GREMLIN Database
TraU - TraU protein
PFAM: PF06834 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 298 (288)
Sequences: 1735 (1221)
Seq/√Len: 71.9
META: 0.714

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_C184_C5.3031.00
204_S288_Y4.8761.00
176_D243_S4.8111.00
10_C13_C4.6021.00
13_C258_C4.0091.00
142_D194_F3.2761.00
101_V211_A2.9501.00
182_A206_L2.9101.00
51_V103_W2.8721.00
161_Q187_S2.8441.00
51_V208_A2.7561.00
18_V43_G2.6691.00
131_Y136_D2.6361.00
164_C181_C2.6311.00
102_H134_E2.6311.00
101_V207_L2.5271.00
173_F246_K2.3171.00
260_P263_R2.3011.00
212_L261_F2.2941.00
182_A188_V2.2891.00
32_C297_C2.2771.00
98_F193_G2.2551.00
247_W261_F2.2531.00
223_D237_G2.2441.00
62_S287_A2.1421.00
169_A175_L2.0801.00
214_K218_Q2.0411.00
133_S211_A1.9571.00
209_Q261_F1.9461.00
191_R213_A1.9371.00
179_F189_Y1.9331.00
225_L244_Q1.9131.00
185_W205_A1.9061.00
138_L148_L1.9001.00
188_V213_A1.8811.00
278_G284_E1.8731.00
255_S259_H1.8651.00
103_W212_L1.8471.00
48_A292_R1.8251.00
133_S218_Q1.8221.00
14_L291_W1.8221.00
230_A235_Y1.8081.00
131_Y214_K1.8051.00
223_D235_Y1.7651.00
105_G130_A1.7411.00
172_G263_R1.7371.00
100_Q140_N1.7231.00
60_F104_Y1.7061.00
138_L218_Q1.7001.00
53_V204_S1.6801.00
18_V23_T1.6721.00
250_L289_L1.6721.00
120_C296_C1.6601.00
18_V27_N1.6581.00
149_N152_A1.6461.00
274_P277_K1.6340.99
185_W209_Q1.6340.99
151_E217_R1.6290.99
206_L210_R1.6260.99
52_E60_F1.6110.99
176_D241_E1.6040.99
104_Y129_P1.5600.99
52_E62_S1.5420.99
201_G273_N1.5220.99
222_W236_P1.5080.99
249_M272_K1.4970.99
54_V61_P1.4960.99
99_Y200_G1.4830.99
74_G77_G1.4810.99
20_G41_K1.4740.99
212_L247_W1.4710.99
101_V133_S1.4680.99
49_R105_G1.4420.99
98_F140_N1.4410.99
4_N7_T1.4390.99
222_W234_K1.4330.99
151_E179_F1.3970.98
169_A174_P1.3940.98
155_F179_F1.3900.98
145_A192_T1.3890.98
33_F38_T1.3830.98
195_V203_A1.3710.98
265_T269_G1.3380.98
27_N295_N1.3350.98
195_V206_L1.3170.98
139_W193_G1.3130.98
182_A209_Q1.2990.97
146_E149_N1.2990.97
70_P74_G1.2880.97
274_P284_E1.2750.97
103_W211_A1.2630.97
213_A240_M1.2560.97
3_V250_L1.2500.97
239_I245_Y1.2500.97
148_L218_Q1.2480.97
20_G28_P1.2440.97
195_V207_L1.2150.96
53_V101_V1.2070.96
97_S198_H1.1970.96
223_D244_Q1.1970.96
60_F129_P1.1890.96
52_E61_P1.1880.96
19_I24_I1.1850.95
189_Y213_A1.1850.95
50_L62_S1.1830.95
195_V210_R1.1820.95
223_D228_D1.1790.95
136_D214_K1.1770.95
209_Q213_A1.1400.94
58_G132_L1.1370.94
211_A214_K1.1280.94
133_S214_K1.1240.94
252_P297_C1.1190.94
152_A156_G1.1180.94
105_G125_T1.1150.94
138_L145_A1.0980.93
50_L250_L1.0860.93
25_T30_S1.0760.92
54_V102_H1.0670.92
60_F132_L1.0650.92
76_L79_S1.0640.92
51_V247_W1.0580.92
248_Q258_C1.0580.92
27_N41_K1.0570.92
142_D192_T1.0540.92
31_I38_T1.0500.92
65_G68_L1.0460.91
207_L210_R1.0440.91
49_R103_W1.0410.91
145_A194_F1.0280.91
224_T244_Q1.0140.90
53_V288_Y1.0060.90
106_Y289_L0.9990.89
27_N30_S0.9990.89
14_L17_I0.9980.89
139_W210_R0.9930.89
62_S104_Y0.9830.89
99_Y204_S0.9810.88
277_K284_E0.9780.88
200_G204_S0.9730.88
57_P134_E0.9730.88
223_D226_G0.9730.88
48_A224_T0.9680.88
192_T196_T0.9620.88
