GREMLIN Database
LtrA - Bacterial low temperature requirement A protein (LtrA)
PFAM: PF06772 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 353 (347)
Sequences: 8272 (6041)
Seq/√Len: 324.3
META: 0.731

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_L152_L3.7551.00
84_E89_R3.5421.00
94_A142_A3.1521.00
182_E186_L3.1401.00
101_R160_D2.9951.00
27_D32_G2.8881.00
73_A220_L2.8241.00
27_D35_R2.6101.00
230_Y259_H2.5521.00
69_L224_A2.5401.00
234_A239_E2.5261.00
130_G164_V2.3641.00
226_L269_V2.3441.00
31_G35_R2.2731.00
234_A237_A2.2671.00
335_L339_A2.2521.00
239_E243_R2.2181.00
144_L148_A2.1791.00
84_E87_G2.1491.00
321_G351_L2.1381.00
4_P185_G2.1261.00
121_R125_R2.1121.00
90_G142_A2.0991.00
25_A274_E2.0951.00
122_R126_R2.0661.00
17_V187_F2.0461.00
279_H282_E2.0241.00
95_L99_V1.9841.00
235_A238_A1.9441.00
91_L95_L1.9421.00
136_V140_A1.9221.00
220_L224_A1.8461.00
115_D120_R1.8361.00
218_L342_A1.7851.00
210_A213_V1.7791.00
151_A155_V1.7751.00
258_L261_P1.7671.00
188_V262_L1.7671.00
308_R312_G1.7601.00
137_L156_A1.7551.00
269_V296_V1.7451.00
235_A239_E1.7431.00
123_A126_R1.7391.00
137_L155_V1.7331.00
234_A238_A1.7261.00
238_A241_A1.7201.00
258_L305_A1.7131.00
150_L154_A1.7031.00
41_F260_L1.6941.00
148_A151_A1.6931.00
336_P339_A1.6721.00
286_L290_L1.6591.00
112_A125_R1.6591.00
188_V266_I1.6541.00
30_W34_L1.6521.00
72_M220_L1.6491.00
41_F161_L1.6381.00
261_P302_G1.6301.00
243_R246_R1.6111.00
319_L323_A1.6081.00
77_V96_A1.6071.00
323_A327_A1.5901.00
70_V103_G1.5511.00
184_Y256_G1.5351.00
317_S320_V1.5321.00
73_A217_V1.5291.00
65_R228_W1.5291.00
122_R125_R1.5261.00
254_A306_F1.5261.00
74_G99_V1.5241.00
318_R321_G1.5231.00
22_H26_H1.5181.00
24_L36_F1.5181.00
134_A159_I1.5161.00
78_L96_A1.5161.00
20_L39_L1.5011.00
147_P151_A1.5001.00
265_G302_G1.5001.00
188_V263_V1.4691.00
242_L245_A1.4641.00
9_F71_Q1.4571.00
23_L39_L1.4561.00
308_R314_L1.4501.00
254_A310_L1.4481.00
28_L291_A1.4331.00
120_R123_A1.4271.00
253_D309_R1.4181.00
238_A242_L1.4181.00
121_R124_A1.4081.00
105_V132_L1.3971.00
222_L269_V1.3941.00
141_G152_L1.3811.00
147_P150_L1.3791.00
188_V259_H1.3451.00
98_V135_A1.3401.00
140_A144_L1.3401.00
37_L264_A1.3261.00
245_A250_L1.3201.00
325_L344_L1.3151.00
145_P149_R1.3071.00
315_S318_R1.3071.00
241_A245_A1.3051.00
78_L93_F1.2961.00
98_V102_V1.2901.00
337_A341_L1.2891.00
275_L288_A1.2861.00
74_G100_V1.2851.00
338_L341_L1.2821.00
94_A138_W1.2781.00
163_A166_L1.2771.00
242_L246_R1.2731.00
123_A127_Y1.2671.00
336_P340_L1.2661.00
57_F120_R1.2601.00
327_A330_P1.2561.00
12_V72_M1.2531.00
38_L150_L1.2451.00
311_R315_S1.2441.00
41_F157_L1.2341.00
15_F200_G1.2291.00
46_A100_V1.2271.00
316_R319_L1.2161.00
94_A141_G1.2151.00
165_P168_G1.2111.00
102_V106_A1.2081.00
132_L136_V1.2031.00
