ThrE - PFAM28P - GREMLIN Contacts

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ThrE - Putative threonine/serine exporter

PFAM:	PF06738	Sequences: DLALRLGRALLESGAETYRVEDTMERIARALGLERVEVFVTPTGIIVSFDDDGEPVTRVRRVPPRGVNLDRLAAVNRLSRDVEAGRLSLEEARARLDEIERAPPRYPRWLVVLAAGLAAAAFALLFGGGWLDALVAFVAGLLGGLLRRLLARRGLNAFLQEFLAAFVATLLAALAVRLGLGLSPDLVIIGSIMVLVPGLPLTNAVRDLASGDLVSGTARLAEALLILLAIAFGVALGLALW	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	241 (239)
Sequences:	8603 (6210)
Seq/√Len:	401.7
META:	0.673

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
81_D	95_R	4.500	1.00
88_S	91_E	4.317	1.00
95_R	98_E	3.900	1.00
116_G	137_F	3.571	1.00
107_P	110_L	3.433	1.00
116_G	141_L	3.364	1.00
81_D	86_R	3.190	1.00
78_L	99_I	2.959	1.00
70_D	74_A	2.909	1.00
120_A	137_F	2.865	1.00
217_T	221_A	2.803	1.00
5_R	97_D	2.773	1.00
204_A	220_L	2.743	1.00
10_L	15_A	2.680	1.00
129_G	132_D	2.665	1.00
7_G	24_M	2.508	1.00
119_A	140_G	2.452	1.00
82_V	92_A	2.438	1.00
6_L	27_I	2.345	1.00
74_A	102_A	2.324	1.00
77_R	81_D	2.315	1.00
8_R	12_E	2.229	1.00
31_L	82_V	2.148	1.00
24_M	38_V	2.066	1.00
5_R	93_R	2.058	1.00
166_F	237_G	2.027	1.00
120_A	133_A	1.992	1.00
9_A	75_V	1.979	1.00
28_A	36_V	1.956	1.00
7_G	45_I	1.907	1.00
139_A	171_L	1.855	1.00
108_R	148_R	1.819	1.00
208_L	216_G	1.817	1.00
146_L	167_V	1.803	1.00
124_L	133_A	1.789	1.00
26_R	83_E	1.766	1.00
112_V	141_L	1.733	1.00
149_L	153_R	1.679	1.00
27_I	82_V	1.672	1.00
2_L	92_A	1.654	1.00
3_A	28_A	1.654	1.00
169_T	237_G	1.638	1.00
33_L	49_F	1.634	1.00
55_P	58_R	1.624	1.00
123_A	190_G	1.623	1.00
9_A	100_E	1.574	1.00
46_I	59_V	1.574	1.00
89_L	93_R	1.572	1.00
123_A	128_G	1.561	1.00
135_V	175_A	1.533	1.00
115_A	144_G	1.524	1.00
145_L	149_L	1.467	1.00
8_R	60_R	1.442	1.00
193_M	196_V	1.435	1.00
23_T	79_S	1.421	1.00
3_A	24_M	1.411	1.00
97_D	101_R	1.402	1.00
3_A	27_I	1.396	1.00
6_L	75_V	1.395	1.00
78_L	92_A	1.386	1.00
143_G	168_A	1.383	1.00
38_V	47_V	1.361	1.00
173_A	237_G	1.359	1.00
93_R	97_D	1.357	1.00
91_E	94_A	1.353	1.00
132_D	183_S	1.352	1.00
5_R	100_E	1.336	1.00
169_T	234_V	1.333	1.00
98_E	102_A	1.302	1.00
186_L	190_G	1.299	1.00
70_D	102_A	1.287	1.00
149_L	152_R	1.283	1.00
123_A	136_A	1.277	1.00
87_L	92_A	1.260	1.00
81_D	87_L	1.259	1.00
21_E	61_R	1.257	1.00
75_V	96_L	1.255	1.00
