GREMLIN Database
PrkA - PrkA serine protein kinase C-terminal domain
PFAM: PF06798 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 257 (255)
Sequences: 4157 (1877)
Seq/√Len: 117.6
META: 0.888

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_C250_C9.9661.00
60_C250_C7.2451.00
60_C247_C6.0511.00
238_E242_K5.3651.00
141_D148_E5.1401.00
1_L4_M3.6251.00
230_Q234_D2.9101.00
152_E156_R2.9061.00
84_E87_R2.7921.00
5_K98_E2.6251.00
226_D229_T2.5781.00
5_K10_E2.4581.00
207_K211_D2.3601.00
102_I106_E2.1321.00
159_E173_R2.1291.00
62_N253_E2.0961.00
227_K231_K2.0431.00
235_E239_R2.0311.00
198_E201_R2.0221.00
231_K238_E2.0221.00
158_I162_I1.9931.00
71_E96_R1.9281.00
82_E86_K1.9221.00
241_I248_E1.8961.00
46_L66_V1.8871.00
252_R256_E1.8481.00
156_R166_E1.8411.00
133_Y170_K1.8391.00
33_G36_G1.8331.00
106_E246_Y1.8291.00
3_K7_Y1.7631.00
200_L204_I1.7511.00
83_E86_K1.7331.00
239_R243_K1.7311.00
120_Q124_D1.7261.00
170_K174_R1.7111.00
22_K26_D1.6621.00
15_F18_K1.6211.00
13_P16_T1.6041.00
91_F94_V1.5941.00
210_E213_K1.5601.00
216_L219_I1.5491.00
124_D191_K1.5301.00
28_A31_R1.5261.00
204_I209_F1.5161.00
94_V97_E1.4841.00
231_K235_E1.4741.00
183_A187_R1.4661.00
100_D257_Y1.4551.00
130_V155_M1.4431.00
90_E93_K1.4331.00
152_E155_M1.4221.00
140_K145_G1.3931.00
185_L190_K1.3801.00
183_A186_A1.3771.00
67_L96_R1.3541.00
140_K147_E1.3431.00
198_E204_I1.3421.00
41_F73_G1.3401.00
77_H80_I1.3381.00
165_P168_R1.3371.00
2_Q15_F1.3321.00
234_D238_E1.3081.00
74_L77_H1.2971.00
31_R35_T1.2971.00
7_Y32_E1.2851.00
219_I222_S1.2821.00
125_N154_L1.2791.00
20_D23_E1.2791.00
193_D196_S1.2710.99
225_P230_Q1.2590.99
214_D218_L1.2510.99
242_K248_E1.2440.99
93_K97_E1.2410.99
119_I204_I1.2390.99
84_E88_Y1.2240.99
135_Q178_N1.2200.99
86_K90_E1.2180.99
126_Y159_E1.2010.99
81_P84_E1.1980.99
200_L203_A1.1940.99
156_R169_K1.1880.99
132_A139_V1.1830.99
215_L218_L1.1650.99
240_L251_A1.1600.99
202_E206_K1.1410.99
218_L233_I1.1410.99
68_N72_K1.1380.99
99_Y103_I1.1340.99
59_K249_K1.1290.99
233_I236_V1.1240.99
13_P17_A1.1240.99
234_D248_E1.1130.99
60_C249_K1.1090.99
115_Y204_I1.1040.99
216_L220_S1.1000.98
45_I73_G1.0860.98
171_D175_E1.0790.98
2_Q13_P1.0760.98
105_K109_K1.0730.98
41_F45_I1.0680.98
220_S229_T1.0640.98
151_D154_L1.0640.98
106_E244_Y1.0620.98
126_Y173_R1.0550.98
118_Q121_R1.0540.98
103_I254_L1.0500.98
37_I41_F1.0500.98
37_I80_I1.0430.98
120_Q193_D1.0380.98
36_G40_R1.0260.98
228_E232_K1.0260.98
207_K210_E1.0260.98
65_D253_E1.0210.98
237_V241_I1.0210.98
148_E151_D1.0130.97
201_R204_I1.0120.97
13_P18_K1.0110.97
6_L21_V1.0020.97
50_L53_S1.0000.97
39_P42_I0.9960.97
129_N154_L0.9950.97
76_R79_L0.9940.97
217_K220_S0.9910.97
214_D220_S0.9870.97
240_L244_Y0.9840.97
26_D29_G0.9830.97
87_R91_F0.9810.97
