GREMLIN Database
LMF1 - Lipase maturation factor
PFAM: PF06762 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 416 (397)
Sequences: 1414 (1118)
Seq/√Len: 56.1
META: 0.809

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_W47_R4.8321.00
231_L234_V4.5201.00
392_T395_E4.2051.00
74_Y95_H3.9931.00
54_V58_L3.1441.00
59_S285_A2.9691.00
87_A138_T2.9581.00
241_A245_L2.8441.00
229_L234_V2.7571.00
240_Y244_A2.7501.00
242_T246_L2.6821.00
246_L249_M2.6811.00
229_L233_F2.6761.00
245_L249_M2.6751.00
228_A231_L2.6131.00
241_A244_A2.5491.00
226_L229_L2.5281.00
245_L248_F2.4901.00
242_T245_L2.4871.00
243_A246_L2.4751.00
318_L401_A2.4531.00
240_Y246_L2.4421.00
240_Y245_L2.4421.00
227_V231_L2.3231.00
230_L233_F2.3221.00
241_A246_L2.3001.00
63_T289_R2.2931.00
228_A234_V2.2741.00
74_Y98_T2.2401.00
228_A233_F2.2341.00
55_V285_A2.1981.00
261_L264_P2.1961.00
298_G373_F2.1811.00
264_P268_P2.1451.00
100_A104_A2.1421.00
14_F18_F2.1191.00
71_D92_H2.1181.00
67_L100_A2.0381.00
226_L231_L2.0361.00
300_N376_A2.0321.00
293_E314_K2.0321.00
248_F251_S2.0251.00
67_L99_V2.0111.00
226_L234_V2.0111.00
227_V233_F1.9981.00
244_A248_F1.9921.00
185_V188_F1.9891.00
294_I383_A1.9821.00
110_P124_C1.9361.00
93_W97_A1.9291.00
342_G347_N1.9241.00
101_A105_L1.8630.99
74_Y94_F1.8500.99
227_V234_V1.8450.99
244_A249_M1.8440.99
259_P262_L1.8320.99
181_A184_T1.8100.99
320_R323_G1.8090.99
19_F38_L1.8040.99
352_R356_R1.8020.99
244_A247_L1.7780.99
240_Y243_A1.7680.99
223_A234_V1.7680.99
109_L127_I1.7440.99
226_L233_F1.7370.99
352_R355_E1.7360.99
313_Y323_G1.7330.99
229_L232_V1.7280.99
55_V59_S1.7270.99
246_L250_L1.7090.99
242_T249_M1.6980.99
14_F277_I1.6920.99
129_T149_L1.6670.99
125_F156_L1.6590.99
296_F350_V1.6300.99
92_H96_A1.6180.99
98_T134_G1.6170.99
105_L131_L1.6140.99
95_H98_T1.5960.98
242_T248_F1.5950.98
131_L135_I1.5900.98
298_G309_Y1.5700.98
173_P177_R1.5660.98
101_A135_I1.5590.98
391_T401_A1.5470.98
142_T329_Q1.5430.98
11_E47_R1.5340.98
132_Q150_A1.5330.98
227_V230_L1.5240.98
223_A230_L1.5170.98
225_A229_L1.5120.98
241_A249_M1.5100.98
241_A248_F1.5010.98
230_L234_V1.4980.98
245_L250_L1.4870.97
108_V112_M1.4800.97
126_F160_F1.4780.97
296_F353_T1.4720.97
223_A231_L1.4690.97
71_D96_A1.4660.97
225_A232_V1.4620.97
59_S286_V1.4500.97
394_A398_A1.4450.97
247_L250_L1.4320.97
172_L175_L1.4300.97
241_A247_L1.4250.97
240_Y248_F1.4190.97
338_F341_L1.4140.97
105_L135_I1.4080.96
243_A247_L1.3970.96
63_T66_N1.3950.96
19_F34_S1.3940.96
38_L42_R1.3840.96
223_A228_A1.3820.96
75_Q88_Q1.3640.96
