GREMLIN Database
Lung_7-TM_R - Lung seven transmembrane receptor
PFAM: PF06814 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 295 (290)
Sequences: 1007 (642)
Seq/√Len: 37.7
META: 0.232

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_G105_N4.9901.00
268_V271_A3.4961.00
128_L167_V3.4221.00
52_G56_L3.1071.00
81_Y84_T2.9701.00
55_S59_L2.9171.00
61_L278_L2.8871.00
62_G87_I2.8501.00
60_V64_L2.8161.00
205_I216_L2.6771.00
37_Y49_P2.6501.00
148_G219_R2.6381.00
208_S216_L2.5981.00
130_F198_D2.4471.00
52_G55_S2.3921.00
173_E176_G2.3371.00
69_L84_T2.3251.00
102_H106_R2.3161.00
11_F27_Y2.2871.00
38_G42_A2.2620.99
57_V60_V2.2550.99
90_G125_K2.2170.99
64_L85_A2.1540.99
289_R294_N2.0630.99
27_Y35_N2.0230.99
84_T157_L2.0110.99
29_G38_G2.0090.99
174_E177_P2.0050.99
277_Y285_A2.0040.99
130_F161_L1.9870.99
158_G162_F1.9620.98
65_W84_T1.9500.98
25_V30_R1.9200.98
72_H75_D1.8660.98
278_L282_V1.8400.98
62_G88_L1.8320.98
65_W267_W1.8260.98
47_L271_A1.8250.97
187_V192_L1.7940.97
224_K227_L1.7870.97
216_L221_N1.7620.97
69_L81_Y1.7550.97
52_G60_V1.7060.96
41_P46_P1.6700.96
61_L282_V1.6420.95
111_P114_W1.6410.95
53_V60_V1.6120.95
50_F129_S1.5920.94
23_S26_S1.5750.94
25_V35_N1.5740.94
234_V283_V1.5710.94
142_V193_P1.5700.94
204_W209_L1.5690.94
45_Y105_N1.5600.94
29_G33_F1.5550.94
221_N277_Y1.5540.94
157_L201_F1.5480.94
90_G130_F1.5460.94
267_W274_E1.5330.93
10_Y13_N1.4890.92
11_F14_C1.4530.91
187_V190_L1.4500.91
3_K17_E1.4480.91
205_I212_T1.4420.91
27_Y31_V1.4310.91
80_Q90_G1.4240.90
149_D153_K1.4200.90
138_L208_S1.3960.89
64_L109_T1.3920.89
49_P52_G1.3870.89
57_V278_L1.3840.89
46_P84_T1.3790.89
138_L205_I1.3780.89
144_K267_W1.3770.89
24_G28_T1.3660.88
29_G35_N1.3650.88
177_P180_S1.3580.88
254_K257_D1.3500.88
83_I146_T1.3490.88
136_V148_G1.3450.88
221_N231_F1.3260.87
14_C25_V1.3190.87
80_Q83_I1.3120.86
22_S25_V1.2990.86
50_F76_L1.2990.86
240_Y243_R1.2970.86
100_D115_L1.2840.85
262_S265_Y1.2750.85
136_V169_Y1.2740.85
279_A283_V1.2610.84
229_R233_N1.2590.84
83_I86_V1.2420.83
35_N38_G1.2420.83
120_I124_L1.2310.82
123_A164_F1.2290.82
155_L160_P1.2270.82
59_L63_L1.2210.82
131_F193_P1.2180.82
63_L72_H1.2160.82
276_L280_F1.2140.82
268_V272_F1.2130.81
48_L79_I1.2050.81
143_V224_K1.2040.81
263_W272_F1.2030.81
201_F208_S1.2010.81
156_M160_P1.1810.80
127_T131_F1.1790.80
53_V64_L1.1780.80
269_I284_I1.1660.79
8_C14_C1.1530.78
138_L216_L1.1440.77
10_Y57_V1.1340.77
167_V189_F1.1310.77
201_F205_I1.1280.76
86_V128_L1.1280.76
126_G195_A1.1280.76
21_S29_G1.1010.75
255_A261_E1.0950.74
58_Y77_L1.0930.74
6_Y10_Y1.0910.74
69_L129_S1.0900.74
54_M101_Y1.0790.73
71_R292_A1.0790.73
53_V263_W1.0710.73
22_S30_R1.0680.72
134_L251_L1.0640.72
144_K239_V1.0640.72
199_L239_V1.0630.72
263_W288_W1.0580.72
177_P192_L1.0580.72
52_G95_A1.0580.72
102_H228_Y1.0490.71
24_G29_G1.0490.71
286_Y289_R1.0440.71
228_Y236_I1.0350.70
16_P31_V1.0320.70
11_F17_E1.0290.70
38_G45_Y1.0290.70
277_Y280_F1.0200.69
6_Y9_L1.0200.69
130_F242_T1.0160.69
46_P49_P1.0150.68
90_G281_L1.0110.68
58_Y87_I1.0090.68
95_A172_I1.0050.68
157_L164_F1.0040.68