6_L	79_S	1.249	1.00
139_A	168_A	1.246	1.00
71_R	99_I	1.234	1.00
94_A	98_E	1.233	1.00
128_G	132_D	1.223	1.00
25_E	29_R	1.208	1.00
143_G	164_A	1.204	1.00
120_A	124_L	1.189	1.00
70_D	105_R	1.180	1.00
171_L	175_A	1.168	1.00
39_F	44_G	1.165	1.00
95_R	99_I	1.144	1.00
78_L	87_L	1.143	1.00
91_E	95_R	1.131	1.00
87_L	95_R	1.130	1.00
27_I	79_S	1.130	1.00
37_E	60_R	1.123	1.00
74_A	99_I	1.123	1.00
81_D	85_G	1.113	1.00
123_A	133_A	1.111	1.00
44_G	59_V	1.103	1.00
5_R	9_A	1.093	1.00
48_S	57_T	1.086	1.00
162_F	229_A	1.084	1.00
110_L	114_A	1.082	1.00
112_V	116_G	1.079	1.00
212_D	215_S	1.071	1.00
13_S	71_R	1.066	1.00
82_V	87_L	1.054	1.00
116_G	120_A	1.049	1.00
13_S	72_L	1.039	1.00
76_N	80_R	1.033	1.00
168_A	194_V	1.033	1.00
140_G	144_G	1.029	1.00
224_L	228_L	1.028	1.00
112_V	144_G	1.020	1.00
76_N	79_S	1.007	1.00
113_L	117_L	1.005	1.00
174_L	178_L	0.997	1.00
6_L	9_A	0.991	1.00
30_A	83_E	0.982	1.00
30_A	85_G	0.982	1.00
134_L	137_F	0.978	1.00
74_A	77_R	0.976	1.00
25_E	38_V	0.956	1.00
11_L	20_V	0.955	1.00
176_V	179_G	0.954	1.00
122_F	193_M	0.949	1.00
39_F	46_I	0.948	1.00
87_L	91_E	0.942	1.00
176_V	184_P	0.931	1.00
22_D	26_R	0.919	1.00
161_E	226_I	0.918	1.00
40_V	45_I	0.915	1.00
204_A	223_A	0.913	1.00
6_L	96_L	0.909	1.00
79_S	83_E	0.901	1.00
106_Y	110_L	0.901	1.00
219_R	222_E	0.900	1.00
115_A	119_A	0.894	1.00
5_R	8_R	0.894	1.00
217_T	220_L	0.893	1.00
112_V	145_L	0.890	1.00
56_V	60_R	0.887	1.00
9_A	13_S	0.883	1.00
97_D	100_E	0.883	1.00
31_L	88_S	0.880	1.00
170_L	237_G	0.878	1.00
50_D	55_P	0.877	1.00
172_A	187_V	0.872	1.00
139_A	175_A	0.868	1.00
108_R	111_V	0.858	1.00
134_L	138_V	0.856	1.00
173_A	177_R	0.853	1.00
74_A	95_R	0.850	1.00
169_T	188_I	0.846	1.00
130_W	133_A	0.844	1.00
201_L	227_L	0.843	1.00
16_E	21_E	0.836	1.00
13_S	75_V	0.834	1.00
23_T	76_N	0.830	1.00
166_F	236_L	0.829	1.00
6_L	23_T	0.825	1.00
112_V	148_R	0.825	1.00
175_A	178_L	0.821	1.00
142_L	171_L	0.812	1.00
23_T	26_R	0.808	1.00
57_T	61_R	0.806	1.00
203_N	206_R	0.804	1.00
4_L	47_V	0.804	1.00
15_A	20_V	0.803	1.00
2_L	6_L	0.799	1.00
71_R	100_E	0.798	1.00
9_A	96_L	0.790	1.00
116_G	140_G	0.789	1.00
51_D	54_E	0.781	1.00
162_F	232_F	0.774	1.00
143_G	194_V	0.772	1.00
26_R	79_S	0.767	1.00
109_W	113_L	0.767	1.00
26_R	80_R	0.760	1.00
139_A	191_S	0.757	1.00