142_T147_L1.3620.96
247_L251_S1.3480.95
70_M74_Y1.3470.95
82_W324_I1.3450.95
296_F336_L1.3320.95
115_L120_L1.3300.95
227_V232_V1.3270.95
391_T399_T1.3150.95
356_R361_D1.2940.94
77_Q139_G1.2910.94
19_F154_L1.2790.94
391_T404_R1.2770.94
309_Y371_N1.2730.94
260_P264_P1.2700.94
298_G372_P1.2690.94
251_S254_P1.2690.94
97_A100_A1.2680.94
384_V407_L1.2680.94
8_M48_I1.2650.94
258_V262_L1.2570.93
221_A233_F1.2550.93
223_A233_F1.2540.93
221_A229_L1.2500.93
244_A250_L1.2360.93
354_E412_A1.2320.93
354_E383_A1.2110.92
244_A251_S1.2060.92
343_S346_Q1.2010.92
240_Y247_L1.2000.92
259_P263_S1.1980.92
299_S302_G1.1960.92
252_L256_A1.1900.91
258_V261_L1.1820.91
228_A232_V1.1730.91
380_Y416_E1.1590.90
353_T368_F1.1560.90
113_L124_C1.1550.90
14_F17_L1.1530.90
118_R157_D1.1440.90
252_L255_L1.1420.90
320_R369_A1.1390.89
395_E404_R1.1340.89
97_A101_A1.1340.89
94_F98_T1.1340.89
373_F377_P1.1320.89
83_I137_L1.1290.89
5_W8_M1.1290.89
242_T247_L1.1270.89
11_E15_L1.1250.89
350_V353_T1.1210.89
223_A227_V1.1040.88
214_L217_V1.1020.88
216_R219_A1.1010.88
317_D401_A1.1010.88
243_A248_F1.1010.88
44_L47_R1.1000.88
298_G371_N1.0990.88
317_D320_R1.0960.88
240_Y249_M1.0910.87
261_L268_P1.0860.87
100_A108_V1.0860.87
356_R359_E1.0820.87
58_L99_V1.0800.87
201_S204_A1.0760.87
337_W341_L1.0750.87
184_T187_L1.0740.87
213_W220_A1.0720.86
326_A329_Q1.0700.86
297_Q308_A1.0690.86
319_N401_A1.0690.86
248_F255_L1.0650.86
222_L229_L1.0640.86
89_H393_P1.0570.86
297_Q384_V1.0570.86
226_L232_V1.0570.86
224_L229_L1.0510.85
195_E198_P1.0480.85
34_S37_S1.0170.83
73_Y77_Q1.0090.83
118_R122_I1.0040.83
243_A249_M1.0030.83
42_R113_L1.0010.82
343_S347_N0.9970.82
14_F371_N0.9950.82
136_I149_L0.9930.82
104_A109_L0.9880.82
73_Y139_G0.9850.81
15_L37_S0.9790.81
181_A185_V0.9780.81
313_Y330_P0.9700.80
348_P352_R0.9680.80
309_Y373_F0.9680.80
99_V103_L0.9670.80
279_N346_Q0.9660.80
101_A131_L0.9640.80
131_L395_E0.9630.80
334_W337_W0.9610.80
296_F354_E0.9580.79
242_T250_L0.9580.79
25_R30_R0.9530.79
58_L285_A0.9480.79
250_L255_L0.9470.79
70_M98_T0.9460.79
125_F129_T0.9450.79
283_L287_M0.9360.78
173_P176_V0.9350.78
250_L256_A0.9330.78
72_Y289_R0.9310.78
389_W404_R0.9290.77
347_N411_Y0.9290.77
144_L335_N0.9280.77
248_F252_L0.9270.77
358_L381_V0.9270.77
323_G333_D0.9220.77
234_V240_Y0.9200.77
128_V132_Q0.9190.77
81_T141_Y0.9140.76
220_A233_F0.9090.76
371_N375_D0.9060.76
99_V352_R0.9040.75
49_Y73_Y0.9010.75
54_V132_Q0.8990.75
249_M252_L0.8960.75
216_R222_L0.8960.75
246_L251_S0.8910.74
48_I144_L0.8880.74