42_A138_W1.2011.00
77_V92_V1.2011.00
20_L36_F1.1951.00
40_F264_A1.1911.00
293_A297_A1.1911.00
272_G292_L1.1871.00
94_A98_V1.1831.00
151_A154_A1.1781.00
241_A246_R1.1721.00
226_L299_Y1.1641.00
140_A143_F1.1611.00
236_A239_E1.1611.00
31_G34_L1.1521.00
57_F111_A1.1491.00
209_T212_L1.1491.00
34_L150_L1.1421.00
239_E242_L1.1401.00
133_V137_L1.1371.00
331_L335_L1.1321.00
43_V78_L1.1231.00
294_G298_L1.1221.00
92_V213_V1.1201.00
240_R244_S1.1131.00
222_L345_A1.1091.00
137_L159_I1.1091.00
313_R316_R1.1061.00
146_G149_R1.1001.00
27_D31_G1.0941.00
211_G214_A1.0931.00
141_G149_R1.0911.00
16_A43_V1.0861.00
74_G96_A1.0861.00
91_L143_F1.0811.00
105_V131_F1.0721.00
129_V164_V1.0691.00
191_A266_I1.0671.00
213_V217_V1.0601.00
219_G273_L1.0521.00
53_L57_F1.0451.00
191_A267_V1.0441.00
316_R320_V1.0441.00
51_T54_T1.0421.00
195_S223_A1.0401.00
8_F11_L1.0391.00
85_A93_F1.0341.00
285_P288_A1.0331.00
50_Y64_V1.0321.00
65_R232_D1.0291.00
302_G306_F1.0281.00
321_G324_A1.0251.00
101_R105_V1.0231.00
128_A132_L1.0211.00
322_A326_L1.0201.00
311_R314_L1.0181.00
40_F44_W1.0171.00
57_F64_V1.0131.00
234_A241_A1.0111.00
340_L343_L1.0011.00
144_L149_R0.9901.00
56_A108_Y0.9891.00
153_W157_L0.9871.00
105_V128_A0.9871.00
67_L107_L0.9851.00
77_V99_V0.9831.00
36_F267_V0.9821.00
154_A158_A0.9811.00
199_I202_G0.9801.00
200_G204_A0.9791.00
23_L27_D0.9751.00
325_L332_A0.9701.00
85_A153_W0.9681.00
223_A273_L0.9661.00
23_L36_F0.9651.00
98_V136_V0.9641.00
229_L300_L0.9621.00
339_A342_A0.9581.00
339_A343_L0.9561.00
289_A293_A0.9531.00
107_L111_A0.9461.00
331_L334_A0.9451.00
326_L330_P0.9431.00
333_L340_L0.9371.00
39_L85_A0.9341.00
84_E88_D0.9321.00
215_A276_A0.9321.00
152_L156_A0.9301.00
5_L69_L0.9291.00
134_A160_D0.9281.00
226_L266_I0.9251.00
39_L82_I0.9241.00
134_A156_A0.9221.00
265_G298_L0.9211.00
272_G295_G0.9191.00
210_A214_A0.9191.00
28_L271_A0.9171.00
225_A349_V0.9131.00
34_L37_L0.9071.00
60_D65_R0.9051.00
282_E337_A0.9011.00
241_A244_S0.9011.00
91_L142_A0.8991.00
290_L294_G0.8991.00
144_L147_P0.8991.00
308_R311_R0.8971.00
45_W257_Y0.8961.00
341_L345_A0.8961.00
129_V133_V0.8921.00
198_A274_E0.8921.00
81_A92_V0.8901.00
74_G103_G0.8861.00
221_V349_V0.8861.00
284_L289_A0.8861.00
7_L14_V0.8851.00
332_A340_L0.8851.00
35_R150_L0.8841.00
34_L154_A0.8831.00
15_F18_T0.8791.00
146_G151_A0.8791.00
97_Y228_W0.8791.00
326_L329_L0.8771.00
297_A322_A0.8761.00
73_A77_V0.8751.00
24_L271_A0.8741.00
226_L296_V0.8731.00
315_S319_L0.8721.00
299_Y303_L0.8711.00
29_T32_G0.8701.00
6_E179_H0.8691.00
61_D110_R0.8691.00
38_L153_W0.8681.00
320_V324_A0.8651.00
304_A322_A0.8631.00
302_G305_A0.8621.00
134_A164_V0.8591.00
67_L103_G0.8541.00
298_L302_G0.8481.00
48_V256_G0.8461.00
321_G347_V0.8451.00
150_L157_L0.8441.00
125_R129_V0.8441.00
