GREMLIN Database
Senescence - Senescence-associated protein
PFAM: PF06911 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 175 (173)
Sequences: 636 (459)
Seq/√Len: 34.9
META: 0.233

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_L149_A5.1851.00
100_K103_K4.7331.00
138_V146_A3.5781.00
31_K136_T2.9891.00
163_V166_D2.7471.00
13_V118_G2.6141.00
139_G147_G2.6091.00
166_D169_G2.3510.99
135_T147_G2.3350.99
30_L34_T2.2700.99
55_K152_D2.2580.99
131_S154_L2.2450.99
150_T154_L2.2410.99
50_R53_R2.1880.99
20_A129_S2.1080.99
168_F173_K2.0760.99
8_I11_G2.0540.99
36_P40_P2.0490.98
93_K99_E2.0180.98
16_S20_A1.9510.98
32_K47_T1.9300.98
72_V84_A1.8880.97
139_G144_E1.8610.97
47_T51_L1.7890.96
94_S97_P1.7740.96
26_G30_L1.6750.95
138_V150_T1.6440.94
40_P140_H1.6320.94
89_G98_G1.5980.93
75_V160_V1.5940.93
76_A80_G1.5640.92
46_A49_K1.5630.92
14_T17_D1.5610.92
7_Q175_L1.5520.92
164_A169_G1.5320.92
93_K97_P1.5120.91
48_H145_E1.4780.90
163_V169_G1.4590.90
85_N88_A1.4550.89
94_S99_E1.4500.89
51_L156_A1.4490.89
149_A157_A1.4170.88
122_A154_L1.3830.87
107_A110_D1.3440.85
94_S98_G1.3380.85
31_K122_A1.3340.85
51_L157_A1.3320.85
127_L130_T1.3160.84
44_S47_T1.3080.84
31_K140_H1.3070.84
162_L173_K1.2780.82
45_P49_K1.2690.82
17_D79_V1.2590.81
156_A159_N1.2530.81
95_L98_G1.2520.81
93_K96_L1.2430.80
49_K115_V1.2170.79
106_N119_L1.2000.78
5_A147_G1.1910.77
5_A9_S1.1810.77
149_A152_D1.1790.77
17_D120_E1.1720.76
37_N41_M1.1630.76
58_T152_D1.1610.76
92_F95_L1.1570.75
40_P43_F1.1540.75
50_R112_F1.1520.75
8_I50_R1.1220.73
90_K100_K1.0980.71
161_G170_V1.0970.71
71_G74_K1.0820.70
29_S119_L1.0750.70
76_A111_A1.0540.68
120_E124_K1.0320.67
9_S164_A1.0270.66
67_K122_A1.0200.66
24_Q115_V1.0180.65
80_G83_L1.0160.65
96_L99_E1.0140.65
62_A65_S1.0110.65
71_G75_V1.0080.65
162_L169_G1.0020.64
15_G22_G0.9940.64
28_E98_G0.9920.63
5_A20_A0.9900.63
58_T115_V0.9790.62
17_D125_N0.9690.62
169_G172_R0.9530.60
114_T118_G0.9530.60
110_D130_T0.9530.60
110_D122_A0.9440.60
12_I118_G0.9430.59
158_G162_L0.9290.58
51_L125_N0.9260.58
38_E141_K0.9160.57
35_K132_T0.9160.57
123_G130_T0.9120.57
165_I169_G0.9110.57
20_A157_A0.9060.56
3_S122_A0.8930.55
29_S32_K0.8920.55
86_S97_P0.8820.54
166_D173_K0.8700.53
118_G122_A0.8680.53
95_L99_E0.8670.53
152_D175_L0.8600.52
115_V135_T0.8520.52
91_K94_S0.8510.52
164_A172_R0.8470.51
33_K140_H0.8450.51
162_L166_D0.8430.51
104_V116_A0.8430.51
86_S90_K0.8420.51
158_G169_G0.8370.51
28_E61_A0.8360.50
5_A115_V0.8360.50
9_S68_T0.8330.50
80_G84_A0.8330.50
73_G120_E0.8250.49
108_S113_S0.8240.49
10_R108_S0.8240.49
12_I23_L0.8210.49
65_S72_V0.8170.49
4_G20_A0.8150.49
135_T139_G0.8120.48
3_S7_Q0.8040.48
125_N135_T0.8040.48
128_S173_K0.8030.48
157_A161_G0.7950.47
111_A134_T0.7940.47
120_E123_G0.7930.47
27_A141_K0.7910.47
120_E129_S0.7900.46
139_G151_R0.7850.46
39_K75_V0.7850.46
69_V114_T0.7840.46