120_L123_V0.8870.74
221_A226_L0.8860.74
311_F368_F0.8850.74
97_A126_F0.8810.74
67_L96_A0.8790.73
371_N374_P0.8750.73
223_A229_L0.8740.73
72_Y75_Q0.8730.73
309_Y372_P0.8660.72
211_R215_R0.8630.72
259_P264_P0.8630.72
290_G349_W0.8620.72
220_A229_L0.8620.72
226_L230_L0.8610.72
225_A231_L0.8590.72
251_S255_L0.8580.72
19_F41_L0.8570.71
221_A231_L0.8480.71
192_A218_L0.8460.70
342_G346_Q0.8450.70
66_N99_V0.8440.70
316_Q320_R0.8440.70
225_A233_F0.8430.70
220_A234_V0.8390.70
131_L290_G0.8380.70
221_A227_V0.8310.69
245_L251_S0.8300.69
221_A230_L0.8290.69
183_G189_P0.8290.69
219_A223_A0.8270.69
316_Q336_L0.8260.69
177_R180_L0.8220.68
5_W144_L0.8210.68
48_I325_Y0.8210.68
197_G203_T0.8190.68
23_G26_P0.8190.68
4_Q8_M0.8160.68
284_F287_M0.8130.67
221_A228_A0.8120.67
388_Y405_R0.8090.67
183_G188_F0.8080.67
296_F368_F0.8080.67
209_R213_W0.8070.67
396_K399_T0.8030.66
334_W338_F0.8030.66
221_A234_V0.7980.66
75_Q389_W0.7960.66
97_A134_G0.7950.66
202_A205_F0.7880.65
287_M334_W0.7860.65
213_W217_V0.7840.65
82_W323_G0.7830.64
260_P263_S0.7820.64
285_A303_Q0.7800.64
203_T208_S0.7780.64
249_M255_L0.7780.64
11_E16_A0.7760.64
131_L349_W0.7740.64
62_P66_N0.7740.64
219_A234_V0.7730.63
223_A232_V0.7710.63
219_A222_L0.7700.63
60_G65_R0.7690.63
283_L288_T0.7680.63
47_R57_L0.7660.63
54_V352_R0.7650.63
109_L132_Q0.7640.63
288_T341_L0.7630.62
195_E207_P0.7600.62
241_A252_L0.7560.62
3_Y335_N0.7550.62
55_V132_Q0.7540.62
219_A227_V0.7520.61
249_M256_A0.7500.61
73_Y282_G0.7490.61
172_L176_V0.7440.60
224_L233_F0.7420.60
72_Y76_N0.7390.60
42_R45_W0.7370.60
355_E359_E0.7360.60
136_I146_Y0.7360.60
105_L395_E0.7350.60
41_L154_L0.7320.59
63_T105_L0.7320.59
87_A90_L0.7310.59
360_N371_N0.7310.59
218_L227_V0.7290.59
120_L414_T0.7270.59
383_A410_L0.7260.59
9_L13_G0.7250.58
131_L289_R0.7240.58
63_T72_Y0.7230.58
38_L154_L0.7210.58
310_P370_G0.7180.58
282_G287_M0.7170.58
99_V134_G0.7170.58
96_A99_V0.7170.58
220_A227_V0.7150.57
81_T84_G0.7120.57
109_L124_C0.7090.57
200_S205_F0.7090.57
241_A250_L0.7080.57
37_S41_L0.7080.57
217_V234_V0.7080.57
298_G377_P0.7050.56
354_E381_V0.7040.56
288_T337_W0.7020.56
57_L65_R0.7000.56
52_S69_A0.6990.56
282_G339_A0.6960.55
283_L341_L0.6950.55
182_R185_V0.6950.55
184_T190_L0.6930.55
362_P366_A0.6930.55
225_A230_L0.6910.55
241_A251_S0.6900.55
11_E44_L0.6890.55
222_L227_V0.6880.55
104_A108_V0.6880.55
335_N340_S0.6850.54
62_P72_Y0.6850.54
183_G187_L0.6830.54
253_V256_A0.6810.54
19_F37_S0.6800.54
58_L289_R0.6800.54
76_N325_Y0.6800.54
62_P289_R0.6790.54