91_L139_L0.8431.00
92_V95_L0.8421.00
33_L37_L0.8411.00
258_L309_R0.8401.00
200_G207_G0.8401.00
333_L336_P0.8401.00
48_V51_T0.8401.00
165_P170_R0.8351.00
310_L315_S0.8341.00
314_L317_S0.8291.00
175_V248_G0.8211.00
335_L340_L0.8211.00
192_L223_A0.8191.00
35_R86_F0.8171.00
234_A240_R0.8161.00
308_R313_R0.8161.00
62_G66_L0.8151.00
66_L70_V0.8151.00
200_G206_L0.8091.00
313_R317_S0.8091.00
196_I223_A0.8081.00
25_A275_L0.8081.00
204_A207_G0.8071.00
291_A295_G0.8051.00
318_R330_P0.8001.00
24_L33_L0.7981.00
330_P334_A0.7971.00
105_V109_L0.7931.00
42_A93_F0.7901.00
43_V82_I0.7891.00
221_V345_A0.7881.00
139_L143_F0.7881.00
98_V142_A0.7881.00
333_L342_A0.7851.00
237_A241_A0.7781.00
335_L338_L0.7771.00
129_V132_L0.7751.00
15_F196_I0.7741.00
324_A328_L0.7691.00
70_V99_V0.7681.00
14_V186_L0.7671.00
287_A291_A0.7661.00
328_L332_A0.7661.00
22_H25_A0.7651.00
199_I207_G0.7631.00
199_I223_A0.7621.00
195_S198_A0.7610.99
101_R104_L0.7590.99
271_A275_L0.7570.99
278_A281_G0.7560.99
343_L347_V0.7550.99
164_V167_L0.7540.99
113_R116_P0.7510.99
126_R171_R0.7510.99
102_V132_L0.7450.99
94_A153_W0.7420.99
320_V323_A0.7410.99
23_L35_R0.7400.99
236_A241_A0.7380.99
196_I220_L0.7370.99
262_L306_F0.7350.99
6_E10_D0.7340.99
133_V136_V0.7330.99
288_A292_L0.7300.99
330_P333_L0.7260.99
138_W156_A0.7260.99
4_P8_F0.7260.99
120_R124_A0.7260.99
336_P344_L0.7250.99
332_A335_L0.7230.99
152_L155_V0.7200.99
341_L346_A0.7200.99
18_T197_V0.7190.99
126_R167_L0.7180.99
237_A240_R0.7140.99
293_A344_L0.7140.99
222_L225_A0.7140.99
328_L331_L0.7130.99
228_W231_F0.7130.99
190_I274_E0.7120.99
22_H274_E0.7110.99
309_R312_G0.7100.99
310_L313_R0.7100.99
109_L128_A0.7090.99
142_A145_P0.7060.99
218_L221_V0.7050.99
265_G269_V0.7040.99
58_D64_V0.7040.99
149_R160_D0.7030.99
217_V221_V0.7000.99
37_L260_L0.6990.99
332_A343_L0.6980.99
325_L329_L0.6980.99
141_G144_L0.6980.99
336_P341_L0.6980.99
91_L94_A0.6950.99
19_Q22_H0.6890.99
240_R243_R0.6880.99
340_L348_L0.6880.99
7_L11_L0.6860.99
278_A282_E0.6840.99
341_L344_L0.6840.99
67_L110_R0.6830.99
332_A336_P0.6830.99
24_L28_L0.6820.99
46_A75_V0.6820.99
28_L287_A0.6790.99
92_V96_A0.6780.99
50_Y54_T0.6760.99
334_A338_L0.6710.99
133_V164_V0.6690.99
26_H30_W0.6680.99
89_R208_L0.6670.99
191_A263_V0.6660.99
44_W260_L0.6650.99
24_L268_A0.6650.99
161_L260_L0.6650.99
244_S247_R0.6640.99
288_A291_A0.6610.99
338_L342_A0.6600.99
324_A330_P0.6590.99
140_A152_L0.6590.99
286_L289_A0.6580.99
336_P345_A0.6580.99
297_A301_L0.6560.99
115_D174_P0.6550.98
49_G104_L0.6540.98
90_G94_A0.6540.98
290_L293_A0.6540.98
315_S321_G0.6540.98
105_V108_Y0.6510.98
304_A314_L0.6490.98
262_L302_G0.6480.98
17_V191_A0.6480.98
25_A271_A0.6470.98
14_V197_V0.6460.98
229_L303_L0.6450.98
303_L307_R0.6410.98
59_P68_L0.6400.98
236_A240_R0.6400.98
