GREMLIN Database
FAST_1 - FAST kinase-like protein, subdomain 1
PFAM: PF06743 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 69 (67)
Sequences: 1013 (651)
Seq/√Len: 79.6
META: 0.253

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_N51_G2.7711.00
25_E47_L2.6581.00
38_Q42_N2.6251.00
36_S39_D2.5081.00
14_P54_P2.4701.00
8_A45_W2.3951.00
45_W49_V1.9421.00
12_Y52_Y1.8791.00
27_A30_S1.8731.00
15_P55_E1.8221.00
27_A31_R1.6951.00
29_T56_N1.6901.00
47_L53_F1.4910.99
8_A49_V1.4390.99
10_L50_L1.4040.99
64_P68_Q1.4000.99
47_L58_L1.3910.99
2_N38_Q1.3690.99
55_E59_D1.2400.97
65_D68_Q1.2380.97
20_F32_L1.2160.97
19_E56_N1.2130.97
17_A65_D1.1890.97
28_L43_L1.1830.97
28_L35_F1.1670.96
61_V66_F1.1570.96
30_S34_E1.1510.96
31_R34_E1.1500.96
13_L53_F1.1320.96
17_A68_Q1.0880.95
8_A46_S1.0800.94
25_E44_V1.0690.94
35_F42_N1.0630.94
14_P50_L1.0560.94
7_F26_S1.0350.93
35_F46_S1.0190.92
7_F33_S0.9840.91
2_N6_A0.9710.90
42_N45_W0.9610.90
21_F52_Y0.9580.90
36_S43_L0.9080.87
60_K66_F0.9040.87
21_F54_P0.8910.86
40_L43_L0.8870.86
63_S66_F0.8820.86
4_L44_V0.8670.85
7_F47_L0.8530.84
22_E52_Y0.8520.84
21_F58_L0.8450.83
10_L20_F0.8200.81
24_L39_D0.8140.81
20_F24_L0.8080.80
24_L33_S0.7990.80
52_Y59_D0.7960.79
6_A40_L0.7770.78
33_S47_L0.7740.77
4_L24_L0.7710.77
18_E23_A0.7670.77
45_W62_L0.7650.77
32_L48_A0.7600.76
11_N46_S0.7540.75
2_N42_N0.7520.75
18_E68_Q0.7410.74
9_T12_Y0.7410.74
9_T49_V0.7350.74
48_A58_L0.7340.73
24_L28_L0.7010.70
30_S56_N0.7000.70
19_E26_S0.6850.68
57_L62_L0.6660.66
39_D42_N0.6590.65
25_E58_L0.6560.65
27_A53_F0.6530.65
3_I59_D0.6510.64
64_P67_L0.6460.64
7_F13_L0.6290.62
47_L50_L0.6120.60
46_S50_L0.6120.60
7_F12_Y0.6110.59
3_I7_F0.6000.58
13_L41_L0.5990.58
56_N67_L0.5930.57
23_A65_D0.5850.56
7_F14_P0.5750.55
31_R40_L0.5740.55
6_A46_S0.5520.52
24_L51_G0.5420.51
30_S49_V0.5390.50
5_W42_N0.5370.50
14_P37_P0.5370.50
55_E58_L0.5350.50
31_R38_Q0.5280.49
63_S67_L0.5210.48
42_N50_L0.5210.48
54_P57_L0.5190.48
38_Q47_L0.5130.47
5_W45_W0.5060.46
16_N51_G0.5030.46
3_I24_L0.5010.45
48_A63_S0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uadA 1 1 34.8 0.816 Contact Map
2jdqA 2 1 31.7 0.82 Contact Map
3tpoA 1 1 26 0.827 Contact Map
4wz9A 2 0.913 23.4 0.831 Contact Map
4jbsA 1 0.913 22.8 0.832 Contact Map
4uafB 1 1 20.8 0.835 Contact Map
3nowA 3 1 20 0.836 Contact Map
1wa5B 1 1 19.5 0.837 Contact Map
4fkeA 1 0.913 19.1 0.838 Contact Map
4b8jA 1 1 18.6 0.838 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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