173_P181_A0.6780.53
217_V220_A0.6770.53
191_E318_L0.6770.53
219_A232_V0.6770.53
180_L216_R0.6770.53
142_T280_R0.6770.53
222_L231_L0.6760.53
68_T99_V0.6760.53
248_F256_A0.6760.53
4_Q52_S0.6740.53
311_F314_K0.6730.53
207_P215_R0.6730.53
222_L233_F0.6700.53
9_L147_L0.6680.52
112_M120_L0.6680.52
287_M338_F0.6670.52
49_Y152_G0.6660.52
75_Q141_Y0.6660.52
5_W148_V0.6650.52
141_Y283_L0.6640.52
210_F216_R0.6630.52
208_S212_R0.6610.52
85_W89_H0.6610.52
243_A250_L0.6610.52
55_V58_L0.6610.52
52_S144_L0.6610.52
34_S42_R0.6600.52
188_F193_S0.6590.51
221_A225_A0.6570.51
184_T188_F0.6560.51
234_V241_A0.6550.51
3_Y8_M0.6520.51
111_W347_N0.6500.50
43_W57_L0.6470.50
280_R346_Q0.6460.50
288_T338_F0.6450.50
242_T251_S0.6440.50
174_L177_R0.6400.49
284_F337_W0.6400.49
45_W49_Y0.6390.49
199_V205_F0.6380.49
85_W391_T0.6380.49
105_L289_R0.6380.49
81_T326_A0.6360.49
180_L183_G0.6350.49
387_Q408_L0.6340.49
210_F217_V0.6330.49
53_G56_K0.6330.49
112_M124_C0.6330.49
211_R219_A0.6300.48
349_W392_T0.6300.48
143_F147_L0.6270.48
344_W347_N0.6260.48
116_P120_L0.6260.48
181_A186_R0.6250.48
84_G329_Q0.6240.48
105_L349_W0.6240.48
346_Q355_E0.6220.47
127_I130_P0.6220.47
400_G409_G0.6220.47
203_T206_T0.6210.47
70_M73_Y0.6210.47
194_A197_G0.6210.47
287_M337_W0.6200.47
189_P216_R0.6190.47
13_G329_Q0.6180.47
153_L320_R0.6170.47
185_V191_E0.6150.47
401_A404_R0.6150.47
333_D370_G0.6150.47
217_V221_A0.6140.47
55_V280_R0.6130.46
187_L190_L0.6130.46
258_V263_S0.6120.46
360_N393_P0.6100.46
38_L394_A0.6090.46
293_E311_F0.6070.46
215_R219_A0.6060.46
412_A415_L0.6040.45
213_W222_L0.6030.45
286_V333_D0.5990.45
124_C142_T0.5970.45
215_R220_A0.5960.45
410_L414_T0.5960.45
386_Y405_R0.5950.44
222_L226_L0.5940.44
46_F157_D0.5940.44
214_L218_L0.5940.44
256_A262_L0.5910.44
294_I353_T0.5910.44
188_F192_A0.5910.44
220_A228_A0.5900.44
336_L350_V0.5890.44
219_A230_L0.5890.44
392_T404_R0.5890.44
247_L348_P0.5880.44
73_Y76_N0.5870.44
32_P345_R0.5870.44
294_I339_A0.5870.44
113_L128_V0.5870.44
292_Y340_S0.5860.44
193_S208_S0.5860.44
193_S201_S0.5850.43
225_A228_A0.5840.43
244_A252_L0.5840.43
160_F342_G0.5840.43
260_P268_P0.5840.43
318_L393_P0.5830.43
255_L262_L0.5820.43
4_Q330_P0.5820.43
118_R158_D0.5820.43
45_W48_I0.5820.43
273_E414_T0.5810.43
45_W151_L0.5800.43
5_W9_L0.5780.43
190_L195_E0.5780.43
6_D9_L0.5770.43
288_T336_L0.5770.43
284_F338_F0.5770.43
247_L255_L0.5750.42
130_P321_A0.5730.42
362_P374_P0.5730.42
79_L330_P0.5730.42
322_P390_F0.5730.42
251_S256_A0.5720.42
158_D309_Y0.5720.42
49_Y106_E0.5720.42
