GREMLIN Database
DUF1282 - Protein of unknown function (DUF1282)
PFAM: PF06930 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 172 (167)
Sequences: 8664 (6818)
Seq/√Len: 527.6
META: 0.904

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_S7_T4.3821.00
10_P145_V3.2161.00
27_V103_A2.9161.00
91_G149_I2.7261.00
13_A148_K2.5691.00
82_I102_A2.4111.00
112_A131_A2.2611.00
97_Q100_K2.2031.00
20_A24_T2.1361.00
50_F53_T2.0151.00
101_L146_L1.9491.00
37_A41_G1.8831.00
17_A21_S1.8831.00
83_D93_K1.8701.00
18_T21_S1.8511.00
67_V70_Y1.8121.00
149_I155_A1.7971.00
56_R59_L1.7891.00
151_P154_K1.7831.00
94_N97_Q1.7771.00
27_V110_W1.7501.00
1_I4_S1.7241.00
79_A95_F1.7231.00
69_F73_L1.7011.00
155_A159_T1.6611.00
159_T163_V1.6071.00
108_P135_S1.5981.00
65_I69_F1.5751.00
40_I43_S1.5391.00
57_L60_G1.5191.00
8_E11_V1.5181.00
48_S51_G1.4961.00
157_G160_V1.4891.00
83_D95_F1.4781.00
63_L67_V1.4481.00
24_T28_L1.4351.00
98_A147_M1.4331.00
122_W125_L1.4231.00
153_D157_G1.4121.00
79_A99_L1.4111.00
109_A135_S1.3981.00
157_G161_V1.3921.00
62_A66_A1.3871.00
21_S24_T1.3781.00
21_S25_G1.3621.00
67_V71_L1.3551.00
137_Y141_L1.3441.00
78_L166_A1.3401.00
63_L71_L1.3341.00
68_V71_L1.2981.00
105_S139_L1.2961.00
156_V160_V1.2951.00
84_A93_K1.2681.00
39_F43_S1.2521.00
78_L102_A1.2511.00
84_A88_T1.2501.00
48_S52_G1.2471.00
66_A70_Y1.2461.00
10_P13_A1.2421.00
96_K100_K1.2231.00
80_L84_A1.2181.00
92_E148_K1.2051.00
49_I52_G1.1981.00
19_V23_Y1.1921.00
108_P138_L1.1901.00
63_L66_A1.1881.00
27_V30_L1.1541.00
19_V99_L1.1491.00
70_Y73_L1.1391.00
120_S123_L1.1341.00
63_L70_Y1.1191.00
25_G29_P1.1171.00
55_V59_L1.1071.00
66_A69_F1.1031.00
36_V40_I1.1001.00
95_F99_L1.0951.00
68_V72_L1.0931.00
101_L143_L1.0861.00
82_I162_V1.0831.00
153_D156_V1.0821.00
153_D158_Y1.0761.00
76_F80_L1.0711.00
45_I48_S1.0711.00
38_A42_G1.0671.00
17_A104_Y1.0631.00
26_Y30_L1.0531.00
25_G28_L1.0421.00
22_L103_A1.0411.00
156_V159_T1.0341.00
42_G47_W1.0261.00
37_A117_L1.0241.00
58_T61_S1.0231.00
90_G154_K1.0211.00
69_F72_L0.9881.00
56_R61_S0.9871.00
56_R60_G0.9761.00
7_T10_P0.9651.00
64_I68_V0.9551.00
64_I67_V0.9411.00
101_L142_G0.9371.00
8_E12_I0.9311.00
30_L33_I0.9301.00
60_G64_I0.9201.00
16_P19_V0.9191.00
11_V14_A0.9191.00
75_V79_A0.9161.00
38_A41_G0.9131.00
47_W51_G0.9111.00
102_A106_Y0.9081.00
154_K157_G0.9031.00
26_Y107_T0.9011.00
6_K10_P0.8941.00
133_L137_Y0.8911.00
112_A115_F0.8891.00
23_Y27_V0.8871.00
121_L124_L0.8831.00
64_I70_Y0.8791.00
83_D147_M0.8711.00
61_S65_I0.8561.00
57_L61_S0.8561.00
23_Y28_L0.8471.00
79_A102_A0.8461.00
22_L27_V0.8451.00
6_K141_L0.8431.00
26_Y29_P0.8371.00
65_I68_V0.8321.00
29_P33_I0.8281.00
129_L132_G0.8241.00
80_L83_D0.8221.00
65_I70_Y0.8141.00
162_V166_A0.8121.00
55_V58_T0.8071.00
