GREMLIN Database
DUF1257 - Protein of unknown function (DUF1257)
PFAM: PF06868 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 104 (103)
Sequences: 3250 (2178)
Seq/√Len: 214.6
META: 0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_N49_E3.9231.00
4_D77_H3.3991.00
4_D73_R2.7261.00
82_E85_K2.6621.00
78_K82_E2.5901.00
76_Y93_E2.5801.00
10_E31_R2.3791.00
26_A29_V2.1901.00
3_E9_V2.0961.00
43_N47_E2.0211.00
73_R76_Y1.9991.00
76_Y80_L1.9791.00
66_F70_L1.9191.00
27_D41_R1.9081.00
42_W46_G1.8511.00
73_R77_H1.8301.00
27_D42_W1.7031.00
15_P25_K1.6701.00
96_N100_S1.6351.00
55_Q58_G1.6121.00
16_V39_G1.6071.00
82_E86_Q1.5721.00
42_W48_Y1.4981.00
53_D56_W1.4701.00
29_V37_D1.4261.00
18_G22_Q1.4091.00
41_R49_E1.3961.00
79_V83_A1.3791.00
69_K72_Q1.3781.00
75_A79_V1.3631.00
19_Y22_Q1.3561.00
15_P23_T1.3351.00
60_P64_E1.3091.00
1_A77_H1.2501.00
16_V26_A1.2111.00
40_F50_L1.1891.00
65_R69_K1.1831.00
59_Q64_E1.1831.00
18_G26_A1.1601.00
77_H80_L1.1551.00
26_A39_G1.1261.00
96_N102_R1.1081.00
9_V12_G1.0901.00
90_V93_E1.0861.00
54_L57_W1.0761.00
72_Q101_I1.0711.00
76_Y101_I1.0681.00
44_G47_E1.0481.00
80_L90_V1.0451.00
42_W45_D1.0441.00
67_L71_T1.0441.00
10_E13_E1.0411.00
17_R23_T1.0261.00
41_R51_V1.0171.00
80_L93_E1.0161.00
1_A4_D1.0121.00
9_V13_E0.9741.00
77_H97_E0.9721.00
60_P63_V0.9531.00
30_I38_I0.9310.99
40_F48_Y0.9240.99
94_E97_E0.9010.99
24_R41_R0.8990.99
65_R68_G0.8910.99
3_E10_E0.8870.99
45_D49_E0.8790.99
78_K86_Q0.8740.99
64_E68_G0.8560.99
62_P66_F0.8420.99
10_E14_E0.8340.99
3_E8_E0.8270.99
54_L63_V0.8250.99
64_E67_L0.8160.99
50_L67_L0.8130.99
80_L83_A0.8130.99
80_L84_K0.8000.98
68_G72_Q0.7860.98
94_E102_R0.7810.98
20_R24_R0.7800.98
11_E14_E0.7780.98
92_E95_V0.7700.98
2_L40_F0.7440.97
24_R36_Y0.7360.97
32_Q79_V0.7330.97
69_K73_R0.7320.97
40_F88_F0.7300.97
95_V98_D0.7230.97
43_N48_Y0.7160.97
96_N99_G0.7100.97
52_A57_W0.7030.96
63_V66_F0.7020.96
87_G90_V0.6880.96
25_K41_R0.6700.95
28_L32_Q0.6690.95
26_A37_D0.6630.95
8_E31_R0.6590.95
61_I66_F0.6580.95
62_P65_R0.6560.95
26_A30_I0.6500.94
81_A85_K0.6490.94
30_I40_F0.6460.94
75_A88_F0.6410.94
28_L31_R0.6380.94
53_D57_W0.6350.94
8_E11_E0.6290.93
95_V101_I0.6280.93
18_G51_V0.6270.93
5_L73_R0.6270.93
88_F96_N0.6230.93
7_Y40_F0.6210.93
3_E13_E0.6190.93
54_L58_G0.6180.93
17_R21_G0.6170.93
18_G21_G0.6170.93
36_Y58_G0.6150.93
80_L103_L0.6150.93
61_I64_E0.6140.93
7_Y11_E0.6120.92
11_E28_L0.6110.92
56_W59_Q0.6090.92
93_E101_I0.6030.92
61_I65_R0.5980.92
78_K81_A0.5970.92
6_G9_V0.5940.91
99_G103_L0.5860.91
68_G71_T0.5740.90
79_V103_L0.5700.90
53_D58_G0.5670.89
32_Q37_D0.5620.89
16_V34_N0.5610.89
52_A67_L0.5600.89
62_P69_K0.5570.88
26_A41_R0.5570.88
81_A84_K0.5520.88
84_K89_Q0.5450.87
73_R92_E0.5440.87
21_G24_R0.5420.87
59_Q63_V0.5400.87
54_L60_P0.5380.87
20_R23_T0.5370.87
5_L12_G0.5350.86
50_L62_P0.5340.86
24_R35_G0.5280.86
96_N103_L0.5250.85
70_L74_Y0.5240.85
78_K85_K0.5210.85
34_N79_V0.5190.85
17_R20_R0.5170.85
18_G24_R0.5160.84
99_G102_R0.5070.83
16_V22_Q0.5070.83
72_Q95_V0.5010.83
7_Y61_I0.5000.83
60_P65_R0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o2hA 2 0.6538 21.7 0.88 Contact Map
1v58A 2 0.8365 14.5 0.889 Contact Map
1ob8A 1 0.3173 14.5 0.889 Contact Map
1e2bA 1 0.7308 10.9 0.895 Contact Map
1cw0A 1 0.8173 9.8 0.897 Contact Map
1vsrA 1 0.8173 9.1 0.899 Contact Map
4mgeA 3 0.7596 9 0.899 Contact Map
2wcwA 2 0.3462 8 0.901 Contact Map
1hh1A 2 0.2788 7.1 0.903 Contact Map
2eo0A 2 0.2788 6.6 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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