GREMLIN Database
T6SS_VasB - Type VI secretion, VasB, ImpH, VC_A0111
PFAM: PF06996 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 299 (297)
Sequences: 5763 (4305)
Seq/√Len: 249.8
META: 0.738

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_G223_W3.8001.00
159_Y179_D3.5191.00
237_S240_Q3.1841.00
172_G261_Y2.9851.00
15_E18_D2.8791.00
35_F107_L2.8661.00
36_R61_R2.8431.00
70_T99_L2.7951.00
177_L185_V2.7021.00
230_R269_D2.5971.00
188_E232_R2.5431.00
185_V233_L2.5241.00
64_V107_L2.4891.00
186_E232_R2.4291.00
238_L242_E2.3731.00
7_F66_F2.3301.00
38_D49_A2.2681.00
6_D47_E2.2411.00
11_V35_F2.2371.00
51_L62_L2.2311.00
193_R228_K2.2251.00
15_E20_P2.1711.00
228_K269_D2.1621.00
237_S278_E2.1401.00
243_R250_A2.1101.00
15_E19_R2.0891.00
232_R273_V2.0641.00
211_R215_G2.0491.00
243_R249_D2.0441.00
49_A65_N1.9961.00
129_D132_S1.9961.00
174_E187_V1.9851.00
203_T216_A1.9201.00
16_R19_R1.9161.00
150_A256_A1.9011.00
84_A95_L1.8881.00
188_E230_R1.8831.00
38_D65_N1.8711.00
187_V231_I1.8701.00
10_A62_L1.8321.00
170_A189_Q1.8261.00
240_Q243_R1.8071.00
211_R214_V1.7771.00
173_L261_Y1.7551.00
230_R271_Q1.7441.00
67_L107_L1.7401.00
229_F268_W1.7051.00
229_F262_L1.7011.00
17_P20_P1.6811.00
193_R224_D1.6741.00
156_L260_F1.6571.00
8_F111_Y1.6571.00
181_F254_L1.6491.00
36_R63_T1.6461.00
104_H108_S1.6421.00
242_E291_R1.6271.00
149_R153_D1.6181.00
174_E178_S1.6041.00
236_L272_L1.5961.00
231_I258_V1.5951.00
232_R271_Q1.5721.00
240_Q250_A1.5671.00
237_S275_K1.5571.00
181_F244_F1.5571.00
100_D103_N1.5521.00
174_E186_E1.5471.00
194_W221_R1.5441.00
87_R92_D1.5211.00
198_P201_Q1.5181.00
168_R261_Y1.5151.00
25_A31_E1.5111.00
183_V233_L1.4861.00
196_P221_R1.4771.00
96_R100_D1.4721.00
10_A48_I1.4651.00
177_L231_I1.4551.00
136_L157_L1.4441.00
191_V230_R1.4081.00
70_T103_N1.4031.00
93_P97_D1.3801.00
275_K278_E1.3691.00
136_L147_R1.3381.00
95_L99_L1.3301.00
9_Q13_L1.3251.00
137_A142_G1.3161.00
163_L261_Y1.3121.00
123_Y154_E1.2911.00
97_D100_D1.2791.00
241_Y274_L1.2761.00
233_L236_L1.2631.00
199_P202_R1.2451.00
282_L290_P1.2411.00
229_F258_V1.2381.00
194_W223_W1.2301.00
39_P70_T1.2301.00
114_W121_V1.2211.00
86_E89_R1.2171.00
7_F11_V1.2131.00
184_P234_G1.2081.00
70_T84_A1.2041.00
141_L260_F1.2031.00
67_L106_L1.2031.00
188_E191_V1.1961.00
176_I261_Y1.1901.00
228_K267_D1.1861.00
50_S63_T1.1841.00
37_Q103_N1.1821.00
191_V228_K1.1821.00
