GREMLIN Database
IcmF-related - Intracellular multiplication and human macrophage-killing
PFAM: PF06761 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 309 (304)
Sequences: 4500 (3417)
Seq/√Len: 196.0
META: 0.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_Y260_D5.2351.00
209_D213_E4.4201.00
208_R212_E3.7551.00
84_L150_R3.4971.00
98_K126_A3.4701.00
82_A97_L3.0801.00
269_L304_V2.9571.00
196_S271_D2.9191.00
178_F303_A2.8521.00
32_Q35_K2.7841.00
5_D120_A2.7421.00
277_F286_V2.7101.00
277_F283_A2.5691.00
160_E256_L2.5531.00
61_E142_D2.4531.00
179_T182_D2.4031.00
159_A252_D2.3821.00
206_F260_D2.3561.00
84_L146_V2.3371.00
59_R104_D2.3211.00
88_D91_H2.3061.00
248_A252_D2.2931.00
167_K260_D2.2751.00
137_P140_P2.2441.00
22_A27_R2.2171.00
143_A147_A2.2151.00
272_L300_L2.2141.00
65_R142_D2.1621.00
82_A96_F2.1361.00
124_H128_L2.0981.00
259_A263_A2.0651.00
303_A307_N2.0251.00
7_L47_A2.0201.00
258_F262_I2.0021.00
263_A267_A1.9951.00
194_R271_D1.9721.00
220_D250_A1.8591.00
145_L149_A1.8521.00
177_D201_G1.8441.00
111_G118_R1.7631.00
10_L13_G1.7591.00
178_F183_A1.7501.00
64_L149_A1.7471.00
278_A282_D1.7391.00
245_D248_A1.7281.00
82_A100_W1.7051.00
5_D9_D1.7021.00
85_M93_D1.7011.00
147_A151_A1.6771.00
255_R259_A1.6661.00
72_D75_A1.6591.00
298_L302_R1.6501.00
167_K206_F1.6351.00
282_D286_V1.6291.00
163_Y167_K1.6011.00
56_L101_L1.5971.00
112_D115_A1.5941.00
15_Y18_R1.5911.00
193_T275_V1.5881.00
290_L297_L1.5741.00
57_A61_E1.5581.00
61_E65_R1.5311.00
279_S282_D1.5291.00
224_K228_G1.5281.00
77_Y229_E1.5041.00
114_G117_Q1.4931.00
176_P204_G1.4791.00
203_P264_A1.4701.00
41_R45_F1.4611.00
217_P221_E1.4581.00
138_L141_L1.4511.00
16_G20_D1.4451.00
252_D255_R1.4401.00
121_L124_H1.4351.00
115_A118_R1.4331.00
190_L285_D1.4331.00
193_T273_R1.4271.00
167_K205_L1.4061.00
92_L97_L1.4001.00
184_L188_A1.4001.00
52_L105_W1.3931.00
81_K96_F1.3901.00
256_L260_D1.3801.00
13_G16_G1.3681.00
124_H127_A1.3671.00
113_A116_Q1.3661.00
300_L304_V1.3641.00
175_L204_G1.3611.00
179_T201_G1.3531.00
281_A285_D1.3321.00
211_Y258_F1.3201.00
257_Y261_Y1.3151.00
218_A221_E1.3071.00
44_Y124_H1.3021.00
93_D96_F1.2981.00
22_A31_Y1.2981.00
17_Y20_D1.2871.00
63_Q79_A1.2821.00
275_V282_D1.2771.00
69_A72_D1.2571.00
126_A130_A1.2571.00
162_V222_A1.2411.00
18_R34_D1.2391.00
59_R62_E1.2371.00
201_G271_D1.2291.00
102_A122_L1.2251.00
9_D12_A1.2131.00
23_P26_L1.2091.00
119_E123_A1.1961.00
280_L284_A1.1741.00
