DUF1302 - PFAM28P - GREMLIN Contacts

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DUF1302 - Protein of unknown function (DUF1302)

PFAM:	PF06980	Sequences: EFDTGDLEGSFDTTLSYGASWRTEDPDPDLIGKANGGGANSPNGDDGNLNFDKGDLVSNRLKGLSELDLKYGDNYGAFVRGAAWYDFELMKDNDRPFTPLSDDGFSDAARDLAGSGAELLDAFVYGNFDLGDMPLSVRLGRQVVSWGESLFIQNGINSINPVDVSKLRVPGAELKEALLPVNMLSASLGLTDNLSLEAFYQFEWEPTRLDPCGTYFSTNDFAGAGGCRLILGFGALPDPGGPAGPGLAVPRGGDREPRDSGQFGVALRYFAEELNTEFGLYYMNYHSRLPQLSGAAGAAAAAAGLAAAGTGSYFLEYPEDIKLYGLSFNTTLGGTAVGGELSYRPNMPLQIDDVDLLFAAAGLSPLLAGGSQLGAVAPGQDIPGYARGDTTQAQLTATKVFGPTLGADQLTLVGEVGYTHVLDLPDLRYGRPGTFGANANPNGCETDGFATRFSWGYRLRFTPTYNNVFPGVDLSPPLAFSHDVKGNSPGPGGNFNEGRKSLSLGLDADYLNKWTADLSYTNFFGGGTYNLLRDRDFVSLSVKYSF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	546 (541)
Sequences:	2923 (2079)
Seq/√Len:	89.4
META:	0.65

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
182_N	202_F	5.097	1.00
139_L	184_L	4.260	1.00
418_Y	453_F	4.248	1.00
23_T	538_V	3.968	1.00
328_F	339_G	3.925	1.00
9_G	69_L	3.882	1.00
284_N	322_K	3.763	1.00
280_L	326_L	3.734	1.00
420_H	453_F	3.464	1.00
135_L	188_L	3.389	1.00
17_Y	59_N	3.332	1.00
25_D	53_K	3.299	1.00
474_L	506_L	3.225	1.00
391_T	422_L	3.205	1.00
141_R	182_N	3.177	1.00
284_N	320_D	3.142	1.00
26_P	52_D	3.099	1.00
474_L	508_A	3.053	1.00
182_N	203_E	3.050	1.00
271_A	278_F	3.011	1.00
194_L	269_Y	3.003	1.00
282_Y	322_K	2.958	1.00
75_Y	126_G	2.894	1.00
133_M	188_L	2.827	1.00
20_S	57_V	2.818	1.00
457_Y	482_H	2.768	1.00
345_P	389_D	2.686	1.00
335_T	399_K	2.666	1.00
341_L	391_T	2.656	1.00
514_W	542_V	2.622	1.00
455_W	484_V	2.578	1.00
341_L	393_A	2.555	1.00
251_R	254_D	2.547	1.00
19_A	56_L	2.547	1.00
196_L	267_L	2.521	1.00
346_N	389_D	2.513	1.00
161_P	181_V	2.482	1.00
142_Q	185_S	2.479	1.00
79_V	122_A	2.416	1.00
13_T	63_G	2.401	1.00
11_F	65_S	2.384	1.00
139_L	202_F	2.361	1.00
252_G	312_S	2.345	1.00
322_K	346_N	2.328	1.00
507_D	517_D	2.272	1.00
144_V	183_M	2.227	1.00
286_H	319_E	2.205	1.00
77_A	124_V	2.199	1.00
11_F	67_L	2.180	1.00
76_G	125_Y	2.153	1.00
168_R	210_D	2.148	1.00
257_P	319_E	2.144	1.00
13_T	65_S	2.139	1.00
468_V	474_L	2.125	1.00
268_R	277_E	2.116	1.00
126_G	135_L	2.105	1.00
21_W	56_L	2.097	1.00
141_R	203_E	2.080	1.00
464_T	475_S	2.076	1.00
293_S	316_E	2.060	1.00
516_A	540_L	2.047	1.00
63_G	83_A	2.029	1.00
197_E	266_A	2.004	1.00
455_W	485_K	1.993	1.00
472_V	508_A	1.991	1.00
81_G	117_A	1.963	1.00
207_T	289_L	1.962	1.00
51_F	89_L	1.945	1.00
477_P	505_G	1.945	1.00
282_Y	324_Y	1.941	1.00
518_L	540_L	1.936	1.00
