PrkA - PFAM28P - GREMLIN Contacts

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PrkA - PrkA serine protein kinase C-terminal domain

PFAM:	PF06798	Sequences: LQKMKLYDGEELPGFTAKEDVKELRDEAGVREGMTGISPRFIIKILSNALVRSEDPEEKCINPVDVLNELEKGLKRHSLIPEEERKRYLEFLKVVREEYDEIIKKEVQKAFLYSYEEQIQRLFDNYLDNVEAYIQKEKVKDPYTGEEEEPDERLMRSIEEKIGIPESRKKDFRREIVNYILRAALAREGKKFDYTSYERLREAIEKKLFEDVKDLLKLISFSKTPDKETQKKIDEVVERLIKKYGYCEKCARELLEY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	257 (255)
Sequences:	4157 (1877)
Seq/√Len:	117.6
META:	0.888

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
247_C	250_C	9.966	1.00
60_C	250_C	7.245	1.00
60_C	247_C	6.051	1.00
238_E	242_K	5.365	1.00
141_D	148_E	5.140	1.00
1_L	4_M	3.625	1.00
230_Q	234_D	2.910	1.00
152_E	156_R	2.906	1.00
84_E	87_R	2.792	1.00
5_K	98_E	2.625	1.00
226_D	229_T	2.578	1.00
5_K	10_E	2.458	1.00
207_K	211_D	2.360	1.00
102_I	106_E	2.132	1.00
159_E	173_R	2.129	1.00
62_N	253_E	2.096	1.00
227_K	231_K	2.043	1.00
235_E	239_R	2.031	1.00
198_E	201_R	2.022	1.00
231_K	238_E	2.022	1.00
158_I	162_I	1.993	1.00
71_E	96_R	1.928	1.00
82_E	86_K	1.922	1.00
241_I	248_E	1.896	1.00
46_L	66_V	1.887	1.00
252_R	256_E	1.848	1.00
156_R	166_E	1.841	1.00
133_Y	170_K	1.839	1.00
33_G	36_G	1.833	1.00
106_E	246_Y	1.829	1.00
3_K	7_Y	1.763	1.00
200_L	204_I	1.751	1.00
83_E	86_K	1.733	1.00
239_R	243_K	1.731	1.00
120_Q	124_D	1.726	1.00
170_K	174_R	1.711	1.00
22_K	26_D	1.662	1.00
15_F	18_K	1.621	1.00
13_P	16_T	1.604	1.00
91_F	94_V	1.594	1.00
210_E	213_K	1.560	1.00
216_L	219_I	1.549	1.00
124_D	191_K	1.530	1.00
28_A	31_R	1.526	1.00
204_I	209_F	1.516	1.00
94_V	97_E	1.484	1.00
231_K	235_E	1.474	1.00
183_A	187_R	1.466	1.00
100_D	257_Y	1.455	1.00
130_V	155_M	1.443	1.00
90_E	93_K	1.433	1.00
152_E	155_M	1.422	1.00
140_K	145_G	1.393	1.00
185_L	190_K	1.380	1.00
183_A	186_A	1.377	1.00
67_L	96_R	1.354	1.00
140_K	147_E	1.343	1.00
198_E	204_I	1.342	1.00
41_F	73_G	1.340	1.00
77_H	80_I	1.338	1.00
165_P	168_R	1.337	1.00
2_Q	15_F	1.332	1.00
234_D	238_E	1.308	1.00
74_L	77_H	1.297	1.00
31_R	35_T	1.297	1.00
7_Y	32_E	1.285	1.00
219_I	222_S	1.282	1.00
125_N	154_L	1.279	1.00
20_D	23_E	1.279	1.00
193_D	196_S	1.271	0.99
225_P	230_Q	1.259	0.99
214_D	218_L	1.251	0.99
242_K	248_E	1.244	0.99
93_K	97_E	1.241	0.99
119_I	204_I	1.239	0.99
84_E	88_Y	1.224	0.99
135_Q	178_N	1.220	0.99
86_K	90_E	1.218	0.99
126_Y	159_E	1.201	0.99
81_P	84_E	1.198	0.99
200_L	203_A	1.194	0.99
156_R	169_K	1.188	0.99
