GREMLIN Database
DUF1264 - Protein of unknown function (DUF1264)
PFAM: PF06884 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 170 (166)
Sequences: 1206 (741)
Seq/√Len: 57.5
META: 0.65

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_E168_A3.9171.00
62_E66_E3.3841.00
60_I64_L3.2501.00
37_D63_K3.0091.00
153_D160_T2.9681.00
150_A154_K2.9671.00
102_K169_D2.9471.00
31_C41_C2.8061.00
10_Y47_N2.7601.00
81_Y141_D2.5671.00
159_S162_E2.5151.00
89_V158_V2.4961.00
42_V53_L2.2851.00
4_L7_I2.1821.00
90_A104_L2.1531.00
75_L131_E2.1511.00
84_K109_V2.1461.00
26_E155_R2.1051.00
116_W134_L2.0861.00
151_A155_R2.0031.00
162_E165_E1.9961.00
56_V118_T1.9961.00
14_F26_E1.9261.00
146_P150_A1.8531.00
147_E150_A1.7730.99
144_A149_V1.7710.99
70_E73_K1.7710.99
152_R160_T1.6310.99
89_V156_F1.6290.99
60_I68_L1.6200.99
23_R120_Q1.6060.99
24_Q145_D1.5790.98
17_Y23_R1.5760.98
15_H117_H1.5610.98
36_E107_K1.5510.98
10_Y28_H1.5120.98
141_D164_R1.5120.98
8_N12_C1.4250.97
2_A6_A1.4020.97
7_I44_Y1.4020.97
59_I111_T1.3990.97
103_A106_K1.3980.97
162_E166_A1.3970.97
83_V105_M1.3940.97
4_L44_Y1.3840.96
108_L135_M1.3640.96
78_S136_M1.3580.96
62_E110_N1.3560.96
17_Y135_M1.3350.96
144_A148_L1.3310.95
54_I135_M1.3270.95
139_T143_Q1.3080.95
102_K106_K1.2950.95
14_F152_R1.2940.95
82_E117_H1.2910.95
19_G133_Q1.2890.95
108_L111_T1.2880.95
90_A105_M1.2570.94
16_F137_S1.2480.94
120_Q123_R1.2230.93
39_A108_L1.1700.91
140_R143_Q1.1590.91
163_K166_A1.1420.90
97_P100_A1.1400.90
80_N84_K1.1350.90
63_K67_T1.1250.90
126_K129_L1.1140.89
98_E163_K1.1130.89
15_H29_H1.1080.89
78_S139_T1.0820.88
150_A161_A1.0660.87
149_V153_D1.0410.86
33_H39_A1.0350.85
34_L38_F1.0350.85
67_T73_K1.0270.85
145_D150_A1.0180.84
46_G51_A1.0160.84
83_V108_L1.0100.84
12_C16_F1.0070.84
15_H82_E1.0050.83
2_A5_K0.9970.83
79_H113_G0.9950.83
98_E102_K0.9930.83
6_A49_P0.9870.82
5_K8_N0.9780.82
100_A103_A0.9730.81
67_T126_K0.9700.81
102_K166_A0.9420.79
59_I108_L0.9410.79
12_C28_H0.9350.79
103_A107_K0.9300.78
80_N109_V0.9280.78
44_Y48_T0.9280.78
80_N110_N0.9160.77
49_P56_V0.9130.77
82_E88_L0.9050.76
9_A33_H0.9040.76
62_E112_Y0.8980.76
24_Q148_L0.8970.76
20_D23_R0.8960.76
106_K169_D0.8900.75
27_A43_I0.8840.75
41_C116_W0.8660.73
146_P149_V0.8620.73
11_L104_L0.8600.73
7_I42_V0.8580.73
37_D67_T0.8250.70
154_K157_G0.8220.69
23_R123_R0.8200.69
120_Q125_D0.8040.68
66_E73_K0.8040.68
66_E70_E0.8030.67
158_V163_K0.8000.67
23_R122_D0.7980.67
147_E151_A0.7960.67
9_A104_L0.7950.67
79_H82_E0.7910.66
107_K127_L0.7880.66
118_T125_D0.7850.66
120_Q135_M0.7830.65
17_Y54_I0.7780.65
160_T163_K0.7710.64
36_E63_K0.7690.64
154_K165_E0.7640.64
24_Q138_F0.7580.63
138_F145_D0.7550.63
149_V152_R0.7550.63
71_E74_K0.7470.62
118_T124_G0.7450.62
18_K75_L0.7360.61