128_F	137_V	1.891	1.00
129_D	132_D	1.870	1.00
93_N	96_P	1.856	1.00
351_I	386_A	1.851	1.00
335_T	397_A	1.837	1.00
269_Y	280_L	1.805	1.00
62_K	176_E	1.797	1.00
349_L	390_T	1.796	1.00
337_V	397_A	1.793	1.00
65_S	83_A	1.792	1.00
88_E	95_R	1.790	1.00
24_E	522_N	1.788	1.00
144_V	185_S	1.786	1.00
408_D	466_N	1.768	1.00
337_V	395_L	1.764	1.00
457_Y	484_V	1.759	1.00
150_L	396_T	1.758	1.00
283_M	323_L	1.750	1.00
113_A	214_T	1.748	1.00
167_L	177_A	1.742	1.00
410_L	461_F	1.721	1.00
338_G	396_T	1.699	1.00
514_W	544_Y	1.694	1.00
496_N	499_R	1.681	1.00
9_G	67_L	1.677	1.00
347_M	390_T	1.674	1.00
261_G	286_H	1.668	1.00
119_L	122_A	1.646	1.00
2_F	9_G	1.642	1.00
285_Y	323_L	1.641	1.00
462_T	475_S	1.631	1.00
20_S	58_S	1.631	1.00
105_F	109_A	1.626	1.00
135_L	186_A	1.604	1.00
500_K	524_F	1.602	1.00
46_D	220_D	1.600	1.00
262_Q	286_H	1.597	1.00
516_A	542_V	1.592	1.00
255_R	314_F	1.589	1.00
199_F	283_M	1.585	1.00
83_A	117_A	1.581	1.00
187_S	195_S	1.557	1.00
149_S	394_Q	1.557	1.00
56_L	59_N	1.548	1.00
181_V	201_Q	1.541	1.00
193_N	272_E	1.517	1.00
472_V	510_Y	1.491	1.00
286_H	320_D	1.490	1.00
324_Y	345_P	1.484	1.00
206_P	317_Y	1.472	1.00
321_I	348_P	1.468	0.99
338_G	398_T	1.465	0.99
191_T	194_L	1.458	0.99
137_V	184_L	1.451	0.99
457_Y	480_F	1.436	0.99
416_V	455_W	1.427	0.99
271_A	274_L	1.426	0.99
465_Y	476_P	1.424	0.99
137_V	186_A	1.417	0.99
451_T	487_N	1.416	0.99
23_T	26_P	1.412	0.99
194_L	267_L	1.412	0.99
70_K	125_Y	1.410	0.99
257_P	286_H	1.401	0.99
346_N	387_R	1.397	0.99
502_L	524_F	1.396	0.99
505_G	519_S	1.394	0.99
203_E	259_D	1.393	0.99
159_I	199_F	1.391	0.99
6_D	72_G	1.390	0.99
200_Y	261_G	1.390	0.99
386_A	429_Y	1.390	0.99
377_A	380_Q	1.389	0.99
519_S	539_S	1.385	0.99
251_R	313_Y	1.381	0.99
502_L	522_N	1.363	0.99
186_A	198_A	1.358	0.99
255_R	316_E	1.354	0.99
128_F	135_L	1.351	0.99
173_E	543_K	1.331	0.99
190_L	267_L	1.324	0.99
57_V	215_Y	1.318	0.99
293_S	314_F	1.316	0.99
19_A	59_N	1.315	0.99
410_L	463_P	1.312	0.99
16_S	62_K	1.310	0.99
7_L	71_Y	1.309	0.99
287_S	321_I	1.307	0.99
156_I	342_S	1.294	0.99
2_F	5_G	1.290	0.99
322_K	345_P	1.287	0.99
23_T	54_G	1.284	0.99
31_I	49_L	1.270	0.99
280_L	324_Y	1.263	0.98
343_Y	391_T	1.260	0.98
144_V	199_F	1.253	0.98
481_S	501_S	1.245	0.98
254_D	315_L	1.244	0.98
397_A	414_G	1.241	0.98
113_A	211_P	1.240	0.98
517_D	541_S	1.234	0.98
201_Q	288_R	1.227	0.98
469_F	472_V	1.226	0.98
407_A	465_Y	1.221	0.98
223_G	226_G	1.220	0.98
349_L	388_G	1.218	0.98
414_G	459_L	1.215	0.98
64_L	82_A	1.213	0.98
20_S	539_S	1.211	0.98
