GREMLIN Database
LsmAD - LsmAD domain
PFAM: PF06741 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 70 (70)
Sequences: 884 (661)
Seq/√Len: 79.0
META: 0.526

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_E32_R3.2171.00
34_A38_E3.1131.00
22_D26_R2.6731.00
23_Y26_R2.6171.00
25_E29_E2.3591.00
62_E67_A2.1791.00
10_N15_K2.1781.00
27_E31_E2.1311.00
24_K28_A1.9591.00
46_H49_E1.9451.00
31_E35_R1.8141.00
46_H51_R1.7201.00
60_D63_D1.6241.00
32_R36_E1.5390.99
7_Y11_L1.4930.99
44_N49_E1.4820.99
18_R27_E1.4280.99
16_L20_S1.4140.99
3_V6_T1.4140.99
22_D25_E1.3980.99
24_K27_E1.3740.99
44_N47_V1.3620.99
26_R29_E1.3010.98
42_S48_A1.2720.98
17_D20_S1.2390.97
56_D59_L1.1970.97
29_E33_I1.1920.97
59_L63_D1.1860.97
47_V50_E1.1060.95
49_E65_Y1.0990.95
46_H50_E1.0500.93
55_D64_K1.0480.93
1_F14_T1.0360.93
8_D11_L1.0190.92
22_D27_E1.0120.92
20_S26_R1.0010.92
40_S53_Q0.9720.90
25_E28_A0.9550.90
48_A53_Q0.9430.89
13_T38_E0.9430.89
44_N51_R0.9130.87
5_S11_L0.9010.87
35_R39_G0.9000.87
16_L23_Y0.8680.85
44_N53_Q0.8680.85
45_A64_K0.8580.84
42_S47_V0.8400.83
18_R23_Y0.8310.82
34_A37_I0.8310.82
14_T60_D0.8240.81
63_D67_A0.8190.81
63_D69_V0.8150.81
38_E60_D0.8040.80
65_Y68_V0.7970.79
47_V51_R0.7940.79
1_F20_S0.7730.77
23_Y27_E0.7700.77
10_N16_L0.7590.76
54_D57_S0.7590.76
31_E34_A0.7580.76
44_N48_A0.7470.75
53_Q56_D0.7380.74
59_L64_K0.7320.73
42_S50_E0.7180.72
1_F52_G0.7090.71
66_S70_R0.7050.70
21_P32_R0.6690.66
35_R38_E0.6610.65
2_G13_T0.6590.65
1_F9_E0.6550.65
19_S22_D0.6360.62
7_Y48_A0.6300.62
10_N31_E0.6190.60
41_A57_S0.6180.60
49_E52_G0.6120.59
3_V8_D0.6050.58
12_Y66_S0.6000.58
46_H52_G0.5980.58
9_E13_T0.5940.57
19_S23_Y0.5840.56
13_T16_L0.5840.56
28_A32_R0.5800.55
2_G14_T0.5750.55
7_Y47_V0.5640.53
18_R21_P0.5630.53
6_T40_S0.5620.53
51_R65_Y0.5590.53
55_D58_G0.5590.53
47_V62_E0.5540.52
55_D59_L0.5520.52
6_T11_L0.5500.51
49_E64_K0.5390.50
3_V56_D0.5370.50
7_Y53_Q0.5350.50
31_E38_E0.5290.49
46_H53_Q0.5290.49
16_L21_P0.5120.47
13_T34_A0.5110.46
17_D66_S0.5090.46
9_E14_T0.5060.46
28_A50_E0.5060.46
7_Y27_E0.5050.46
46_H62_E0.5030.45
48_A54_D0.5010.45
22_D66_S0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wb9A 2 0.5857 5 0.897 Contact Map
3kz5E 2 0.5714 4.6 0.899 Contact Map
1ewqA 2 0.5714 4.2 0.901 Contact Map
1w4rA 3 0.8429 3.5 0.904 Contact Map
2p1mA 1 0.3429 3.1 0.907 Contact Map
2kqrA 1 0.4143 2.9 0.908 Contact Map
4c9bB 1 0.4857 2.8 0.909 Contact Map
4lo0C 1 0.7286 2.7 0.91 Contact Map
1xrsA 2 0.6286 2.6 0.911 Contact Map
3winC 1 0.7286 2.4 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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