GREMLIN Database
DUF1230 - Protein of unknown function (DUF1230)
PFAM: PF06799 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 142 (141)
Sequences: 723 (450)
Seq/√Len: 37.9
META: 0.712

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_E15_E4.4941.00
32_Y140_T4.2951.00
82_R85_L3.3161.00
22_F86_G3.0181.00
119_L123_R2.7861.00
12_E89_Y2.5811.00
60_S63_K2.4481.00
30_K34_K2.4091.00
14_I17_K2.2480.99
91_R126_A2.2010.99
61_P65_I2.1690.99
133_I137_L2.0930.99
5_K8_Q2.0900.99
97_E119_L2.0100.99
40_W44_F1.9430.98
4_P7_Q1.8760.98
92_K121_R1.8470.98
10_L125_I1.8160.97
82_R86_G1.8150.97
44_F72_A1.7560.97
24_W84_Y1.7320.97
99_V118_V1.7320.97
22_F85_L1.7320.97
112_W115_P1.7280.97
85_L89_Y1.7160.96
44_F48_G1.6210.95
82_R89_Y1.5890.94
121_R125_I1.5730.94
57_P64_F1.5390.93
35_K75_I1.5180.93
135_K139_Q1.5130.93
96_S99_V1.5040.93
27_L50_I1.4690.92
2_P112_W1.4690.92
12_E17_K1.4610.91
126_A130_V1.4600.91
44_F68_S1.3870.89
9_P12_E1.3840.89
46_L131_K1.3380.87
56_P81_L1.3180.87
103_E110_Q1.2950.86
93_R108_D1.2560.84
10_L50_I1.2360.83
22_F82_R1.2320.83
28_S98_T1.2310.83
80_L83_L1.2060.81
8_Q121_R1.1890.80
4_P9_P1.1740.79
32_Y111_V1.1690.79
21_F83_L1.1690.79
38_W42_L1.1680.79
49_P64_F1.1490.78
32_Y99_V1.1480.78
3_V94_L1.1400.77
40_W76_P1.1130.76
30_K36_L1.1120.76
40_W72_A1.0960.74
25_P121_R1.0760.73
52_A55_F1.0700.73
27_L35_K1.0460.71
51_A68_S1.0400.71
14_I121_R1.0360.70
75_I120_E1.0340.70
98_T113_E1.0270.70
89_Y94_L1.0240.69
61_P71_G1.0220.69
86_G140_T1.0180.69
1_C4_P1.0100.68
95_L126_A0.9980.67
35_K38_W0.9740.65
49_P55_F0.9630.64
36_L80_L0.9580.64
86_G129_E0.9570.64
42_L90_V0.9460.63
61_P77_L0.9300.62
12_E93_R0.9220.61
40_W69_A0.9130.60
3_V7_Q0.9120.60
8_Q89_Y0.9100.60
94_L109_G0.9050.60
36_L75_I0.9000.59
33_L60_S0.8960.59
105_G128_Y0.8940.59
1_C107_Y0.8860.58
48_G64_F0.8850.58
13_Y17_K0.8800.57
45_L70_F0.8750.57
48_G68_S0.8740.57
24_W39_F0.8690.56
40_W54_S0.8690.56
105_G121_R0.8680.56
1_C13_Y0.8600.56
2_P13_Y0.8580.56
5_K11_N0.8430.54
47_F72_A0.8430.54
11_N74_L0.8420.54
88_S92_K0.8380.54
37_I63_K0.8320.53
138_K141_L0.8200.52
81_L113_E0.8070.51
49_P71_G0.8020.51
10_L95_L0.7990.50
17_K26_T0.7990.50
13_Y112_W0.7970.50
80_L141_L0.7930.50
110_Q134_L0.7920.50
70_F141_L0.7910.50
121_R127_S0.7890.49
115_P118_V0.7820.49
11_N14_I0.7800.49
16_L85_L0.7790.49
31_S74_L0.7750.48
29_K125_I0.7750.48