206_L209_T0.6380.98
293_A329_L0.6370.98
32_G35_R0.6360.98
290_L329_L0.6330.98
71_Q100_V0.6310.98
76_L200_G0.6280.98
5_L68_L0.6270.98
344_L348_L0.6270.98
284_L337_A0.6260.98
15_F20_L0.6220.98
228_W232_D0.6180.98
17_V22_H0.6180.98
293_A296_V0.6160.98
334_A343_L0.6160.98
7_L10_D0.6140.98
279_H285_P0.6120.98
235_A242_L0.6110.98
293_A332_A0.6110.98
55_N179_H0.6060.98
55_N175_V0.6050.97
334_A339_A0.6050.97
325_L330_P0.6030.97
225_A348_L0.6020.97
252_R256_G0.6020.97
98_V139_L0.6010.97
255_Y306_F0.6000.97
72_M79_A0.5960.97
90_G149_R0.5880.97
334_A341_L0.5870.97
2_V51_T0.5870.97
46_A49_G0.5850.97
3_T60_D0.5850.97
30_W33_L0.5840.97
61_D64_V0.5840.97
141_G145_P0.5800.97
338_L345_A0.5760.97
289_A333_L0.5740.97
57_F115_D0.5740.97
163_A167_L0.5730.97
93_F153_W0.5720.96
156_A160_D0.5700.96
168_G171_R0.5690.96
131_F135_A0.5680.96
337_A340_L0.5660.96
61_D65_R0.5660.96
38_L141_G0.5660.96
38_L42_A0.5650.96
238_A306_F0.5650.96
345_A349_V0.5640.96
321_G325_L0.5640.96
145_P148_A0.5630.96
328_L340_L0.5570.96
27_D30_W0.5550.96
52_W56_A0.5540.96
76_L196_I0.5530.96
134_A137_L0.5520.96
304_A319_L0.5520.96
317_S322_A0.5510.96
283_P288_A0.5500.96
285_P289_A0.5500.96
316_R321_G0.5500.96
15_F19_Q0.5480.96
175_V251_A0.5470.95
199_I206_L0.5460.95
148_A152_L0.5450.95
111_A124_A0.5440.95
99_V103_G0.5420.95
342_A345_A0.5410.95
342_A346_A0.5390.95
106_A110_R0.5390.95
71_Q107_L0.5390.95
226_L348_L0.5380.95
303_L306_F0.5380.95
314_L321_G0.5360.95
291_A294_G0.5360.95
64_V107_L0.5350.95
155_V159_I0.5340.95
46_A101_R0.5340.95
335_L343_L0.5330.95
312_G319_L0.5320.95
166_L169_R0.5310.95
340_L351_L0.5290.95
246_R249_R0.5280.95
104_L131_F0.5270.94
98_V104_L0.5260.94
112_A128_A0.5240.94
339_A346_A0.5230.94
49_G131_F0.5220.94
307_R315_S0.5220.94
322_A325_L0.5200.94
167_L171_R0.5190.94
317_S321_G0.5190.94
15_F76_L0.5190.94
311_R317_S0.5180.94
307_R313_R0.5160.94
105_V135_A0.5150.94
324_A327_A0.5140.94
308_R318_R0.5130.94
313_R325_L0.5110.94
216_A274_E0.5080.93
327_A331_L0.5080.93
304_A315_S0.5080.93
312_G317_S0.5070.93
345_A351_L0.5070.93
181_A235_A0.5070.93
112_A117_A0.5050.93
14_V194_E0.5050.93
289_A332_A0.5050.93
337_A348_L0.5040.93
59_P62_G0.5040.93
187_F191_A0.5040.93
108_Y120_R0.5020.93
45_W48_V0.5010.93
215_A277_L0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m64A 1 0.8385 10.6 0.962 Contact Map
2cfqA 1 0.8442 9.8 0.963 Contact Map
4w6vA 1 0.3314 9.5 0.963 Contact Map
3wdoA 1 0.3173 6.9 0.965 Contact Map
2gfpA 2 0.8159 6.7 0.966 Contact Map
4tphA 2 0.3059 5 0.968 Contact Map
2htgA 1 0.0765 4.8 0.968 Contact Map
4xnjA 1 0.3173 4.6 0.968 Contact Map
3m73A 3 0.762 3.7 0.97 Contact Map
4q65A 1 0.2975 3.1 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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