GREMLIN Database
DUF1249 - Protein of unknown function (DUF1249)
PFAM: PF06853 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (115)
Sequences: 3658 (2348)
Seq/√Len: 219.0
META: 0.88

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_T63_H5.4831.00
59_V68_A4.6341.00
34_S39_T3.0241.00
29_E41_R2.6691.00
31_L41_R2.2871.00
40_L61_V2.1391.00
41_R58_R2.0311.00
18_S115_H2.0001.00
19_R25_D1.9571.00
61_V68_A1.9421.00
14_G33_R1.8831.00
6_L9_L1.8791.00
79_L83_Y1.8401.00
33_R38_T1.8011.00
39_T71_L1.7751.00
1_R108_E1.7501.00
8_D11_A1.6851.00
87_N90_M1.6801.00
92_Q95_E1.6561.00
44_Y106_W1.6131.00
27_H45_L1.5981.00
43_T56_D1.5871.00
32_E39_T1.5721.00
17_V27_H1.4991.00
15_S27_H1.4871.00
83_Y86_P1.4801.00
59_V103_L1.4701.00
85_Y90_M1.4421.00
79_L82_L1.4141.00
3_L7_P1.3471.00
39_T60_R1.3421.00
76_R91_R1.3281.00
79_L85_Y1.3181.00
58_R72_S1.3131.00
30_V38_T1.3111.00
99_L102_F1.2911.00
17_V25_D1.2891.00
31_L58_R1.2761.00
30_V33_R1.2711.00
36_Y65_A1.2431.00
86_P90_M1.2361.00
32_E60_R1.1931.00
57_L102_F1.1891.00
80_Q83_Y1.1641.00
73_C76_R1.1611.00
37_T64_D1.1601.00
94_D98_Q1.1441.00
10_R33_R1.1421.00
8_D12_L1.1391.00
95_E98_Q1.1341.00
15_S29_E1.1301.00
45_L53_P1.1201.00
81_A84_G1.0791.00
12_L16_R1.0441.00
83_Y96_K1.0271.00
108_E112_E1.0271.00
43_T46_F1.0261.00
38_T110_C1.0071.00
81_A85_Y0.9951.00
28_L42_L0.9931.00
82_L85_Y0.9611.00
24_L44_Y0.9581.00
41_R56_D0.9551.00
106_W109_Y0.9321.00
83_Y87_N0.9311.00
101_R104_N0.9250.99
44_Y97_W0.9240.99
60_R65_A0.9130.99
19_R22_G0.9110.99
14_G18_S0.9010.99
4_R111_L0.8860.99
3_L10_R0.8830.99
104_N108_E0.8810.99
35_R93_L0.8770.99
9_L13_G0.8600.99
42_L59_V0.8570.99
26_L42_L0.8570.99
13_G16_R0.8550.99
8_D13_G0.8420.99
7_P12_L0.8330.99
18_S26_L0.8330.99
44_Y55_P0.8320.99
96_K104_N0.8300.99
97_W105_K0.8240.99
104_N112_E0.8120.99
39_T58_R0.8090.99
36_Y60_R0.7990.98
74_Q79_L0.7960.98
46_F54_D0.7940.98
4_R10_R0.7820.98
23_D113_Q0.7740.98
73_C102_F0.7690.98
13_G19_R0.7650.98
62_Y67_L0.7650.98
8_D16_R0.7640.98
74_Q77_R0.7610.98
70_V99_L0.7560.98
36_Y64_D0.7490.98
41_R45_L0.7490.98
81_A87_N0.7380.97
31_L39_T0.7320.97
97_W106_W0.7300.97
65_A93_L0.7110.97
97_W101_R0.7090.97
63_H110_C0.7030.97
109_Y113_Q0.7010.97
79_L87_N0.6970.96
18_S22_G0.6810.96
3_L61_V0.6790.96
17_V45_L0.6730.96
14_G20_V0.6620.95
80_Q84_G0.6610.95
83_Y91_R0.6590.95
91_R94_D0.6530.95
99_L110_C0.6510.95
30_V40_L0.6480.95
44_Y109_Y0.6440.94
40_L68_A0.6370.94
3_L13_G0.6360.94
79_L99_L0.6350.94
60_R69_E0.6300.94
70_V98_Q0.6280.94
45_L51_W0.6260.94
90_M94_D0.6220.93
43_T93_L0.6190.93
23_D56_D0.6190.93
37_T65_A0.6170.93
44_Y105_K0.6140.93
95_E105_K0.6110.93
6_L12_L0.6080.93
96_K110_C0.6030.92
55_P106_W0.5960.92
10_R13_G0.5920.92
14_G21_A0.5880.91
34_S70_V0.5860.91
69_E96_K0.5850.91
103_L106_W0.5840.91
56_D93_L0.5780.91
27_H46_F0.5750.90
57_L73_C0.5720.90
20_V23_D0.5710.90
92_Q96_K0.5700.90
7_P10_R0.5690.90
87_N92_Q0.5660.90
82_L87_N0.5640.90
28_L59_V0.5600.89
37_T60_R0.5570.89
65_A106_W0.5530.89
72_S106_W0.5500.88
58_R84_G0.5500.88
9_L14_G0.5490.88
40_L59_V0.5450.88
5_L20_V0.5450.88
3_L8_D0.5440.88
53_P93_L0.5390.87
27_H43_T0.5370.87
73_C77_R0.5350.87
37_T62_Y0.5310.87
27_H53_P0.5300.86
49_G52_L0.5230.86
34_S38_T0.5190.85
75_G91_R0.5180.85
5_L111_L0.5180.85
87_N94_D0.5090.84
75_G83_Y0.5090.84
42_L73_C0.5080.84
73_C91_R0.5070.84
60_R71_L0.5060.84
42_L60_R0.5020.83
46_F97_W0.5020.83
84_G87_N0.5000.83
26_L56_D0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o5nA 2 0.9483 21 0.912 Contact Map
1svdM 3 0.3276 8.9 0.926 Contact Map
1nycA 1 0.3707 5 0.934 Contact Map
4nejA 1 0.7931 4.8 0.934 Contact Map
1elkA 1 0.7155 4 0.937 Contact Map
4hn3A 3 0.75 3.3 0.939 Contact Map
1mu5A 1 0.3448 3.3 0.939 Contact Map
2ogkA 4 0.5862 3 0.94 Contact Map
2mewA 1 0.2586 2.8 0.942 Contact Map
3r2cJ 1 0.2672 2.7 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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