12_R124_D1.1781.00
8_F114_W1.1731.00
16_R20_P1.1651.00
229_F266_L1.1631.00
158_F179_D1.1521.00
180_Y253_R1.1501.00
150_A252_R1.1431.00
162_L169_S1.1391.00
291_R294_W1.1361.00
282_L296_T1.1361.00
37_Q70_T1.1331.00
139_I160_A1.1291.00
195_L224_D1.1281.00
151_V257_L1.1261.00
162_L175_A1.1251.00
171_E174_E1.1241.00
52_E61_R1.1241.00
85_L88_R1.1211.00
36_R100_D1.1191.00
197_L217_V1.1041.00
51_L60_P1.0991.00
84_A96_R1.0981.00
224_D227_S1.0961.00
248_G252_R1.0911.00
259_R264_D1.0801.00
54_P61_R1.0801.00
111_Y114_W1.0791.00
193_R267_D1.0791.00
48_I62_L1.0771.00
170_A187_V1.0771.00
171_E175_A1.0741.00
169_S172_G1.0671.00
176_I257_L1.0661.00
22_L35_F1.0661.00
11_V22_L1.0591.00
209_N215_G1.0561.00
103_N107_L1.0531.00
114_W118_R1.0491.00
27_R30_D1.0491.00
203_T210_A1.0491.00
238_L280_P1.0381.00
183_V244_F1.0361.00
174_E189_Q1.0331.00
273_V276_A1.0271.00
204_R208_A1.0241.00
34_R59_P1.0221.00
242_E295_T1.0201.00
130_R133_R1.0181.00
163_L260_F1.0121.00
234_G273_V1.0081.00
250_A253_R1.0001.00
180_Y257_L0.9991.00
115_A125_R0.9971.00
203_T218_L0.9961.00
45_P49_A0.9911.00
122_S129_D0.9871.00
33_V62_L0.9841.00
178_S185_V0.9801.00
24_R116_K0.9781.00
165_Q169_S0.9761.00
22_L108_S0.9711.00
258_V268_W0.9701.00
274_L278_E0.9681.00
247_G291_R0.9661.00
291_R295_T0.9561.00
208_A211_R0.9511.00
49_A63_T0.9461.00
123_Y132_S0.9461.00
152_P155_A0.9441.00
83_L95_L0.9401.00
202_R220_S0.9391.00
196_P202_R0.9381.00
87_R93_P0.9351.00
119_P123_Y0.9331.00
9_Q12_R0.9311.00
162_L165_Q0.9241.00
192_G225_R0.9211.00
132_S157_L0.9191.00
86_E90_A0.9171.00
151_V154_E0.9141.00
146_L149_R0.9131.00
285_G290_P0.9121.00
38_D63_T0.9041.00
22_L32_P0.9041.00
103_N106_L0.9021.00
233_L244_F0.9021.00
236_L240_Q0.9011.00
193_R227_S0.9001.00
248_G253_R0.8991.00
162_L172_G0.8951.00
210_A215_G0.8951.00
249_D253_R0.8941.00
238_L295_T0.8941.00
143_T146_L0.8921.00
39_P84_A0.8921.00
236_L241_Y0.8901.00
141_L156_L0.8891.00
67_L110_F0.8791.00
88_R93_P0.8771.00
23_G112_R0.8771.00
239_A242_E0.8771.00
173_L258_V0.8751.00
139_I156_L0.8680.99
139_I157_L0.8660.99
28_P31_E0.8650.99
203_T209_N0.8610.99
20_P30_D0.8600.99
123_Y129_D0.8550.99
204_R207_R0.8510.99
3_Y46_S0.8510.99
196_P220_S0.8490.99
252_R255_R0.8430.99
254_L270_V0.8400.99
246_P294_W0.8400.99
41_L81_T0.8330.99
233_L270_V0.8290.99
119_P131_F0.8270.99
5_F10_A0.8230.99
31_E108_S0.8220.99
3_Y45_P0.8220.99