482_H	500_K	1.210	0.98
477_P	517_D	1.210	0.98
258_R	320_D	1.205	0.98
134_P	189_G	1.202	0.98
79_V	119_L	1.200	0.98
174_L	178_L	1.193	0.98
32_G	42_P	1.192	0.98
23_T	215_Y	1.188	0.98
485_K	497_E	1.182	0.98
458_R	481_S	1.179	0.98
515_T	543_K	1.172	0.97
198_A	265_V	1.171	0.97
52_D	55_D	1.170	0.97
480_F	500_K	1.170	0.97
388_G	429_Y	1.169	0.97
401_F	410_L	1.166	0.97
3_D	6_D	1.163	0.97
271_A	276_T	1.163	0.97
31_I	45_D	1.160	0.97
158_S	283_M	1.154	0.97
430_G	436_G	1.152	0.97
164_V	209_L	1.144	0.97
505_G	517_D	1.142	0.97
252_G	314_F	1.138	0.97
390_T	421_V	1.138	0.97
509_D	512_N	1.136	0.97
393_A	418_Y	1.133	0.97
156_I	323_L	1.132	0.97
59_N	87_F	1.128	0.97
388_G	425_P	1.123	0.97
22_R	48_N	1.121	0.97
261_G	284_N	1.121	0.97
468_V	473_D	1.117	0.97
255_R	381_D	1.115	0.97
416_V	484_V	1.112	0.97
92_D	95_R	1.111	0.97
470_P	473_D	1.102	0.96
522_N	536_D	1.096	0.96
80_R	121_D	1.095	0.96
525_G	530_N	1.092	0.96
89_L	95_R	1.091	0.96
14_T	543_K	1.087	0.96
118_E	208_R	1.086	0.96
274_L	278_F	1.086	0.96
8_E	70_K	1.084	0.96
3_D	8_E	1.083	0.96
47_G	50_N	1.080	0.96
341_L	422_L	1.080	0.96
429_Y	433_G	1.079	0.96
212_C	223_G	1.078	0.96
258_R	319_E	1.078	0.96
361_A	365_P	1.076	0.96
81_G	119_L	1.076	0.96
88_E	92_D	1.074	0.96
15_L	63_G	1.069	0.96
101_S	104_G	1.063	0.96
57_V	216_F	1.062	0.96
445_E	448_G	1.059	0.95
483_D	499_R	1.059	0.95
150_L	398_T	1.057	0.95
263_F	284_N	1.054	0.95
420_H	452_R	1.053	0.95
430_G	433_G	1.052	0.95
152_I	417_G	1.049	0.95
106_S	109_A	1.049	0.95
335_T	412_L	1.047	0.95
222_A	315_L	1.045	0.95
366_L	369_G	1.039	0.95
216_F	537_F	1.039	0.95
69_L	77_A	1.037	0.95
404_T	410_L	1.037	0.95
150_L	413_V	1.035	0.95
405_L	463_P	1.032	0.95
475_S	509_D	1.031	0.95
65_S	81_G	1.031	0.95
133_M	190_L	1.025	0.95
151_F	460_R	1.024	0.95
293_S	350_Q	1.013	0.94
87_F	92_D	1.013	0.94
17_Y	61_L	1.012	0.94
89_L	94_D	1.011	0.94
397_A	416_V	1.011	0.94
412_L	459_L	1.008	0.94
88_E	93_N	1.005	0.94
218_T	531_L	1.004	0.94
322_K	389_D	1.002	0.94
425_P	429_Y	0.999	0.94
371_S	374_G	0.999	0.94
141_R	205_E	0.998	0.94
89_L	96_P	0.996	0.94
45_D	49_L	0.992	0.94
43_N	46_D	0.990	0.93
513_K	544_Y	0.988	0.93
278_F	328_F	0.988	0.93
261_G	320_D	0.988	0.93
26_P	31_I	0.987	0.93
89_L	93_N	0.986	0.93
263_F	282_Y	0.984	0.93
172_A	177_A	0.977	0.93
91_K	94_D	0.970	0.93
468_V	506_L	0.965	0.93
398_T	413_V	0.965	0.93
11_F	83_A	0.954	0.92
361_A	364_S	0.950	0.92
193_N	269_Y	0.948	0.92
148_E	327_S	0.947	0.92
330_T	339_G	0.947	0.92
276_T	330_T	0.944	0.92
164_V	167_L	0.943	0.92
82_A	166_K	0.940	0.92