215_L220_L0.9520.87
216_H245_Y0.9500.87
49_R225_L0.9490.87
259_H268_W0.9450.87
237_G241_E0.9360.86
52_E102_H0.9340.86
132_L135_L0.9310.86
191_R240_M0.9300.86
204_S286_F0.9290.86
268_W272_K0.9190.85
12_S257_S0.9180.85
134_E164_C0.9170.85
263_R267_L0.9120.85
49_R128_D0.9120.85
208_A247_W0.9120.85
102_H181_C0.9110.85
5_P8_D0.9080.84
32_C252_P0.8980.84
222_W235_Y0.8890.83
10_C258_C0.8860.83
50_L106_Y0.8840.83
167_D242_K0.8820.83
160_A163_A0.8800.82
192_T259_H0.8790.82
55_R99_Y0.8780.82
195_V202_Q0.8760.82
131_Y215_L0.8750.82
46_E294_R0.8740.82
242_K245_Y0.8700.82
21_G29_S0.8640.81
61_P104_Y0.8620.81
208_A211_A0.8570.81
205_A288_Y0.8530.80
106_Y151_E0.8490.80
223_D230_A0.8490.80
55_R285_D0.8420.80
208_A290_L0.8380.79
198_H273_N0.8340.79
97_S203_A0.8310.79
255_S272_K0.8300.79
2_F148_L0.8300.79
219_G238_P0.8280.78
188_V240_M0.8280.78
114_L118_F0.8270.78
43_G295_N0.8270.78
50_L287_A0.8250.78
185_W261_F0.8250.78
52_E104_Y0.8240.78
113_E118_F0.8240.78
102_H164_C0.8230.78
52_E287_A0.8220.78
103_W208_A0.8190.78
146_E191_R0.8180.78
9_I108_L0.8180.78
5_P11_W0.8090.77
19_I40_I0.8090.77
248_Q291_W0.8070.77
18_V295_N0.8020.76
151_E167_D0.7970.76
53_V99_Y0.7960.76
148_L214_K0.7920.75
26_A30_S0.7910.75
249_M288_Y0.7880.75
98_F194_F0.7860.75
216_H221_V0.7860.75
166_A169_A0.7840.74
59_C285_D0.7820.74
101_V214_K0.7780.74
179_F248_Q0.7720.73
62_S251_Y0.7680.73
135_L269_G0.7660.73
3_V106_Y0.7640.73
241_E244_Q0.7610.72
259_H263_R0.7610.72
8_D11_W0.7610.72
211_A218_Q0.7590.72
131_Y218_Q0.7580.72
139_W189_Y0.7570.72
273_N286_F0.7540.72
188_V210_R0.7520.71
163_A180_W0.7510.71
4_N11_W0.7470.71
177_S236_P0.7450.71
66_I69_S0.7450.71
23_T30_S0.7440.71
212_L290_L0.7410.70
113_E123_E0.7410.70
138_L144_L0.7390.70
134_E181_C0.7380.70
3_V50_L0.7360.70
275_P278_G0.7360.70
59_C246_K0.7340.70
212_L245_Y0.7340.70
147_I207_L0.7340.70
269_G287_A0.7330.69
22_V26_A0.7280.69
146_E153_L0.7220.68
213_A244_Q0.7210.68
104_Y127_F0.7200.68
100_Q133_S0.7190.68
223_D241_E0.7160.68
16_P19_I0.7140.67
255_S258_C0.7130.67
186_G206_L0.7130.67
30_S177_S0.7120.67
164_C167_D0.7110.67
131_Y138_L0.7110.67
218_Q222_W0.7090.67
142_D145_A0.7090.67
46_E292_R0.7080.67
202_Q265_T0.7050.66
198_H201_G0.7010.66
28_P295_N0.7000.66
184_C264_S0.6990.66
26_A243_S0.6970.66
43_G217_R0.6960.65
55_R284_E0.6950.65
41_K231_L0.6930.65
67_S70_P0.6890.65
120_C193_G0.6880.65
137_P167_D0.6820.64
170_A175_L0.6750.63
159_I162_A0.6750.63
103_W215_L0.6750.63
99_Y207_L0.6710.63
19_I43_G0.6710.63
143_E152_A0.6700.62
198_H203_A0.6700.62
244_Q291_W0.6700.62
21_G261_F0.6680.62
5_P9_I0.6670.62
220_L247_W0.6650.62
157_N164_C0.6650.62
53_V207_L0.6640.62
19_I257_S0.6630.62
162_A165_A0.6630.62
185_W259_H0.6620.62
16_P39_G0.6570.61
226_G235_Y0.6570.61
13_C291_W0.6540.61
205_A209_Q0.6540.61
257_S265_T0.6520.60
79_S83_G0.6520.60
14_L109_L0.6510.60
257_S291_W0.6500.60
106_Y221_V0.6460.60
178_L181_C0.6460.60
24_I28_P0.6450.60
65_G71_G0.6430.59
96_L194_F0.6410.59
146_E161_Q0.6390.59
34_C39_G0.6380.59
46_E122_L0.6380.59
246_K287_A0.6370.59
13_C107_P0.6370.59
205_A268_W0.6360.58