105_N221_N1.0040.68
147_L209_L1.0030.68
29_G32_E1.0000.67
189_F282_V0.9990.67
22_S31_V0.9900.67
62_G91_M0.9860.66
122_S195_A0.9850.66
226_K230_K0.9780.66
214_T218_A0.9730.65
39_Y108_G0.9680.65
129_S142_V0.9680.65
177_P182_W0.9670.65
133_L242_T0.9670.65
62_G73_R0.9670.65
6_Y14_C0.9660.65
84_T90_G0.9600.64
25_V32_E0.9570.64
237_F292_A0.9570.64
176_G180_S0.9550.64
69_L76_L0.9530.64
27_Y34_K0.9500.63
30_R34_K0.9500.63
225_L230_K0.9480.63
71_R278_L0.9470.63
9_L39_Y0.9340.62
57_V237_F0.9330.62
135_L274_E0.9320.62
50_F198_D0.9280.61
217_K222_L0.9250.61
34_K171_V0.9210.61
39_Y72_H0.9200.61
104_I168_A0.9180.61
104_I236_I0.9170.60
142_V224_K0.9130.60
142_V160_P0.9120.60
166_N244_I0.9100.60
25_V137_S0.9090.60
64_L67_F0.9080.60
271_A288_W0.9050.59
154_V204_W0.9020.59
13_N27_Y0.9000.59
221_N224_K0.9000.59
100_D110_R0.8970.59
34_K38_G0.8970.59
177_P181_S0.8950.59
162_F166_N0.8910.58
212_T216_L0.8890.58
33_F42_A0.8830.58
56_L60_V0.8820.57
114_W118_A0.8780.57
76_L192_L0.8740.57
196_C200_F0.8720.57
41_P44_E0.8710.57
26_S63_L0.8680.56
93_E122_S0.8670.56
281_L285_A0.8670.56
158_G190_L0.8660.56
208_S284_I0.8650.56
56_L85_A0.8610.56
71_R95_A0.8610.56
126_G198_D0.8570.55
227_L230_K0.8540.55
215_D236_I0.8490.55
263_W273_W0.8460.54
132_L145_P0.8440.54
138_L147_L0.8430.54
79_I192_L0.8340.53
27_Y212_T0.8330.53
82_L90_G0.8330.53
76_L84_T0.8330.53
74_R116_V0.8320.53
255_A258_F0.8270.53
134_L172_I0.8260.53
245_F248_L0.8160.52
137_S205_I0.8150.52
222_L231_F0.8120.51
67_F171_V0.8100.51
190_L194_L0.8080.51
62_G66_L0.8080.51
8_C12_A0.8050.51
272_F278_L0.8020.50
186_L190_L0.8000.50
42_A64_L0.7990.50
37_Y45_Y0.7950.50
57_V236_I0.7880.49
134_L156_M0.7880.49
59_L92_L0.7880.49
127_T272_F0.7860.49
95_A293_N0.7860.49
238_Y242_T0.7810.49
53_V67_F0.7800.48
176_G179_D0.7740.48
196_C203_V0.7720.48
52_G291_S0.7650.47
74_R154_V0.7640.47
166_N228_Y0.7630.47
55_S125_K0.7630.47
131_F197_A0.7620.47
65_W81_Y0.7620.47
236_I253_F0.7610.47
17_E24_G0.7600.47
201_F227_L0.7590.47
41_P104_I0.7580.47
202_I238_Y0.7570.46
4_T8_C0.7550.46
64_L128_L0.7530.46
254_K259_C0.7520.46
60_V84_T0.7520.46
170_I244_I0.7500.46
267_W293_N0.7490.46
59_L154_V0.7480.46
34_K64_L0.7440.45
155_L163_V0.7430.45
227_L242_T0.7380.45
154_V161_L0.7380.45
273_W276_L0.7340.44
193_P205_I0.7320.44
25_V29_G0.7310.44
80_Q235_L0.7310.44
93_E248_L0.7300.44
65_W219_R0.7250.44
165_A227_L0.7250.44
149_D211_E0.7240.44
195_A199_L0.7190.43
55_S101_Y0.7160.43
86_V126_G0.7160.43
21_S32_E0.7150.43
206_F210_R0.7140.43
120_I166_N0.7140.43
126_G137_S0.7120.42
206_F236_I0.7120.42
158_G161_L0.7080.42
30_R163_V0.7070.42
113_G159_I0.7050.42
271_A285_A0.6980.41
60_V241_F0.6980.41
79_I294_N0.6980.41
202_I239_V0.6960.41
161_L198_D0.6920.41
43_G47_L0.6920.41
68_L289_R0.6920.41
26_S101_Y0.6910.41
204_W235_L0.6900.41
197_A204_W0.6880.40
52_G184_T0.6860.40
58_Y129_S0.6840.40
284_I294_N0.6810.40
106_R279_A0.6810.40
163_V189_F0.6810.40
232_Y238_Y0.6800.40
150_K153_K0.6790.40
267_W271_A0.6780.40
271_A274_E0.6770.39
36_P56_L0.6750.39
18_L23_S0.6730.39
47_L246_V0.6720.39
105_N216_L0.6720.39
