GREMLIN Database
PhnG - Phosphonate metabolism protein PhnG
PFAM: PF06754 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 141 (141)
Sequences: 3868 (2688)
Seq/√Len: 226.3
META: 0.785

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_A79_L3.8521.00
4_R114_A3.1041.00
16_E116_A2.9881.00
31_E67_R2.9321.00
32_V87_E2.7341.00
78_V85_K2.6651.00
14_A82_D2.6651.00
65_A75_H2.4661.00
72_E98_D2.4571.00
6_M89_A2.3681.00
122_A126_A2.3581.00
43_V59_A2.2151.00
18_A84_R2.2031.00
8_V110_L2.1611.00
13_P16_E2.1301.00
5_W96_L2.1001.00
7_A11_R2.0911.00
44_R55_N2.0151.00
76_G89_A1.8261.00
42_M58_E1.6851.00
41_V61_V1.6771.00
44_R53_P1.6521.00
32_V66_V1.6381.00
84_R87_E1.6301.00
11_R117_Q1.6061.00
32_V35_A1.6061.00
38_T83_K1.5791.00
104_A108_A1.5661.00
18_A88_L1.5131.00
98_D101_R1.4881.00
115_A119_A1.4791.00
68_L91_L1.4661.00
62_T83_K1.4501.00
30_Y91_L1.4221.00
29_A69_A1.4181.00
114_A118_A1.3861.00
8_V114_A1.3751.00
65_A73_V1.3681.00
64_A86_A1.3231.00
102_A106_E1.3211.00
14_A18_A1.3021.00
92_I109_V1.2891.00
123_R127_K1.2661.00
31_E69_A1.2601.00
21_L27_L1.2591.00
70_D98_D1.2521.00
21_L92_I1.2451.00
47_I52_A1.2431.00
117_Q121_R1.2391.00
118_A122_A1.2131.00
84_R88_L1.1911.00
68_L72_E1.1841.00
119_A123_R1.1821.00
30_Y87_E1.1621.00
16_E19_A1.1581.00
16_E113_L1.1511.00
116_A120_R1.1481.00
18_A22_A1.1461.00
78_V86_A1.1361.00
21_L88_L1.1121.00
6_M76_G1.1111.00
82_D85_K1.0991.00
33_L73_V1.0851.00
96_L106_E1.0831.00
103_A107_A1.0691.00
106_E111_A1.0621.00
34_R65_A1.0601.00
8_V117_Q1.0551.00
14_A85_K1.0501.00
20_L92_I1.0441.00
113_L116_A1.0261.00
106_E114_A1.0251.00
92_I96_L1.0221.00
119_A122_A0.9991.00
35_A65_A0.9901.00
113_L117_Q0.9811.00
85_K89_A0.9801.00
35_A83_K0.9711.00
61_V77_Y0.9581.00
2_R5_W0.9551.00
62_T76_G0.9521.00
101_R104_A0.9481.00
47_I53_P0.9451.00
96_L102_A0.9451.00
38_T81_R0.9411.00
129_A132_R0.9401.00
17_L85_K0.9281.00
111_A115_A0.9241.00
42_M55_N0.9221.00
96_L110_L0.9201.00
41_V59_A0.9130.99
78_V89_A0.8940.99
68_L94_A0.8930.99
32_V64_A0.8840.99
66_V91_L0.8760.99
3_Q7_A0.8660.99
2_R93_D0.8590.99
67_R73_V0.8580.99
109_V112_P0.8580.99
107_A111_A0.8570.99
105_L112_P0.8480.99
15_A19_A0.8430.99
1_A4_R0.8200.99
12_A113_L0.8160.99
74_G93_D0.8150.99
14_A88_L0.8070.99
55_N58_E0.7920.99
124_R127_K0.7860.98
125_A128_A0.7850.98
87_E91_L0.7830.98
116_A119_A0.7770.98
4_R106_E0.7740.98
12_A117_Q0.7630.98
