GREMLIN Database
DUF1292 - Protein of unknown function (DUF1292)
PFAM: PF06949 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (73)
Sequences: 9098 (6872)
Seq/√Len: 804.4
META: 0.819

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_K42_R3.6491.00
15_E20_E2.7591.00
24_L41_L2.4231.00
10_V13_T2.4091.00
69_A72_E2.3321.00
16_V65_A2.2781.00
12_D73_L2.1391.00
42_R62_E2.0251.00
63_L67_A1.9761.00
42_R55_E1.9221.00
14_F66_V1.7181.00
17_E65_A1.6181.00
44_V55_E1.6151.00
23_A40_I1.6091.00
62_E66_V1.5581.00
67_A71_E1.5281.00
16_V69_A1.5221.00
21_Y62_E1.4741.00
13_T20_E1.4181.00
8_F24_L1.4121.00
14_F69_A1.3951.00
47_D50_G1.3401.00
23_A70_F1.2791.00
10_V22_V1.2261.00
13_T22_V1.2131.00
40_I66_V1.2061.00
68_E71_E1.1791.00
43_Y52_E1.1661.00
69_A73_L1.1631.00
23_A38_V1.1611.00
19_K62_E1.0721.00
70_F74_L1.0651.00
25_T28_E1.0401.00
64_E68_E1.0361.00
22_V54_L0.9971.00
11_L70_F0.9791.00
33_E36_E0.9791.00
16_V62_E0.9671.00
48_E53_E0.9351.00
23_A66_V0.9301.00
68_E72_E0.9171.00
59_D62_E0.9151.00
57_I62_E0.9111.00
61_E64_E0.9021.00
14_F23_A0.8981.00
46_E52_E0.8951.00
47_D53_E0.8921.00
22_V43_Y0.8811.00
39_Y56_P0.8661.00
32_D35_D0.8641.00
13_T43_Y0.8461.00
46_E50_G0.8361.00
61_E65_A0.8111.00
57_I63_L0.8081.00
20_E43_Y0.7991.00
44_V53_E0.7961.00
64_E67_A0.7951.00
60_D63_L0.7871.00
41_L54_L0.7771.00
52_E55_E0.7721.00
16_V66_V0.7721.00
60_D64_E0.7671.00
10_V24_L0.7661.00
62_E65_A0.7531.00
47_D51_E0.7471.00
15_E18_G0.7461.00
27_N32_D0.7401.00
11_L38_V0.7261.00
38_V70_F0.7261.00
46_E49_D0.7241.00
8_F39_Y0.7221.00
32_D36_E0.7191.00
26_D29_E0.6941.00
22_V41_L0.6841.00
71_E74_L0.6831.00
24_L39_Y0.6831.00
28_E31_E0.6821.00
65_A69_A0.6821.00
27_N30_D0.6481.00
45_E52_E0.6471.00
23_A71_E0.6411.00
70_F73_L0.6231.00
31_E36_E0.6221.00
30_D33_E0.6181.00
55_E58_E0.6161.00
26_D30_D0.6141.00
65_A68_E0.6111.00
27_N33_E0.6031.00
38_V74_L0.6021.00
29_E33_E0.5971.00
16_V19_K0.5971.00
14_F70_F0.5801.00
27_N31_E0.5771.00
9_E12_D0.5741.00
12_D16_V0.5711.00
28_E32_D0.5601.00
38_V67_A0.5581.00
31_E35_D0.5551.00
67_A70_F0.5481.00
29_E32_D0.5471.00
25_T31_E0.5461.00
22_V70_F0.5371.00
8_F63_L0.5311.00
23_A67_A0.5311.00
6_V67_A0.5151.00
12_D23_A0.5131.00
45_E50_G0.5091.00
20_E23_A0.5081.00
4_N7_E0.5051.00
38_V63_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jalA 1 0.4667 3.6 0.853 Contact Map
2dbyA 1 0.44 2.8 0.861 Contact Map
1ni3A 1 0.4267 2.7 0.862 Contact Map
3zbeA 1 0.4533 1.9 0.872 Contact Map
2q83A 1 0.24 1.9 0.872 Contact Map
4q5yA 2 0.52 1.7 0.875 Contact Map
3blzA 4 0.3067 1.6 0.876 Contact Map
3dukA 4 0.3467 1.4 0.881 Contact Map
2x5yA 1 0.3467 1.4 0.883 Contact Map
3cnxA 2 0.28 1.4 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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