GREMLIN Database
DUF1318 - Protein of unknown function (DUF1318)
PFAM: PF07027 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 92 (90)
Sequences: 8121 (5550)
Seq/√Len: 585.0
META: 0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_T26_G2.8961.00
81_W91_K2.5971.00
24_Y47_R2.3361.00
84_D88_S2.3211.00
84_D90_V2.1371.00
17_V39_V2.1261.00
77_P80_E1.9831.00
41_A45_D1.9441.00
28_R81_W1.9251.00
76_A80_E1.9021.00
49_L52_E1.8941.00
51_A55_K1.8201.00
32_S35_V1.6971.00
21_N83_Q1.6671.00
20_T83_Q1.6211.00
52_E56_A1.6111.00
76_A82_Y1.6001.00
27_V39_V1.5931.00
36_R40_A1.5721.00
40_A44_A1.5591.00
24_Y65_G1.5371.00
70_K74_E1.5301.00
7_A10_A1.4811.00
12_K80_E1.4701.00
73_I82_Y1.4631.00
61_V65_G1.4071.00
13_A80_E1.4001.00
47_R65_G1.3851.00
63_E66_A1.3541.00
32_S36_R1.3061.00
8_L25_L1.2871.00
10_A14_S1.2691.00
69_A73_I1.2621.00
59_V63_E1.2351.00
7_A38_L1.2311.00
27_V31_A1.2161.00
15_G91_K1.2101.00
47_R51_A1.2091.00
53_I64_V1.1911.00
62_E66_A1.1651.00
53_I57_N1.1501.00
42_E46_R1.1501.00
9_D13_A1.0941.00
42_E45_D1.0801.00
11_A35_V1.0691.00
68_F72_W1.0691.00
82_Y90_V1.0621.00
48_A51_A1.0611.00
5_A9_D1.0561.00
33_A36_R1.0271.00
15_G81_W1.0141.00
22_D26_G1.0001.00
51_A61_V0.9941.00
52_E55_K0.9201.00
26_G83_Q0.9121.00
5_A12_K0.9101.00
33_A37_A0.9051.00
22_D65_G0.9001.00
16_A27_V0.9001.00
67_T70_K0.8971.00
72_W76_A0.8961.00
37_A41_A0.8941.00
57_N67_T0.8801.00
18_G89_W0.8551.00
62_E65_G0.8511.00
16_A32_S0.8511.00
49_L53_I0.8441.00
19_E25_L0.8351.00
63_E67_T0.8291.00
53_I68_F0.8131.00
8_L12_K0.8121.00
44_A47_R0.8101.00
67_T71_K0.8101.00
50_Y68_F0.7871.00
12_K76_A0.7861.00
66_A85_A0.7681.00
71_K74_E0.7641.00
35_V39_V0.7551.00
71_K75_K0.7521.00
44_A48_A0.7521.00
13_A77_P0.7521.00
68_F71_K0.7511.00
59_V67_T0.7461.00
50_Y72_W0.7381.00
69_A72_W0.7361.00
18_G28_R0.7241.00
12_K19_E0.7031.00
30_A36_R0.6971.00
20_T24_Y0.6941.00
48_A52_E0.6791.00
49_L68_F0.6731.00
4_R42_E0.6671.00
24_Y50_Y0.6621.00
53_I56_A0.6601.00
9_D12_K0.6521.00
45_D49_L0.6471.00
11_A14_S0.6341.00
57_N68_F0.6321.00
72_W75_K0.6271.00
17_V25_L0.6271.00
4_R45_D0.6221.00
66_A70_K0.6161.00
23_G65_G0.6101.00
19_E46_R0.6021.00
8_L38_L0.6011.00
8_L42_E0.5991.00
9_D77_P0.5971.00
31_A35_V0.5911.00
16_A31_A0.5811.00
21_N66_A0.5671.00
49_L72_W0.5671.00
47_R61_V0.5580.99
21_N85_A0.5560.99
45_D48_A0.5550.99
41_A44_A0.5540.99
60_P63_E0.5490.99
50_Y65_G0.5480.99
44_A51_A0.5460.99
9_D80_E0.5450.99
70_K85_A0.5430.99
73_I85_A0.5430.99
83_Q86_D0.5400.99
7_A11_A0.5390.99
23_G50_Y0.5380.99
12_K25_L0.5380.99
6_P10_A0.5360.99
27_V35_V0.5320.99
70_K73_I0.5250.99
32_S37_A0.5230.99
57_N63_E0.5210.99
82_Y92_K0.5130.99
18_G26_G0.5100.99
16_A35_V0.5040.99
43_N46_R0.5040.99
12_K72_W0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bw2A 1 0.7935 9.2 0.895 Contact Map
2nr7A 1 0.8261 8 0.898 Contact Map
2krcA 1 0.8261 7.6 0.899 Contact Map
3dwbA 1 0.3913 3.5 0.914 Contact Map
3quaA 2 0.4457 3.5 0.914 Contact Map
2marA 1 0.8261 3.1 0.916 Contact Map
3tqnA 2 0.663 3 0.917 Contact Map
2cu2A 2 0.4674 3 0.917 Contact Map
1avyA 3 0.4674 2.7 0.919 Contact Map
4kbmB 1 0.7826 2.6 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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