GREMLIN Database
DUF1290 - Protein of unknown function (DUF1290)
PFAM: PF06947 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 86 (86)
Sequences: 1876 (810)
Seq/√Len: 87.4
META: 0.852

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_R29_E4.0841.00
65_A71_G3.2821.00
69_V72_V3.2301.00
68_V72_V3.1461.00
39_S43_S2.6591.00
64_L68_V2.3911.00
65_A68_V2.3631.00
7_P61_D2.3631.00
43_S78_L2.3391.00
47_L78_L2.3081.00
7_P10_A2.0291.00
29_E84_H1.8891.00
72_V76_Q1.8441.00
64_L67_V1.6501.00
52_A64_L1.5981.00
24_I50_L1.5101.00
12_A15_A1.5091.00
14_L74_I1.4881.00
18_D73_R1.4560.99
19_S45_A1.3860.99
62_L71_G1.3810.99
66_A70_F1.3150.99
79_A83_R1.3140.99
23_G32_F1.2890.99
61_D64_L1.2860.99
28_L81_I1.2730.98
49_A56_D1.2580.98
51_L71_G1.1950.98
19_S23_G1.1850.97
23_G27_G1.1370.97
22_G40_G1.1130.96
5_Y14_L1.1130.96
14_L71_G1.0610.95
50_L54_L1.0280.94
22_G26_A0.9770.93
13_I16_A0.9710.92
59_G66_A0.9560.92
19_S78_L0.9510.92
52_A86_L0.9510.92
80_I84_H0.9510.92
61_D72_V0.9480.91
1_I9_L0.9480.91
49_A79_A0.9450.91
22_G82_R0.9430.91
41_F45_A0.9400.91
10_A61_D0.9300.91
76_Q79_A0.9290.91
37_F68_V0.9270.91
77_N82_R0.9220.90
6_A10_A0.9160.90
13_I72_V0.9110.90
21_F47_L0.8970.89
11_V52_A0.8940.89
80_I83_R0.8730.88
62_L67_V0.8720.88
21_F43_S0.8710.88
21_F24_I0.8630.87
23_G76_Q0.8570.87
38_V84_H0.8570.87
8_Y65_A0.8490.86
2_P48_A0.8220.84
47_L58_L0.8200.84
20_V41_F0.8180.84
46_L85_L0.8170.84
7_P52_A0.8040.83
71_G75_F0.7940.82
18_D82_R0.7900.82
66_A86_L0.7600.79
25_R80_I0.7590.79
10_A14_L0.7490.78
28_L84_H0.7400.78
66_A69_V0.7380.77
12_A49_A0.7100.75
45_A66_A0.7080.74
31_K35_K0.7000.74
36_V83_R0.6980.73
4_E24_I0.6980.73
21_F34_D0.6930.73
22_G39_S0.6900.73
41_F44_N0.6890.72
45_A50_L0.6850.72
20_V52_A0.6830.72
52_A75_F0.6810.72
34_D37_F0.6790.71
53_Y57_R0.6750.71
60_V67_V0.6690.70
29_E74_I0.6610.69
1_I4_E0.6600.69
4_E7_P0.6550.69
14_L28_L0.6370.66
9_L23_G0.6360.66
53_Y63_Y0.6340.66
12_A19_S0.6330.66
37_F44_N0.6330.66
30_G49_A0.6330.66
19_S31_K0.6300.66
12_A48_A0.6230.65
71_G79_A0.6070.63
27_G34_D0.6050.63
34_D38_V0.6020.62
51_L66_A0.5940.61
56_D61_D0.5860.60
24_I74_I0.5860.60
49_A60_V0.5830.60
47_L75_F0.5730.58
56_D63_Y0.5700.58
73_R77_N0.5660.57
7_P11_V0.5650.57
81_I86_L0.5620.57
67_V71_G0.5590.57
45_A76_Q0.5570.56
10_A13_I0.5550.56
40_G66_A0.5540.56
15_A49_A0.5520.56
54_L58_L0.5440.54
13_I70_F0.5350.53
12_A29_E0.5330.53
20_V27_G0.5320.53
44_N48_A0.5250.52
20_V84_H0.5250.52
29_E75_F0.5220.52
60_V81_I0.5190.51
38_V60_V0.5190.51
31_K51_L0.5170.51
7_P30_G0.5100.50
40_G82_R0.5100.50
18_D22_G0.5090.50
10_A69_V0.5000.49
61_D78_L0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lssA 2 0.2209 2.6 0.934 Contact Map
2w2dB 1 0.2791 2.1 0.938 Contact Map
4xp4A 1 1 1.9 0.939 Contact Map
1ihsI 1 0.0698 1.8 0.939 Contact Map
3o10A 2 0.3488 1.6 0.942 Contact Map
2nwlA 3 0.5116 1.5 0.942 Contact Map
2yvaA 4 0.3605 1.4 0.943 Contact Map
3swhA 1 0.6744 1.2 0.946 Contact Map
2fozA 1 0.3372 1 0.948 Contact Map
1vkyA 2 0.5 1 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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