24_Q148_E0.7800.46
33_K134_T0.7800.46
43_F146_A0.7790.46
166_D172_R0.7750.45
57_L130_T0.7720.45
142_Y168_F0.7720.45
111_A115_V0.7700.45
4_G116_A0.7700.45
1_I129_S0.7660.44
34_T111_A0.7620.44
89_G141_K0.7610.44
117_D135_T0.7570.44
23_L140_H0.7550.44
168_F172_R0.7550.44
90_K94_S0.7540.43
93_K98_G0.7520.43
27_A134_T0.7460.43
27_A133_A0.7440.43
169_G174_A0.7430.43
21_K173_K0.7390.42
45_P132_T0.7340.42
21_K24_Q0.7340.42
109_L112_F0.7330.42
76_A116_A0.7320.42
23_L132_T0.7310.42
34_T43_F0.7280.41
49_K53_R0.7260.41
36_P140_H0.7240.41
58_T159_N0.7240.41
56_K109_L0.7200.41
45_P54_V0.7190.41
59_K123_G0.7170.40
47_T50_R0.7120.40
34_T140_H0.7050.39
40_P160_V0.7040.39
37_N115_V0.6970.39
15_G123_G0.6970.39
20_A118_G0.6950.39
32_K125_N0.6870.38
90_K144_E0.6850.38
3_S24_Q0.6800.37
9_S159_N0.6670.36
23_L118_G0.6660.36
4_G55_K0.6640.36
48_H152_D0.6640.36
47_T68_T0.6630.36
22_G26_G0.6630.36
128_S141_K0.6620.36
3_S21_K0.6610.36
113_S171_G0.6570.36
121_Q124_K0.6540.35
4_G72_V0.6520.35
33_K142_Y0.6470.35
61_A66_A0.6440.35
122_A151_R0.6430.34
31_K34_T0.6420.34
66_A161_G0.6420.34
90_K93_K0.6370.34
37_N119_L0.6370.34
83_L147_G0.6350.34
15_G19_T0.6350.34
82_S122_A0.6340.34
113_S117_D0.6340.34
5_A142_Y0.6260.33
165_I174_A0.6230.33
111_A133_A0.6170.32
108_S111_A0.6160.32
81_A145_E0.6140.32
99_E141_K0.6130.32
34_T175_L0.6080.32
82_S125_N0.6040.31
121_Q129_S0.6040.31
6_G11_G0.6040.31
161_G164_A0.6040.31
95_L157_A0.6030.31
32_K36_P0.6020.31
113_S119_L0.5970.31
9_S118_G0.5960.31
111_A116_A0.5920.31
106_N170_V0.5870.30
32_K175_L0.5810.30
69_V83_L0.5730.29
62_A158_G0.5720.29
133_A136_T0.5710.29
124_K162_L0.5710.29
15_G62_A0.5690.29
67_K71_G0.5660.29
65_S70_G0.5650.29
4_G34_T0.5650.29
1_I104_V0.5630.29
23_L128_S0.5610.28
113_S116_A0.5610.28
115_V160_V0.5550.28
65_S127_L0.5550.28
70_G150_T0.5520.28
4_G7_Q0.5500.28
162_L168_F0.5490.28
163_V170_V0.5440.27
24_Q140_H0.5420.27
105_L161_G0.5420.27
16_S42_T0.5380.27
74_K150_T0.5360.27
48_H149_A0.5350.27
165_I172_R0.5300.26
86_S89_G0.5300.26
24_Q126_L0.5290.26
104_V108_S0.5260.26
91_K96_L0.5220.26
131_S135_T0.5200.26
54_V77_G0.5160.25
14_T29_S0.5150.25
18_Y22_G0.5140.25
41_M56_K0.5120.25
27_A70_G0.5120.25
59_K150_T0.5110.25
141_K173_K0.5100.25
2_V107_A0.5080.25
68_T163_V0.5080.25
8_I82_S0.5060.25
18_Y156_A0.5030.25
60_M63_K0.5030.25
73_G136_T0.5020.24
52_R152_D0.5010.24
31_K38_E0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5nC 1 0.1829 3.8 0.94 Contact Map
1un8A 2 0.6114 2.3 0.946 Contact Map
3pnlB 1 0.6971 2.2 0.946 Contact Map
2k6oA 1 0.2114 1.6 0.951 Contact Map
2p58B 1 0.2171 1.3 0.953 Contact Map
2cx0A 1 0.4171 1.3 0.953 Contact Map
2i88A 1 0.28 1.2 0.955 Contact Map
2ca5A 1 0.3829 1.1 0.955 Contact Map
1n7sC 1 0.2457 1.1 0.956 Contact Map
1l4aC 1 0.2286 1.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.007 seconds.