48_N73_G0.9770.97
124_D193_D0.9770.97
220_S223_K0.9760.97
180_I183_A0.9720.97
41_F44_K0.9600.96
171_D174_R0.9540.96
212_V216_L0.9540.96
11_E17_A0.9370.96
45_I70_L0.9310.96
215_L220_S0.9280.96
14_G18_K0.9270.96
214_D217_K0.9250.96
129_N155_M0.9170.95
1_L94_V0.9120.95
95_V104_K0.8990.95
156_R160_E0.8910.95
108_Q111_F0.8830.94
111_F115_Y0.8820.94
98_E101_E0.8790.94
141_D144_T0.8780.94
109_K205_E0.8780.94
164_I174_R0.8760.94
223_K229_T0.8750.94
22_K25_R0.8750.94
200_L207_K0.8730.94
48_N69_E0.8580.93
118_Q122_L0.8520.93
208_L212_V0.8460.93
90_E94_V0.8430.93
209_F212_V0.8410.93
45_I69_E0.8400.93
179_Y197_Y0.8400.93
115_Y119_I0.8350.92
45_I48_N0.8330.92
128_D132_A0.8250.92
227_K230_Q0.8210.92
238_E248_E0.8200.92
141_D145_G0.8180.92
225_P229_T0.8170.92
154_L157_S0.8160.92
232_K235_E0.8160.92
123_F197_Y0.8130.91
21_V25_R0.8120.91
49_A61_I0.8120.91
125_N151_D0.8050.91
152_E169_K0.8050.91
61_I65_D0.8010.91
71_E93_K0.8010.91
211_D214_D0.8000.91
201_R205_E0.7970.91
91_F97_E0.7970.91
138_K147_E0.7940.90
197_Y208_L0.7900.90
62_N80_I0.7900.90
221_F236_V0.7860.90
31_R37_I0.7860.90
53_S56_P0.7830.90
195_T201_R0.7820.90
33_G40_R0.7800.90
71_E241_I0.7790.90
122_L158_I0.7790.90
211_D216_L0.7740.89
189_G192_F0.7700.89
75_K89_L0.7690.89
197_Y203_A0.7670.89
214_D229_T0.7640.89
222_S237_V0.7620.89
121_R125_N0.7590.88
32_E36_G0.7550.88
65_D68_N0.7540.88
241_I247_C0.7510.88
92_L198_E0.7480.88
70_L92_L0.7460.88
200_L208_L0.7460.88
104_K108_Q0.7450.87
247_C251_A0.7440.87
175_E197_Y0.7440.87
14_G17_A0.7420.87
156_R196_S0.7420.87
160_E164_I0.7410.87
31_R34_M0.7360.87
206_K213_K0.7350.87
2_Q12_L0.7310.86
62_N250_C0.7310.86
122_L154_L0.7280.86
72_K76_R0.7270.86
201_R208_L0.7230.86
82_E92_L0.7190.86
2_Q18_K0.7180.85
8_D11_E0.7160.85
81_P88_Y0.7160.85
129_N132_A0.7150.85
10_E13_P0.7150.85
35_T84_E0.7110.85
105_K108_Q0.7110.85
3_K32_E0.7100.85
238_E241_I0.7100.85
179_Y194_Y0.7000.84
204_I212_V0.6950.84
181_L185_L0.6930.83
139_V240_L0.6920.83
174_R183_A0.6910.83
3_K159_E0.6890.83
133_Y155_M0.6890.83
179_Y184_A0.6870.83
3_K8_D0.6870.83
17_A20_D0.6840.83
157_S161_K0.6830.82
234_D237_V0.6810.82
125_N146_E0.6800.82
246_Y255_L0.6800.82
158_I183_A0.6790.82
44_K47_S0.6780.82
241_I244_Y0.6730.82
146_E153_R0.6710.81
43_I119_I0.6700.81
198_E202_E0.6690.81
150_P155_M0.6680.81
58_E65_D0.6670.81
214_D221_F0.6650.81
92_L95_V0.6650.81
18_K22_K0.6630.81
201_R206_K0.6620.81
207_K213_K0.6600.80
88_Y200_L0.6580.80
50_L61_I0.6570.80
168_R171_D0.6570.80
104_K107_V0.6550.80
38_S63_P0.6520.80
120_Q195_T0.6500.79
164_I170_K0.6480.79
62_N65_D0.6440.79
68_N96_R0.6440.79
89_L241_I0.6410.78
17_A23_E0.6370.78
5_K8_D0.6350.78
197_Y212_V0.6340.78
3_K173_R0.6330.77
208_L213_K0.6310.77
38_S106_E0.6310.77
66_V127_L0.6280.77
