GREMLIN Database
DUF1275 - Protein of unknown function (DUF1275)
PFAM: PF06912 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 192 (189)
Sequences: 12880 (9578)
Seq/√Len: 696.7
META: 0.738

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_V138_G3.6271.00
75_R82_E3.4821.00
32_V163_L3.0461.00
3_L161_A2.8341.00
63_L108_F2.7601.00
56_A104_A2.6281.00
113_Q127_T2.5911.00
78_A82_E2.5881.00
114_N128_T2.3911.00
129_V132_G2.3851.00
7_F168_L2.2121.00
62_A142_A2.1961.00
152_L155_R2.1751.00
177_W180_L2.0921.00
32_V159_I2.0321.00
26_A110_M1.9521.00
65_G143_R1.9271.00
28_M31_N1.8911.00
19_G173_F1.8821.00
16_G25_T1.8681.00
62_A138_G1.8541.00
35_L47_A1.7781.00
83_A190_A1.7771.00
79_L82_E1.7381.00
64_G115_A1.7231.00
126_R129_V1.6841.00
38_A43_D1.6691.00
43_D46_S1.6681.00
8_V186_L1.6381.00
60_G108_F1.6191.00
58_V134_L1.6151.00
64_G112_L1.6061.00
32_V130_L1.5951.00
130_L133_T1.5831.00
74_R82_E1.5591.00
56_A60_G1.5551.00
14_A169_G1.5461.00
56_A107_A1.5451.00
83_A187_L1.5351.00
90_A180_L1.5301.00
62_A145_L1.5021.00
65_G139_I1.4711.00
76_R82_E1.4511.00
46_S49_A1.4181.00
11_F169_G1.4111.00
84_L88_A1.3881.00
171_L175_H1.3841.00
150_R154_R1.3771.00
83_A87_L1.3601.00
77_L82_E1.3191.00
15_V178_A1.3121.00
7_F161_A1.3111.00
36_G166_A1.3011.00
11_F181_L1.2921.00
93_G96_G1.2901.00
152_L156_L1.2811.00
89_A93_G1.2781.00
17_F22_G1.2721.00
118_R136_D1.2351.00
114_N129_V1.2241.00
28_M53_A1.1961.00
87_L183_A1.1881.00
134_L159_I1.1671.00
141_L144_L1.1641.00
137_L156_L1.1631.00
76_R79_L1.1581.00
140_D155_R1.1571.00
128_T132_G1.1541.00
84_L87_L1.1531.00
54_L134_L1.1441.00
87_L91_L1.1381.00
6_A158_L1.1181.00
151_R155_R1.1141.00
62_A141_L1.1121.00
137_L159_I1.1031.00
75_R79_L1.1021.00
32_V134_L1.0941.00
72_R76_R1.0891.00
94_A97_G1.0871.00
153_R157_L1.0851.00
56_A108_F1.0831.00
72_R75_R1.0801.00
16_G106_L1.0801.00
74_R77_L1.0601.00
135_T139_I1.0431.00
91_L95_A1.0361.00
52_L104_A1.0361.00
90_A94_A1.0361.00
83_A86_L1.0301.00
177_W182_P1.0271.00
73_R78_A1.0161.00
17_F24_F1.0051.00
82_E113_Q1.0031.00
11_F15_V1.0001.00
25_T106_L0.9991.00
114_N135_T0.9971.00
163_L167_V0.9961.00
24_F34_L0.9921.00
50_S53_A0.9891.00
45_L49_A0.9801.00
17_F34_L0.9801.00
31_N54_L0.9781.00
73_R76_R0.9651.00
184_A188_L0.9621.00
61_A138_G0.9521.00
37_A170_A0.9491.00
78_A112_L0.9461.00
179_L182_P0.9461.00
38_A47_A0.9391.00
85_L90_A0.9371.00
58_V62_A0.9341.00
46_S50_S0.9341.00
120_L123_A0.9321.00
90_A183_A0.9271.00
66_L142_A0.9201.00
141_L145_L0.9191.00
89_A106_L0.9181.00
138_G142_A0.9171.00
133_T159_I0.9141.00
172_L178_A0.9131.00
137_L152_L0.9091.00
92_L95_A0.9041.00
126_R136_D0.9031.00
39_L47_A0.9001.00
27_H33_V0.8961.00
160_L164_A0.8941.00
93_G97_G0.8911.00
4_L8_V0.8911.00
38_A41_G0.8891.00
83_A93_G0.8891.00
73_R81_L0.8891.00
178_A182_P0.8861.00
28_M134_L0.8831.00
88_A92_L0.8801.00
77_L81_L0.8801.00
182_P185_L0.8791.00
11_F172_L0.8791.00
66_L70_R0.8711.00
97_G100_P0.8661.00
8_V12_V0.8641.00
75_R78_A0.8621.00
4_L185_L0.8601.00
35_L50_S0.8601.00
35_L51_L0.8441.00
40_A170_A0.8401.00
61_A65_G0.8391.00
74_R78_A0.8391.00
13_D33_V0.8381.00
14_A37_A0.8381.00
