GREMLIN Database
DUF1284 - Protein of unknown function (DUF1284)
PFAM: PF06935 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (102)
Sequences: 2093 (1707)
Seq/√Len: 169.0
META: 0.766

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_E69_R5.2191.00
48_E52_R3.7031.00
24_P69_R2.8991.00
72_W76_L2.6331.00
78_R82_K2.6111.00
29_E66_P2.5011.00
22_D73_D2.3591.00
65_K68_E2.2601.00
71_T74_E2.2331.00
89_L99_L2.1991.00
47_S50_K2.1931.00
31_P41_K2.0751.00
70_L75_L1.8951.00
4_P8_E1.7171.00
14_V18_R1.6821.00
58_V61_L1.6401.00
27_L64_L1.6011.00
29_E56_R1.5201.00
31_P54_R1.5121.00
63_G82_K1.4931.00
77_E81_E1.4211.00
50_K54_R1.4181.00
9_N62_L1.4071.00
57_A60_E1.3921.00
16_R23_T1.3801.00
17_L72_W1.3651.00
53_E57_A1.3431.00
31_P44_H1.3401.00
54_R92_I1.3391.00
84_F87_G1.3391.00
10_M34_I1.3251.00
57_A61_L1.3081.00
5_E37_P1.2961.00
83_I92_I1.2831.00
59_L64_L1.2711.00
13_I34_I1.2451.00
56_R60_E1.2451.00
58_V92_I1.2361.00
50_K97_E1.2041.00
29_E59_L1.1541.00
36_A77_E1.1141.00
24_P71_T1.0691.00
9_N33_D1.0610.99
9_N13_I1.0420.99
44_H48_E1.0420.99
52_R60_E1.0350.99
90_R99_L1.0160.99
53_E56_R0.9950.99
51_V54_R0.9930.99
15_E19_A0.9850.99
47_S54_R0.9850.99
33_D36_A0.9810.99
83_I87_G0.9530.99
13_I33_D0.9270.99
2_Y6_F0.9100.98
26_E67_G0.9030.98
12_R15_E0.8990.98
53_E95_G0.8930.98
48_E51_V0.8750.98
10_M14_V0.8690.98
22_D69_R0.8670.98
61_L92_I0.8660.98
89_L92_I0.8640.98
97_E101_L0.8590.98
54_R83_I0.8570.98
85_P102_C0.8560.98
84_F90_R0.8520.98
38_C43_G0.8520.98
4_P7_V0.8380.97
76_L80_R0.8210.97
1_G6_F0.8160.97
1_G10_M0.8080.97
40_N47_S0.8060.97
11_T34_I0.8040.97
80_R102_C0.8010.97
16_R20_G0.7990.96
46_G52_R0.7970.96
64_L70_L0.7940.96
67_G70_L0.7730.96
57_A91_E0.7600.95
16_R19_A0.7590.95
82_K88_W0.7570.95
61_L88_W0.7540.95
62_L78_R0.7520.95
21_P73_D0.7490.95
47_S79_I0.7490.95
90_R95_G0.7410.95
40_N46_G0.7380.95
9_N34_I0.7320.94
75_L87_G0.7120.93
48_E95_G0.7110.93
9_N37_P0.7080.93
30_G46_G0.7000.93
93_C96_C0.6930.92
54_R101_L0.6910.92
80_R85_P0.6840.92
11_T15_E0.6820.92
48_E54_R0.6750.91
12_R19_A0.6630.91
25_I75_L0.6630.91
46_G49_E0.6570.90
15_E18_R0.6530.90
41_K44_H0.6520.90
18_R73_D0.6460.90
97_E100_E0.6430.89
68_E71_T0.6420.89
20_G23_T0.6360.89
9_N12_R0.6250.88
1_G7_V0.6190.88
87_G99_L0.6180.87
10_M39_P0.6170.87
29_E52_R0.6140.87
54_R58_V0.6100.87
62_L84_F0.6060.86
38_C41_K0.6050.86
69_R75_L0.6010.86
72_W83_I0.5990.86
7_V10_M0.5950.85
16_R21_P0.5940.85
28_V33_D0.5870.85
15_E22_D0.5850.85
72_W80_R0.5840.84
22_D71_T0.5840.84
90_R102_C0.5830.84
51_V58_V0.5820.84
65_K74_E0.5810.84
14_V72_W0.5780.84
32_D96_C0.5750.83
18_R77_E0.5720.83
49_E53_E0.5680.83
15_E42_E0.5660.83
85_P89_L0.5630.82
16_R33_D0.5580.82
2_Y98_W0.5570.82
59_L68_E0.5520.81
84_F102_C0.5510.81
89_L102_C0.5500.81
84_F88_W0.5490.81
20_G61_L0.5260.78
78_R83_I0.5250.78
76_L79_I0.5250.78
71_T100_E0.5230.77
3_S75_L0.5210.77
46_G65_K0.5190.77
83_I101_L0.5190.77
61_L91_E0.5170.77
62_L102_C0.5170.77
91_E94_G0.5150.76
51_V94_G0.5100.76
10_M17_L0.5080.75
62_L99_L0.5070.75
56_R66_P0.5040.75
10_M18_R0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u4qB 1 0.6275 24 0.889 Contact Map
3idwA 1 0.4608 20.3 0.893 Contact Map
2xu0A 1 0.5294 17.7 0.896 Contact Map
2yk0A 1 0.9706 4.8 0.92 Contact Map
1ylfA 5 0.5784 4.5 0.92 Contact Map
4ic1A 5 0.4314 4.3 0.921 Contact Map
2hw4A 1 0.3039 3.9 0.923 Contact Map
2nmmA 3 0.3039 3.8 0.923 Contact Map
4nrdA 3 0.8235 3.8 0.924 Contact Map
1uwvA 1 0.6667 3.5 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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