GREMLIN Database
Mo-nitro_C - Mo-dependent nitrogenase C-terminus
PFAM: PF06967 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (82)
Sequences: 755 (386)
Seq/√Len: 42.6
META: 0.57

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_D46_H5.1171.00
10_D59_Q4.1671.00
34_E61_V3.5221.00
10_D66_R3.4241.00
38_K43_K3.1841.00
23_L27_I2.9961.00
34_E46_H2.9561.00
10_D62_G2.6651.00
21_H77_E2.2651.00
21_H82_Y2.1601.00
24_C79_I2.1150.99
49_P52_K1.7850.98
5_L56_L1.6660.97
6_R59_Q1.4230.93
29_A83_C1.3620.91
58_E62_G1.3260.90
29_A68_L1.2790.88
24_C80_S1.2590.87
23_L60_L1.2300.86
6_R43_K1.2280.86
34_E50_L1.2120.85
25_K73_D1.1900.84
78_D82_Y1.1280.81
30_Q69_C1.0680.77
24_C72_A1.0530.76
67_A70_Y1.0500.76
27_I60_L1.0210.74
25_K39_L1.0160.73
69_C83_C1.0100.73
18_K22_F1.0020.72
77_E82_Y0.9700.70
15_H42_R0.9630.69
23_L72_A0.9620.69
73_D76_G0.9520.68
30_Q49_P0.9380.67
38_K41_G0.9270.66
7_Q29_A0.9180.66
14_I67_A0.9140.65
2_L6_R0.9090.65
50_L53_L0.9080.65
67_A80_S0.9030.64
17_P42_R0.9030.64
12_I56_L0.9000.64
24_C70_Y0.8660.61
3_Q7_Q0.8640.61
49_P53_L0.8570.60
19_L58_E0.8510.60
40_F43_K0.8510.60
37_I49_P0.8430.59
62_G66_R0.8380.58
78_D83_C0.8340.58
23_L63_L0.8130.56
4_P56_L0.8040.55
53_L70_Y0.7970.55
41_G46_H0.7960.55
22_F26_L0.7920.54
9_L23_L0.7750.53
24_C45_F0.7730.52
9_L81_P0.7730.52
9_L60_L0.7720.52
50_L58_E0.7680.52
69_C72_A0.7530.51
21_H24_C0.7500.50
50_L56_L0.7390.49
35_R47_I0.7360.49
16_D67_A0.7290.48
29_A76_G0.7240.48
38_K45_F0.7240.48
17_P77_E0.7180.47
53_L61_V0.7140.47
22_F60_L0.7130.47
52_K58_E0.7080.46
10_D60_L0.7070.46
15_H19_L0.7030.46
53_L67_A0.6990.45
18_K40_F0.6970.45
7_Q42_R0.6910.45
19_L39_L0.6890.44
36_D41_G0.6860.44
69_C75_C0.6800.44
36_D45_F0.6780.43
35_R43_K0.6740.43
31_C64_R0.6710.43
7_Q70_Y0.6670.42
13_E82_Y0.6560.41
27_I57_Y0.6550.41
28_P31_C0.6510.41
25_K62_G0.6510.41
20_A33_F0.6420.40
39_L69_C0.6410.40
8_W12_I0.6270.39
24_C67_A0.6260.39
33_F57_Y0.6170.38
9_L30_Q0.6130.38
69_C81_P0.6090.37
17_P81_P0.6000.36
28_P48_P0.5940.36
32_P47_I0.5840.35
65_F69_C0.5790.35
17_P80_S0.5770.34
25_K81_P0.5720.34
65_F77_E0.5700.34
51_C54_N0.5530.32
25_K38_K0.5530.32
15_H23_L0.5500.32
47_I52_K0.5450.32
72_A83_C0.5440.32
48_P51_C0.5430.32
19_L23_L0.5430.32
26_L62_G0.5340.31
2_L56_L0.5320.31
70_Y75_C0.5300.30
14_I79_I0.5250.30
31_C51_C0.5250.30
37_I45_F0.5210.30
37_I62_G0.5170.29
19_L70_Y0.5160.29
66_R83_C0.5150.29
5_L52_K0.5140.29
52_K65_F0.5080.29
22_F43_K0.5050.29
69_C80_S0.5020.28
27_I56_L0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xfjA 4 0.9759 22.3 0.93 Contact Map
1korA 4 0.8795 12.3 0.938 Contact Map
4hsuA 1 0.9036 6.7 0.944 Contact Map
3agtA 1 0.3494 5.8 0.946 Contact Map
3j8eG 3 0.8193 5.6 0.947 Contact Map
2lvfA 1 0.4819 4.6 0.949 Contact Map
1k92A 4 0.9639 4.4 0.949 Contact Map
2nz2A 4 0.988 4.2 0.95 Contact Map
3wynA 1 0.3976 4.1 0.95 Contact Map
1jfrA 1 0.4217 4 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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