91_K	95_R	0.940	0.92
411_T	464_T	0.938	0.91
199_F	288_R	0.935	0.91
201_Q	262_Q	0.935	0.91
102_D	105_F	0.934	0.91
318_P	348_P	0.931	0.91
294_G	357_L	0.930	0.91
66_E	78_F	0.927	0.91
94_D	97_F	0.918	0.91
74_N	126_G	0.915	0.90
271_A	275_N	0.913	0.90
316_E	383_P	0.910	0.90
23_T	53_K	0.908	0.90
507_D	515_T	0.908	0.90
130_L	135_L	0.906	0.90
419_T	490_G	0.904	0.90
27_D	30_L	0.903	0.90
35_N	49_L	0.901	0.90
235_A	238_D	0.898	0.90
291_Q	318_P	0.898	0.90
343_Y	422_L	0.897	0.90
249_V	311_G	0.897	0.90
152_I	394_Q	0.891	0.89
430_G	435_F	0.890	0.89
332_L	337_V	0.889	0.89
365_P	369_G	0.888	0.89
77_A	81_G	0.888	0.89
508_A	516_A	0.887	0.89
66_E	80_R	0.887	0.89
428_R	431_R	0.886	0.89
276_T	328_F	0.883	0.89
45_D	220_D	0.882	0.89
7_L	69_L	0.880	0.89
150_L	338_G	0.879	0.89
126_G	137_V	0.877	0.89
391_T	420_H	0.868	0.88
421_V	489_P	0.867	0.88
389_D	423_D	0.867	0.88
164_V	207_T	0.866	0.88
46_D	50_N	0.866	0.88
287_S	318_P	0.866	0.88
71_Y	75_Y	0.865	0.88
162_V	178_L	0.863	0.88
179_L	205_E	0.861	0.88
133_M	191_T	0.860	0.88
127_N	136_S	0.860	0.88
13_T	83_A	0.859	0.87
287_S	291_Q	0.856	0.87
155_G	456_G	0.855	0.87
438_N	441_P	0.852	0.87
347_M	490_G	0.852	0.87
252_G	255_R	0.852	0.87
77_A	122_A	0.851	0.87
46_D	49_L	0.844	0.87
273_E	276_T	0.844	0.87
139_L	182_N	0.841	0.86
478_L	504_L	0.838	0.86
190_L	196_L	0.837	0.86
516_A	543_K	0.836	0.86
409_Q	466_N	0.830	0.86
33_K	38_G	0.830	0.86
409_Q	464_T	0.827	0.85
78_F	121_D	0.825	0.85
155_G	488_S	0.824	0.85
509_D	513_K	0.823	0.85
133_M	189_G	0.822	0.85
393_A	416_V	0.821	0.85
303_A	306_A	0.821	0.85
237_P	240_G	0.818	0.85
430_G	434_T	0.816	0.85
33_K	37_G	0.816	0.85
407_A	463_P	0.816	0.85
526_G	530_N	0.815	0.85
166_K	169_V	0.813	0.84
111_D	116_G	0.813	0.84
342_S	392_Q	0.812	0.84
350_Q	356_L	0.808	0.84
163_D	166_K	0.807	0.84
454_S	489_P	0.807	0.84
457_Y	500_K	0.806	0.84
79_V	124_V	0.805	0.84
129_D	134_P	0.803	0.84
503_S	519_S	0.802	0.84
407_A	461_F	0.801	0.84
88_E	96_P	0.800	0.83
510_Y	516_A	0.798	0.83
226_G	251_R	0.796	0.83
235_A	239_P	0.793	0.83
390_T	419_T	0.788	0.83
458_R	479_A	0.788	0.83
367_L	370_G	0.785	0.82
244_G	247_L	0.785	0.82
181_V	205_E	0.784	0.82
483_D	495_F	0.784	0.82
292_L	315_L	0.784	0.82
145_S	155_G	0.783	0.82
145_S	396_T	0.781	0.82
475_S	507_D	0.780	0.82
289_L	491_P	0.779	0.82
100_L	105_F	0.775	0.81
344_R	390_T	0.774	0.81
305_L	308_A	0.773	0.81
258_R	286_H	0.772	0.81
85_Y	115_S	0.772	0.81
285_Y	288_R	0.763	0.80
458_R	483_D	0.763	0.80
268_R	279_G	0.762	0.80
419_T	488_S	0.762	0.80
23_T	520_Y	0.761	0.80
