GREMLIN Database
DUF1211 - Protein of unknown function (DUF1211)
PFAM: PF06736 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (85)
Sequences: 41113 (20253)
Seq/√Len: 2196.7
META: 0.966

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_G75_L4.5121.00
76_H80_W3.2821.00
43_V79_F2.2391.00
10_F77_L2.1141.00
33_L36_W2.0791.00
28_L31_A2.0271.00
42_Y82_S1.9371.00
54_N71_L1.9261.00
51_I55_N1.7031.00
54_N72_W1.6391.00
29_L33_L1.6341.00
35_L38_V1.6151.00
31_A34_P1.6021.00
30_A33_L1.5411.00
60_F63_V1.5271.00
5_F14_I1.5141.00
2_L66_V1.4981.00
4_A8_G1.4561.00
56_H74_N1.4511.00
18_V21_L1.4481.00
30_A34_P1.4461.00
68_G72_W1.4021.00
36_W40_L1.3841.00
27_A30_A1.3781.00
27_A31_A1.3721.00
5_F8_G1.3531.00
66_V70_L1.3441.00
58_H68_G1.3391.00
52_Y81_L1.3381.00
69_R73_A1.3191.00
26_G30_A1.1891.00
14_I50_G1.1581.00
63_V70_L1.1571.00
69_R72_W1.1261.00
28_L33_L1.1251.00
26_G31_A1.1141.00
52_Y77_L1.1101.00
6_S56_H1.1101.00
13_A49_I1.1061.00
8_G11_A1.0991.00
4_A12_I1.0921.00
48_Y52_Y1.0481.00
25_H29_L1.0481.00
40_L44_L1.0471.00
13_A81_L1.0431.00
54_N68_G1.0431.00
14_I49_I1.0161.00
8_G15_T1.0071.00
58_H61_H0.9811.00
13_A16_L0.9521.00
36_W39_F0.9301.00
58_H62_A0.9281.00
28_L32_L0.9221.00
6_S78_L0.9221.00
18_V83_L0.9161.00
12_I20_E0.9101.00
34_P38_V0.9001.00
38_V41_A0.8841.00
10_F81_L0.8711.00
9_V14_I0.8691.00
42_Y79_F0.8601.00
46_F79_F0.8501.00
35_L39_F0.8401.00
80_W83_L0.8361.00
21_L35_L0.8341.00
45_S84_I0.8301.00
52_Y55_N0.8241.00
12_I19_L0.8061.00
25_H28_L0.7931.00
79_F83_L0.7921.00
6_S74_N0.7811.00
79_F82_S0.7811.00
5_F50_G0.7801.00
4_A11_A0.7791.00
44_L48_Y0.7781.00
9_V78_L0.7701.00
47_V79_F0.7561.00
57_H60_F0.7461.00
10_F13_A0.7461.00
42_Y46_F0.7421.00
55_N58_H0.7341.00
49_I84_I0.7221.00
66_V71_L0.7161.00
73_A76_H0.7151.00
47_V72_W0.7131.00
39_F83_L0.7111.00
20_E38_V0.7011.00
60_F70_L0.7001.00
2_L60_F0.6791.00
12_I16_L0.6771.00
46_F75_L0.6661.00
33_L37_P0.6661.00
13_A82_S0.6641.00
54_N58_H0.6571.00
3_E66_V0.6541.00
47_V51_I0.6511.00
2_L71_L0.6511.00
77_L81_L0.6261.00
21_L38_V0.6171.00
67_D70_L0.6121.00
14_I46_F0.6121.00
57_H71_L0.6101.00
11_A14_I0.6071.00
3_E60_F0.5891.00
34_P37_P0.5881.00
26_G29_L0.5861.00
1_R7_D0.5761.00
12_I82_S0.5761.00
54_N75_L0.5691.00
8_G16_L0.5651.00
42_Y45_S0.5641.00
63_V66_V0.5591.00
8_G12_I0.5561.00
74_N77_L0.5551.00
63_V67_D0.5531.00
6_S10_F0.5451.00
62_A65_R0.5411.00
41_A45_S0.5411.00
57_H61_H0.5411.00
37_P41_A0.5391.00
3_E6_S0.5341.00
81_L84_I0.5261.00
59_L63_V0.5211.00
21_L39_F0.5151.00
61_H64_R0.5151.00
14_I59_L0.5101.00
76_H79_F0.5091.00
72_W76_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wn4A 1 0 6.2 0.883 Contact Map
2m59A 2 0.4353 2.7 0.902 Contact Map
3m73A 3 1 1.6 0.914 Contact Map
1oedE 1 0.6588 1.3 0.918 Contact Map
4wwxB 1 1 1.2 0.92 Contact Map
3gnaA 2 0.4471 1.1 0.921 Contact Map
1oedA 1 0.6471 1 0.923 Contact Map
2hacA 2 0.3294 1 0.924 Contact Map
1oedC 1 0.6471 1 0.924 Contact Map
3j1zP 8 0.9765 1 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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