73_A	77_R	0.756	1.00
162_F	236_L	0.755	1.00
10_L	20_V	0.755	1.00
89_L	92_A	0.753	1.00
131_L	135_V	0.752	1.00
142_L	167_V	0.746	1.00
113_L	137_F	0.745	1.00
5_R	60_R	0.740	1.00
131_L	134_L	0.740	1.00
4_L	8_R	0.737	1.00
74_A	98_E	0.730	1.00
222_E	226_I	0.729	1.00
10_L	23_T	0.726	1.00
6_L	78_L	0.720	1.00
227_L	231_A	0.718	1.00
108_R	112_V	0.718	1.00
164_A	168_A	0.713	1.00
143_G	147_R	0.711	1.00
90_E	94_A	0.711	1.00
26_R	76_N	0.710	1.00
165_A	195_L	0.708	1.00
136_A	140_G	0.705	1.00
12_E	100_E	0.705	1.00
68_N	71_R	0.705	1.00
25_E	63_P	0.700	1.00
85_G	92_A	0.698	1.00
213_L	221_A	0.697	1.00
132_D	181_G	0.690	1.00
24_M	47_V	0.688	1.00
126_F	193_M	0.687	1.00
138_V	142_L	0.687	1.00
122_F	125_L	0.685	1.00
9_A	71_R	0.680	0.99
43_T	218_A	0.679	0.99
20_V	40_V	0.679	0.99
214_V	218_A	0.677	0.99
69_L	72_L	0.676	0.99
166_F	170_L	0.674	0.99
147_R	160_Q	0.673	0.99
50_D	54_E	0.673	0.99
43_T	215_S	0.671	0.99
209_A	216_G	0.671	0.99
165_A	169_T	0.669	0.99
208_L	225_L	0.668	0.99
158_F	229_A	0.666	0.99
19_R	79_S	0.666	0.99
2_L	9_A	0.666	0.99
196_V	230_I	0.664	0.99
17_T	40_V	0.664	0.99
132_D	187_V	0.659	0.99
115_A	194_V	0.659	0.99
233_G	237_G	0.654	0.99
2_L	78_L	0.653	0.99
197_P	227_L	0.647	0.99
201_L	223_A	0.646	0.99
150_L	156_N	0.640	0.99
201_L	205_V	0.639	0.99
24_M	45_I	0.638	0.99
131_L	182_L	0.636	0.99
54_E	57_T	0.635	0.99
135_V	187_V	0.635	0.99
203_N	207_D	0.634	0.99
16_E	206_R	0.634	0.99
23_T	80_R	0.631	0.99
195_L	230_I	0.631	0.99
135_V	181_G	0.629	0.99
206_R	222_E	0.628	0.99
206_R	231_A	0.627	0.99
139_A	172_A	0.626	0.99
164_A	195_L	0.625	0.99
27_I	31_L	0.624	0.99
206_R	210_S	0.624	0.99
213_L	216_G	0.622	0.99
88_S	94_A	0.621	0.99
179_G	182_L	0.620	0.99
31_L	85_G	0.619	0.99
202_T	215_S	0.618	0.99
8_R	100_E	0.617	0.99
30_A	82_V	0.616	0.99
170_L	174_L	0.612	0.99
25_E	36_V	0.612	0.99
90_E	93_R	0.609	0.99
24_M	36_V	0.609	0.99
146_L	163_L	0.608	0.99
2_L	93_R	0.608	0.99
3_A	47_V	0.603	0.99
160_Q	164_A	0.602	0.99
118_A	121_A	0.601	0.99
209_A	229_A	0.600	0.99
192_I	230_I	0.598	0.99
15_A	19_R	0.598	0.99
185_D	189_I	0.596	0.99
75_V	99_I	0.595	0.99
172_A	188_I	0.593	0.99
94_A	97_D	0.593	0.99
56_V	59_V	0.591	0.99
2_L	82_V	0.590	0.99
200_P	222_E	0.590	0.99
111_V	148_R	0.590	0.99
115_A	143_G	0.589	0.99
118_A	122_F	0.589	0.99