18_K25_M0.7340.60
7_I32_S0.7340.60
11_L14_F0.7320.60
29_H79_H0.7280.60
27_A137_S0.7250.60
27_A118_T0.7230.59
18_K78_S0.7220.59
89_V152_R0.7210.59
32_S52_R0.7180.59
44_Y95_G0.7180.59
18_K136_M0.7140.58
50_D74_K0.7130.58
99_A103_A0.7090.58
35_N63_K0.7070.58
71_E154_K0.7040.57
35_N127_L0.7030.57
18_K21_P0.7030.57
38_F127_L0.6970.57
37_D64_L0.6870.55
82_E137_S0.6870.55
9_A12_C0.6860.55
46_G121_T0.6820.55
64_L127_L0.6810.55
151_A154_K0.6780.54
47_N156_F0.6780.54
36_E97_P0.6770.54
98_E166_A0.6730.54
43_I115_T0.6710.54
43_I54_I0.6690.53
72_E114_K0.6650.53
90_A100_A0.6630.53
12_C26_E0.6620.53
35_N121_T0.6590.52
15_H27_A0.6580.52
75_L110_N0.6570.52
74_K131_E0.6500.51
15_H88_L0.6490.51
149_V160_T0.6490.51
153_D159_S0.6490.51
125_D129_L0.6470.51
37_D61_S0.6430.51
17_Y43_I0.6400.50
15_H79_H0.6390.50
23_R121_T0.6370.50
111_T136_M0.6280.49
27_A117_H0.6270.49
13_G26_E0.6260.49
120_Q133_Q0.6220.48
23_R54_I0.6210.48
15_H31_C0.6190.48
131_E136_M0.6170.48
43_I117_H0.6170.48
32_S44_Y0.6160.48
6_A42_V0.6160.48
41_C87_Q0.6110.47
84_K170_I0.6060.47
54_I122_D0.6060.47
30_Y47_N0.5980.46
120_Q124_G0.5980.46
87_Q144_A0.5970.46
97_P102_K0.5960.45
88_L117_H0.5950.45
98_E157_G0.5940.45
25_M120_Q0.5940.45
99_A163_K0.5930.45
11_L108_L0.5920.45
13_G115_T0.5900.45
89_V105_M0.5880.45
20_D32_S0.5880.45
16_F136_M0.5850.44
23_R30_Y0.5830.44
78_S109_V0.5820.44
44_Y133_Q0.5820.44
32_S43_I0.5800.44
97_P101_E0.5780.43
68_L129_L0.5770.43
27_A82_E0.5760.43
23_R125_D0.5740.43
81_Y87_Q0.5670.42
90_A101_E0.5650.42
75_L78_S0.5640.42
7_I23_R0.5640.42
39_A59_I0.5630.42
29_H117_H0.5560.41
14_F148_L0.5550.41
29_H82_E0.5510.41
6_A9_A0.5500.40
53_L144_A0.5480.40
10_Y156_F0.5470.40
2_A48_T0.5470.40
11_L39_A0.5450.40
49_P74_K0.5430.40
102_K105_M0.5410.40
83_V164_R0.5380.39
56_V123_R0.5370.39
20_D71_E0.5360.39
54_I123_R0.5280.38
58_Y118_T0.5280.38
31_C88_L0.5250.38
35_N64_L0.5240.38
66_E169_D0.5220.38
126_K157_G0.5210.37
146_P168_A0.5200.37
20_D81_Y0.5200.37
11_L19_G0.5180.37
25_M121_T0.5170.37
32_S151_A0.5170.37
26_E83_V0.5170.37
12_C155_R0.5170.37
16_F21_P0.5140.37
39_A80_N0.5140.37
166_A169_D0.5130.37
78_S84_K0.5120.37
142_G146_P0.5110.36
136_M139_T0.5110.36
19_G22_G0.5110.36
129_L134_L0.5010.35
121_T125_D0.5010.35
17_Y122_D0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zdfC 1 0.1353 14.1 0.963 Contact Map
2y38A 1 0.7118 10 0.966 Contact Map
3b1jC 1 0.1294 9.6 0.966 Contact Map
2lj9A 1 0.1294 7.1 0.968 Contact Map
3qv1G 1 0.1235 6.3 0.969 Contact Map
1s99A 2 0.4353 5.1 0.97 Contact Map
1oaoA 2 0.3294 4.9 0.97 Contact Map
3b5mA 2 0.3824 4.9 0.97 Contact Map
2c43A 1 0.6529 4.4 0.971 Contact Map
1aabA 1 0.4529 4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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