GREMLIN Database
ThrE - Putative threonine/serine exporter
PFAM: PF06738 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 241 (239)
Sequences: 8603 (6210)
Seq/√Len: 401.7
META: 0.673

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_D95_R4.5001.00
88_S91_E4.3171.00
95_R98_E3.9001.00
116_G137_F3.5711.00
107_P110_L3.4331.00
116_G141_L3.3641.00
81_D86_R3.1901.00
78_L99_I2.9591.00
70_D74_A2.9091.00
120_A137_F2.8651.00
217_T221_A2.8031.00
5_R97_D2.7731.00
204_A220_L2.7431.00
10_L15_A2.6801.00
129_G132_D2.6651.00
7_G24_M2.5081.00
119_A140_G2.4521.00
82_V92_A2.4381.00
6_L27_I2.3451.00
74_A102_A2.3241.00
77_R81_D2.3151.00
8_R12_E2.2291.00
31_L82_V2.1481.00
24_M38_V2.0661.00
5_R93_R2.0581.00
166_F237_G2.0271.00
120_A133_A1.9921.00
9_A75_V1.9791.00
28_A36_V1.9561.00
7_G45_I1.9071.00
139_A171_L1.8551.00
108_R148_R1.8191.00
208_L216_G1.8171.00
146_L167_V1.8031.00
124_L133_A1.7891.00
26_R83_E1.7661.00
112_V141_L1.7331.00
149_L153_R1.6791.00
27_I82_V1.6721.00
2_L92_A1.6541.00
3_A28_A1.6541.00
169_T237_G1.6381.00
33_L49_F1.6341.00
55_P58_R1.6241.00
123_A190_G1.6231.00
9_A100_E1.5741.00
46_I59_V1.5741.00
89_L93_R1.5721.00
123_A128_G1.5611.00
135_V175_A1.5331.00
115_A144_G1.5241.00
145_L149_L1.4671.00
8_R60_R1.4421.00
193_M196_V1.4351.00
23_T79_S1.4211.00
3_A24_M1.4111.00
97_D101_R1.4021.00
3_A27_I1.3961.00
6_L75_V1.3951.00
78_L92_A1.3861.00
143_G168_A1.3831.00
38_V47_V1.3611.00
173_A237_G1.3591.00
93_R97_D1.3571.00
91_E94_A1.3531.00
132_D183_S1.3521.00
5_R100_E1.3361.00
169_T234_V1.3331.00
98_E102_A1.3021.00
186_L190_G1.2991.00
70_D102_A1.2871.00
149_L152_R1.2831.00
123_A136_A1.2771.00
87_L92_A1.2601.00
81_D87_L1.2591.00
21_E61_R1.2571.00
75_V96_L1.2551.00
6_L79_S1.2491.00
139_A168_A1.2461.00
71_R99_I1.2341.00
94_A98_E1.2331.00
128_G132_D1.2231.00
25_E29_R1.2081.00
143_G164_A1.2041.00
120_A124_L1.1891.00
70_D105_R1.1801.00
171_L175_A1.1681.00
39_F44_G1.1651.00
95_R99_I1.1441.00
78_L87_L1.1431.00
91_E95_R1.1311.00
87_L95_R1.1301.00
27_I79_S1.1301.00
37_E60_R1.1231.00
74_A99_I1.1231.00
81_D85_G1.1131.00
123_A133_A1.1111.00
44_G59_V1.1031.00
5_R9_A1.0931.00
48_S57_T1.0861.00
162_F229_A1.0841.00
110_L114_A1.0821.00
112_V116_G1.0791.00
212_D215_S1.0711.00
13_S71_R1.0661.00
82_V87_L1.0541.00
116_G120_A1.0491.00
13_S72_L1.0391.00
76_N80_R1.0331.00
168_A194_V1.0331.00
140_G144_G1.0291.00
224_L228_L1.0281.00
112_V144_G1.0201.00
76_N79_S1.0071.00
113_L117_L1.0051.00
174_L178_L0.9971.00
6_L9_A0.9911.00
30_A83_E0.9821.00
30_A85_G0.9821.00
134_L137_F0.9781.00
74_A77_R0.9761.00