211_G	222_E	0.588	0.99
147_R	164_A	0.586	0.98
188_I	191_S	0.584	0.98
21_E	197_P	0.584	0.98
168_A	191_S	0.581	0.98
13_S	68_N	0.581	0.98
80_R	84_A	0.574	0.98
136_A	190_G	0.574	0.98
129_G	182_L	0.572	0.98
29_R	35_R	0.572	0.98
18_Y	210_S	0.568	0.98
104_P	107_P	0.568	0.98
5_R	96_L	0.567	0.98
126_F	194_V	0.565	0.98
151_A	160_Q	0.561	0.98
109_W	112_V	0.560	0.98
139_A	187_V	0.558	0.98
144_G	148_R	0.556	0.98
4_L	68_N	0.555	0.98
120_A	136_A	0.555	0.98
21_E	40_V	0.554	0.98
183_S	186_L	0.554	0.98
16_E	22_D	0.551	0.98
32_G	35_R	0.550	0.98
227_L	230_I	0.550	0.98
204_A	208_L	0.547	0.98
144_G	192_I	0.547	0.98
7_G	11_L	0.545	0.98
82_V	86_R	0.544	0.98
168_A	190_G	0.541	0.97
31_L	78_L	0.540	0.97
110_L	113_L	0.540	0.97
213_L	222_E	0.538	0.97
98_E	130_W	0.538	0.97
222_E	225_L	0.535	0.97
47_V	122_F	0.535	0.97
174_L	177_R	0.535	0.97
2_L	89_L	0.533	0.97
216_G	225_L	0.533	0.97
114_A	121_A	0.532	0.97
115_A	147_R	0.532	0.97
103_P	153_R	0.530	0.97
18_Y	212_D	0.530	0.97
26_R	29_R	0.528	0.97
115_A	140_G	0.528	0.97
132_D	182_L	0.525	0.97
166_F	240_L	0.524	0.97
188_I	238_L	0.521	0.97
129_G	183_S	0.521	0.97
16_E	23_T	0.520	0.97
168_A	187_V	0.520	0.97
166_F	169_T	0.520	0.97
19_R	132_D	0.520	0.97
158_F	236_L	0.519	0.97
16_E	19_R	0.518	0.97
118_A	126_F	0.518	0.97
192_I	201_L	0.517	0.97
39_F	59_V	0.516	0.97
121_A	124_L	0.515	0.97
81_D	84_A	0.515	0.97
111_V	144_G	0.514	0.97
135_V	172_A	0.514	0.97
19_R	22_D	0.514	0.97
118_A	162_F	0.513	0.97
70_D	106_Y	0.512	0.96
7_G	20_V	0.511	0.96
3_A	7_G	0.511	0.96
80_R	169_T	0.511	0.96
213_L	217_T	0.511	0.96
4_L	58_R	0.509	0.96
35_R	50_D	0.509	0.96
192_I	234_V	0.508	0.96
3_A	33_L	0.507	0.96
182_L	187_V	0.507	0.96
165_A	230_I	0.506	0.96
130_W	134_L	0.504	0.96
209_A	227_L	0.502	0.96
204_A	216_G	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ucsA	2	0.361	13.1	0.947	Contact Map
4tn5A	2	0.4357	12.8	0.948	Contact Map
4bbjA	1	0.639	12.5	0.948	Contact Map
3h90A	3	0.3817	11.6	0.949	Contact Map
2kt2A	1	0.2863	10.9	0.949	Contact Map
1rfzA	4	0.556	10.1	0.95	Contact Map
1cpzA	1	0.278	9.4	0.951	Contact Map
2kyrA	1	0.3983	9.3	0.951	Contact Map
4dx5A	3	0.9668	8.9	0.951	Contact Map
1ydoA	3	0.3402	8.1	0.952	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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