99_V105_G0.7740.48
87_W122_D0.7740.48
38_W104_S0.7710.48
55_F71_G0.7700.48
63_K99_V0.7690.48
39_F45_L0.7680.48
35_K76_P0.7650.47
40_W68_S0.7610.47
89_Y99_V0.7580.47
36_L76_P0.7540.46
120_E129_E0.7440.45
19_S22_F0.7420.45
48_G76_P0.7240.44
34_K41_L0.7230.44
42_L135_K0.7200.43
8_Q98_T0.7170.43
41_L69_A0.7140.43
73_L100_E0.7140.43
29_K34_K0.7080.42
22_F125_I0.6980.41
9_P106_W0.6970.41
82_R90_V0.6950.41
88_S130_V0.6930.41
107_Y110_Q0.6930.41
116_L120_E0.6910.41
27_L32_Y0.6880.41
2_P19_S0.6870.40
5_K72_A0.6860.40
8_Q105_G0.6810.40
99_V111_V0.6780.40
68_S95_L0.6750.39
26_T47_F0.6690.39
27_L31_S0.6670.39
20_W24_W0.6670.39
135_K138_K0.6630.38
45_L125_I0.6580.38
92_K135_K0.6570.38
86_G94_L0.6330.36
32_Y124_L0.6320.36
75_I96_S0.6320.36
116_L119_L0.6310.36
80_L125_I0.6300.36
54_S133_I0.6270.35
17_K89_Y0.6260.35
10_L120_E0.6240.35
42_L58_K0.6200.35
44_F52_A0.6180.35
24_W113_E0.6170.35
97_E113_E0.6170.35
49_P53_G0.6140.34
23_S71_G0.6130.34
44_F64_F0.6120.34
1_C112_W0.6080.34
20_W25_P0.6060.34
19_S83_L0.6010.33
83_L123_R0.5990.33
80_L90_V0.5960.33
51_A67_L0.5930.33
32_Y136_R0.5910.33
70_F135_K0.5890.32
3_V9_P0.5880.32
18_E139_Q0.5880.32
2_P10_L0.5870.32
98_T120_E0.5850.32
15_E89_Y0.5850.32
8_Q100_E0.5840.32
28_S97_E0.5810.32
45_L137_L0.5800.32
9_P13_Y0.5760.31
22_F27_L0.5680.31
59_K141_L0.5640.30
76_P120_E0.5600.30
15_E137_L0.5590.30
41_L59_K0.5570.30
93_R109_G0.5550.30
59_K64_F0.5470.29
82_R94_L0.5470.29
47_F77_L0.5470.29
56_P59_K0.5440.29
52_A78_L0.5350.28
6_E27_L0.5350.28
2_P7_Q0.5330.28
89_Y105_G0.5310.28
11_N41_L0.5310.28
18_E31_S0.5300.28
11_N120_E0.5290.28
85_L135_K0.5290.28
86_G89_Y0.5260.28
98_T111_V0.5230.27
91_R130_V0.5210.27
26_T37_I0.5200.27
50_I94_L0.5160.27
96_S100_E0.5080.26
57_P71_G0.5080.26
45_L65_I0.5060.26
60_S126_A0.5060.26
39_F79_I0.5040.26
58_K61_P0.5030.26
47_F58_K0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4d2gD 1 0.1127 11.3 0.949 Contact Map
1acfA 1 0.331 3.1 0.961 Contact Map
3ov1A 2 0.2958 3 0.961 Contact Map
1h9oA 1 0.338 2.8 0.962 Contact Map
1r1pA 4 0.331 2.7 0.962 Contact Map
2c9wA 1 0.3662 2.6 0.962 Contact Map
2eyzA 1 0.3451 2.4 0.963 Contact Map
2mdlA 1 0.1268 2.4 0.963 Contact Map
1i3zA 1 0.2887 2.2 0.964 Contact Map
1nrvA 1 0.3028 2 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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