GREMLIN Database
TraN - Type-1V conjugative transfer system mating pair stabilisation
PFAM: PF06986 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 240 (239)
Sequences: 691 (555)
Seq/√Len: 35.9
META: 0.724

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_C207_C6.5021.00
190_C198_C5.6401.00
93_C98_C5.0321.00
208_F221_R4.3031.00
10_E28_K3.7471.00
184_H228_W3.7151.00
8_C26_C3.5001.00
214_R218_E3.0171.00
149_F159_G2.9511.00
226_I237_R2.8391.00
227_G235_D2.7661.00
171_E174_L2.7071.00
109_F113_V2.6521.00
14_T21_P2.6341.00
141_T204_S2.5931.00
14_T23_T2.5751.00
185_Y203_K2.5251.00
56_S69_Y2.5231.00
16_T21_P2.5221.00
155_D178_R2.4831.00
178_R205_Y2.3791.00
10_E13_E2.2990.99
58_C66_C2.1740.99
9_T30_E1.9960.98
191_S202_K1.9720.98
53_Q71_Q1.9620.98
53_Q56_S1.9510.98
111_D115_A1.9230.98
184_H218_E1.9220.98
194_V197_V1.8930.98
51_C75_C1.8680.97
143_R200_T1.8370.97
149_F158_W1.8210.97
121_E125_D1.8090.97
6_E31_R1.8000.97
217_Q221_R1.7260.96
192_K199_L1.6980.96
185_Y205_Y1.6460.95
188_T203_K1.6390.95
11_G14_T1.6380.95
219_Q222_P1.6300.94
220_G223_Q1.5980.94
177_A207_C1.5870.94
193_K201_K1.5770.93
190_C193_K1.5700.93
56_S71_Q1.5490.93
57_E70_E1.5420.93
221_R228_W1.5340.92
41_N44_G1.5290.92
1_C35_C1.5080.92
133_T136_K1.5030.92
229_G234_P1.4880.91
169_S172_K1.4850.91
191_S200_T1.4760.91
9_T28_K1.4300.89
177_A183_C1.4120.89
177_A182_L1.4110.89
47_R50_G1.3950.88
192_K200_T1.3870.88
139_A204_S1.3830.88
100_D103_R1.3740.87
217_Q224_L1.3440.86
220_G224_L1.3290.85
188_T201_K1.3250.85
226_I235_D1.3060.84
212_L220_G1.2840.83
168_S171_E1.2560.82
117_A121_E1.2520.82
118_A122_A1.2300.81
12_P23_T1.2170.80
210_S213_A1.2160.80
208_F237_R1.2150.80
150_S163_G1.2130.80
212_L219_Q1.2060.79
93_C96_G1.2040.79
19_G22_V1.1800.78
3_L6_E1.1780.78
87_C93_C1.1710.77
159_G165_A1.1680.77
159_G164_L1.1400.75
91_V94_L1.1370.75
87_C98_C1.1350.75
158_W163_G1.1270.75
194_V199_L1.1260.74
159_G163_G1.1250.74
193_K198_C1.1190.74
184_H214_R1.0940.72
176_K180_K1.0750.71
113_V213_A1.0720.71
176_K179_E1.0650.70
140_M207_C1.0480.69
158_W165_A1.0430.69
175_A179_E1.0400.68
111_D119_L1.0370.68
56_S72_T1.0230.67
121_E128_P1.0090.66
189_Y204_S1.0060.66
61_D64_G1.0020.65
150_S160_L1.0000.65
144_K161_D0.9940.65
155_D175_A0.9910.65
161_D164_L0.9880.64
189_Y232_K0.9860.64
229_G236_C0.9810.64
42_D57_E0.9810.64
220_G239_F0.9780.64
178_R203_K0.9760.63
20_V45_A0.9740.63
208_F217_Q0.9670.63
146_V191_S0.9620.62
189_Y198_C0.9600.62
113_V116_L0.9570.62
189_Y202_K0.9500.61
143_R168_S0.9450.61
152_C167_C0.9450.61
12_P25_D0.9440.61
139_A234_P0.9410.60
17_I23_T0.9400.60