291_Q	347_M	0.760	0.80
32_G	35_N	0.756	0.80
232_G	238_D	0.755	0.80
526_G	533_R	0.755	0.80
431_R	434_T	0.753	0.80
343_Y	389_D	0.751	0.79
263_F	267_L	0.750	0.79
498_G	525_G	0.749	0.79
215_Y	333_G	0.747	0.79
143_V	178_L	0.747	0.79
212_C	227_C	0.745	0.79
413_V	460_R	0.743	0.79
320_D	423_D	0.742	0.79
104_G	109_A	0.742	0.79
450_A	487_N	0.741	0.79
157_N	178_L	0.740	0.78
66_E	175_K	0.738	0.78
437_A	441_P	0.737	0.78
427_L	432_P	0.735	0.78
412_L	461_F	0.734	0.78
401_F	412_L	0.733	0.78
466_N	473_D	0.731	0.78
209_L	223_G	0.729	0.77
160_N	183_M	0.728	0.77
141_R	202_F	0.726	0.77
471_G	511_L	0.726	0.77
474_L	516_A	0.726	0.77
379_G	382_I	0.724	0.77
85_Y	114_G	0.724	0.77
105_F	211_P	0.723	0.77
398_T	411_T	0.722	0.77
285_Y	347_M	0.720	0.77
479_A	503_S	0.719	0.76
74_N	127_N	0.718	0.76
328_F	395_L	0.717	0.76
493_G	498_G	0.717	0.76
364_S	368_A	0.717	0.76
109_A	214_T	0.715	0.76
238_D	241_G	0.715	0.76
257_P	261_G	0.715	0.76
270_F	277_E	0.714	0.76
263_F	322_K	0.712	0.76
279_G	327_S	0.711	0.76
33_K	36_G	0.710	0.76
441_P	445_E	0.710	0.76
221_F	226_G	0.709	0.75
269_Y	272_E	0.709	0.75
468_V	508_A	0.708	0.75
373_L	376_V	0.708	0.75
400_V	409_Q	0.708	0.75
521_T	537_F	0.707	0.75
26_P	30_L	0.705	0.75
204_W	256_E	0.704	0.75
431_R	436_G	0.702	0.75
148_E	329_N	0.702	0.75
314_F	381_D	0.701	0.75
225_G	229_L	0.699	0.74
3_D	215_Y	0.699	0.74
124_V	139_L	0.698	0.74
89_L	114_G	0.698	0.74
421_V	424_L	0.697	0.74
432_P	435_F	0.697	0.74
111_D	115_S	0.697	0.74
18_G	62_K	0.695	0.74
59_N	88_E	0.694	0.74
397_A	412_L	0.691	0.74
193_N	271_A	0.691	0.74
480_F	484_V	0.691	0.74
2_F	6_D	0.691	0.74
153_Q	167_L	0.690	0.73
258_R	261_G	0.689	0.73
339_G	393_A	0.688	0.73
361_A	370_G	0.688	0.73
400_V	411_T	0.687	0.73
235_A	240_G	0.687	0.73
167_L	174_L	0.686	0.73
206_P	254_D	0.686	0.73
92_D	96_P	0.685	0.73
154_N	494_N	0.684	0.73
204_W	257_P	0.681	0.72
393_A	397_A	0.680	0.72
419_T	489_P	0.680	0.72
340_E	394_Q	0.679	0.72
183_M	203_E	0.678	0.72
321_I	387_R	0.677	0.72
369_G	372_Q	0.676	0.72
535_R	546_F	0.674	0.72
366_L	370_G	0.672	0.71
285_Y	321_I	0.671	0.71
367_L	371_S	0.671	0.71
93_N	97_F	0.670	0.71
238_D	242_P	0.670	0.71
458_R	501_S	0.669	0.71
429_Y	432_P	0.668	0.71
399_K	412_L	0.668	0.71
395_L	416_V	0.668	0.71
196_L	265_V	0.667	0.71
322_K	387_R	0.665	0.71
184_L	453_F	0.665	0.71
259_D	286_H	0.663	0.70
300_A	303_A	0.663	0.70
53_K	345_P	0.661	0.70
429_Y	436_G	0.660	0.70
293_S	384_G	0.659	0.70
120_L	176_E	0.658	0.70
169_V	172_A	0.657	0.70
75_Y	128_F	0.657	0.70
116_G	166_K	0.657	0.70
145_S	178_L	0.657	0.70