353_T357_L0.5700.42
216_R228_A0.5700.42
175_L178_G0.5690.42
185_V189_P0.5690.42
109_L128_V0.5670.41
284_F288_T0.5640.41
215_R233_F0.5640.41
5_W335_N0.5620.41
205_F217_V0.5610.41
220_A231_L0.5600.41
73_Y287_M0.5600.41
309_Y378_P0.5590.41
249_M253_V0.5590.41
199_V203_T0.5560.40
222_L225_A0.5560.40
87_A134_G0.5550.40
135_I351_P0.5520.40
360_N365_L0.5520.40
245_L255_L0.5480.40
282_G334_W0.5460.39
207_P210_F0.5460.39
376_A414_T0.5450.39
221_A232_V0.5440.39
123_V207_P0.5430.39
193_S202_A0.5420.39
412_A416_E0.5420.39
122_I160_F0.5410.39
291_R314_K0.5410.39
176_V180_L0.5400.39
372_P377_P0.5390.39
66_N142_T0.5390.39
217_V222_L0.5380.38
131_L392_T0.5380.38
383_A411_Y0.5380.38
160_F163_R0.5380.38
225_A234_V0.5380.38
310_P320_R0.5360.38
205_F209_R0.5350.38
75_Q325_Y0.5350.38
184_T192_A0.5340.38
145_N282_G0.5330.38
310_P316_Q0.5320.38
56_K64_W0.5310.38
212_R216_R0.5290.38
348_P386_Y0.5280.37
176_V179_A0.5280.37
351_P392_T0.5270.37
203_T218_L0.5260.37
105_L379_R0.5260.37
55_V283_L0.5250.37
37_S71_D0.5250.37
206_T209_R0.5240.37
289_R410_L0.5230.37
66_N70_M0.5230.37
350_V354_E0.5220.37
91_P107_L0.5220.37
69_A283_L0.5210.37
209_R220_A0.5210.37
63_T69_A0.5210.37
208_S213_W0.5210.37
224_L231_L0.5200.37
246_L252_L0.5200.37
217_V223_A0.5190.37
391_T395_E0.5190.37
89_H95_H0.5170.36
349_W353_T0.5170.36
164_L173_P0.5170.36
85_W402_W0.5170.36
408_L412_A0.5150.36
13_G18_F0.5150.36
282_G288_T0.5150.36
394_A399_T0.5150.36
220_A223_A0.5150.36
190_L193_S0.5140.36
4_Q283_L0.5130.36
210_F215_R0.5130.36
351_P412_A0.5130.36
218_L225_A0.5120.36
253_V263_S0.5100.36
395_E415_L0.5100.36
198_P210_F0.5100.36
120_L307_T0.5100.36
215_R218_L0.5100.36
5_W336_L0.5090.36
30_R120_L0.5090.36
374_P377_P0.5080.35
366_A380_Y0.5080.35
145_N334_W0.5060.35
213_W216_R0.5060.35
209_R221_A0.5050.35
5_W77_Q0.5050.35
118_R402_W0.5050.35
63_T290_G0.5050.35
45_W152_G0.5040.35
246_L256_A0.5040.35
298_G378_P0.5040.35
190_L201_S0.5040.35
111_W361_D0.5010.35
51_E54_V0.5010.35
39_F42_R0.5000.35
219_A231_L0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bzyA 2 0.0913 6.4 0.983 Contact Map
1yfnE 1 0.0385 5.5 0.983 Contact Map
4z88A 3 0.101 3.3 0.985 Contact Map
1i1jA 1 0.1418 2.5 0.986 Contact Map
2ed1A 1 0.113 2.4 0.986 Contact Map
2frxA 1 0.1346 2.3 0.986 Contact Map
2nnuB 2 0.0361 1.9 0.987 Contact Map
1ue9A 1 0.1058 1.9 0.987 Contact Map
4j9cA 1 0.0913 1.9 0.987 Contact Map
2fpeA 6 0.0962 1.9 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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