13_E21_P0.9380.60
181_G211_K0.9310.60
204_S234_P0.9170.58
227_G234_P0.9120.58
181_G184_H0.9080.58
158_W175_A0.9020.57
236_C240_T0.8880.56
221_R237_R0.8870.56
208_F220_G0.8840.56
116_L157_G0.8840.56
11_G25_D0.8830.56
119_L127_D0.8810.55
15_R27_W0.8790.55
189_Y193_K0.8780.55
54_V74_S0.8770.55
236_C239_F0.8760.55
17_I21_P0.8740.55
135_F167_C0.8720.55
211_K219_Q0.8720.55
118_A216_I0.8700.54
143_R202_K0.8690.54
187_G229_G0.8660.54
121_E124_K0.8660.54
115_A119_L0.8610.54
134_I239_F0.8600.54
141_T234_P0.8540.53
151_N196_G0.8530.53
204_S235_D0.8520.53
10_E15_R0.8500.53
53_Q73_Y0.8500.53
117_A208_F0.8370.52
201_K232_K0.8330.51
158_W179_E0.8290.51
161_D166_K0.8280.51
198_C201_K0.8270.51
145_K150_S0.8260.51
53_Q69_Y0.8260.51
218_E228_W0.8150.50
115_A125_D0.8140.50
143_R171_E0.8110.49
7_V30_E0.8110.49
150_S215_I0.8110.49
165_A177_A0.8100.49
15_R73_Y0.8060.49
157_G160_L0.8050.49
94_L97_D0.7980.48
87_C95_D0.7910.48
157_G163_G0.7900.48
141_T227_G0.7890.47
142_C153_C0.7890.47
207_C228_W0.7850.47
214_R239_F0.7840.47
50_G71_Q0.7830.47
154_K201_K0.7820.47
60_D104_E0.7810.47
146_V210_S0.7790.47
17_I22_V0.7780.46
95_D228_W0.7780.46
206_C210_S0.7780.46
151_N154_K0.7770.46
23_T45_A0.7760.46
9_T29_Y0.7750.46
162_L165_A0.7740.46
190_C199_L0.7730.46
14_T17_I0.7720.46
177_A228_W0.7680.46
26_C29_Y0.7670.46
109_F157_G0.7670.46
48_N231_A0.7660.45
50_G54_V0.7610.45
144_K188_T0.7590.45
227_G230_S0.7570.45
89_G95_D0.7560.45
206_C236_C0.7470.44
74_S79_T0.7420.43
4_T7_V0.7420.43
4_T32_T0.7420.43
136_K201_K0.7320.43
13_E16_T0.7300.42
157_G164_L0.7290.42
186_V231_A0.7280.42
215_I220_G0.7270.42
191_S198_C0.7250.42
202_K232_K0.7220.42
169_S173_A0.7210.42
95_D107_T0.7190.41
3_L31_R0.7140.41
158_W178_R0.7080.41
228_W239_F0.6990.40
91_V144_K0.6910.39
13_E23_T0.6910.39
88_G124_K0.6900.39
106_N125_D0.6880.39
50_G209_G0.6860.39
7_V12_P0.6850.39
11_G18_N0.6850.39
72_T89_G0.6820.38
52_T74_S0.6790.38
148_G155_D0.6750.38
127_D130_N0.6750.38
122_A217_Q0.6740.38
86_V232_K0.6730.38
120_A124_K0.6720.38
6_E29_Y0.6720.38
160_L163_G0.6680.37
151_N203_K0.6680.37
46_L50_G0.6640.37
17_I27_W0.6630.37
110_G114_S0.6620.37
28_K238_G0.6600.37
157_G161_D0.6600.37
50_G69_Y0.6550.36
217_Q222_P0.6490.36
109_F217_Q0.6480.36
63_G67_V0.6480.36
4_T9_T0.6460.35
26_C87_C0.6450.35
189_Y231_A0.6410.35
154_K168_S0.6380.35
222_P235_D0.6360.35
191_S233_S0.6340.35
137_G142_C0.6300.34
19_G26_C0.6260.34
137_G153_C0.6250.34
16_T19_G0.6230.34
16_T24_R0.6200.33
135_F217_Q0.6200.33
228_W238_G0.6170.33
214_R228_W0.6170.33
107_T195_L0.6120.33
87_C96_G0.6120.33
140_M170_E0.6080.32