480_F	502_L	0.655	0.70
376_V	380_Q	0.655	0.70
158_S	285_Y	0.655	0.70
118_E	179_L	0.654	0.69
62_K	82_A	0.652	0.69
440_N	443_G	0.651	0.69
233_F	238_D	0.651	0.69
131_G	134_P	0.651	0.69
490_G	499_R	0.651	0.69
141_R	179_L	0.650	0.69
509_D	515_T	0.650	0.69
107_D	111_D	0.649	0.69
451_T	497_E	0.648	0.69
523_F	532_L	0.648	0.69
102_D	106_S	0.647	0.69
365_P	368_A	0.647	0.69
490_G	494_N	0.645	0.68
21_W	54_G	0.644	0.68
124_V	265_V	0.644	0.68
66_E	121_D	0.644	0.68
433_G	436_G	0.639	0.68
342_S	394_Q	0.639	0.68
334_G	399_K	0.639	0.68
17_Y	60_R	0.638	0.68
365_P	370_G	0.637	0.67
276_T	339_G	0.636	0.67
417_G	495_F	0.636	0.67
27_D	533_R	0.635	0.67
504_L	538_V	0.635	0.67
437_A	440_N	0.633	0.67
523_F	537_F	0.633	0.67
527_G	530_N	0.632	0.67
151_F	458_R	0.632	0.67
74_N	129_D	0.631	0.67
107_D	110_R	0.631	0.67
467_N	470_P	0.630	0.67
431_R	435_F	0.630	0.67
105_F	110_R	0.630	0.67
206_P	224_A	0.630	0.67
473_D	509_D	0.630	0.67
527_G	533_R	0.629	0.66
64_L	120_L	0.628	0.66
442_N	445_E	0.628	0.66
472_V	516_A	0.627	0.66
161_P	288_R	0.627	0.66
11_F	63_G	0.626	0.66
67_L	81_G	0.626	0.66
55_D	95_R	0.626	0.66
146_W	283_M	0.626	0.66
269_Y	278_F	0.625	0.66
431_R	487_N	0.625	0.66
145_S	175_K	0.625	0.66
364_S	370_G	0.624	0.66
72_G	75_Y	0.624	0.66
88_E	94_D	0.624	0.66
291_Q	316_E	0.624	0.66
299_A	303_A	0.623	0.66
291_Q	385_Y	0.622	0.66
121_D	336_A	0.622	0.66
255_R	293_S	0.622	0.66
104_G	108_A	0.622	0.66
221_F	292_L	0.621	0.65
259_D	319_E	0.619	0.65
30_L	215_Y	0.619	0.65
440_N	444_C	0.618	0.65
427_L	434_T	0.618	0.65
183_M	283_M	0.617	0.65
229_L	232_G	0.617	0.65
222_A	292_L	0.617	0.65
221_F	357_L	0.616	0.65
200_Y	260_S	0.615	0.65
4_T	7_L	0.614	0.65
84_W	544_Y	0.614	0.65
14_T	545_S	0.614	0.65
438_N	442_N	0.614	0.65
502_L	536_D	0.612	0.64
41_S	44_G	0.610	0.64
218_T	532_L	0.609	0.64
221_F	229_L	0.609	0.64
82_A	176_E	0.607	0.64
428_R	433_G	0.607	0.64
491_P	494_N	0.607	0.64
356_L	384_G	0.606	0.64
189_G	195_S	0.606	0.64
294_G	356_L	0.606	0.64
368_A	374_G	0.604	0.63
30_L	48_N	0.601	0.63
454_S	488_S	0.601	0.63
364_S	367_L	0.601	0.63
119_L	141_R	0.601	0.63
439_A	442_N	0.600	0.63
221_F	294_G	0.599	0.63
520_Y	536_D	0.599	0.63
259_D	284_N	0.599	0.63
91_K	115_S	0.599	0.63
28_P	52_D	0.599	0.63
421_V	488_S	0.598	0.63
217_S	535_R	0.595	0.62
371_S	376_V	0.594	0.62
429_Y	434_T	0.593	0.62
83_A	115_S	0.593	0.62
57_V	537_F	0.592	0.62
371_S	375_A	0.592	0.62
405_L	461_F	0.591	0.62
25_D	52_D	0.591	0.62
60_R	169_V	0.590	0.61
275_N	330_T	0.590	0.61
427_L	430_G	0.589	0.61
389_D	422_L	0.588	0.61
