GREMLIN Database
DUF1315 - Protein of unknown function (DUF1315)
PFAM: PF07023 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 81 (71)
Sequences: 1109 (665)
Seq/√Len: 78.9
META: 0.676

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_E50_L4.0951.00
22_G35_R3.0671.00
14_R25_P2.7181.00
7_M12_Y2.4771.00
40_Q44_A2.4391.00
46_E56_V2.4121.00
17_T20_E2.3261.00
17_T21_L2.2941.00
19_V35_R2.1211.00
5_A48_R2.0731.00
45_Y49_H1.9581.00
32_P36_E1.9371.00
52_E55_R1.6431.00
19_V38_C1.6381.00
14_R17_T1.6071.00
12_Y45_Y1.5170.99
50_L53_E1.4370.99
30_L38_C1.4290.99
59_I64_K1.3950.99
59_I62_K1.3200.98
33_E37_L1.2900.98
19_V39_L1.2850.98
16_K46_E1.2660.98
23_K29_A1.2470.97
2_Q5_A1.2380.97
51_P54_E1.2280.97
3_L6_S1.1660.96
46_E55_R1.1590.96
15_L19_V1.1300.95
38_C42_V1.1280.95
70_K73_F1.1060.95
10_E14_R1.0900.94
33_E57_G1.0370.93
45_Y50_L0.9510.89
41_A59_I0.9080.87
13_E16_K0.9040.87
71_D74_S0.8920.86
59_I65_A0.8650.84
37_L41_A0.8350.82
30_L35_R0.8190.81
11_I25_P0.8090.80
12_Y24_W0.8070.80
68_E72_E0.8030.80
6_S39_L0.8020.79
19_V42_V0.7920.79
39_L69_L0.7890.78
18_A38_C0.7840.78
33_E36_E0.7710.77
7_M37_L0.7690.77
63_S72_E0.7620.76
9_P13_E0.7370.73
43_I55_R0.7290.73
41_A58_Y0.7290.73
36_E40_Q0.7240.72
21_L29_A0.7220.72
68_E71_D0.7100.71
26_D57_G0.7090.71
4_I11_I0.7030.70
4_I44_A0.6990.69
43_I46_E0.6940.69
44_A58_Y0.6910.69
7_M40_Q0.6900.68
25_P62_K0.6890.68
45_Y74_S0.6890.68
61_R64_K0.6850.68
55_R58_Y0.6810.67
43_I63_S0.6800.67
69_L72_E0.6690.66
32_P49_H0.6670.66
59_I63_S0.6670.66
57_G64_K0.6570.65
47_A55_R0.6480.64
16_K20_E0.6450.63
23_K68_E0.6430.63
30_L43_I0.6340.62
55_R69_L0.6320.62
7_M11_I0.6290.61
7_M41_A0.6240.61
50_L55_R0.6230.61
40_Q43_I0.6210.60
35_R42_V0.6160.60
7_M16_K0.6160.60
70_K74_S0.6120.59
21_L71_D0.6040.58
15_L45_Y0.6030.58
11_I44_A0.6010.58
14_R21_L0.5850.56
31_T42_V0.5760.55
12_Y16_K0.5720.54
25_P28_R0.5670.54
26_D32_P0.5610.53
21_L25_P0.5580.52
34_Q42_V0.5580.52
29_A35_R0.5530.52
3_L44_A0.5450.51
18_A34_Q0.5260.48
51_P70_K0.5250.48
30_L42_V0.5240.48
62_K65_A0.5160.47
4_I48_R0.5080.46
68_E73_F0.5040.45
18_A25_P0.5040.45
10_E23_K0.5040.45
38_C46_E0.5030.45
14_R43_I0.5010.45
6_S11_I0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ek5A 4 0.9259 40.9 0.889 Contact Map
3bwgA 2 0.8765 35.3 0.893 Contact Map
4h0eA 2 0.8642 33.6 0.894 Contact Map
3sxyA 2 0.9012 32.4 0.895 Contact Map
2di3A 2 0.9506 27.9 0.899 Contact Map
3neuA 2 0.963 26.2 0.9 Contact Map
3ic7A 2 0.9259 24.6 0.901 Contact Map
1zbdB 1 0.5926 23.9 0.902 Contact Map
4p9fA 1 0.9136 23.8 0.902 Contact Map
2hs5A 1 0.9136 23.8 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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