262_I266_D1.1711.00
61_E83_Y1.1681.00
5_D8_R1.1611.00
159_A256_L1.1581.00
80_L84_L1.1581.00
170_A214_V1.1551.00
144_A147_A1.1541.00
85_M92_L1.1501.00
44_Y48_L1.1461.00
254_R258_F1.1461.00
77_Y81_K1.1421.00
8_R12_A1.1411.00
111_G117_Q1.1411.00
11_P15_Y1.1371.00
96_F100_W1.1301.00
285_D288_R1.1271.00
84_L232_W1.1191.00
105_W125_L1.1081.00
26_L33_G1.1011.00
60_L79_A1.0991.00
282_D285_D1.0981.00
195_S271_D1.0911.00
192_F272_L1.0801.00
109_L112_D1.0781.00
303_A306_R1.0761.00
7_L10_L1.0761.00
16_G19_R1.0741.00
79_A100_W1.0741.00
81_K233_V1.0731.00
61_E145_L1.0731.00
194_R198_L1.0601.00
48_L53_L1.0601.00
111_G115_A1.0491.00
164_Q168_A1.0441.00
219_I250_A1.0371.00
202_V264_A1.0371.00
77_Y150_R1.0371.00
39_A42_A1.0271.00
209_D307_N1.0261.00
85_M91_H1.0121.00
210_G215_F1.0091.00
122_L126_A1.0091.00
144_A148_Q1.0051.00
111_G114_G1.0021.00
73_P156_L0.9981.00
45_F128_L0.9971.00
62_E66_A0.9891.00
26_L31_Y0.9881.00
24_W27_R0.9851.00
275_V286_V0.9820.99
13_G17_Y0.9790.99
215_F219_I0.9730.99
110_P118_R0.9730.99
284_A291_S0.9720.99
242_S245_D0.9620.99
195_S273_R0.9610.99
22_A33_G0.9550.99
97_L101_L0.9550.99
76_L149_A0.9510.99
3_A6_A0.9510.99
137_P141_L0.9480.99
127_A130_A0.9460.99
194_R201_G0.9420.99
9_D16_G0.9210.99
187_D190_L0.9160.99
25_S28_F0.9150.99
10_L15_Y0.9150.99
206_F264_A0.9100.99
160_E164_Q0.9060.99
150_R232_W0.9060.99
18_R21_G0.9050.99
251_A255_R0.9020.99
148_Q151_A0.9000.99
125_L129_L0.8990.99
58_A61_E0.8980.99
30_L33_G0.8950.99
154_R236_D0.8920.99
46_R50_R0.8910.99
196_S264_A0.8880.99
80_L146_V0.8880.99
281_A284_A0.8870.99
58_A62_E0.8840.99
204_G210_G0.8810.99
286_V289_L0.8800.99
145_L148_Q0.8800.99
76_L152_T0.8760.99
98_K123_A0.8750.99
135_I138_L0.8730.99
77_Y233_V0.8700.99
217_P220_D0.8690.99
207_T261_Y0.8660.99
212_E216_L0.8590.99
192_F274_V0.8540.99
106_Q110_P0.8520.99
53_L128_L0.8510.99
75_A103_R0.8490.99
194_R272_L0.8470.98
260_D264_A0.8450.98
289_L296_P0.8440.98
111_G116_Q0.8400.98
63_Q104_D0.8390.98
81_K229_E0.8380.98
43_A46_R0.8340.98
196_S201_G0.8340.98
184_L192_F0.8300.98
213_E217_P0.8230.98
63_Q75_A0.8220.98
47_A50_R0.8220.98
241_A245_D0.8200.98
12_A16_G0.8180.98
305_A308_T0.8150.98
94_A130_A0.8090.98
125_L128_L0.8090.98
112_D118_R0.8040.98
165_R169_E0.8010.98
151_A155_R0.8000.98
113_A117_Q0.7990.98
260_D263_A0.7960.98
202_V268_F0.7960.98
162_V253_L0.7920.98
221_E224_K0.7900.98
150_R235_G0.7830.97
277_F282_D0.7810.97
122_L125_L0.7780.97
