GREMLIN Database
Seipin - Putative adipose-regulatory protein (Seipin)
PFAM: PF06775 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 198 (192)
Sequences: 585 (458)
Seq/√Len: 33.1
META: 0.154

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_R132_Q4.3871.00
11_Y15_Y4.3851.00
154_A170_L4.3681.00
107_S130_E4.3011.00
191_F195_S3.0921.00
14_F18_Y2.8611.00
85_E96_S2.5521.00
15_Y20_P2.5361.00
70_E132_Q2.5241.00
69_P74_N2.4991.00
15_Y19_I2.4270.99
11_Y183_M2.3030.99
69_P166_Y2.2820.99
28_L40_A2.2760.99
78_G107_S2.2060.99
186_W189_T2.1010.98
83_R98_R1.9280.97
14_F58_Q1.8640.97
125_G132_Q1.8600.97
15_Y18_Y1.8400.96
11_Y20_P1.8230.96
81_M178_G1.8070.96
13_L17_L1.8030.96
71_S164_Q1.7740.96
10_L14_F1.7300.95
158_L165_I1.6910.94
65_E171_R1.6780.94
7_S13_L1.6460.93
103_L158_L1.6370.93
25_E138_L1.6100.93
62_V76_D1.6050.92
64_L138_L1.5650.91
11_Y19_I1.5650.91
190_S194_G1.4630.88
64_L154_A1.4340.87
9_F16_Y1.4160.87
177_P180_R1.3940.86
8_V134_L1.3890.86
60_Y178_G1.3870.86
84_L154_A1.3840.85
176_L185_N1.3810.85
29_H100_P1.3730.85
41_T153_S1.3680.85
178_G181_Y1.3670.85
70_E104_R1.3450.84
95_A139_F1.3370.83
71_S130_E1.3340.83
71_S166_Y1.3310.83
62_V71_S1.3100.82
38_P78_G1.3090.82
15_Y183_M1.3080.82
166_Y174_A1.2980.81
189_T193_V1.2970.81
71_S74_N1.2900.81
92_K117_L1.2900.81
62_V86_L1.2870.81
111_R132_Q1.2620.80
44_L47_N1.2600.79
159_S184_Y1.2520.79
187_P190_S1.2480.79
147_G156_V1.2400.78
65_E133_T1.2320.78
81_M100_P1.2220.77
57_G138_L1.2170.77
4_L165_I1.2140.77
80_F101_A1.2010.76
30_F158_L1.1900.75
79_N102_M1.1810.75
3_L32_Y1.1730.74
10_L13_L1.1680.74
57_G68_L1.1560.73
14_F179_L1.1530.73
32_Y192_V1.1510.73
123_L130_E1.1510.73
65_E135_T1.1210.71
65_E169_S1.0980.69
174_A184_Y1.0900.69
68_L154_A1.0770.68
122_L132_Q1.0750.68
9_F19_I1.0720.67
31_Q100_P1.0700.67
14_F17_L1.0620.67
107_S115_T1.0540.66
123_L186_W1.0520.66
27_P99_R1.0490.66
69_P78_G1.0490.66
22_V176_L1.0460.65
137_P140_E1.0450.65
74_N107_S1.0410.65
103_L164_Q1.0270.64
11_Y14_F1.0230.64
102_M163_L1.0130.63
85_E155_R1.0090.63
162_E177_P1.0050.62
90_D189_T1.0040.62
83_R159_S1.0020.62
85_E121_P0.9960.62
28_L156_V0.9920.61
66_L80_F0.9830.61
176_L184_Y0.9820.60
46_S138_L0.9810.60
31_Q79_N0.9750.60
27_P76_D0.9690.59
79_N194_G0.9610.59
73_Y189_T0.9580.59
69_P107_S0.9530.58
42_V168_A0.9510.58
128_E131_T0.9460.58
6_L94_L0.9420.57
28_L134_L0.9390.57
165_I189_T0.9390.57
174_A178_G0.9380.57
106_R132_Q0.9380.57
114_R192_V0.9380.57
15_Y60_Y0.9290.56
21_P168_A0.9290.56
15_Y81_M0.9270.56
71_S107_S0.9250.56
14_F31_Q0.9230.56
61_D99_R0.9220.56
60_Y81_M0.9150.55
54_L60_Y0.9120.55
3_L14_F0.9100.55
109_L123_L0.9070.54
39_Y94_L0.9000.54
120_P156_V0.8990.54
101_A134_L0.8960.53
14_F54_L0.8960.53
183_M190_S0.8910.53
31_Q81_M0.8880.53
69_P102_M0.8870.53
78_G105_Y0.8870.53
144_E164_Q0.8870.53
12_G19_I0.8780.52
118_F161_R0.8780.52
113_L119_S0.8740.52
5_W18_Y0.8700.51
72_P76_D0.8660.51
29_H99_R0.8590.50
62_V139_F0.8550.50
84_L156_V0.8470.49
21_P176_L0.8460.49
83_R96_S0.8460.49
108_P136_V0.8410.49
89_A93_V0.8300.48
136_V145_D0.8290.48
120_P189_T0.8250.48
19_I180_R0.8160.47
58_Q174_A0.8130.47
122_L130_E0.8030.46
95_A114_R0.8030.46
