GREMLIN Database
DUF1279 - Protein of unknown function (DUF1279)
PFAM: PF06916 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 92 (88)
Sequences: 950 (672)
Seq/√Len: 71.6
META: 0.378

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_F68_F4.6291.00
25_S75_H3.6591.00
20_G24_V2.9351.00
6_L14_A2.5231.00
12_W16_G2.4751.00
22_S75_H2.4741.00
80_P84_P2.3941.00
34_S67_T2.1701.00
22_S72_Y2.1061.00
19_L23_L2.0271.00
17_V89_L1.9711.00
72_Y75_H1.8951.00
18_Y79_A1.7781.00
30_Y64_L1.7501.00
29_C33_V1.7481.00
22_S79_A1.7461.00
6_L87_L1.6731.00
18_Y83_V1.5850.99
22_S25_S1.5770.99
73_A78_L1.5120.99
11_G16_G1.5090.99
17_V76_K1.3920.98
5_K9_K1.3880.98
14_A18_Y1.2400.96
27_G31_L1.2340.96
22_S76_K1.2340.96
3_L14_A1.2180.96
21_L25_S1.1880.95
38_D41_A1.1230.94
48_L70_L1.1130.94
70_L73_A1.1110.94
41_A45_K1.1080.93
41_A44_E1.1070.93
14_A86_T1.0980.93
23_L27_G1.0890.93
30_Y66_G1.0850.93
18_Y25_S1.0810.93
43_L48_L1.0750.92
76_K79_A1.0630.92
78_L81_V1.0510.91
88_A91_P1.0230.90
79_A83_V1.0170.90
33_V70_L0.9790.88
74_I78_L0.9680.88
6_L13_V0.9640.88
85_L89_L0.9480.87
55_S58_E0.9360.86
13_V90_T0.9200.85
11_G91_P0.9090.84
42_L45_K0.8850.83
9_K12_W0.8820.82
77_A80_P0.8750.82
53_A56_A0.8720.82
72_Y78_L0.8690.81
7_L14_A0.8640.81
7_L15_L0.8640.81
29_C78_L0.8230.78
32_A48_L0.8200.78
18_Y86_T0.8150.77
66_G69_A0.8130.77
8_K88_A0.8130.77
21_L27_G0.8060.76
40_A45_K0.7920.75
87_L90_T0.7910.75
55_S61_K0.7880.75
84_P88_A0.7840.74
53_A57_T0.7720.73
29_C75_H0.7690.73
42_L65_A0.7600.72
25_S78_L0.7510.71
65_A69_A0.7460.71
36_G72_Y0.7380.70
37_V71_A0.7300.69
26_F71_A0.7300.69
54_E57_T0.7270.69
32_A35_S0.7250.68
44_E47_G0.7220.68
31_L35_S0.7140.67
43_L47_G0.7050.66
82_R86_T0.7030.66
18_Y85_L0.7020.66
24_V85_L0.6980.65
55_S59_S0.6840.64
22_S82_R0.6770.63
83_V87_L0.6770.63
75_H83_V0.6700.62
3_L12_W0.6660.62
15_L44_E0.6650.62
2_R59_S0.6610.61
14_A91_P0.6530.60
2_R8_K0.6520.60
44_E49_S0.6460.60
77_A84_P0.6440.59
42_L46_V0.6430.59
2_R5_K0.6390.59
32_A63_S0.6290.57
33_V75_H0.6270.57
46_V77_A0.6270.57
18_Y76_K0.6200.56
40_A61_K0.6190.56
6_L12_W0.6160.56
17_V91_P0.6140.56
73_A90_T0.6100.55
8_K32_A0.6040.54
71_A75_H0.6000.54
20_G23_L0.5950.53
16_G19_L0.5860.52
61_K81_V0.5780.51
84_P89_L0.5750.51
29_C74_I0.5750.51
54_E58_E0.5730.51
56_A59_S0.5700.50
10_Y81_V0.5640.50
39_V42_L0.5630.49
24_V28_G0.5610.49
35_S81_V0.5530.48
55_S60_L0.5410.47
36_G75_H0.5380.46
19_L72_Y0.5370.46
46_V88_A0.5350.46
30_Y34_S0.5300.45
31_L44_E0.5290.45
19_L52_S0.5290.45
7_L12_W0.5170.44
33_V82_R0.5170.44
70_L83_V0.5140.43
59_S63_S0.5100.43
47_G66_G0.5090.43
22_S33_V0.5060.43
19_L24_V0.5050.42
75_H79_A0.5040.42
25_S66_G0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zdjA 1 0.7391 9.1 0.893 Contact Map
2zjsY 2 0.9239 6.6 0.9 Contact Map
3j01A 1 0.8804 6.2 0.901 Contact Map
3vn0A 2 0.163 5.2 0.904 Contact Map
3dl8G 1 0.9239 4.8 0.906 Contact Map
2jbwA 2 0.9565 3.8 0.911 Contact Map
1lnsA 2 0.9674 3.7 0.911 Contact Map
2b9vA 5 0.9674 3.7 0.911 Contact Map
1ytrA 1 0.1304 3.6 0.911 Contact Map
1mpxA 4 0.9674 3.4 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0046 seconds.