287_S	348_P	0.588	0.61
323_L	344_R	0.588	0.61
158_S	323_L	0.588	0.61
88_E	91_K	0.587	0.61
503_S	521_T	0.586	0.61
237_P	242_P	0.585	0.61
216_F	521_T	0.585	0.61
77_A	139_L	0.585	0.61
441_P	444_C	0.583	0.61
424_L	452_R	0.583	0.61
321_I	347_M	0.581	0.60
444_C	447_D	0.581	0.60
66_E	173_E	0.579	0.60
439_A	443_G	0.579	0.60
417_G	456_G	0.578	0.60
152_I	174_L	0.578	0.60
301_A	305_L	0.577	0.60
211_P	224_A	0.574	0.59
47_G	217_S	0.574	0.59
31_I	46_D	0.574	0.59
148_E	279_G	0.573	0.59
43_N	50_N	0.573	0.59
311_G	360_A	0.572	0.59
416_V	459_L	0.572	0.59
8_E	130_L	0.572	0.59
428_R	434_T	0.571	0.59
31_I	35_N	0.571	0.59
112_L	165_S	0.570	0.59
215_Y	537_F	0.570	0.59
345_P	387_R	0.569	0.59
238_D	243_A	0.569	0.59
228_R	248_A	0.568	0.59
139_L	200_Y	0.568	0.59
106_S	225_G	0.568	0.59
149_S	396_T	0.568	0.59
259_D	497_E	0.567	0.58
121_D	143_V	0.567	0.58
134_P	191_T	0.566	0.58
372_Q	375_A	0.565	0.58
155_G	158_S	0.564	0.58
254_D	257_P	0.563	0.58
321_I	346_N	0.563	0.58
153_Q	289_L	0.563	0.58
329_N	398_T	0.561	0.58
250_P	312_S	0.559	0.57
336_A	396_T	0.558	0.57
103_D	109_A	0.558	0.57
138_R	177_A	0.558	0.57
212_C	226_G	0.558	0.57
148_E	268_R	0.558	0.57
239_P	242_P	0.558	0.57
361_A	367_L	0.557	0.57
275_N	454_S	0.556	0.57
123_F	344_R	0.555	0.57
92_D	442_N	0.555	0.57
354_V	357_L	0.554	0.57
108_A	111_D	0.553	0.57
487_N	497_E	0.553	0.57
152_I	396_T	0.553	0.57
480_F	524_F	0.552	0.56
149_S	152_I	0.552	0.56
182_N	205_E	0.551	0.56
364_S	369_G	0.551	0.56
351_I	356_L	0.551	0.56
405_L	408_D	0.551	0.56
453_F	485_K	0.550	0.56
48_N	55_D	0.550	0.56
47_G	51_F	0.550	0.56
536_D	544_Y	0.550	0.56
281_Y	327_S	0.549	0.56
517_D	543_K	0.549	0.56
145_S	159_I	0.549	0.56
64_L	176_E	0.549	0.56
26_P	49_L	0.549	0.56
232_G	239_P	0.548	0.56
272_E	278_F	0.548	0.56
236_L	243_A	0.548	0.56
143_V	160_N	0.547	0.56
406_G	476_P	0.547	0.56
532_L	535_R	0.547	0.56
316_E	381_D	0.547	0.56
262_Q	288_R	0.546	0.56
357_L	360_A	0.545	0.56
370_G	374_G	0.545	0.56
159_I	183_M	0.545	0.56
105_F	108_A	0.545	0.56
428_R	435_F	0.544	0.55
82_A	118_E	0.544	0.55
295_A	298_A	0.544	0.55
142_Q	268_R	0.544	0.55
145_S	157_N	0.544	0.55
215_Y	523_F	0.543	0.55
219_N	226_G	0.543	0.55
275_N	280_L	0.543	0.55
47_G	532_L	0.542	0.55
124_V	420_H	0.541	0.55
165_S	479_A	0.541	0.55
432_P	436_G	0.540	0.55
162_V	167_L	0.539	0.55
437_A	442_N	0.539	0.55
184_L	202_F	0.539	0.55
234_G	238_D	0.538	0.55
224_A	317_Y	0.538	0.55
477_P	507_D	0.536	0.54
56_L	88_E	0.536	0.54
374_G	381_D	0.536	0.54
14_T	66_E	0.536	0.54
347_M	389_D	0.536	0.54
7_L	280_L	0.536	0.54