168_A194_L0.6720.39
201_F288_W0.6720.39
94_M124_L0.6680.39
100_D122_S0.6620.38
169_Y172_I0.6590.38
44_E89_L0.6590.38
205_I208_S0.6590.38
198_D201_F0.6580.38
144_K203_V0.6580.38
82_L135_L0.6560.38
140_Y143_V0.6540.38
67_F189_F0.6500.37
91_M161_L0.6490.37
35_N105_N0.6480.37
124_L128_L0.6480.37
224_K228_Y0.6470.37
29_G36_P0.6380.36
139_G147_L0.6370.36
79_I144_K0.6330.36
257_D261_E0.6330.36
79_I272_F0.6320.36
123_A222_L0.6310.36
89_L124_L0.6290.35
55_S117_L0.6280.35
77_L141_G0.6260.35
10_Y220_R0.6250.35
96_F180_S0.6240.35
3_K26_S0.6230.35
188_L193_P0.6230.35
174_E178_G0.6180.35
152_K226_K0.6120.34
231_F247_F0.6100.34
136_V161_L0.6090.34
61_L149_D0.6070.34
209_L228_Y0.6060.34
9_L89_L0.6020.33
277_Y288_W0.6020.33
102_H140_Y0.6010.33
155_L159_I0.5990.33
169_Y173_E0.5980.33
57_V220_R0.5950.33
234_V249_L0.5940.33
92_L120_I0.5940.33
70_A96_F0.5930.33
87_I281_L0.5880.32
140_Y228_Y0.5870.32
135_L214_T0.5850.32
148_G151_E0.5850.32
230_K237_F0.5840.32
108_G113_G0.5830.32
22_S36_P0.5820.32
232_Y236_I0.5820.32
46_P294_N0.5810.32
220_R236_I0.5810.32
11_F202_I0.5790.31
66_L95_A0.5740.31
135_L163_V0.5740.31
90_G161_L0.5730.31
226_K234_V0.5730.31
60_V155_L0.5720.31
129_S280_F0.5710.31
3_K6_Y0.5710.31
12_A15_D0.5700.31
158_G165_A0.5690.31
52_G179_D0.5680.31
263_W266_R0.5680.31
191_L278_L0.5660.30
32_E35_N0.5650.30
13_N39_Y0.5630.30
77_L294_N0.5620.30
90_G98_Y0.5620.30
22_S27_Y0.5620.30
168_A171_V0.5620.30
21_S30_R0.5620.30
118_A130_F0.5610.30
192_L195_A0.5610.30
79_I254_K0.5600.30
60_V63_L0.5600.30
65_W204_W0.5550.30
37_Y58_Y0.5540.30
73_R233_N0.5520.29
66_L189_F0.5510.29
109_T153_K0.5510.29
215_D218_A0.5480.29
280_F283_V0.5470.29
46_P65_W0.5470.29
12_A33_F0.5450.29
89_L266_R0.5430.29
18_L72_H0.5390.28
163_V170_I0.5390.28
54_M76_L0.5370.28
65_W144_K0.5340.28
231_F243_R0.5340.28
17_E22_S0.5320.28
83_I195_A0.5310.28
6_Y13_N0.5310.28
21_S27_Y0.5300.28
32_E43_G0.5290.28
13_N58_Y0.5290.28
154_V162_F0.5290.28
62_G156_M0.5270.28
168_A199_L0.5270.28
167_V207_R0.5260.28
245_F294_N0.5260.28
45_Y288_W0.5260.28
245_F276_L0.5250.27
189_F251_L0.5250.27
96_F99_A0.5240.27
260_P294_N0.5220.27
132_L141_G0.5210.27
22_S26_S0.5210.27
67_F292_A0.5200.27
173_E177_P0.5190.27
23_S56_L0.5190.27
50_F93_E0.5180.27
130_F140_Y0.5180.27
117_L243_R0.5180.27
268_V275_L0.5160.27
24_G34_K0.5120.27
91_M133_L0.5120.27
53_V70_A0.5090.26
125_K201_F0.5060.26
63_L78_R0.5060.26
172_I190_L0.5060.26
97_W285_A0.5040.26
57_V61_L0.5040.26
25_V59_L0.5040.26
237_F252_T0.5030.26
180_S183_A0.5030.26
51_Y122_S0.5010.26
40_L235_L0.5010.26
209_L212_T0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z73A 2 0.9085 26.1 0.946 Contact Map
4zwjA 1 0.9627 9.7 0.956 Contact Map
4jkvA 2 0.8576 7 0.958 Contact Map
3emlA 1 0.7898 6 0.96 Contact Map
4phzK 1 0.2475 5.8 0.96 Contact Map
4grvA 1 0.8237 5.8 0.96 Contact Map
4xesA 1 0.8102 5.6 0.96 Contact Map
2r4rA 1 0.6339 4.7 0.962 Contact Map
4pxzA 1 0.8203 4.6 0.962 Contact Map
4txvB 1 0.1458 4 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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