GREMLIN Database
DUF1294 - Protein of unknown function (DUF1294)
PFAM: PF06961 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 55 (55)
Sequences: 13815 (10110)
Seq/√Len: 1363.2
META: 0.873

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_G46_F2.8361.00
10_I14_A2.8211.00
7_L30_L2.5481.00
8_Y39_A2.4911.00
4_T39_A2.2141.00
4_T30_L2.1621.00
5_F45_L2.1391.00
13_R17_R1.9141.00
31_A55_F1.8861.00
31_A39_A1.8671.00
28_H31_A1.6601.00
14_A19_R1.6371.00
5_F42_A1.4941.00
9_G13_R1.4491.00
28_H54_S1.4041.00
23_P26_T1.3781.00
6_L10_I1.3671.00
47_R50_T1.3671.00
13_R19_R1.3101.00
42_A46_F1.2341.00
38_G42_A1.1671.00
8_Y28_H1.1001.00
4_T8_Y1.0991.00
40_L44_R1.0801.00
41_L45_L1.0721.00
10_I22_I1.0591.00
4_T31_A1.0341.00
3_V26_T1.0241.00
5_F46_F1.0151.00
13_R16_R1.0021.00
27_L39_A0.9661.00
40_L43_M0.9031.00
14_A20_W0.8831.00
36_W40_L0.8781.00
28_H43_M0.8441.00
31_A36_W0.8421.00
7_L22_I0.8341.00
47_R51_R0.8131.00
29_L33_L0.7871.00
14_A22_I0.7731.00
22_I26_T0.7691.00
44_R50_T0.7281.00
25_K29_L0.7161.00
7_L27_L0.7151.00
1_N36_W0.7141.00
43_M52_K0.7081.00
4_T34_G0.7011.00
1_N38_G0.7011.00
46_F50_T0.6951.00
4_T35_G0.6941.00
26_T30_L0.6831.00
6_L9_G0.6591.00
30_L34_G0.6541.00
20_W23_P0.6481.00
14_A17_R0.6451.00
21_R24_E0.6421.00
10_I19_R0.6391.00
8_Y42_A0.6391.00
1_N4_T0.6301.00
9_G42_A0.6101.00
5_F41_L0.6071.00
3_V7_L0.6031.00
8_Y40_L0.6001.00
28_H40_L0.5911.00
26_T29_L0.5891.00
28_H32_L0.5801.00
10_I13_R0.5781.00
36_W43_M0.5701.00
12_K15_A0.5531.00
51_R54_S0.5511.00
4_T7_L0.5451.00
29_L32_L0.5451.00
15_A21_R0.5381.00
20_W25_K0.5291.00
35_G38_G0.5231.00
8_Y31_A0.5171.00
3_V30_L0.5111.00
20_W26_T0.5111.00
44_R47_R0.5091.00
28_H36_W0.5041.00
5_F9_G0.5031.00
43_M50_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qtsA 4 0.8364 12.2 0.847 Contact Map
3cx5D 2 0.9455 7 0.863 Contact Map
1pp9D 2 0.9455 6.8 0.864 Contact Map
4d6uD 1 0.9455 6.2 0.866 Contact Map
1afoA 2 0.7273 5.6 0.869 Contact Map
2w3zA 1 0 5.5 0.869 Contact Map
1k7kA 1 1 5 0.872 Contact Map
2qjyB 1 0.8364 4.2 0.876 Contact Map
3tquA 2 1 3.5 0.881 Contact Map
4bnqA 2 1 3.3 0.882 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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