GREMLIN Database
UPF0262 - Uncharacterised protein family (UPF0262)
PFAM: PF06793 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 152 (152)
Sequences: 3814 (1879)
Seq/√Len: 152.4
META: 0.898

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_A112_G3.9771.00
118_N122_E3.4231.00
5_A48_R3.3961.00
38_A133_E3.3171.00
64_D68_E3.0091.00
122_E125_R2.7041.00
48_R67_G2.6161.00
122_E136_F2.5321.00
54_E72_T2.4451.00
7_T50_H2.3901.00
50_H63_R2.3491.00
64_D70_L2.2301.00
3_L49_L2.1951.00
1_Q38_A2.1221.00
29_F33_E2.0471.00
121_S136_F1.9351.00
34_E137_D1.9351.00
61_D72_T1.9311.00
4_V48_R1.9191.00
9_D12_S1.8481.00
48_R65_E1.8461.00
122_E126_E1.8321.00
61_D69_P1.7971.00
101_A105_Q1.7591.00
111_M115_G1.7591.00
73_H132_V1.7261.00
28_I32_L1.7251.00
88_F147_C1.7001.00
39_P42_R1.6681.00
13_I16_R1.6621.00
90_I116_L1.6491.00
63_R67_G1.6231.00
59_V74_I1.5081.00
90_I112_G1.4851.00
3_L6_I1.4631.00
39_P70_L1.4281.00
76_S79_P1.4031.00
86_D119_E1.3991.00
69_P72_T1.3951.00
80_F123_L1.3881.00
98_I106_I1.3451.00
42_R64_D1.2981.00
29_F98_I1.2981.00
22_H26_V1.2971.00
92_E96_E1.2941.00
42_R70_L1.2901.00
42_R47_Y1.2811.00
126_E129_E1.2741.00
26_V29_F1.2301.00
125_R136_F1.2291.00
63_R69_P1.2291.00
118_N137_D1.2191.00
59_V72_T1.2131.00
6_I32_L1.2091.00
7_T48_R1.1871.00
9_D13_I1.1831.00
100_T105_Q1.1821.00
51_L60_F1.1801.00
32_L35_N1.1731.00
83_I120_G1.1621.00
57_R74_I1.1281.00
95_Y99_R1.1050.99
44_G47_Y1.0830.99
85_K89_L1.0810.99
53_I77_L1.0700.99
129_E133_E1.0610.99
41_G71_A1.0570.99
42_R71_A1.0510.99
15_R25_A1.0510.99
16_R20_I1.0470.99
40_V130_G1.0390.99
52_S72_T1.0360.99
39_P43_P1.0360.99
80_F146_I1.0240.99
1_Q36_S1.0060.99
125_R134_V1.0030.99
44_G64_D0.9910.99
90_I93_S0.9900.99
37_F62_I0.9860.99
6_I49_L0.9830.99
84_V88_F0.9780.99
82_R85_K0.9600.98
18_P25_A0.9470.98
10_E16_R0.9390.98
79_P127_R0.9290.98
62_I132_V0.9280.98
19_D33_E0.9240.98
102_T105_Q0.9150.98
40_V133_E0.9120.98
91_C95_Y0.9110.98
109_I115_G0.9060.98
21_E24_R0.9060.98
148_V151_W0.9030.98
96_E100_T0.9000.98
83_I123_L0.8970.98
118_N136_F0.8950.98
41_G44_G0.8730.97
22_H29_F0.8680.97
53_I150_H0.8660.97
96_E99_R0.8560.97
147_C150_H0.8520.97
52_S61_D0.8440.97
84_V147_C0.8440.97
16_R21_E0.8430.96
48_R63_R0.8400.96
78_T81_R0.8400.96
39_P47_Y0.8390.96
50_H61_D0.8350.96
43_P64_D0.8170.96
112_G115_G0.8120.96
64_D67_G0.8110.96
17_S22_H0.8020.95
19_D22_H0.8010.95
12_S16_R0.8000.95
6_I31_L0.7930.95
96_E101_A0.7900.95
98_I102_T0.7880.95
104_S112_G0.7860.95
105_Q108_A0.7830.95
54_E59_V0.7660.94
75_L127_R0.7530.94