44_L169_S0.7930.45
191_F194_G0.7880.44
44_L146_R0.7860.44
35_C154_A0.7850.44
110_V130_E0.7850.44
7_S179_L0.7780.44
102_M134_L0.7770.44
101_A164_Q0.7730.43
86_L93_V0.7690.43
38_P77_L0.7670.43
100_P124_L0.7640.42
2_L195_S0.7620.42
145_D149_P0.7590.42
120_P190_S0.7490.41
9_F57_G0.7480.41
2_L9_F0.7470.41
106_R114_R0.7400.41
183_M194_G0.7380.40
124_L188_I0.7320.40
41_T155_R0.7300.40
25_E64_L0.7290.40
122_L125_G0.7250.39
58_Q68_L0.7240.39
148_S165_I0.7220.39
71_S105_Y0.7210.39
137_P191_F0.7120.38
16_Y19_I0.7050.38
73_Y116_L0.7040.38
56_P86_L0.7020.38
142_Y191_F0.6980.37
23_S138_L0.6980.37
72_P99_R0.6940.37
124_L141_N0.6920.37
64_L134_L0.6900.37
42_V84_L0.6870.36
58_Q179_L0.6850.36
98_R134_L0.6840.36
32_Y69_P0.6840.36
70_E82_V0.6780.36
54_L193_V0.6750.35
37_F136_V0.6730.35
111_R168_A0.6680.35
174_A183_M0.6670.35
66_L155_R0.6670.35
29_H54_L0.6590.34
119_S191_F0.6550.34
172_I184_Y0.6540.34
68_L183_M0.6510.34
143_E186_W0.6500.34
88_S149_P0.6460.33
94_L151_T0.6450.33
66_L168_A0.6440.33
91_G113_L0.6370.33
134_L154_A0.6370.33
81_M163_L0.6320.32
32_Y83_R0.6300.32
109_L117_L0.6300.32
125_G193_V0.6290.32
83_R134_L0.6290.32
120_P187_P0.6270.32
70_E79_N0.6270.32
72_P75_R0.6250.32
124_L158_L0.6250.32
93_V145_D0.6250.32
32_Y81_M0.6200.31
105_Y196_S0.6180.31
176_L180_R0.6170.31
76_D196_S0.6160.31
6_L126_L0.6160.31
115_T166_Y0.6150.31
64_L139_F0.6140.31
56_P165_I0.6130.31
139_F170_L0.6100.31
25_E169_S0.6090.31
77_L138_L0.6080.31
81_M101_A0.6080.31
48_G136_V0.6070.30
113_L160_S0.6020.30
8_V64_L0.5990.30
144_E149_P0.5980.30
11_Y174_A0.5980.30
9_F183_M0.5950.30
63_S135_T0.5950.30
121_P163_L0.5940.30
142_Y165_I0.5930.29
116_L120_P0.5920.29
183_M195_S0.5890.29
25_E103_L0.5880.29
64_L126_L0.5880.29
83_R94_L0.5880.29
60_Y174_A0.5800.29
12_G155_R0.5790.29
133_T156_V0.5770.28
120_P179_L0.5770.28
135_T168_A0.5760.28
121_P126_L0.5760.28
174_A180_R0.5740.28
136_V164_Q0.5720.28
42_V159_S0.5720.28
39_Y136_V0.5720.28
107_S121_P0.5670.28
139_F167_S0.5660.28
32_Y58_Q0.5640.27
70_E186_W0.5630.27
72_P109_L0.5630.27
38_P80_F0.5570.27
124_L133_T0.5570.27
11_Y194_G0.5540.27
33_G81_M0.5520.27
105_Y174_A0.5510.27
53_V131_T0.5490.27
105_Y130_E0.5460.26
53_V154_A0.5440.26
74_N166_Y0.5440.26
40_A158_L0.5430.26
42_V148_S0.5420.26
8_V14_F0.5400.26
94_L146_R0.5400.26
16_Y44_L0.5350.26
9_F157_E0.5310.25
167_S196_S0.5300.25
64_L136_V0.5300.25
34_L162_E0.5290.25
9_F25_E0.5250.25
30_F156_V0.5210.25
156_V168_A0.5210.25
180_R183_M0.5210.25
192_V196_S0.5170.24
91_G162_E0.5150.24
23_S175_R0.5150.24
47_N165_I0.5140.24
148_S158_L0.5130.24
135_T191_F0.5090.24
99_R144_E0.5060.24
58_Q69_P0.5050.24
78_G103_L0.5030.24
74_N105_Y0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u0aA 4 0.4949 2 0.962 Contact Map
3mtxA 1 0.4495 1.7 0.963 Contact Map
3m7oA 3 0.4545 1.7 0.963 Contact Map
1c8uA 2 0.4848 1.7 0.964 Contact Map
3vq2C 1 0.4495 1.4 0.965 Contact Map
3webA 1 0.4545 1.4 0.965 Contact Map
4r9zA 2 0.4495 1.3 0.966 Contact Map
1ou9A 4 0.4545 1.3 0.966 Contact Map
1yfnA 2 0.4495 1.2 0.966 Contact Map
4kt0J 1 0.1162 1.2 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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