25_E38_V0.9561.00
11_L20_V0.9551.00
176_V179_G0.9541.00
122_F193_M0.9491.00
39_F46_I0.9481.00
87_L91_E0.9421.00
176_V184_P0.9311.00
22_D26_R0.9191.00
161_E226_I0.9181.00
40_V45_I0.9151.00
204_A223_A0.9131.00
6_L96_L0.9091.00
79_S83_E0.9011.00
106_Y110_L0.9011.00
219_R222_E0.9001.00
115_A119_A0.8941.00
5_R8_R0.8941.00
217_T220_L0.8931.00
112_V145_L0.8901.00
56_V60_R0.8871.00
9_A13_S0.8831.00
97_D100_E0.8831.00
31_L88_S0.8801.00
170_L237_G0.8781.00
50_D55_P0.8771.00
172_A187_V0.8721.00
139_A175_A0.8681.00
108_R111_V0.8581.00
134_L138_V0.8561.00
173_A177_R0.8531.00
74_A95_R0.8501.00
169_T188_I0.8461.00
130_W133_A0.8441.00
201_L227_L0.8431.00
16_E21_E0.8361.00
13_S75_V0.8341.00
23_T76_N0.8301.00
166_F236_L0.8291.00
6_L23_T0.8251.00
112_V148_R0.8251.00
175_A178_L0.8211.00
142_L171_L0.8121.00
23_T26_R0.8081.00
57_T61_R0.8061.00
203_N206_R0.8041.00
4_L47_V0.8041.00
15_A20_V0.8031.00
2_L6_L0.7991.00
71_R100_E0.7981.00
9_A96_L0.7901.00
116_G140_G0.7891.00
51_D54_E0.7811.00
162_F232_F0.7741.00
143_G194_V0.7721.00
26_R79_S0.7671.00
109_W113_L0.7671.00
26_R80_R0.7601.00
139_A191_S0.7571.00
73_A77_R0.7561.00
162_F236_L0.7551.00
10_L20_V0.7551.00
89_L92_A0.7531.00
131_L135_V0.7521.00
142_L167_V0.7461.00
113_L137_F0.7451.00
5_R60_R0.7401.00
131_L134_L0.7401.00
4_L8_R0.7371.00
74_A98_E0.7301.00
222_E226_I0.7291.00
10_L23_T0.7261.00
6_L78_L0.7201.00
227_L231_A0.7181.00
108_R112_V0.7181.00
164_A168_A0.7131.00
143_G147_R0.7111.00
90_E94_A0.7111.00
26_R76_N0.7101.00
165_A195_L0.7081.00
136_A140_G0.7051.00
12_E100_E0.7051.00
68_N71_R0.7051.00
25_E63_P0.7001.00
85_G92_A0.6981.00
213_L221_A0.6971.00
132_D181_G0.6901.00
24_M47_V0.6881.00
126_F193_M0.6871.00
138_V142_L0.6871.00
122_F125_L0.6851.00
9_A71_R0.6800.99
43_T218_A0.6790.99
20_V40_V0.6790.99
214_V218_A0.6770.99
69_L72_L0.6760.99
166_F170_L0.6740.99
147_R160_Q0.6730.99
50_D54_E0.6730.99
43_T215_S0.6710.99
209_A216_G0.6710.99
165_A169_T0.6690.99
208_L225_L0.6680.99
158_F229_A0.6660.99
19_R79_S0.6660.99
2_L9_A0.6660.99
196_V230_I0.6640.99
17_T40_V0.6640.99
132_D187_V0.6590.99
115_A194_V0.6590.99
233_G237_G0.6540.99
2_L78_L0.6530.99
197_P227_L0.6470.99
201_L223_A0.6460.99
150_L156_N0.6400.99
201_L205_V0.6390.99
24_M45_I0.6380.99
131_L182_L0.6360.99
54_E57_T0.6350.99
135_V187_V0.6350.99
203_N207_D0.6340.99
16_E206_R0.6340.99
23_T80_R0.6310.99
195_L230_I0.6310.99
135_V181_G0.6290.99
206_R222_E0.6280.99
206_R231_A0.6270.99
139_A172_A0.6260.99
164_A195_L0.6250.99
27_I31_L0.6240.99
206_R210_S0.6240.99
213_L216_G0.6220.99
88_S94_A0.6210.99
