GREMLIN Database
DUF1304 - Protein of unknown function (DUF1304)
PFAM: PF06993 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 110 (107)
Sequences: 8170 (4768)
Seq/√Len: 460.9
META: 0.848

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_V17_L2.9741.00
19_T35_A2.6151.00
31_P35_A2.5351.00
33_F36_A2.3681.00
19_T39_K2.2911.00
59_G72_K2.2621.00
83_G99_A2.1841.00
11_L50_G2.1421.00
43_A85_Y2.0121.00
74_F78_C1.9931.00
80_I99_A1.9761.00
73_L106_L1.9761.00
55_G74_F1.7861.00
93_R97_V1.7661.00
22_R26_T1.6551.00
30_T34_A1.6381.00
29_L33_F1.6361.00
32_E36_A1.6161.00
6_L10_I1.6151.00
69_F72_K1.5631.00
67_W70_A1.4391.00
33_F37_T1.3851.00
58_W71_V1.3841.00
8_V57_I1.3781.00
11_L15_M1.3741.00
4_A57_I1.3621.00
80_I103_L1.3491.00
64_D70_A1.3381.00
24_R29_L1.3321.00
55_G75_F1.3061.00
104_L108_L1.2941.00
13_L23_G1.2921.00
76_L105_A1.2811.00
24_R31_P1.2771.00
22_R25_K1.2631.00
51_F78_C1.2611.00
15_M85_Y1.2571.00
18_W41_L1.2431.00
62_L67_W1.2281.00
30_T33_F1.2201.00
3_V79_V1.1971.00
69_F73_L1.1901.00
20_T23_G1.1811.00
8_V53_A1.1731.00
17_L20_T1.1651.00
24_R34_A1.1611.00
73_L77_G1.1561.00
59_G71_V1.1411.00
11_L16_F1.1391.00
15_M47_L1.1321.00
62_L71_V1.1171.00
62_L70_A1.1101.00
56_L75_F1.1001.00
31_P34_A1.0941.00
72_K109_L1.0751.00
47_L85_Y1.0651.00
87_A95_L1.0631.00
19_T24_R1.0581.00
73_L109_L1.0511.00
95_L103_L1.0431.00
12_V16_F1.0381.00
9_Y26_T1.0131.00
59_G68_G1.0031.00
34_A37_T0.9931.00
58_W70_A0.9891.00
58_W75_F0.9711.00
60_L72_K0.9681.00
13_L26_T0.9601.00
20_T24_R0.9511.00
84_I88_A0.9411.00
51_F82_A0.9331.00
95_L99_A0.9271.00
80_I106_L0.9201.00
29_L34_A0.9181.00
23_G26_T0.9151.00
11_L53_A0.8931.00
43_A88_A0.8671.00
30_T36_A0.8651.00
67_W71_V0.8451.00
19_T36_A0.8431.00
57_I61_L0.8421.00
47_L51_F0.8391.00
9_Y22_R0.8201.00
41_L90_A0.8141.00
99_A103_L0.8111.00
10_I97_V0.8091.00
6_L11_L0.8001.00
39_K43_A0.7931.00
77_G81_V0.7891.00
17_L23_G0.7841.00
40_V90_A0.7801.00
64_D67_W0.7751.00
17_L22_R0.7711.00
96_F100_L0.7591.00
24_R32_E0.7521.00
63_G68_G0.7521.00
66_A70_A0.7471.00
30_T37_T0.7471.00
56_L76_L0.7421.00
18_W42_A0.7331.00
58_W62_L0.7281.00
65_P69_F0.7201.00
65_P70_A0.7051.00
47_L50_G0.7001.00
62_L65_P0.6921.00
6_L9_Y0.6921.00
18_W37_T0.6911.00
92_R96_F0.6901.00
99_A102_A0.6871.00
32_E35_A0.6811.00
53_A57_I0.6801.00
56_L79_V0.6791.00
29_L37_T0.6781.00
86_G94_I0.6771.00
79_V102_A0.6751.00
3_V6_L0.6691.00
68_G72_K0.6651.00
29_L35_A0.6641.00
29_L36_A0.6401.00
19_T34_A0.6360.99
3_V80_I0.6360.99
62_L68_G0.6290.99
40_V89_T0.6240.99
44_N98_Q0.6230.99
24_R35_A0.6190.99
92_R95_L0.6190.99
2_L101_P0.6170.99
37_T41_L0.6160.99
30_T35_A0.6130.99
37_T42_A0.6060.99
36_A40_V0.6030.99
29_L40_V0.5930.99
90_A94_I0.5930.99
78_C82_A0.5890.99
11_L47_L0.5890.99
21_P24_R0.5850.99
44_N48_Y0.5830.99
2_L6_L0.5820.99
41_L45_Q0.5740.99
87_A96_F0.5730.99
86_G95_L0.5710.99
56_L72_K0.5690.99
71_V75_F0.5600.99
21_P31_P0.5530.99
44_N89_T0.5480.99
3_V76_L0.5470.98
66_A69_F0.5450.98
43_A47_L0.5330.98
14_E44_N0.5320.98
28_G34_A0.5290.98
44_N82_A0.5280.98
5_L57_I0.5220.98
77_G106_L0.5190.98
42_A45_Q0.5160.98
12_V22_R0.5120.98
43_A89_T0.5030.97
58_W77_G0.5020.97
63_G67_W0.5010.97
28_G91_S0.5000.97
8_V12_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n7wA 2 0.8 5.9 0.923 Contact Map
4gd3A 2 0.1727 4.1 0.928 Contact Map
4jc95 3 0.2182 3.5 0.93 Contact Map
3wmmA 3 0.2909 2.2 0.938 Contact Map
1khyA 1 0.3636 1.7 0.941 Contact Map
2y1qA 1 0.4091 1.5 0.943 Contact Map
1lghA 5 0.2636 1.5 0.944 Contact Map
1xrdA 1 0.2727 1.5 0.944 Contact Map
3j01B 1 0.4091 1.4 0.944 Contact Map
2zf9A 1 0.5364 1.4 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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