206_P	256_E	0.536	0.54
329_N	337_V	0.535	0.54
145_S	283_M	0.534	0.54
233_F	237_P	0.533	0.54
64_L	80_R	0.533	0.54
131_G	191_T	0.533	0.54
187_S	197_E	0.533	0.54
403_P	408_D	0.532	0.54
483_D	494_N	0.532	0.54
48_N	215_Y	0.532	0.54
361_A	366_L	0.532	0.54
76_G	126_G	0.531	0.54
48_N	167_L	0.530	0.53
336_A	398_T	0.529	0.53
8_E	11_F	0.529	0.53
240_G	243_A	0.529	0.53
297_G	301_A	0.529	0.53
372_Q	376_V	0.529	0.53
146_W	197_E	0.528	0.53
444_C	449_F	0.528	0.53
319_E	497_E	0.528	0.53
130_L	516_A	0.527	0.53
29_D	38_G	0.527	0.53
159_I	283_M	0.527	0.53
152_I	456_G	0.527	0.53
372_Q	377_A	0.526	0.53
107_D	259_D	0.526	0.53
41_S	45_D	0.525	0.53
16_S	169_V	0.525	0.53
24_E	536_D	0.525	0.53
344_R	347_M	0.524	0.53
378_P	382_I	0.523	0.53
15_L	61_L	0.523	0.53
249_V	294_G	0.522	0.52
134_P	541_S	0.521	0.52
4_T	8_E	0.521	0.52
168_R	172_A	0.520	0.52
221_F	353_D	0.520	0.52
324_Y	346_N	0.519	0.52
487_N	496_N	0.518	0.52
146_W	264_G	0.518	0.52
55_D	59_N	0.518	0.52
62_K	80_R	0.518	0.52
365_P	372_Q	0.518	0.52
444_C	448_G	0.517	0.52
254_D	317_Y	0.517	0.52
76_G	123_F	0.517	0.52
68_D	78_F	0.517	0.52
159_I	490_G	0.516	0.52
174_L	177_A	0.516	0.52
135_L	139_L	0.516	0.52
50_N	55_D	0.515	0.51
129_D	133_M	0.515	0.51
522_N	538_V	0.513	0.51
278_F	326_L	0.512	0.51
153_Q	174_L	0.511	0.51
373_L	377_A	0.511	0.51
210_D	214_T	0.511	0.51
368_A	373_L	0.511	0.51
350_Q	450_A	0.511	0.51
229_L	233_F	0.510	0.51
60_R	84_W	0.510	0.51
451_T	486_G	0.509	0.51
519_S	537_F	0.508	0.50
185_S	266_A	0.508	0.50
307_A	310_T	0.508	0.50
260_S	286_H	0.507	0.50
304_G	308_A	0.507	0.50
125_Y	175_K	0.505	0.50
328_F	338_G	0.505	0.50
167_L	172_A	0.505	0.50
350_Q	385_Y	0.505	0.50
89_L	92_D	0.505	0.50
374_G	377_A	0.504	0.50
206_P	223_G	0.504	0.50
365_P	374_G	0.503	0.50
448_G	451_T	0.502	0.50
349_L	397_A	0.502	0.50
79_V	117_A	0.502	0.50
152_I	458_R	0.501	0.49
293_S	381_D	0.501	0.49
48_N	52_D	0.501	0.49
506_L	518_L	0.501	0.49
110_R	115_S	0.501	0.49
84_W	118_E	0.500	0.49
411_T	462_T	0.500	0.49

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gufA	1	0.5733	51.4	0.977	Contact Map
3nb3A	2	0.2436	47.5	0.978	Contact Map
2ervA	1	0.2582	39.9	0.979	Contact Map
3qlbA	1	0.6062	39.7	0.979	Contact Map
3qraA	1	0.2729	39.4	0.979	Contact Map
2jmmA	1	0.2509	38.4	0.979	Contact Map
3efmA	1	0.6044	28.5	0.98	Contact Map
1qjpA	1	0.2436	28.4	0.98	Contact Map
1kmoA	1	0.6795	26.6	0.981	Contact Map
1ormA	1	0.2656	13.9	0.983	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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