179_G182_L0.6200.99
31_L85_G0.6190.99
202_T215_S0.6180.99
8_R100_E0.6170.99
30_A82_V0.6160.99
170_L174_L0.6120.99
25_E36_V0.6120.99
90_E93_R0.6090.99
24_M36_V0.6090.99
146_L163_L0.6080.99
2_L93_R0.6080.99
3_A47_V0.6030.99
160_Q164_A0.6020.99
118_A121_A0.6010.99
209_A229_A0.6000.99
192_I230_I0.5980.99
15_A19_R0.5980.99
185_D189_I0.5960.99
75_V99_I0.5950.99
172_A188_I0.5930.99
94_A97_D0.5930.99
56_V59_V0.5910.99
2_L82_V0.5900.99
200_P222_E0.5900.99
111_V148_R0.5900.99
115_A143_G0.5890.99
118_A122_F0.5890.99
211_G222_E0.5880.99
147_R164_A0.5860.98
188_I191_S0.5840.98
21_E197_P0.5840.98
168_A191_S0.5810.98
13_S68_N0.5810.98
80_R84_A0.5740.98
136_A190_G0.5740.98
129_G182_L0.5720.98
29_R35_R0.5720.98
18_Y210_S0.5680.98
104_P107_P0.5680.98
5_R96_L0.5670.98
126_F194_V0.5650.98
151_A160_Q0.5610.98
109_W112_V0.5600.98
139_A187_V0.5580.98
144_G148_R0.5560.98
4_L68_N0.5550.98
120_A136_A0.5550.98
21_E40_V0.5540.98
183_S186_L0.5540.98
16_E22_D0.5510.98
32_G35_R0.5500.98
227_L230_I0.5500.98
204_A208_L0.5470.98
144_G192_I0.5470.98
7_G11_L0.5450.98
82_V86_R0.5440.98
168_A190_G0.5410.97
31_L78_L0.5400.97
110_L113_L0.5400.97
213_L222_E0.5380.97
98_E130_W0.5380.97
222_E225_L0.5350.97
47_V122_F0.5350.97
174_L177_R0.5350.97
2_L89_L0.5330.97
216_G225_L0.5330.97
114_A121_A0.5320.97
115_A147_R0.5320.97
103_P153_R0.5300.97
18_Y212_D0.5300.97
26_R29_R0.5280.97
115_A140_G0.5280.97
132_D182_L0.5250.97
166_F240_L0.5240.97
188_I238_L0.5210.97
129_G183_S0.5210.97
16_E23_T0.5200.97
168_A187_V0.5200.97
166_F169_T0.5200.97
19_R132_D0.5200.97
158_F236_L0.5190.97
16_E19_R0.5180.97
118_A126_F0.5180.97
192_I201_L0.5170.97
39_F59_V0.5160.97
121_A124_L0.5150.97
81_D84_A0.5150.97
111_V144_G0.5140.97
135_V172_A0.5140.97
19_R22_D0.5140.97
118_A162_F0.5130.97
70_D106_Y0.5120.96
7_G20_V0.5110.96
3_A7_G0.5110.96
80_R169_T0.5110.96
213_L217_T0.5110.96
4_L58_R0.5090.96
35_R50_D0.5090.96
192_I234_V0.5080.96
3_A33_L0.5070.96
182_L187_V0.5070.96
165_A230_I0.5060.96
130_W134_L0.5040.96
209_A227_L0.5020.96
204_A216_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ucsA 2 0.361 13.1 0.947 Contact Map
4tn5A 2 0.4357 12.8 0.948 Contact Map
4bbjA 1 0.639 12.5 0.948 Contact Map
3h90A 3 0.3817 11.6 0.949 Contact Map
2kt2A 1 0.2863 10.9 0.949 Contact Map
1rfzA 4 0.556 10.1 0.95 Contact Map
1cpzA 1 0.278 9.4 0.951 Contact Map
2kyrA 1 0.3983 9.3 0.951 Contact Map
4dx5A 3 0.9668 8.9 0.951 Contact Map
1ydoA 3 0.3402 8.1 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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