GREMLIN Database
GutM - Glucitol operon activator protein (GutM)
PFAM: PF06923 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (100)
Sequences: 1079 (828)
Seq/√Len: 82.8
META: 0.635

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_K64_D4.6341.00
27_A66_E4.1361.00
54_L83_L2.6161.00
64_D79_P2.5521.00
23_H76_R2.4961.00
24_F39_I2.3561.00
15_L19_L2.3251.00
7_A11_L2.2191.00
61_R87_S2.1971.00
3_I7_A2.1691.00
66_E79_P2.0441.00
22_K26_K2.0391.00
27_A30_E1.9671.00
54_L65_A1.9071.00
81_P84_E1.8461.00
64_D84_E1.6881.00
36_R56_V1.6771.00
30_E66_E1.6461.00
37_V55_A1.5170.99
11_L15_L1.4860.99
7_A10_W1.4360.99
86_L90_E1.4150.99
3_I10_W1.3370.99
75_A78_K1.3240.99
16_L20_Q1.3110.98
17_G41_R1.2910.98
27_A77_F1.2770.98
28_F39_I1.2750.98
13_Q20_Q1.2720.98
49_G77_F1.2220.98
10_W73_V1.2110.97
32_R36_R1.2070.97
65_A83_L1.1440.96
6_L16_L1.1410.96
34_K55_A1.1190.96
38_G56_V1.1020.95
53_L77_F1.1020.95
44_G47_R1.0920.95
24_F77_F1.0800.95
78_K90_E1.0560.94
14_L31_L1.0360.94
14_L18_Y1.0320.94
65_A84_E1.0280.93
21_I68_M1.0250.93
8_V59_D1.0170.93
35_G40_G1.0040.93
17_G21_I0.9940.92
19_L26_K0.9860.92
43_K51_I0.9850.92
49_G68_M0.9690.91
4_L8_V0.9680.91
24_F28_F0.9620.91
32_R38_G0.9600.91
96_L99_E0.9350.90
17_G51_I0.9190.89
37_V41_R0.9170.89
31_L66_E0.9160.89
49_G71_V0.9140.89
79_P84_E0.9110.88
32_R91_L0.9080.88
72_T75_A0.9070.88
43_K46_F0.9010.88
14_L17_G0.8970.88
67_K82_E0.8900.87
65_A80_L0.8810.87
8_V82_E0.8590.85
33_R79_P0.8520.85
57_D61_R0.8370.84
90_E94_E0.8290.83
25_N37_V0.8250.83
51_I68_M0.8140.82
83_L99_E0.8110.82
27_A68_M0.8110.82
75_A79_P0.8070.82
4_L81_P0.8020.81
37_V53_L0.8010.81
67_K80_L0.7970.81
39_I48_A0.7920.80
38_G72_T0.7840.80
21_I62_I0.7750.79
18_Y47_R0.7740.79
9_A45_R0.7610.78
42_S50_A0.7580.77
28_F69_Q0.7460.76
10_W25_N0.7390.76
75_A83_L0.7380.75
41_R50_A0.7300.75
38_G46_F0.7290.75
30_E72_T0.7260.74
40_G68_M0.7120.73
87_S90_E0.7110.73
49_G53_L0.7080.72
75_A87_S0.7010.72
69_Q100_D0.6970.71
50_A69_Q0.6930.71
10_W18_Y0.6900.70
38_G48_A0.6880.70
53_L66_E0.6860.70
8_V15_L0.6820.70
79_P82_E0.6800.69
3_I17_G0.6800.69
38_G88_L0.6790.69
56_V65_A0.6780.69
44_G51_I0.6660.68
21_I69_Q0.6640.67
2_L100_D0.6590.67
24_F32_R0.6580.67
55_A63_V0.6550.66
9_A65_A0.6480.66
7_A14_L0.6450.65
51_I92_R0.6440.65
82_E91_L0.6430.65
14_L88_L0.6420.65
33_R36_R0.6360.64
54_L80_L0.6320.64
56_V60_G0.6260.63
41_R69_Q0.6240.63
70_G74_F0.6220.62
8_V94_E0.6160.62
3_I14_L0.6110.61
17_G69_Q0.6060.60
31_L55_A0.6030.60
86_L89_D0.6030.60
44_G50_A0.6020.60
58_E81_P0.5980.59
29_R33_R0.5920.59
23_H27_A0.5920.59
46_F77_F0.5900.58
19_L51_I0.5840.58
25_N28_F0.5830.58
16_L66_E0.5760.57
9_A93_E0.5660.55
31_L42_S0.5620.55
36_R58_E0.5610.55
52_V84_E0.5580.54
97_F101_K0.5580.54
17_G37_V0.5540.54
10_W74_F0.5520.53
45_R50_A0.5470.53
38_G68_M0.5400.52
10_W47_R0.5400.52
81_P93_E0.5380.52
51_I77_F0.5330.51
75_A90_E0.5310.51
82_E86_L0.5280.50
13_Q72_T0.5250.50
42_S77_F0.5150.49
13_Q70_G0.5010.47
66_E77_F0.5000.47
22_K74_F0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b33A 2 0.5701 33.8 0.891 Contact Map
2qkpA 2 0.7664 24.9 0.898 Contact Map
4hh2A 4 0.5234 22.3 0.9 Contact Map
1ll8A 1 0.5421 22 0.901 Contact Map
3ewkA 1 0.4579 21.6 0.901 Contact Map
4i5sA 2 0.8037 18.6 0.904 Contact Map
3a0sA 1 0.4673 17.1 0.906 Contact Map
1nwzA 1 0.7196 15.2 0.908 Contact Map
2gj3A 7 0.6075 15 0.908 Contact Map
3nhqA 2 0.5888 13.4 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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