GREMLIN Database
DiS_P_DiS - Bacterial Peptidase A24 N-terminal domain
PFAM: PF06750 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 81 (80)
Sequences: 50794 (33108)
Seq/√Len: 3701.6
META: 0.936

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_H54_Y3.3851.00
29_S57_A2.9491.00
38_D53_R2.9421.00
70_T74_F2.6271.00
24_R33_P2.3641.00
38_D54_Y2.2581.00
35_R38_D2.2531.00
38_D48_L2.1551.00
6_I10_L2.0061.00
4_L71_G1.8791.00
35_R54_Y1.7051.00
19_S23_P1.6461.00
26_H31_G1.6251.00
61_P65_L1.4371.00
13_V17_L1.3731.00
15_Y28_P1.3661.00
32_H38_D1.3161.00
20_I23_P1.2781.00
19_S22_R1.2741.00
61_P64_P1.2491.00
75_A79_W1.2191.00
42_V64_P1.2051.00
9_F20_I1.1981.00
32_H35_R1.1851.00
34_I54_Y1.1711.00
48_L53_R1.1641.00
57_A60_S1.1381.00
3_G71_G1.1331.00
10_L70_T1.1261.00
11_N66_V1.1161.00
7_G70_T1.1141.00
27_C30_C1.1091.00
77_V80_R1.1031.00
10_L14_I1.0621.00
28_P59_I1.0331.00
44_S47_L1.0241.00
62_R66_V1.0201.00
44_S48_L1.0171.00
74_F77_V1.0081.00
60_S63_Y1.0031.00
26_H33_P0.9951.00
6_I74_F0.9931.00
14_I66_V0.9911.00
45_W61_P0.9781.00
3_G74_F0.9741.00
52_C55_C0.9731.00
28_P63_Y0.9701.00
74_F78_A0.9581.00
23_P26_H0.9431.00
4_L42_V0.9361.00
71_G75_A0.9331.00
34_I39_N0.9291.00
43_L47_L0.9081.00
12_V15_Y0.8971.00
46_L64_P0.8941.00
35_R53_R0.8891.00
58_P61_P0.8831.00
76_L80_R0.8821.00
11_N62_R0.8761.00
49_R56_G0.8641.00
15_Y26_H0.8601.00
30_C55_C0.8591.00
64_P68_L0.8541.00
45_W50_G0.8521.00
8_S25_S0.8501.00
65_L69_L0.8491.00
14_I18_P0.8441.00
15_Y62_R0.8441.00
66_V70_T0.8261.00
37_Y47_L0.8111.00
2_L6_I0.8091.00
11_N14_I0.8041.00
34_I38_D0.7951.00
73_L77_V0.7611.00
14_I62_R0.7601.00
42_V68_L0.7411.00
11_N15_Y0.7321.00
70_T73_L0.7291.00
72_L76_L0.7251.00
15_Y63_Y0.7231.00
38_D44_S0.7211.00
16_R23_P0.7131.00
59_I64_P0.7001.00
45_W59_I0.6891.00
37_Y53_R0.6871.00
2_L5_I0.6771.00
30_C52_C0.6771.00
68_L72_L0.6701.00
24_R36_W0.6681.00
69_L72_L0.6671.00
52_C57_A0.6641.00
72_L75_A0.6621.00
69_L73_L0.6601.00
12_V18_P0.6511.00
27_C55_C0.6411.00
25_S39_N0.6401.00
62_R65_L0.6221.00
13_V20_I0.6121.00
13_V18_P0.6091.00
22_R26_H0.6051.00
8_S39_N0.5951.00
42_V46_L0.5851.00
76_L79_W0.5821.00
45_W64_P0.5741.00
75_A78_A0.5741.00
1_L4_L0.5631.00
40_I43_L0.5561.00
1_L5_I0.5541.00
36_W39_N0.5531.00
70_T77_V0.5411.00
25_S41_P0.5391.00
15_Y18_P0.5341.00
28_P57_A0.5231.00
19_S26_H0.5171.00
4_L64_P0.5161.00
32_H53_R0.5131.00
21_V26_H0.5111.00
51_R58_P0.5061.00
4_L7_G0.5051.00
27_C52_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lcqA 1 0.6543 44.5 0.836 Contact Map
2fiyA 1 0.9753 38.1 0.842 Contact Map
2ct0A 1 0.7654 26.7 0.854 Contact Map
1vq8Z 1 0.8642 23.2 0.858 Contact Map
3py7A 1 0.642 20.2 0.863 Contact Map
1iymA 1 0.5185 18.8 0.864 Contact Map
4l2nA 2 0.7778 15.9 0.869 Contact Map
3nw0A 1 0.8642 13.2 0.873 Contact Map
2qkdA 2 0.7037 12.5 0.875 Contact Map
2l0bA 1 0.7778 12.2 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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