238_L278_E0.8120.99
45_P65_N0.8110.99
251_L255_R0.8080.99
23_G31_E0.8070.99
214_V218_L0.8060.99
147_R153_D0.8030.99
252_R256_A0.8030.99
134_Y137_A0.7980.99
69_L103_N0.7980.99
37_Q68_G0.7960.99
10_A13_L0.7950.99
255_R259_R0.7900.99
99_L103_N0.7790.99
34_R104_H0.7770.99
22_L31_E0.7640.99
184_P235_P0.7620.99
177_L254_L0.7610.99
238_L274_L0.7610.99
41_L78_L0.7600.99
196_P199_P0.7590.99
163_L168_R0.7540.99
136_L141_L0.7540.99
233_L254_L0.7520.99
31_E104_H0.7500.99
69_L99_L0.7500.99
187_V229_F0.7500.99
170_A174_E0.7400.98
211_R216_A0.7380.98
136_L156_L0.7360.98
177_L181_F0.7350.98
54_P60_P0.7320.98
245_L295_T0.7300.98
183_V240_Q0.7280.98
131_F134_Y0.7270.98
93_P96_R0.7220.98
31_E112_R0.7220.98
276_A279_V0.7200.98
35_F64_V0.7190.98
247_G251_L0.7180.98
80_Y99_L0.7170.98
47_E66_F0.7150.98
21_R24_R0.7090.98
282_L298_L0.7080.98
12_R125_R0.7060.98
82_E86_E0.7030.98
244_F250_A0.6970.98
64_V67_L0.6950.98
245_L272_L0.6950.98
195_L227_S0.6930.98
55_E58_G0.6910.97
290_P296_T0.6890.97
177_L180_Y0.6890.97
35_F108_S0.6880.97
39_P88_R0.6870.97
173_L177_L0.6850.97
142_G146_L0.6850.97
76_L80_Y0.6840.97
130_R134_Y0.6810.97
238_L241_Y0.6770.97
186_E234_G0.6770.97
53_R60_P0.6760.97
7_F64_V0.6720.97
87_R96_R0.6690.97
205_L210_A0.6690.97
191_V269_D0.6680.97
135_L160_A0.6680.97
247_G294_W0.6670.97
54_P59_P0.6660.97
39_P81_T0.6640.97
247_G253_R0.6640.97
178_S184_P0.6630.97
181_F233_L0.6600.97
162_L171_E0.6600.97
5_F13_L0.6570.97
23_G28_P0.6570.97
10_A14_L0.6550.97
2_P5_F0.6530.96
156_L257_L0.6520.96
48_I66_F0.6500.96
155_A180_Y0.6500.96
102_F106_L0.6490.96
177_L258_V0.6480.96
241_Y297_W0.6460.96
181_F250_A0.6430.96
122_S125_R0.6410.96
207_R210_A0.6400.96
148_G153_D0.6370.96
118_R121_V0.6360.96
151_V155_A0.6350.96
181_F185_V0.6340.96
174_E185_V0.6330.96
159_Y162_L0.6320.96
2_P46_S0.6310.96
70_T81_T0.6310.96
138_L164_A0.6310.96
115_A121_V0.6300.96
197_L222_V0.6300.96
156_L163_L0.6300.96
70_T79_H0.6280.96
48_I64_V0.6270.96
8_F110_F0.6260.95
14_L33_V0.6240.95
197_L202_R0.6230.95
22_L112_R0.6180.95
80_Y84_A0.6170.95
70_T78_L0.6160.95
32_P108_S0.6160.95
22_L25_A0.6160.95
198_P253_R0.6160.95
174_E231_I0.6150.95
245_L294_W0.6130.95
40_S65_N0.6090.95
290_P295_T0.6070.95
256_A260_F0.6060.95
23_G108_S0.6060.95
246_P251_L0.6040.95
44_P49_A0.6000.94
188_E271_Q0.5940.94
6_D9_Q0.5940.94
23_G29_A0.5920.94
54_P57_D0.5910.94
149_R256_A0.5910.94