132_A	139_V	1.183	0.99
215_L	218_L	1.165	0.99
240_L	251_A	1.160	0.99
202_E	206_K	1.141	0.99
218_L	233_I	1.141	0.99
68_N	72_K	1.138	0.99
99_Y	103_I	1.134	0.99
59_K	249_K	1.129	0.99
233_I	236_V	1.124	0.99
13_P	17_A	1.124	0.99
234_D	248_E	1.113	0.99
60_C	249_K	1.109	0.99
115_Y	204_I	1.104	0.99
216_L	220_S	1.100	0.98
45_I	73_G	1.086	0.98
171_D	175_E	1.079	0.98
2_Q	13_P	1.076	0.98
105_K	109_K	1.073	0.98
41_F	45_I	1.068	0.98
220_S	229_T	1.064	0.98
151_D	154_L	1.064	0.98
106_E	244_Y	1.062	0.98
126_Y	173_R	1.055	0.98
118_Q	121_R	1.054	0.98
103_I	254_L	1.050	0.98
37_I	41_F	1.050	0.98
37_I	80_I	1.043	0.98
120_Q	193_D	1.038	0.98
36_G	40_R	1.026	0.98
228_E	232_K	1.026	0.98
207_K	210_E	1.026	0.98
65_D	253_E	1.021	0.98
237_V	241_I	1.021	0.98
148_E	151_D	1.013	0.97
201_R	204_I	1.012	0.97
13_P	18_K	1.011	0.97
6_L	21_V	1.002	0.97
50_L	53_S	1.000	0.97
39_P	42_I	0.996	0.97
129_N	154_L	0.995	0.97
76_R	79_L	0.994	0.97
217_K	220_S	0.991	0.97
214_D	220_S	0.987	0.97
240_L	244_Y	0.984	0.97
26_D	29_G	0.983	0.97
87_R	91_F	0.981	0.97
48_N	73_G	0.977	0.97
124_D	193_D	0.977	0.97
220_S	223_K	0.976	0.97
180_I	183_A	0.972	0.97
41_F	44_K	0.960	0.96
171_D	174_R	0.954	0.96
212_V	216_L	0.954	0.96
11_E	17_A	0.937	0.96
45_I	70_L	0.931	0.96
215_L	220_S	0.928	0.96
14_G	18_K	0.927	0.96
214_D	217_K	0.925	0.96
129_N	155_M	0.917	0.95
1_L	94_V	0.912	0.95
95_V	104_K	0.899	0.95
156_R	160_E	0.891	0.95
108_Q	111_F	0.883	0.94
111_F	115_Y	0.882	0.94
98_E	101_E	0.879	0.94
141_D	144_T	0.878	0.94
109_K	205_E	0.878	0.94
164_I	174_R	0.876	0.94
223_K	229_T	0.875	0.94
22_K	25_R	0.875	0.94
200_L	207_K	0.873	0.94
48_N	69_E	0.858	0.93
118_Q	122_L	0.852	0.93
208_L	212_V	0.846	0.93
90_E	94_V	0.843	0.93
209_F	212_V	0.841	0.93
45_I	69_E	0.840	0.93
179_Y	197_Y	0.840	0.93
115_Y	119_I	0.835	0.92
45_I	48_N	0.833	0.92
128_D	132_A	0.825	0.92
227_K	230_Q	0.821	0.92
238_E	248_E	0.820	0.92
141_D	145_G	0.818	0.92
225_P	229_T	0.817	0.92
154_L	157_S	0.816	0.92
232_K	235_E	0.816	0.92
123_F	197_Y	0.813	0.91
21_V	25_R	0.812	0.91
49_A	61_I	0.812	0.91
125_N	151_D	0.805	0.91
152_E	169_K	0.805	0.91
61_I	65_D	0.801	0.91
71_E	93_K	0.801	0.91
211_D	214_D	0.800	0.91
201_R	205_E	0.797	0.91
91_F	97_E	0.797	0.91
138_K	147_E	0.794	0.90
197_Y	208_L	0.790	0.90
62_N	80_I	0.790	0.90
221_F	236_V	0.786	0.90
31_R	37_I	0.786	0.90
53_S	56_P	0.783	0.90
195_T	201_R	0.782	0.90
33_G	40_R	0.780	0.90
71_E	241_I	0.779	0.90
122_L	158_I	0.779	0.90
211_D	216_L	0.774	0.89