91_H232_W0.7760.97
8_R127_A0.7760.97
267_A271_D0.7760.97
100_W104_D0.7750.97
67_L76_L0.7740.97
6_A10_L0.7720.97
47_A51_L0.7710.97
157_P160_E0.7680.97
75_A78_E0.7590.97
210_G219_I0.7590.97
295_S298_L0.7550.97
208_R306_R0.7550.97
223_A246_P0.7440.97
110_P113_A0.7430.97
7_L11_P0.7370.96
177_D200_E0.7370.96
224_K246_P0.7360.96
150_R233_V0.7360.96
264_A267_A0.7330.96
65_R145_L0.7310.96
274_V277_F0.7310.96
106_Q118_R0.7280.96
83_Y146_V0.7270.96
15_Y19_R0.7270.96
135_I141_L0.7250.96
81_K232_W0.7240.96
180_L184_L0.7240.96
121_L125_L0.7170.96
146_V232_W0.7170.96
80_L233_V0.7150.96
11_P40_A0.7140.96
27_R31_Y0.7130.96
19_R22_A0.7120.96
256_L259_A0.7110.96
226_L229_E0.7100.96
74_E78_E0.7100.96
97_L129_L0.7100.96
64_L79_A0.7100.96
77_Y84_L0.7100.96
8_R11_P0.7080.95
192_F196_S0.7070.95
78_E165_R0.7050.95
243_E246_P0.7050.95
34_D38_A0.7030.95
51_L55_R0.7010.95
123_A126_A0.7000.95
190_L289_L0.6980.95
302_R306_R0.6940.95
37_G41_R0.6930.95
86_L184_L0.6890.95
17_Y21_G0.6880.95
268_F271_D0.6850.95
147_A154_R0.6850.95
180_L272_L0.6820.94
180_L188_A0.6820.94
108_A111_G0.6800.94
288_R292_G0.6780.94
2_P6_A0.6710.94
170_A210_G0.6690.94
240_A243_E0.6690.94
175_L214_V0.6650.94
38_A41_R0.6630.94
10_L26_L0.6620.94
247_A250_A0.6610.93
304_V308_T0.6580.93
101_L104_D0.6540.93
169_E218_A0.6530.93
49_R131_L0.6520.93
44_Y295_S0.6510.93
78_E96_F0.6500.93
74_E164_Q0.6440.93
80_L149_A0.6430.93
183_A303_A0.6430.93
110_P115_A0.6410.92
120_A123_A0.6390.92
185_G190_L0.6370.92
219_I222_A0.6360.92
166_L215_F0.6340.92
83_Y280_L0.6300.92
12_A17_Y0.6300.92
274_V283_A0.6290.92
3_A7_L0.6280.92
89_P126_A0.6250.91
27_R30_L0.6240.91
6_A9_D0.6230.91
261_Y307_N0.6230.91
29_G33_G0.6220.91
288_R291_S0.6220.91
192_F304_V0.6180.91
112_D117_Q0.6170.91
110_P114_G0.6160.91
185_G194_R0.6150.91
23_P27_R0.6120.91
166_L254_R0.6100.90
191_V289_L0.6100.90
196_S267_A0.6090.90
292_G295_S0.6060.90
17_Y23_P0.6050.90
55_R58_A0.6030.90
78_E103_R0.6010.90
47_A72_D0.6010.90
48_L124_H0.5980.90
146_V233_V0.5960.89
73_P152_T0.5950.89
166_L214_V0.5930.89
251_A254_R0.5880.89
249_L252_D0.5870.89
81_K223_A0.5860.89
87_G91_H0.5850.89
220_D238_A0.5850.89
20_D23_P0.5840.88
2_P5_D0.5830.88
223_A253_L0.5830.88
124_H129_L0.5810.88
76_L79_A0.5810.88
52_L125_L0.5800.88
291_S295_S0.5790.88
167_K256_L0.5780.88
215_F254_R0.5770.88
250_A254_R0.5770.88
109_L114_G0.5760.88
216_L254_R0.5740.88
275_V280_L0.5740.88
113_A118_R0.5740.88
297_L300_L0.5730.88
