GREMLIN Database
DUF1272 - Protein of unknown function (DUF1272)
PFAM: PF06906 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 57 (57)
Sequences: 9969 (2937)
Seq/√Len: 389.0
META: 0.952

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_R36_A2.9251.00
7_N12_D2.8641.00
50_E56_I2.5741.00
23_R33_A2.3201.00
10_C39_V2.2371.00
33_A37_E2.0231.00
34_D38_T1.8851.00
26_S57_R1.7831.00
21_E33_A1.7381.00
7_N14_D1.7221.00
23_R42_G1.6741.00
50_E53_P1.5591.00
16_P19_S1.5461.00
31_F46_N1.4021.00
29_C46_N1.3781.00
36_A51_L1.3481.00
13_K21_E1.3361.00
2_L24_I1.2881.00
10_C40_L1.2541.00
7_N10_C1.2301.00
31_F45_P1.2241.00
13_K34_D1.2181.00
32_C35_C1.1871.00
24_I28_E1.1811.00
53_P56_I1.1561.00
5_R9_E1.0811.00
23_R53_P1.0741.00
4_L56_I1.0251.00
17_P56_I1.0181.00
10_C38_T0.9951.00
1_M10_C0.9951.00
31_F39_V0.9651.00
37_E42_G0.9561.00
31_F51_L0.9391.00
20_T56_I0.9361.00
23_R37_E0.9211.00
2_L28_E0.9211.00
6_P14_D0.9041.00
6_P17_P0.8591.00
36_A39_V0.8511.00
34_D37_E0.8451.00
4_L17_P0.8451.00
44_C47_C0.8141.00
43_V48_G0.8041.00
10_C14_D0.7971.00
21_E53_P0.7791.00
38_T41_G0.7761.00
6_P12_D0.7751.00
36_A42_G0.7721.00
52_V56_I0.7671.00
15_L22_A0.7581.00
6_P16_P0.7211.00
36_A40_L0.7111.00
10_C27_F0.7061.00
4_L28_E0.6991.00
18_D56_I0.6900.99
20_T33_A0.6850.99
26_S50_E0.6700.99
37_E41_G0.6610.99
30_T35_C0.6520.99
25_C32_C0.6490.99
54_R57_R0.6400.99
22_A31_F0.6360.99
25_C28_E0.6320.99
2_L26_S0.6120.99
20_T53_P0.6040.99
47_C54_R0.5910.98
37_E40_L0.5840.98
39_V43_V0.5780.98
20_T50_E0.5670.98
43_V50_E0.5620.98
33_A53_P0.5580.98
21_E56_I0.5530.98
28_E35_C0.5460.97
16_P22_A0.5380.97
25_C29_C0.5360.97
25_C35_C0.5360.97
9_E45_P0.5350.97
14_D48_G0.5250.97
26_S30_T0.5240.97
12_D16_P0.5210.96
31_F36_A0.5180.96
2_L48_G0.5140.96
34_D41_G0.5120.96
36_A41_G0.5110.96
13_K19_S0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4txaA 1 1 81.8 0.802 Contact Map
1jm7B 1 0.9474 74.9 0.815 Contact Map
1e4uA 1 1 74.8 0.815 Contact Map
2ct2A 1 1 73 0.818 Contact Map
2jrpA 1 0.8947 72.2 0.819 Contact Map
1iymA 1 0.9123 72 0.819 Contact Map
2ectA 1 0.9825 68.6 0.823 Contact Map
2y1nA 1 0.9298 66.8 0.825 Contact Map
4ladB 1 0.7018 66.3 0.826 Contact Map
2eclA 1 1 65.2 0.827 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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