189_G	192_F	0.770	0.89
75_K	89_L	0.769	0.89
197_Y	203_A	0.767	0.89
214_D	229_T	0.764	0.89
222_S	237_V	0.762	0.89
121_R	125_N	0.759	0.88
32_E	36_G	0.755	0.88
65_D	68_N	0.754	0.88
241_I	247_C	0.751	0.88
92_L	198_E	0.748	0.88
70_L	92_L	0.746	0.88
200_L	208_L	0.746	0.88
104_K	108_Q	0.745	0.87
247_C	251_A	0.744	0.87
175_E	197_Y	0.744	0.87
14_G	17_A	0.742	0.87
156_R	196_S	0.742	0.87
160_E	164_I	0.741	0.87
31_R	34_M	0.736	0.87
206_K	213_K	0.735	0.87
2_Q	12_L	0.731	0.86
62_N	250_C	0.731	0.86
122_L	154_L	0.728	0.86
72_K	76_R	0.727	0.86
201_R	208_L	0.723	0.86
82_E	92_L	0.719	0.86
2_Q	18_K	0.718	0.85
8_D	11_E	0.716	0.85
81_P	88_Y	0.716	0.85
129_N	132_A	0.715	0.85
10_E	13_P	0.715	0.85
35_T	84_E	0.711	0.85
105_K	108_Q	0.711	0.85
3_K	32_E	0.710	0.85
238_E	241_I	0.710	0.85
179_Y	194_Y	0.700	0.84
204_I	212_V	0.695	0.84
181_L	185_L	0.693	0.83
139_V	240_L	0.692	0.83
174_R	183_A	0.691	0.83
3_K	159_E	0.689	0.83
133_Y	155_M	0.689	0.83
179_Y	184_A	0.687	0.83
3_K	8_D	0.687	0.83
17_A	20_D	0.684	0.83
157_S	161_K	0.683	0.82
234_D	237_V	0.681	0.82
125_N	146_E	0.680	0.82
246_Y	255_L	0.680	0.82
158_I	183_A	0.679	0.82
44_K	47_S	0.678	0.82
241_I	244_Y	0.673	0.82
146_E	153_R	0.671	0.81
43_I	119_I	0.670	0.81
198_E	202_E	0.669	0.81
150_P	155_M	0.668	0.81
58_E	65_D	0.667	0.81
214_D	221_F	0.665	0.81
92_L	95_V	0.665	0.81
18_K	22_K	0.663	0.81
201_R	206_K	0.662	0.81
207_K	213_K	0.660	0.80
88_Y	200_L	0.658	0.80
50_L	61_I	0.657	0.80
168_R	171_D	0.657	0.80
104_K	107_V	0.655	0.80
38_S	63_P	0.652	0.80
120_Q	195_T	0.650	0.79
164_I	170_K	0.648	0.79
62_N	65_D	0.644	0.79
68_N	96_R	0.644	0.79
89_L	241_I	0.641	0.78
17_A	23_E	0.637	0.78
5_K	8_D	0.635	0.78
197_Y	212_V	0.634	0.78
3_K	173_R	0.633	0.77
208_L	213_K	0.631	0.77
38_S	106_E	0.631	0.77
66_V	127_L	0.628	0.77
7_Y	34_M	0.625	0.77
104_K	181_L	0.622	0.76
216_L	221_F	0.618	0.76
207_K	212_V	0.618	0.76
46_L	236_V	0.614	0.75
131_E	135_Q	0.614	0.75
240_L	246_Y	0.613	0.75
87_R	93_K	0.612	0.75
161_K	210_E	0.610	0.75
93_K	167_S	0.610	0.75
236_V	239_R	0.609	0.75
215_L	236_V	0.607	0.75
53_S	58_E	0.607	0.75
149_E	174_R	0.607	0.75
73_G	80_I	0.603	0.74
117_E	120_Q	0.602	0.74
71_E	74_L	0.600	0.74
101_E	112_L	0.596	0.73
198_E	212_V	0.593	0.73
24_L	80_I	0.593	0.73
77_H	169_K	0.592	0.73
16_T	22_K	0.591	0.73
239_R	244_Y	0.588	0.72
32_E	155_M	0.586	0.72
163_G	172_F	0.585	0.72
48_N	78_S	0.585	0.72
153_R	156_R	0.584	0.72
226_D	231_K	0.583	0.72
54_E	57_E	0.582	0.71