119_P123_L0.7981.00
9_W12_I0.7941.00
78_L106_Y0.7931.00
152_E155_A0.7921.00
37_A40_I0.7901.00
151_P158_Y0.7871.00
47_W50_F0.7801.00
154_K158_Y0.7791.00
134_Y137_Y0.7741.00
16_P20_A0.7711.00
153_D161_V0.7711.00
48_S53_T0.7701.00
153_D159_T0.7691.00
34_P113_G0.7691.00
64_I71_L0.7681.00
155_A158_Y0.7641.00
58_T62_A0.7601.00
46_G49_I0.7601.00
17_A100_K0.7591.00
13_A97_Q0.7591.00
29_P34_P0.7571.00
45_I49_I0.7551.00
101_L145_V0.7541.00
160_V164_V0.7511.00
106_Y110_W0.7431.00
55_V60_G0.7421.00
37_A114_I0.7391.00
65_I73_L0.7341.00
161_V164_V0.7331.00
17_A22_L0.7311.00
112_A127_V0.7301.00
134_Y138_L0.7261.00
19_V96_K0.7261.00
31_A34_P0.7241.00
2_L108_P0.7221.00
22_L26_Y0.7181.00
117_L121_L0.7181.00
78_L162_V0.7171.00
13_A146_L0.7141.00
31_A35_A0.7121.00
83_D94_N0.7091.00
38_A43_S0.6981.00
117_L120_S0.6981.00
83_D98_A0.6971.00
38_A116_L0.6941.00
116_L125_L0.6911.00
46_G50_F0.6891.00
63_L69_F0.6891.00
13_A92_E0.6891.00
59_L63_L0.6881.00
80_L95_F0.6851.00
154_K161_V0.6821.00
106_Y109_A0.6801.00
27_V75_V0.6801.00
76_F95_F0.6771.00
10_P14_A0.6761.00
39_F42_G0.6711.00
18_T96_K0.6711.00
6_K145_V0.6691.00
155_A160_V0.6681.00
75_V110_W0.6521.00
109_A113_G0.6501.00
19_V22_L0.6501.00
162_V165_V0.6461.00
115_F127_V0.6371.00
64_I69_F0.6361.00
64_I72_L0.6351.00
39_F44_L0.6301.00
62_A69_F0.6221.00
82_I143_L0.6191.00
120_S124_L0.6181.00
139_L143_L0.6131.00
149_I152_E0.6091.00
11_V15_E0.6061.00
151_P155_A0.6061.00
62_A70_Y0.6051.00
75_V102_A0.6021.00
151_P161_V0.5971.00
68_V73_L0.5951.00
55_V61_S0.5940.99
76_F79_A0.5840.99
62_A65_I0.5830.99
34_P37_A0.5790.99
77_V80_L0.5770.99
7_T11_V0.5730.99
158_Y162_V0.5640.99
108_P115_F0.5560.99
1_I12_I0.5550.99
2_L138_L0.5550.99
35_A39_F0.5500.99
152_E157_G0.5480.99
119_P122_W0.5480.99
117_L122_W0.5480.99
81_I166_A0.5480.99
76_F99_L0.5430.99
24_T99_L0.5410.99
23_Y29_P0.5390.99
57_L62_A0.5380.99
116_L120_S0.5370.99
26_Y33_I0.5340.99
92_E97_Q0.5320.99
159_T162_V0.5260.99
128_G131_A0.5250.99
85_L89_F0.5250.99
33_I37_A0.5250.99
30_L34_P0.5230.99
81_I86_A0.5230.99
67_V73_L0.5160.99
17_A25_G0.5100.98
136_L160_V0.5090.98
91_G146_L0.5090.98
101_L105_S0.5060.98
23_Y76_F0.5050.98
130_L133_L0.5050.98
75_V106_Y0.5040.98
18_T23_Y0.5030.98
79_A98_A0.5010.98
41_G44_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pypA 1 0.8314 5.6 0.915 Contact Map
4j05A 3 0.814 3.6 0.923 Contact Map
3o7qA 1 0.8081 3.4 0.923 Contact Map
1pw4A 1 0.9302 2.7 0.927 Contact Map
2kv5A 1 0.1919 2.3 0.93 Contact Map
1nrpR 1 0.0291 2 0.932 Contact Map
3p8bA 1 0.157 1.9 0.933 Contact Map
4zw9A 1 0.8779 1.8 0.934 Contact Map
3klyA 3 0.8721 1.6 0.936 Contact Map
1nroR 1 0.0291 1.6 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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