GREMLIN Database
DUF1266 - Protein of unknown function (DUF1266)
PFAM: PF06889 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (171)
Sequences: 1885 (1567)
Seq/√Len: 119.8
META: 0.655

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_L98_G6.0221.00
10_D13_S5.9261.00
124_Y133_S5.8101.00
11_R15_L4.1081.00
11_R108_E3.9301.00
92_V113_I3.5971.00
120_A130_F3.3971.00
89_G130_F3.2271.00
125_S129_E3.0601.00
93_N97_W2.7971.00
106_E110_W2.7321.00
9_T13_S2.6931.00
105_T108_E2.6721.00
85_A124_Y2.6391.00
20_W25_G2.3751.00
131_A171_W2.2781.00
86_W141_W2.2201.00
91_A116_A2.1791.00
26_H141_W2.1201.00
20_W24_G2.0691.00
10_D103_Y1.9901.00
85_A130_F1.9091.00
88_L120_A1.8431.00
3_E9_T1.8191.00
110_W113_I1.7061.00
118_R121_Q1.6971.00
25_G87_D1.6821.00
131_A160_Y1.6281.00
22_L91_A1.6071.00
85_A133_S1.5811.00
18_L91_A1.5691.00
89_G134_Y1.5341.00
90_R141_W1.5121.00
90_R138_R1.4781.00
86_W90_R1.4741.00
87_D90_R1.4641.00
95_A116_A1.4391.00
14_L95_A1.4181.00
3_E7_G1.4131.00
138_R156_R1.3711.00
169_S172_R1.3251.00
6_W21_L1.3191.00
33_L140_F1.3071.00
17_T20_W1.2921.00
128_E164_L1.2150.99
99_Y106_E1.2100.99
26_H86_W1.2040.99
21_L90_R1.1820.99
126_S129_E1.1710.99
14_L94_L1.1710.99
45_L49_L1.1680.99
95_A113_I1.1460.99
89_G138_R1.1430.99
14_L104_L1.1240.99
70_R74_Y1.1150.99
117_A121_Q1.1010.99
114_L121_Q1.0930.99
18_L112_L1.0890.98
163_L169_S1.0830.98
15_L104_L1.0720.98
92_V120_A1.0700.98
65_A69_A1.0390.98
2_L101_A1.0180.98
79_G83_I1.0170.98
27_R31_D0.9930.97
74_Y136_L0.9890.97
30_F34_A0.9790.97
8_I98_G0.9680.97
6_W141_W0.9660.97
135_L156_R0.9650.97
165_T172_R0.9590.97
19_E23_E0.9530.96
6_W90_R0.9440.96
46_D49_L0.9420.96
83_I140_F0.9230.96
78_L82_G0.9220.96
96_R113_I0.9110.95
61_R64_E0.9100.95
20_W26_H0.9090.95
41_S44_E0.9000.95
70_R77_R0.8850.95
19_E115_R0.8810.95
57_E60_A0.8800.94
94_L98_G0.8790.94
74_Y78_L0.8740.94
62_A66_L0.8730.94
90_R134_Y0.8680.94
109_A113_I0.8650.94
158_E162_E0.8590.94
21_L91_A0.8560.94
44_E47_E0.8500.93
72_R77_R0.8480.93
99_Y109_A0.8470.93
74_Y81_D0.8390.93
51_E56_E0.8290.93
89_G120_A0.8290.93
26_H90_R0.8220.92
18_L95_A0.8210.92
108_E112_L0.8200.92
34_A75_Y0.8190.92
75_Y79_G0.8150.92
158_E166_D0.8140.92
20_W27_R0.8100.92
156_R160_Y0.8040.91
22_L116_A0.8030.91
123_T130_F0.7990.91
153_Y157_L0.7970.91
161_R165_T0.7950.91
120_A133_S0.7930.91
40_L44_E0.7920.91
5_W90_R0.7920.91
96_R110_W0.7910.91
95_A112_L0.7910.91
154_E158_E0.7880.91
17_T26_H0.7850.90
57_E61_R0.7840.90
66_L69_A0.7820.90
74_Y82_G0.7790.90
84_L123_T0.7740.90
64_E67_R0.7700.90
138_R141_W0.7610.89
56_E62_A0.7530.88
30_F176_W0.7530.88
75_Y82_G0.7520.88
48_E52_L0.7520.88
83_I133_S0.7330.87
19_E112_L0.7320.87
77_R80_A0.7290.87
8_I14_L0.7280.87
155_E158_E0.7240.86
52_L59_L0.7190.86
74_Y83_I0.7190.86
15_L108_E0.7160.86
56_E60_A0.7120.86
71_V75_Y0.7110.85
