GREMLIN Database
GlpM - GlpM protein
PFAM: PF06942 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (105)
Sequences: 563 (374)
Seq/√Len: 36.5
META: 0.696

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_L66_A4.9641.00
52_R77_D4.2531.00
71_A91_A3.4521.00
39_H68_Y2.6131.00
47_G50_A2.4961.00
72_V88_A2.3501.00
67_A95_A2.2160.99
55_A72_V2.1820.99
67_A91_A2.1670.99
3_A11_L2.0480.99
101_L105_R1.8810.98
90_L97_A1.8510.97
36_L85_L1.8450.97
29_P65_Y1.8310.97
62_L66_A1.6530.95
79_L84_A1.6320.95
61_S65_Y1.6280.95
29_P34_F1.5950.94
58_G65_Y1.5930.94
43_G81_L1.5230.92
28_V54_T1.5150.92
80_S84_A1.4950.92
34_F38_A1.4800.91
46_R50_A1.4790.91
87_G98_V1.4680.91
3_A7_A1.3230.86
75_L87_G1.2760.84
43_G73_Y1.2680.83
72_V76_S1.2440.82
4_L73_Y1.2400.82
36_L89_T1.2330.81
49_A86_L1.2040.80
83_L87_G1.1940.79
5_L35_A1.1730.78
27_L96_A1.1640.77
17_S56_L1.1540.77
15_L19_S1.0980.73
63_I67_A1.0950.73
74_Y91_A1.0670.71
27_L71_A1.0630.71
91_A95_A1.0500.70
80_S83_L1.0470.70
67_A87_G1.0390.69
71_A75_L1.0270.68
59_L70_L1.0250.68
94_V98_V1.0240.68
51_L68_Y1.0210.68
64_P68_Y1.0180.67
44_S47_G1.0070.66
44_S95_A1.0020.66
74_Y86_L0.9900.65
1_L101_L0.9850.65
66_A84_A0.9840.65
58_G62_L0.9810.64
40_Y85_L0.9770.64
24_I61_S0.9700.64
72_V84_A0.9650.63
10_V58_G0.9630.63
65_Y69_L0.9570.62
68_Y72_V0.9390.61
68_Y81_L0.9290.60
1_L9_V0.9290.60
23_Y31_F0.9240.60
67_A77_D0.9150.59
71_A82_P0.9070.58
29_P33_T0.9020.58
23_Y40_Y0.8940.57
48_A74_Y0.8880.57
55_A59_L0.8680.55
71_A79_L0.8530.54
55_A66_A0.8520.54
9_V45_E0.8480.53
20_K27_L0.8430.53
75_L91_A0.8320.52
75_L88_A0.8190.51
30_L65_Y0.8180.51
55_A84_A0.8180.51
38_A45_E0.8170.50
4_L12_L0.8110.50
8_L74_Y0.8110.50
15_L18_K0.8060.49
62_L94_V0.7960.49
11_L70_L0.7910.48
47_G60_W0.7910.48
55_A80_S0.7880.48
16_L21_N0.7840.48
17_S55_A0.7780.47
57_F64_P0.7780.47
43_G47_G0.7760.47
9_V28_V0.7680.46
79_L87_G0.7680.46
40_Y47_G0.7670.46
9_V18_K0.7530.45
99_L103_W0.7490.45
97_A102_L0.7450.44
57_F61_S0.7350.43
6_G16_L0.7310.43
5_L49_A0.7240.42
97_A100_I0.7190.42
34_F37_I0.7160.42
98_V102_L0.7120.41
93_L104_S0.7070.41
7_A14_A0.7040.41
79_L100_I0.6930.40
13_I30_L0.6890.39
62_L78_R0.6870.39
48_A77_D0.6860.39
17_S38_A0.6820.39
39_H51_L0.6800.39
59_L71_A0.6730.38
15_L104_S0.6700.38
10_V14_A0.6610.37
29_P42_V0.6490.36
48_A97_A0.6490.36
3_A85_L0.6470.36
23_Y72_V0.6460.36
10_V25_A0.6400.35
4_L8_L0.6300.35
101_L104_S0.6300.35
56_L89_T0.6260.34
11_L74_Y0.6130.33
25_A81_L0.6080.33
92_W96_A0.6080.33
78_R94_V0.6070.33
8_L105_R0.6010.32
90_L101_L0.6000.32
27_L67_A0.6000.32
44_S102_L0.5830.31
44_S62_L0.5790.31
70_L83_L0.5770.31
87_G90_L0.5740.30
74_Y83_L0.5730.30
28_V59_L0.5700.30
24_I84_A0.5690.30
3_A40_Y0.5670.30
48_A80_S0.5620.29
94_V102_L0.5610.29
90_L104_S0.5600.29
29_P39_H0.5570.29
24_I48_A0.5540.29
4_L10_V0.5520.29
46_R54_T0.5520.29
24_I86_L0.5500.29
27_L57_F0.5450.28
91_A100_I0.5450.28
19_S34_F0.5440.28
21_N40_Y0.5390.28
53_T86_L0.5390.28
39_H57_F0.5320.27
15_L42_V0.5300.27
94_V105_R0.5220.27
31_F65_Y0.5170.26
65_Y92_W0.5090.26
83_L97_A0.5090.26
14_A38_A0.5060.26
49_A82_P0.5030.25
35_A41_I0.5020.25
1_L90_L0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rceA 1 0.8879 4 0.927 Contact Map
3zuxA 1 0.9533 3.5 0.929 Contact Map
2xq2A 2 0.9159 3.1 0.931 Contact Map
2gfpA 2 0.8411 2.7 0.933 Contact Map
4n7wA 2 0.9439 2.7 0.933 Contact Map
4ldsA 2 0.785 2.3 0.936 Contact Map
3rkoM 1 0.8972 1.9 0.938 Contact Map
3w4tA 1 0.9626 1.7 0.94 Contact Map
3wdoA 1 0.8598 1.6 0.941 Contact Map
4humA 1 0.972 1.4 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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