GREMLIN Database
ACP - Malonate decarboxylase delta subunit (MdcD)
PFAM: PF06857 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (80)
Sequences: 5953 (3701)
Seq/√Len: 413.8
META: 0.867

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_R47_R3.3631.00
27_E59_R2.4131.00
46_I62_I2.3561.00
29_E61_S2.3381.00
14_L62_I2.0391.00
14_L72_I1.9981.00
24_G57_N1.8181.00
35_K43_R1.8181.00
31_E63_N1.7861.00
29_E59_R1.7311.00
19_E59_R1.7211.00
15_E63_N1.7121.00
25_G57_N1.6921.00
41_S45_V1.6591.00
21_A59_R1.6291.00
44_A48_E1.5901.00
53_L80_V1.5321.00
41_S69_P1.4861.00
18_V58_A1.4281.00
17_L61_S1.4031.00
49_T73_A1.3201.00
46_I76_L1.3191.00
35_K39_G1.3161.00
45_V73_A1.2991.00
42_I72_I1.2741.00
28_I47_R1.2701.00
26_I58_A1.2691.00
16_V76_L1.2431.00
39_G43_R1.2361.00
78_A82_R1.2301.00
26_I51_E1.2151.00
48_E52_R1.1931.00
31_E61_S1.1821.00
50_L60_V1.1711.00
47_R51_E1.1551.00
77_E81_K1.1331.00
16_V62_I1.1311.00
49_T76_L1.1281.00
17_L63_N1.1091.00
3_P19_E1.1061.00
46_I60_V1.0861.00
48_E73_A1.0561.00
45_V69_P1.0241.00
51_E56_K1.0021.00
41_S44_A0.9991.00
18_V60_V0.9881.00
45_V49_T0.9861.00
55_V58_A0.9841.00
49_T52_R0.9521.00
40_D44_A0.9411.00
49_T53_L0.9381.00
30_L42_I0.9381.00
23_S57_N0.9211.00
21_A57_N0.9211.00
50_L55_V0.9191.00
3_P17_L0.9101.00
50_L76_L0.8691.00
21_A24_G0.8681.00
26_I50_L0.8591.00
18_V79_A0.8391.00
52_R73_A0.8361.00
68_L71_V0.7981.00
16_V46_I0.7931.00
9_V63_N0.7861.00
26_I47_R0.7811.00
22_D57_N0.7781.00
33_S65_K0.7721.00
42_I45_V0.7691.00
4_A18_V0.7621.00
21_A27_E0.7601.00
30_L43_R0.7571.00
30_L62_I0.7571.00
53_L81_K0.7431.00
40_D43_R0.7371.00
28_I43_R0.7361.00
76_L80_V0.7311.00
78_A81_K0.7241.00
53_L77_E0.7211.00
19_E61_S0.7181.00
48_E51_E0.7111.00
26_I30_L0.7081.00
69_P72_I0.7061.00
62_I72_I0.7031.00
20_P58_A0.6981.00
5_L15_E0.6981.00
10_E65_K0.6781.00
45_V48_E0.6761.00
49_T80_V0.6720.99
52_R77_E0.6650.99
12_S68_L0.6640.99
34_V38_F0.6590.99
50_L80_V0.6550.99
55_V80_V0.6500.99
42_I69_P0.6370.99
11_S69_P0.6370.99
34_V64_D0.6210.99
18_V80_V0.6170.99
22_D27_E0.6130.99
32_S42_I0.6020.99
33_S71_V0.6010.99
5_L17_L0.5960.99
8_T11_S0.5920.99
42_I62_I0.5870.99
31_E35_K0.5790.99
16_V79_A0.5770.98
26_I57_N0.5750.98
32_S35_K0.5690.98
45_V76_L0.5580.98
60_V79_A0.5490.98
40_D47_R0.5420.98
9_V15_E0.5380.98
51_E54_G0.5330.97
32_S37_Q0.5220.97
22_D54_G0.5200.97
27_E47_R0.5070.97
60_V76_L0.5050.96
14_L46_I0.5040.96
5_L77_E0.5030.96
69_P73_A0.5030.96
33_S70_F0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j25A 1 1 26.4 0.877 Contact Map
4fn5A 1 0.988 24.6 0.879 Contact Map
2pokA 2 0.9639 17.3 0.888 Contact Map
2jvfA 1 0.8795 16.2 0.889 Contact Map
4mcaA 7 0.6627 12.2 0.895 Contact Map
3tx8A 2 0.9639 11.2 0.897 Contact Map
2dy1A 1 0.9518 10.4 0.898 Contact Map
3iszA 2 0.9518 10.2 0.898 Contact Map
4mmoA 2 0.9518 10.2 0.898 Contact Map
1kyfA 1 0.5904 9.6 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0045 seconds.