27_H126_R0.8331.00
60_G64_G0.8301.00
36_G40_A0.8251.00
64_G116_A0.8211.00
60_G111_G0.8181.00
28_M130_L0.8161.00
34_L38_A0.8151.00
23_V103_I0.8121.00
78_A116_A0.8061.00
178_A183_A0.8011.00
154_R157_L0.7991.00
36_G163_L0.7981.00
44_W48_L0.7951.00
34_L50_S0.7941.00
150_R153_R0.7911.00
38_A46_S0.7891.00
142_A145_L0.7761.00
176_A181_L0.7761.00
177_W181_L0.7761.00
58_V137_L0.7741.00
37_A41_G0.7721.00
35_L54_L0.7711.00
18_L37_A0.7681.00
8_V11_F0.7681.00
91_L94_A0.7651.00
7_F165_G0.7571.00
130_L159_I0.7501.00
3_L157_L0.7461.00
129_V135_T0.7431.00
60_G107_A0.7421.00
77_L80_L0.7411.00
61_A115_A0.7321.00
96_G100_P0.7311.00
8_V113_Q0.7281.00
35_L38_A0.7281.00
11_F182_P0.7271.00
172_L181_L0.7271.00
83_A183_A0.7261.00
74_R79_L0.7251.00
162_F166_A0.7251.00
137_L141_L0.7151.00
89_A92_L0.7141.00
59_L108_F0.7141.00
168_L172_L0.7101.00
12_V86_L0.7081.00
90_A93_G0.7071.00
27_H135_T0.7031.00
179_L183_A0.7021.00
170_A174_R0.7011.00
34_L37_A0.7001.00
101_L104_A0.6991.00
114_N126_R0.6981.00
11_F178_A0.6941.00
31_N53_A0.6911.00
51_L55_L0.6881.00
178_A181_L0.6881.00
8_V182_P0.6871.00
36_G167_V0.6861.00
179_L186_L0.6851.00
95_A98_A0.6751.00
118_R139_I0.6741.00
35_L39_L0.6711.00
110_M128_T0.6711.00
32_V54_L0.6621.00
52_L55_L0.6551.00
21_G103_I0.6531.00
9_A27_H0.6521.00
118_R121_S0.6521.00
126_R135_T0.6501.00
180_L183_A0.6451.00
94_A177_W0.6441.00
132_G136_D0.6441.00
41_G174_R0.6391.00
164_A168_L0.6381.00
161_A165_G0.6321.00
140_D144_L0.6301.00
93_G102_L0.6291.00
47_A50_S0.6261.00
95_A100_P0.6251.00
45_L48_L0.6251.00
146_R149_P0.6181.00
133_T155_R0.6161.00
48_L51_L0.6141.00
85_L105_L0.6101.00
12_V109_A0.6091.00
87_L95_A0.6041.00
73_R77_L0.6001.00
65_G69_R0.6001.00
67_L71_L0.5951.00
113_Q186_L0.5891.00
126_R132_G0.5881.00
87_L90_A0.5881.00
61_A135_T0.5861.00
120_L125_V0.5831.00
7_F164_A0.5791.00
25_T113_Q0.5791.00
9_A126_R0.5781.00
64_G129_V0.5781.00
28_M32_V0.5771.00
78_A81_L0.5751.00
15_V169_G0.5721.00
4_L189_L0.5721.00
169_G174_R0.5711.00
86_L106_L0.5691.00
2_A161_A0.5671.00
49_A52_L0.5641.00
13_D26_A0.5591.00
176_A179_L0.5571.00
134_L138_G0.5571.00
69_R146_R0.5551.00
164_A167_V0.5541.00
49_A107_A0.5511.00
68_A115_A0.5451.00
23_V31_N0.5431.00
177_W183_A0.5421.00
169_G172_L0.5411.00
171_L174_R0.5401.00
55_L59_L0.5351.00
44_W47_A0.5331.00
6_A24_F0.5331.00
94_A180_L0.5271.00
64_G68_A0.5261.00
34_L53_A0.5241.00
183_A186_L0.5241.00
136_D140_D0.5231.00
12_V110_M0.5191.00
18_L173_F0.5161.00
126_R133_T0.5150.99
27_H162_F0.5140.99
13_D24_F0.5070.99
127_T135_T0.5070.99
66_L145_L0.5020.99
47_A51_L0.5020.99
184_A187_L0.5010.99
35_L163_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pypA 1 0.8958 41.4 0.905 Contact Map
4zw9A 1 0.8958 36.5 0.908 Contact Map
4j05A 3 0.875 33.1 0.91 Contact Map
4ldsA 2 0.8594 32.1 0.91 Contact Map
4gc0A 1 0.8906 19.3 0.919 Contact Map
4tphA 2 0.875 14.9 0.923 Contact Map
3o7qA 1 0.8646 13.9 0.924 Contact Map
1pw4A 1 0.8594 13.5 0.925 Contact Map
2gfpA 2 0.8542 13.1 0.925 Contact Map
4ikvA 1 0.8906 9.9 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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