5_W110_L0.7510.98
127_K130_A0.7510.98
16_E20_L0.7400.98
118_A121_R0.7390.98
123_R126_A0.7340.98
105_L109_V0.7340.98
121_R125_A0.7330.98
19_A23_A0.7320.98
39_G61_V0.7310.98
62_T89_A0.7210.97
104_A107_A0.7170.97
11_R14_A0.7170.97
42_M56_L0.7160.97
48_G55_N0.7150.97
88_L92_I0.7130.97
115_A118_A0.7100.97
137_T141_G0.6990.97
64_A87_E0.6990.97
30_Y68_L0.6980.97
60_T81_R0.6960.97
125_A129_A0.6890.97
85_K88_L0.6750.96
135_F138_M0.6740.96
12_A17_L0.6720.96
9_L92_I0.6710.96
103_A106_E0.6680.96
8_V11_R0.6600.96
14_A84_R0.6540.95
36_P64_A0.6530.95
65_A77_Y0.6490.95
45_G53_P0.6490.95
21_L26_L0.6460.95
24_L92_I0.6410.95
7_A79_L0.6340.94
120_R123_R0.6340.94
1_A106_E0.6310.94
37_E63_R0.6270.94
46_R53_P0.6270.94
76_G86_A0.6240.94
32_V91_L0.6200.94
1_A102_A0.6160.94
4_R111_A0.6130.93
5_W97_Q0.6080.93
71_G81_R0.6070.93
111_A114_A0.6070.93
21_L25_G0.6050.93
21_L91_L0.6050.93
35_A87_E0.6030.93
117_Q120_R0.5950.92
134_D137_T0.5940.92
102_A105_L0.5930.92
4_R8_V0.5910.92
73_V76_G0.5890.92
9_L110_L0.5830.92
9_L89_A0.5820.92
2_R97_Q0.5780.91
34_R39_G0.5750.91
20_L109_V0.5650.90
23_A105_L0.5630.90
27_L101_R0.5570.90
40_L59_A0.5560.90
34_R37_E0.5540.89
13_P116_A0.5480.89
113_L120_R0.5460.89
17_L82_D0.5440.89
4_R7_A0.5440.89
106_E110_L0.5380.88
49_G60_T0.5370.88
6_M10_A0.5360.88
29_A122_A0.5340.88
26_L115_A0.5330.88
68_L98_D0.5320.88
138_M141_G0.5320.88
24_L28_P0.5270.87
22_A27_L0.5270.87
67_R71_G0.5260.87
13_P120_R0.5260.87
10_A89_A0.5260.87
95_L101_R0.5230.87
26_L104_A0.5230.87
19_A122_A0.5230.87
45_G55_N0.5220.87
62_T86_A0.5210.86
86_A89_A0.5210.86
104_A111_A0.5210.86
137_T140_R0.5190.86
17_L21_L0.5180.86
31_E123_R0.5180.86
134_D140_R0.5160.86
64_A89_A0.5160.86
109_V113_L0.5120.86
108_A123_R0.5100.85
93_D97_Q0.5090.85
36_P128_A0.5080.85
20_L23_A0.5060.85
106_E109_V0.5040.85
40_L88_L0.5030.85
110_L113_L0.5010.84
111_A123_R0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3amjB 1 0.2624 11 0.934 Contact Map
2ltrA 1 0.6596 9.2 0.937 Contact Map
2dk8A 1 0.3617 8.4 0.938 Contact Map
1di2A 1 0.4823 5.8 0.942 Contact Map
2jg5A 1 0.7872 4.8 0.944 Contact Map
1kyqA 2 0.3262 4.4 0.945 Contact Map
2wscK 1 0.4965 4.3 0.946 Contact Map
1jb0K 1 0.3262 4.3 0.946 Contact Map
3mf7A 3 0.7589 4 0.947 Contact Map
4xglA 1 0.3333 3.6 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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