169_E225_Q0.5720.87
158_L226_L0.5720.87
15_Y37_G0.5720.87
227_A230_D0.5710.87
246_P250_A0.5700.87
18_R22_A0.5700.87
52_L104_D0.5690.87
280_L283_A0.5690.87
64_L145_L0.5680.87
114_G243_E0.5640.87
285_D289_L0.5640.87
8_R123_A0.5630.87
154_R237_S0.5630.87
209_D212_E0.5620.87
152_T211_Y0.5610.86
78_E164_Q0.5590.86
178_F207_T0.5580.86
48_L54_P0.5570.86
43_A47_A0.5560.86
258_F261_Y0.5560.86
46_R49_R0.5530.86
167_K170_A0.5520.86
191_V275_V0.5510.85
162_V165_R0.5490.85
96_F101_L0.5480.85
95_A99_A0.5470.85
105_W122_L0.5450.85
261_Y268_F0.5450.85
66_A69_A0.5430.85
207_T210_G0.5430.85
92_L129_L0.5420.85
211_Y254_R0.5410.84
283_A307_N0.5400.84
149_A152_T0.5400.84
241_A244_A0.5390.84
298_L301_L0.5380.84
302_R305_A0.5380.84
22_A25_S0.5380.84
252_D256_L0.5370.84
286_V308_T0.5360.84
197_P200_E0.5360.84
4_L52_L0.5350.84
81_K168_A0.5350.84
279_S283_A0.5340.84
5_D12_A0.5340.84
62_E65_R0.5330.84
82_A101_L0.5310.83
156_L161_R0.5290.83
162_V226_L0.5290.83
116_Q119_E0.5290.83
56_L125_L0.5270.83
239_A243_E0.5260.83
128_L131_L0.5250.83
203_P206_F0.5250.83
83_Y257_Y0.5250.83
185_G196_S0.5240.83
23_P31_Y0.5240.83
287_L291_S0.5230.82
166_L218_A0.5230.82
264_A268_F0.5220.82
188_A198_L0.5220.82
80_L150_R0.5220.82
274_V290_L0.5210.82
186_P193_T0.5210.82
105_W129_L0.5180.82
123_A127_A0.5180.82
209_D306_R0.5180.82
15_Y128_L0.5180.82
109_L116_Q0.5170.82
109_L118_R0.5170.82
181_A188_A0.5170.82
153_L286_V0.5170.82
59_R63_Q0.5170.82
60_L256_L0.5150.81
161_R226_L0.5140.81
159_A253_L0.5130.81
237_S240_A0.5130.81
198_L201_G0.5130.81
214_V218_A0.5130.81
105_W232_W0.5110.81
249_L300_L0.5100.81
205_L215_F0.5100.81
66_A285_D0.5080.81
150_R234_L0.5080.81
298_L303_A0.5070.80
17_Y22_A0.5070.80
135_I207_T0.5070.80
75_A79_A0.5060.80
148_Q152_T0.5060.80
87_G146_V0.5050.80
161_R210_G0.5050.80
57_A87_G0.5040.80
147_A150_R0.5040.80
53_L59_R0.5020.80
272_L304_V0.5020.80
76_L104_D0.5010.80
97_L295_S0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qrjA 1 0.4984 3.8 0.964 Contact Map
2qkoA 2 0.3625 3.4 0.964 Contact Map
1oefA 1 0.0777 3 0.966 Contact Map
4rswA 2 0.2233 2.8 0.966 Contact Map
3r84A 2 0.1618 2.6 0.967 Contact Map
1jwyB 1 0.2071 2.2 0.968 Contact Map
4rxiA 1 0.2816 2 0.969 Contact Map
3pmkN 1 0.0809 1.9 0.969 Contact Map
1x60A 1 0.2557 1.8 0.969 Contact Map
2iaiA 2 0.356 1.8 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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