53_Q72_T0.6080.32
50_G53_Q0.6070.32
190_C202_K0.6060.32
157_G179_E0.6050.32
141_T188_T0.6040.32
149_F165_A0.6020.32
39_S42_D0.6010.32
112_A230_S0.5980.32
190_C196_G0.5960.32
230_S234_P0.5950.32
155_D158_W0.5940.31
143_R150_S0.5930.31
99_E112_A0.5920.31
49_P59_L0.5920.31
193_K199_L0.5910.31
237_R240_T0.5900.31
73_Y82_S0.5900.31
109_F175_A0.5890.31
114_S159_G0.5880.31
43_C142_C0.5880.31
207_C239_F0.5880.31
16_T20_V0.5870.31
53_Q74_S0.5860.31
80_C183_C0.5840.31
151_N205_Y0.5830.31
112_A181_G0.5830.31
91_V99_E0.5820.31
53_Q59_L0.5790.30
61_D67_V0.5770.30
145_K151_N0.5750.30
18_N29_Y0.5710.30
125_D213_A0.5710.30
141_T168_S0.5700.30
17_I24_R0.5690.30
172_K179_E0.5670.29
221_R235_D0.5640.29
155_D205_Y0.5630.29
24_R27_W0.5630.29
12_P21_P0.5620.29
109_F120_A0.5620.29
158_W161_D0.5610.29
175_A207_C0.5600.29
54_V174_L0.5600.29
212_L215_I0.5590.29
164_L175_A0.5580.29
144_K180_K0.5560.29
26_C51_C0.5540.29
26_C75_C0.5540.29
6_E9_T0.5530.28
146_V208_F0.5520.28
11_G15_R0.5500.28
86_V184_H0.5500.28
25_D28_K0.5450.28
56_S70_E0.5430.28
193_K204_S0.5420.28
47_R64_G0.5410.28
181_G195_L0.5400.28
17_I39_S0.5390.27
7_V22_V0.5380.27
16_T23_T0.5370.27
38_P52_T0.5350.27
50_G56_S0.5340.27
36_S240_T0.5340.27
49_P53_Q0.5310.27
89_G184_H0.5300.27
140_M177_A0.5300.27
115_A210_S0.5290.27
98_C158_W0.5280.27
58_C98_C0.5270.27
20_V57_E0.5260.27
79_T178_R0.5260.27
222_P239_F0.5250.27
150_S191_S0.5250.27
141_T189_Y0.5250.27
154_K179_E0.5240.26
18_N104_E0.5240.26
2_T25_D0.5230.26
41_N94_L0.5230.26
154_K212_L0.5220.26
15_R19_G0.5220.26
70_E188_T0.5210.26
211_K214_R0.5200.26
83_T188_T0.5190.26
10_E23_T0.5180.26
39_S240_T0.5180.26
135_F152_C0.5180.26
7_V19_G0.5170.26
123_G203_K0.5170.26
156_K179_E0.5150.26
192_K202_K0.5130.26
184_H239_F0.5110.26
166_K205_Y0.5080.25
69_Y74_S0.5080.25
75_C206_C0.5080.25
61_D70_E0.5080.25
13_E25_D0.5070.25
195_L211_K0.5060.25
102_S107_T0.5060.25
12_P79_T0.5060.25
22_V27_W0.5060.25
12_P29_Y0.5060.25
7_V10_E0.5050.25
24_R29_Y0.5050.25
119_L203_K0.5030.25
5_S32_T0.5030.25
77_E177_A0.5020.25
16_T22_V0.5000.25
12_P53_Q0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t4rA 1 0.1125 3.2 0.973 Contact Map
3ssbC 1 0.1333 2.4 0.975 Contact Map
2mjkA 1 0.1542 2.3 0.975 Contact Map
2m0pA 1 0.1917 1.9 0.976 Contact Map
1ajjA 1 0.1542 1.8 0.977 Contact Map
1cr8A 1 0.1708 1.7 0.977 Contact Map
1eyoA 1 0.125 1.7 0.977 Contact Map
1k36A 1 0.1292 1.7 0.977 Contact Map
2jm4A 1 0.175 1.7 0.977 Contact Map
2m96A 1 0.1792 1.7 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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