99
170_D173_L0.5060.99
162_S169_I0.5030.99
133_R137_T0.5020.99
64_L103_V0.5010.99
24_A51_W0.5000.99
153_L156_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eplX 2 0.5254 14 0.943 Contact Map
4ftfA 1 0.5085 13.1 0.944 Contact Map
3b64A 3 0.5932 10.1 0.947 Contact Map
3u52A 2 0.3616 10.1 0.947 Contact Map
1c7kA 1 0.4972 9.2 0.948 Contact Map
2co3A 2 0.3785 7.5 0.95 Contact Map
2incA 2 0.3672 6.6 0.951 Contact Map
2x4kA 4 0.339 5.9 0.952 Contact Map
2db3A 1 0.5198 5.8 0.952 Contact Map
2l61A 1 0.1186 5.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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