149_N191_R0.6360.58
4_N9_I0.6360.58
284_E288_Y0.6350.58
273_N284_E0.6340.58
278_G285_D0.6320.58
47_P291_W0.6270.57
110_Y113_E0.6270.57
51_V290_L0.6270.57
116_T119_P0.6270.57
24_I270_A0.6230.57
209_Q247_W0.6220.57
4_N8_D0.6210.57
274_P285_D0.6200.57
151_E189_Y0.6200.57
161_Q178_L0.6160.56
258_C296_C0.6160.56
105_G126_P0.6160.56
20_G27_N0.6120.56
54_V98_F0.6120.56
251_Y274_P0.6120.56
6_I132_L0.6110.55
106_Y122_L0.6110.55
154_L164_C0.6070.55
221_V244_Q0.6050.55
95_N196_T0.6040.55
58_G70_P0.6030.55
263_R284_E0.6020.54
226_G295_N0.6020.54
30_S176_D0.6020.54
23_T176_D0.5990.54
151_E164_C0.5940.53
92_D95_N0.5910.53
200_G284_E0.5890.53
274_P278_G0.5860.52
169_A172_G0.5860.52
32_C41_K0.5850.52
22_V29_S0.5810.52
64_G68_L0.5800.52
96_L196_T0.5800.52
217_R238_P0.5780.51
18_V25_T0.5750.51
174_P185_W0.5740.51
208_A261_F0.5670.50
39_G102_H0.5670.50
202_Q206_L0.5650.50
188_V209_Q0.5620.49
53_V208_A0.5600.49
17_I23_T0.5580.49
236_P239_I0.5570.49
30_S250_L0.5560.49
71_G192_T0.5550.49
109_L114_L0.5540.48
118_F123_E0.5510.48
136_D215_L0.5510.48
43_G293_K0.5490.48
78_G82_G0.5480.48
200_G270_A0.5460.48
211_A215_L0.5460.48
151_E191_R0.5460.48
2_F6_I0.5440.47
16_P128_D0.5430.47
171_A231_L0.5420.47
128_D134_E0.5400.47
168_C189_Y0.5390.47
134_E137_P0.5380.47
49_R113_E0.5380.47
23_T174_P0.5370.46
293_K296_C0.5370.46
58_G197_Q0.5360.46
50_L68_L0.5350.46
139_W296_C0.5340.46
232_C262_G0.5330.46
77_G224_T0.5330.46
133_S139_W0.5300.46
209_Q233_G0.5290.45
68_L80_S0.5280.45
20_G295_N0.5260.45
190_P296_C0.5250.45
131_Y135_L0.5250.45
254_P259_H0.5240.45
186_G190_P0.5240.45
204_S249_M0.5230.45
288_Y293_K0.5230.45
258_C291_W0.5230.45
18_V28_P0.5220.45
237_G244_Q0.5220.45
26_A29_S0.5210.44
87_T90_G0.5210.44
5_P250_L0.5210.44
31_I40_I0.5210.44
80_S170_A0.5210.44
15_F43_G0.5200.44
13_C248_Q0.5200.44
216_H237_G0.5190.44
30_S173_F0.5180.44
212_L239_I0.5170.44
30_S41_K0.5170.44
153_L156_G0.5170.44
143_E278_G0.5160.44
73_G77_G0.5160.44
39_G245_Y0.5150.44
90_G95_N0.5150.44
22_V40_I0.5150.44
242_K262_G0.5130.43
59_C128_D0.5130.43
49_R123_E0.5120.43
185_W203_A0.5120.43
128_D151_E0.5120.43
26_A129_P0.5110.43
49_R217_R0.5100.43
59_C217_R0.5090.43
77_G80_S0.5090.43
246_K263_R0.5090.43
212_L221_V0.5080.43
205_A255_S0.5070.43
208_A212_L0.5070.43
37_R294_R0.5070.43
82_G176_D0.5070.43
287_A291_W0.5060.43
50_L176_D0.5060.43
224_T230_A0.5050.43
108_L118_F0.5040.42
149_N153_L0.5030.42
170_A263_R0.5030.42
96_L195_V0.5030.42
99_Y201_G0.5020.42
43_G46_E0.5020.42
21_G30_S0.5010.42
61_P100_Q0.5010.42
26_A175_L0.5010.42
226_G230_A0.5010.42
115_L123_E0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wwxX 1 0.2819 3.1 0.975 Contact Map
1bzkA 1 0.0906 2 0.978 Contact Map
2jobA 1 0.3389 1.6 0.979 Contact Map
1pq1B 1 0.1107 1.5 0.979 Contact Map
2mi5A 1 0.1409 1.4 0.979 Contact Map
4aybN 1 0.1544 1.4 0.98 Contact Map
3a9bA 1 0.2081 1.3 0.98 Contact Map
4qiwN 1 0.1544 1.3 0.98 Contact Map
1pxqA 1 0.1107 1.3 0.98 Contact Map
4hicA 1 0.198 1.2 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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