GREMLIN Database
ImpA_N - ImpA, N-terminal, type VI secretion system
PFAM: PF06812 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 119 (118)
Sequences: 9768 (7160)
Seq/√Len: 659.1
META: 0.829

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_G93_R2.5441.00
10_C97_T2.4731.00
47_I51_L2.4301.00
47_I74_L2.3191.00
52_E56_T2.2891.00
47_I71_L2.2671.00
25_E28_R2.1561.00
88_R92_E2.0991.00
47_I70_A2.0961.00
68_T83_G2.0821.00
19_E57_R2.0351.00
42_D45_E1.9981.00
64_A90_L1.9971.00
50_A67_L1.8621.00
45_E49_L1.8361.00
8_N12_E1.8051.00
53_L63_V1.7901.00
47_I75_E1.7251.00
50_A63_V1.7231.00
64_A87_L1.6551.00
61_L98_L1.6441.00
14_L58_S1.6411.00
19_E22_A1.6371.00
19_E53_L1.6111.00
17_D57_R1.5681.00
22_A49_L1.5071.00
67_L71_L1.4831.00
71_L83_G1.4771.00
85_A89_G1.4561.00
59_K94_F1.4411.00
22_A45_E1.4331.00
54_L58_S1.4321.00
19_E52_E1.4251.00
44_R74_L1.3861.00
102_L107_L1.3731.00
45_E48_E1.3711.00
12_E57_R1.3321.00
104_D107_L1.3301.00
26_A45_E1.3041.00
33_D36_R1.3021.00
27_R66_W1.2971.00
43_W70_A1.2841.00
71_L75_E1.2811.00
75_E82_D1.2501.00
97_T101_Q1.2381.00
49_L52_E1.2371.00
51_L67_L1.2371.00
79_G83_G1.2351.00
21_D24_E1.2211.00
10_C94_F1.2111.00
51_L55_A1.2081.00
21_D25_E1.1661.00
26_A29_K1.1211.00
53_L58_S1.1201.00
12_E99_H1.1201.00
65_A87_L1.1151.00
13_D101_Q1.1101.00
62_R113_A1.1031.00
15_R62_R1.0951.00
8_N101_Q1.0581.00
24_E28_R1.0311.00
32_E35_F1.0271.00
68_T87_L1.0261.00
72_L80_L1.0091.00
68_T117_L1.0091.00
81_A85_A1.0091.00
5_S8_N1.0041.00
23_L63_V1.0041.00
104_D108_E1.0011.00
90_L98_L0.9941.00
26_A49_L0.9851.00
95_W110_R0.9791.00
22_A25_E0.9731.00
46_V50_A0.9581.00
23_L50_A0.9551.00
71_L82_D0.9501.00
111_A115_A0.9491.00
3_P6_G0.9461.00
30_D39_K0.9411.00
64_A86_L0.9391.00
27_R69_E0.9341.00
46_V70_A0.9301.00
109_A113_A0.8921.00
9_P97_T0.8891.00
12_E17_D0.8891.00
64_A83_G0.8851.00
16_Y21_D0.8811.00
94_F97_T0.8751.00
4_I8_N0.8621.00
71_L74_L0.8561.00
89_G92_E0.8451.00
80_L84_L0.8281.00
52_E57_R0.8221.00
29_K40_E0.8161.00
20_F62_R0.8141.00
28_R31_D0.8021.00
82_D85_A0.7981.00
69_E73_R0.7811.00
24_E62_R0.7561.00
24_E66_W0.7471.00
32_E38_A0.7461.00
4_I59_K0.7441.00
19_E49_L0.7421.00
78_A81_A0.7391.00
54_L90_L0.7301.00
91_L114_L0.7271.00
18_P22_A0.7231.00
91_L98_L0.7181.00
5_S12_E0.7091.00
54_L59_K0.7081.00
112_N115_A0.6881.00
44_R48_E0.6861.00
48_E52_E0.6831.00
14_L63_V0.6781.00
85_A88_R0.6751.00
65_A113_A0.6661.00
86_L90_L0.6651.00
30_D38_A0.6631.00
30_D41_P0.6611.00
87_L117_L0.6591.00
71_L79_G0.6551.00
20_F24_E0.6521.00
40_E73_R0.6461.00
59_K90_L0.6441.00
86_L89_G0.6411.00
29_K41_P0.6361.00
18_P21_D0.6331.00
52_E55_A0.6311.00
23_L66_W0.6291.00
2_A93_R0.6191.00
75_E79_G0.6161.00
27_R46_V0.6121.00
106_D109_A0.6071.00
47_I50_A0.6051.00
14_L53_L0.6051.00
8_N99_H0.6051.00
91_L95_W0.6041.00
105_D108_E0.5961.00
54_L64_A0.5941.00
14_L17_D0.5911.00
58_S63_V0.5841.00
47_I67_L0.5811.00
50_A54_L0.5811.00
10_C98_L0.5811.00
58_S99_H0.5791.00
67_L86_L0.5691.00
36_R39_K0.5681.00
13_D62_R0.5661.00
103_D107_L0.5591.00
76_G79_G0.5591.00
81_A84_L0.5581.00
75_E78_A0.5521.00
20_F63_V0.5521.00
43_W47_I0.5461.00
64_A68_T0.5421.00
81_A88_R0.5421.00
1_L89_G0.5411.00
13_D16_Y0.5391.00
43_W69_E0.5391.00
26_A46_V0.5381.00
79_G82_D0.5351.00
3_P93_R0.5321.00
15_R109_A0.5280.99
78_A82_D0.5260.99
113_A118_N0.5240.99
77_F84_L0.5200.99
65_A117_L0.5190.99
30_D36_R0.5160.99
113_A116_W0.5160.99
111_A118_N0.5140.99
80_L83_G0.5080.99
38_A41_P0.5080.99
87_L114_L0.5040.99
39_K42_D0.5030.99
46_V53_L0.5010.99
4_I9_P0.5010.99
101_Q110_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mhqA 1 0.7731 34.5 0.887 Contact Map
1juqA 3 0.8487 25.1 0.895 Contact Map
3g2sA 1 0.8319 21.2 0.898 Contact Map
3zyqA 1 0.7731 20.5 0.899 Contact Map
1elkA 1 0.8739 17.7 0.902 Contact Map
4fgvA 1 0.6891 15.6 0.904 Contact Map
3ldzA 1 0.8235 12.5 0.908 Contact Map
1x5bA 1 0.9076 11.9 0.909 Contact Map
1dvpA 2 0.8235 11.8 0.91 Contact Map
2kmfA 1 0.8655 6.9 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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