25_A29_F0.7490.93
139_A146_I0.7490.93
4_V7_T0.7450.93
71_A76_S0.7440.93
14_G151_W0.7350.93
18_P22_H0.7340.93
11_A16_R0.7320.93
96_E105_Q0.7280.92
15_R20_I0.7220.92
49_L127_R0.7170.92
120_G146_I0.7160.92
97_A106_I0.7160.92
23_E92_E0.7120.91
31_L34_E0.7120.91
94_Y99_R0.7040.91
88_F120_G0.7030.91
87_Y117_H0.7020.91
3_L151_W0.6970.91
89_L112_G0.6960.91
122_E129_E0.6930.90
60_F73_H0.6850.90
94_Y98_I0.6810.90
1_Q44_G0.6800.90
63_R70_L0.6760.89
16_R151_W0.6750.89
13_I20_I0.6670.89
120_G147_C0.6650.88
140_R143_F0.6610.88
4_V65_E0.6580.88
130_G134_V0.6580.88
90_I115_G0.6560.88
25_A84_V0.6550.88
44_G70_L0.6410.87
84_V107_E0.6380.86
56_N78_T0.6350.86
104_S115_G0.6350.86
97_A109_I0.6300.86
82_R89_L0.6290.86
86_D89_L0.6260.85
102_T109_I0.6250.85
142_L145_L0.6250.85
27_A37_F0.6240.85
72_T82_R0.6230.85
39_P62_I0.6210.85
130_G133_E0.6020.83
129_E132_V0.6000.83
32_L95_Y0.6000.83
1_Q39_P0.6000.83
27_A144_T0.5990.83
71_A148_V0.5980.83
40_V129_E0.5940.82
84_V151_W0.5860.81
108_A111_M0.5860.81
121_S124_L0.5840.81
10_E14_G0.5820.81
77_L128_L0.5810.81
52_S74_I0.5810.81
39_P79_P0.5800.81
137_D146_I0.5790.81
125_R129_E0.5780.80
20_I151_W0.5740.80
91_C102_T0.5690.79
119_E122_E0.5680.79
1_Q5_A0.5680.79
51_L120_G0.5670.79
124_L134_V0.5650.79
22_H53_I0.5610.78
23_E107_E0.5590.78
127_R131_K0.5590.78
84_V150_H0.5570.78
15_R21_E0.5550.78
104_S116_L0.5540.78
99_R105_Q0.5540.78
59_V69_P0.5520.77
73_H78_T0.5500.77
36_S44_G0.5500.77
19_D121_S0.5490.77
8_L16_R0.5480.77
7_T36_S0.5470.77
33_E98_I0.5470.77
126_E136_F0.5450.76
29_F102_T0.5430.76
80_F83_I0.5410.76
15_R18_P0.5400.76
16_R152_R0.5380.76
29_F106_I0.5370.75
3_L14_G0.5360.75
123_L126_E0.5330.75
58_L77_L0.5320.75
25_A102_T0.5270.74
14_G18_P0.5260.74
9_D28_I0.5230.74
108_A121_S0.5210.73
27_A113_R0.5200.73
59_V86_D0.5190.73
56_N59_V0.5140.72
112_G122_E0.5130.72
93_S115_G0.5130.72
20_I148_V0.5100.72
48_R66_D0.5080.71
35_N95_Y0.5050.71
7_T11_A0.5050.71
62_I73_H0.5030.71
121_S134_V0.5030.71
29_F78_T0.5000.70
8_L28_I0.5000.70
36_S133_E0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1njhA 2 0.4276 14.6 0.945 Contact Map
4doxA 1 0.8816 11.5 0.948 Contact Map
4kwyA 1 0.8224 8.9 0.95 Contact Map
1ry9A 2 0.5724 7.9 0.951 Contact Map
2xgaA 2 0.5724 7.6 0.952 Contact Map
2fvnA 1 0.4671 6.9 0.953 Contact Map
1nv8A 1 0.625 4 0.958 Contact Map
1i60A 1 0.5066 3.3 0.959 Contact Map
5a2tA 12 0.8947 3.3 0.96 Contact Map
2l5aA 1 0.3618 3.1 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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