GREMLIN Database
TPX2 - Targeting protein for Xklp2 (TPX2)
PFAM: PF06886 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 57 (57)
Sequences: 825 (488)
Seq/√Len: 64.7
META: 0.274

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_Q49_S2.2921.00
28_K32_E2.0741.00
45_Q48_K1.9351.00
40_E44_K1.8911.00
5_E9_E1.8831.00
14_D17_L1.8711.00
34_E38_E1.8601.00
32_E36_K1.8021.00
36_K40_E1.7731.00
12_E15_K1.7511.00
46_L50_L1.6950.99
15_K19_E1.6110.99
8_E11_K1.5930.99
52_F55_N1.5380.99
43_I50_L1.4900.98
19_E22_A1.4730.98
2_H5_E1.3910.98
29_E32_E1.3550.97
13_F17_L1.3420.97
30_E34_E1.3310.97
18_E21_E1.2620.96
35_R38_E1.2340.95
25_E29_E1.2040.94
42_E45_Q1.1990.94
26_A30_E1.1960.94
10_R13_F1.1720.94
1_L7_A1.1660.93
38_E42_E1.1550.93
31_R34_E1.1520.93
33_A37_E1.1460.93
37_E41_E1.1290.92
9_E12_E1.1250.92
51_V55_N1.0690.90
23_A27_E1.0090.87
51_V57_M1.0020.87
13_F20_K0.9680.85
19_E23_A0.9660.85
17_L20_K0.9640.85
18_E49_S0.8980.80
15_K22_A0.8580.77
13_F57_M0.8220.74
1_L21_E0.8200.74
35_R39_E0.8130.73
31_R35_R0.8090.73
41_E49_S0.8000.72
27_E30_E0.7960.71
15_K51_V0.7810.70
8_E53_K0.7740.69
5_E37_E0.7740.69
41_E45_Q0.7370.66
14_D56_P0.7330.65
9_E46_L0.7190.64
1_L32_E0.7090.63
30_E33_A0.7070.62
7_A54_A0.6930.61
18_E22_A0.6880.60
20_K23_A0.6880.60
16_K20_K0.6780.59
23_A26_A0.6690.58
29_E57_M0.6610.57
52_F56_P0.6600.57
29_E39_E0.6470.56
20_K38_E0.6430.55
13_F43_I0.6410.55
29_E33_A0.6390.55
43_I57_M0.6370.54
48_K54_A0.6300.54
24_K55_N0.6250.53
9_E41_E0.6240.53
24_K28_K0.6220.53
29_E37_E0.6180.52
16_K27_E0.6020.50
17_L21_E0.6020.50
3_T51_V0.5930.49
14_D57_M0.5930.49
47_R56_P0.5900.49
26_A44_K0.5690.46
14_D51_V0.5610.46
24_K42_E0.5560.45
11_K18_E0.5480.44
5_E17_L0.5330.42
11_K15_K0.5270.42
30_E38_E0.5230.41
38_E41_E0.5140.40
52_F57_M0.5090.40
42_E55_N0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a9aC 1 0.4737 2.1 0.863 Contact Map
3vp9A 3 0.9825 1.8 0.868 Contact Map
4bjtA 1 0.3333 1.6 0.871 Contact Map
4htmA 1 0.3509 1.3 0.88 Contact Map
4q2jA 3 0.3684 1.1 0.883 Contact Map
2dodA 1 0.5088 1.1 0.885 Contact Map
4uera 1 0 0.9 0.889 Contact Map
4trhA 2 1 0.9 0.89 Contact Map
4b2zA 1 1 0.9 0.891 Contact Map
4oojA 3 1 0.8 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0043 seconds.