74_Y77_R0.7100.85
78_L83_I0.7090.85
159_I163_L0.7090.85
34_A37_L0.7020.85
53_E56_E0.7000.85
126_S176_W0.6960.84
7_G17_T0.6890.84
22_L133_S0.6860.83
24_G28_A0.6840.83
54_E57_E0.6840.83
41_S45_L0.6810.83
89_G92_V0.6810.83
113_I116_A0.6800.83
56_E59_L0.6780.83
112_L115_R0.6760.82
58_D61_R0.6720.82
15_L112_L0.6710.82
104_L107_E0.6700.82
50_A53_E0.6690.82
63_E66_L0.6690.82
96_R138_R0.6650.81
14_L18_L0.6630.81
119_L122_E0.6630.81
15_L91_A0.6630.81
139_A153_Y0.6590.81
27_R84_L0.6580.81
153_Y156_R0.6450.79
27_R30_F0.6430.79
33_L36_A0.6420.79
59_L62_A0.6390.79
110_W131_A0.6370.79
27_R88_L0.6370.79
161_R164_L0.6350.78
93_N96_R0.6320.78
12_E16_E0.6240.77
61_R65_A0.6200.77
51_E55_D0.6200.77
29_E33_L0.6180.76
109_A114_L0.6140.76
156_R161_R0.6130.76
46_D50_A0.6130.76
78_L136_L0.6090.75
63_E67_R0.6060.75
2_L6_W0.6050.75
6_W138_R0.6040.75
81_D84_L0.5980.74
79_G82_G0.5960.74
97_W171_W0.5930.74
52_L56_E0.5930.74
27_R87_D0.5920.73
53_E58_D0.5890.73
18_L104_L0.5890.73
95_A136_L0.5890.73
96_R136_L0.5890.73
162_E166_D0.5880.73
62_A65_A0.5870.73
83_I137_G0.5870.73
55_D59_L0.5860.73
75_Y78_L0.5830.72
25_G90_R0.5810.72
159_I165_T0.5800.72
157_L161_R0.5800.72
44_E48_E0.5770.72
22_L115_R0.5770.72
64_E69_A0.5770.72
92_V116_A0.5750.71
85_A120_A0.5730.71
128_E132_A0.5730.71
83_I134_Y0.5730.71
168_D173_T0.5730.71
134_Y141_W0.5730.71
101_A145_D0.5720.71
46_D57_E0.5680.70
110_W138_R0.5640.70
157_L162_E0.5640.70
48_E56_E0.5630.70
47_E50_A0.5610.69
55_D62_A0.5600.69
78_L134_Y0.5550.69
9_T12_E0.5550.69
56_E64_E0.5530.68
162_E165_T0.5530.68
55_D58_D0.5520.68
128_E131_A0.5510.68
90_R94_L0.5510.68
17_T24_G0.5500.68
170_P174_L0.5470.67
52_L55_D0.5470.67
71_V76_E0.5460.67
114_L117_A0.5460.67
86_W138_R0.5430.67
166_D169_S0.5420.67
79_G84_L0.5400.66
156_R159_I0.5350.66
26_H87_D0.5330.65
108_E121_Q0.5270.65
6_W94_L0.5270.65
27_R82_G0.5250.64
6_W86_W0.5240.64
88_L119_L0.5240.64
56_E61_R0.5230.64
89_G124_Y0.5220.64
13_S17_T0.5220.64
134_Y138_R0.5190.63
98_G171_W0.5180.63
85_A138_R0.5180.63
12_E15_L0.5160.63
112_L116_A0.5150.63
115_R122_E0.5120.62
103_Y133_S0.5100.62
152_W160_Y0.5090.62
140_F143_G0.5090.62
155_E159_I0.5080.62
109_A134_Y0.5080.62
54_E58_D0.5060.62
4_E122_E0.5050.61
111_D114_L0.5040.61
27_R113_I0.5020.61
28_A31_D0.5010.61
3_E13_S0.5010.61
32_E35_E0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gl3A 1 0.75 12.6 0.925 Contact Map
3q4oA 2 0.5966 10.6 0.928 Contact Map
1jg7A 1 0.3352 4.7 0.939 Contact Map
3tixB 1 0.3977 3.7 0.942 Contact Map
1wtyA 4 0.6591 3.6 0.942 Contact Map
4kbmB 1 0.5341 3.6 0.942 Contact Map
3kluA 1 0.2216 3.3 0.943 Contact Map
4jrbA 1 0.4432 2.8 0.945 Contact Map
1eswA 1 0.7898 2.8 0.945 Contact Map
3iukA 1 0.9489 2.7 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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