7_Y34_M0.6250.77
104_K181_L0.6220.76
216_L221_F0.6180.76
207_K212_V0.6180.76
46_L236_V0.6140.75
131_E135_Q0.6140.75
240_L246_Y0.6130.75
87_R93_K0.6120.75
161_K210_E0.6100.75
93_K167_S0.6100.75
236_V239_R0.6090.75
215_L236_V0.6070.75
53_S58_E0.6070.75
149_E174_R0.6070.75
73_G80_I0.6030.74
117_E120_Q0.6020.74
71_E74_L0.6000.74
101_E112_L0.5960.73
198_E212_V0.5930.73
24_L80_I0.5930.73
77_H169_K0.5920.73
16_T22_K0.5910.73
239_R244_Y0.5880.72
32_E155_M0.5860.72
163_G172_F0.5850.72
48_N78_S0.5850.72
153_R156_R0.5840.72
226_D231_K0.5830.72
54_E57_E0.5820.71
217_K222_S0.5810.71
130_V181_L0.5800.71
180_I200_L0.5800.71
27_E54_E0.5790.71
5_K13_P0.5770.71
82_E85_R0.5770.71
117_E121_R0.5740.70
251_A257_Y0.5730.70
37_I50_L0.5720.70
218_L221_F0.5710.70
207_K216_L0.5710.70
177_V183_A0.5710.70
101_E108_Q0.5680.70
141_D151_D0.5670.69
231_K241_I0.5670.69
235_E238_E0.5660.69
92_L98_E0.5650.69
32_E40_R0.5640.69
111_F119_I0.5630.69
198_E211_D0.5620.69
171_D231_K0.5620.69
154_L158_I0.5590.68
57_E175_E0.5580.68
216_L252_R0.5580.68
56_P174_R0.5570.68
73_G78_S0.5550.68
198_E208_L0.5550.68
152_E170_K0.5540.68
209_F213_K0.5530.68
75_K143_Y0.5480.67
96_R100_D0.5470.67
253_E256_E0.5440.66
149_E184_A0.5440.66
223_K227_K0.5420.66
149_E153_R0.5420.66
117_E160_E0.5400.66
145_G176_I0.5400.66
233_I237_V0.5390.66
110_A200_L0.5390.66
44_K192_F0.5380.65
212_V229_T0.5350.65
218_L222_S0.5330.65
16_T21_V0.5320.65
205_E209_F0.5320.65
137_E147_E0.5310.64
191_K195_T0.5300.64
62_N146_E0.5290.64
71_E92_L0.5290.64
74_L175_E0.5290.64
203_A217_K0.5280.64
219_I236_V0.5280.64
39_P115_Y0.5270.64
184_A188_E0.5250.64
131_E177_V0.5250.64
8_D56_P0.5250.64
134_I155_M0.5240.63
105_K112_L0.5230.63
141_D147_E0.5220.63
117_E189_G0.5220.63
27_E31_R0.5210.63
73_G76_R0.5200.63
109_K244_Y0.5200.63
110_A240_L0.5190.63
209_F214_D0.5170.62
144_T148_E0.5160.62
58_E143_Y0.5160.62
214_D223_K0.5160.62
39_P44_K0.5150.62
211_D229_T0.5140.62
11_E18_K0.5140.62
199_R203_A0.5110.62
84_E153_R0.5100.61
166_E170_K0.5090.61
218_L229_T0.5090.61
9_G21_V0.5090.61
106_E207_K0.5080.61
206_K211_D0.5060.61
197_Y201_R0.5050.61
157_S160_E0.5030.60
240_L254_L0.5030.60
111_F236_V0.5020.60
30_V35_T0.5010.60
79_L192_F0.5000.60
243_K249_K0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ja82 1 0.3696 52.3 0.934 Contact Map
4r7yA 3 0.2879 44.7 0.937 Contact Map
2r44A 1 0.3852 38.1 0.939 Contact Map
1g8pA 1 0.3346 34.2 0.941 Contact Map
3ja85 1 0.2957 28.1 0.943 Contact Map
4fdgB 1 0.3035 26.6 0.944 Contact Map
4cr2J 1 0.2879 22.7 0.946 Contact Map
4cr2L 1 0.2724 20.5 0.947 Contact Map
2r62A 1 0.2763 19.1 0.948 Contact Map
1lv7A 2 0.2685 15 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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