217_K	222_S	0.581	0.71
130_V	181_L	0.580	0.71
180_I	200_L	0.580	0.71
27_E	54_E	0.579	0.71
5_K	13_P	0.577	0.71
82_E	85_R	0.577	0.71
117_E	121_R	0.574	0.70
251_A	257_Y	0.573	0.70
37_I	50_L	0.572	0.70
218_L	221_F	0.571	0.70
207_K	216_L	0.571	0.70
177_V	183_A	0.571	0.70
101_E	108_Q	0.568	0.70
141_D	151_D	0.567	0.69
231_K	241_I	0.567	0.69
235_E	238_E	0.566	0.69
92_L	98_E	0.565	0.69
32_E	40_R	0.564	0.69
111_F	119_I	0.563	0.69
198_E	211_D	0.562	0.69
171_D	231_K	0.562	0.69
154_L	158_I	0.559	0.68
57_E	175_E	0.558	0.68
216_L	252_R	0.558	0.68
56_P	174_R	0.557	0.68
73_G	78_S	0.555	0.68
198_E	208_L	0.555	0.68
152_E	170_K	0.554	0.68
209_F	213_K	0.553	0.68
75_K	143_Y	0.548	0.67
96_R	100_D	0.547	0.67
253_E	256_E	0.544	0.66
149_E	184_A	0.544	0.66
223_K	227_K	0.542	0.66
149_E	153_R	0.542	0.66
117_E	160_E	0.540	0.66
145_G	176_I	0.540	0.66
233_I	237_V	0.539	0.66
110_A	200_L	0.539	0.66
44_K	192_F	0.538	0.65
212_V	229_T	0.535	0.65
218_L	222_S	0.533	0.65
16_T	21_V	0.532	0.65
205_E	209_F	0.532	0.65
137_E	147_E	0.531	0.64
191_K	195_T	0.530	0.64
62_N	146_E	0.529	0.64
71_E	92_L	0.529	0.64
74_L	175_E	0.529	0.64
203_A	217_K	0.528	0.64
219_I	236_V	0.528	0.64
39_P	115_Y	0.527	0.64
184_A	188_E	0.525	0.64
131_E	177_V	0.525	0.64
8_D	56_P	0.525	0.64
134_I	155_M	0.524	0.63
105_K	112_L	0.523	0.63
141_D	147_E	0.522	0.63
117_E	189_G	0.522	0.63
27_E	31_R	0.521	0.63
73_G	76_R	0.520	0.63
109_K	244_Y	0.520	0.63
110_A	240_L	0.519	0.63
209_F	214_D	0.517	0.62
144_T	148_E	0.516	0.62
58_E	143_Y	0.516	0.62
214_D	223_K	0.516	0.62
39_P	44_K	0.515	0.62
211_D	229_T	0.514	0.62
11_E	18_K	0.514	0.62
199_R	203_A	0.511	0.62
84_E	153_R	0.510	0.61
166_E	170_K	0.509	0.61
218_L	229_T	0.509	0.61
9_G	21_V	0.509	0.61
106_E	207_K	0.508	0.61
206_K	211_D	0.506	0.61
197_Y	201_R	0.505	0.61
157_S	160_E	0.503	0.60
240_L	254_L	0.503	0.60
111_F	236_V	0.502	0.60
30_V	35_T	0.501	0.60
79_L	192_F	0.500	0.60
243_K	249_K	0.500	0.60

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ja82	1	0.3696	52.3	0.934	Contact Map
4r7yA	3	0.2879	44.7	0.937	Contact Map
2r44A	1	0.3852	38.1	0.939	Contact Map
1g8pA	1	0.3346	34.2	0.941	Contact Map
3ja85	1	0.2957	28.1	0.943	Contact Map
4fdgB	1	0.3035	26.6	0.944	Contact Map
4cr2J	1	0.2879	22.7	0.946	Contact Map
4cr2L	1	0.2724	20.5	0.947	Contact Map
2r62A	1	0.2763	19.1	0.948	Contact Map
1lv7A	2	0.2685	15	0.95	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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