206_G210_A0.5910.94
279_V297_W0.5900.94
41_L82_E0.5890.94
70_T100_D0.5890.94
104_H112_R0.5860.94
283_R286_G0.5850.94
63_T97_D0.5850.94
28_P32_P0.5850.94
240_Q275_K0.5840.94
172_G176_I0.5840.94
161_G164_A0.5830.93
233_L272_L0.5820.93
201_Q209_N0.5790.93
119_P132_S0.5770.93
22_L28_P0.5730.93
77_P80_Y0.5690.93
66_F110_F0.5680.93
133_R147_R0.5670.93
98_F101_I0.5660.92
71_G81_T0.5640.92
12_R121_V0.5610.92
115_A122_S0.5570.92
134_Y138_L0.5570.92
212_L216_A0.5560.92
256_A261_Y0.5550.92
106_L109_L0.5540.92
87_R90_A0.5540.92
285_G289_G0.5540.92
208_A215_G0.5540.92
158_F161_G0.5530.92
274_L279_V0.5510.91
159_Y176_I0.5500.91
205_L298_L0.5490.91
37_Q84_A0.5470.91
286_G289_G0.5460.91
262_L265_E0.5460.91
37_Q107_L0.5450.91
40_S81_T0.5440.91
251_L270_V0.5440.91
24_R231_I0.5430.91
44_P72_P0.5430.91
188_E269_D0.5430.91
39_P85_L0.5430.91
43_F46_S0.5420.91
115_A119_P0.5420.91
14_L60_P0.5410.91
143_T147_R0.5400.91
39_P96_R0.5390.91
234_G278_E0.5390.91
108_S112_R0.5390.91
85_L91_G0.5380.90
50_S58_G0.5340.90
92_D98_F0.5330.90
244_F292_L0.5330.90
239_A278_E0.5330.90
78_L81_T0.5310.90
237_S241_Y0.5300.90
285_G288_G0.5300.90
259_R268_W0.5300.90
185_V236_L0.5290.90
177_L257_L0.5280.90
182_G240_Q0.5260.89
25_A28_P0.5260.89
36_R96_R0.5250.89
200_D208_A0.5240.89
86_E92_D0.5220.89
173_L187_V0.5220.89
204_R220_S0.5220.89
119_P122_S0.5220.89
249_D252_R0.5220.89
37_Q96_R0.5220.89
248_G291_R0.5200.89
209_N216_A0.5200.89
199_P220_S0.5180.89
150_A153_D0.5180.89
199_P204_R0.5180.89
43_F114_W0.5160.89
235_P275_K0.5150.88
52_E55_E0.5150.88
178_S183_V0.5140.88
136_L139_I0.5130.88
76_L79_H0.5120.88
142_G147_R0.5100.88
176_I179_D0.5090.88
146_L153_D0.5090.88
110_F113_A0.5060.88
102_F108_S0.5060.88
115_A258_V0.5050.87
52_E58_G0.5050.87
38_D50_S0.5040.87
169_S261_Y0.5040.87
274_L297_W0.5030.87
68_G72_P0.5030.87
132_S154_E0.5010.87
88_R96_R0.5000.87
91_G263_G0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d9rA 1 0.2542 8.4 0.967 Contact Map
4n6aA 3 0.7291 7.9 0.967 Contact Map
4mfgA 3 0.3478 7 0.968 Contact Map
3r3rA 3 0.3612 6.7 0.968 Contact Map
2eyxA 1 0.2074 6.4 0.968 Contact Map
3ixcA 3 0.3478 6.2 0.969 Contact Map
1ycsB 1 0.2676 5.9 0.969 Contact Map
4n78F 1 0 5.9 0.969 Contact Map
3r1wA 3 0.3545 5.4 0.97 Contact Map
4r36A 3 0.398 5.3 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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